Data for Metabolic landscape remodeling in dystrophic muscle through glucocorticoid steroid regimens (Study ST001256)
(Analysis AN002085)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 |
---|---|---|---|
2,3-Diphosphoglyceric acid | 1.2200 | 1.2623 | 0.5176 |
2^-Deoxyguanosine 5^-monophosphate | NA | NA | NA |
2-Ketobutyric acid | 0.7547 | 1.4651 | 0.7803 |
3-Phosphoglyceric acid | 1.2207 | 1.2948 | 0.4845 |
4,5-Dihydroorotic acid | 0.9985 | NA | 1.0022 |
4-Hydroxyproline | 0.8304 | 1.1689 | 1.0007 |
5-Aminolevulinic acid | 0.8062 | 1.6051 | 0.5887 |
5-Thymidylic acid | NA | 1.0000 | NA |
6-Phosphogluconic acid | 0.8497 | 1.5765 | 0.5738 |
6-Phosphonoglucono-D-lactone | NA | 1.2375 | 0.7625 |
Acetoacetic acid | 1.0508 | 1.3617 | 0.5875 |
Acetylcholine | 0.8343 | 1.1215 | 1.0442 |
Adenine | 0.9112 | 1.3664 | 0.7224 |
Adenosine | 0.9817 | 0.9864 | 1.0319 |
Adenylsuccinic acid | 0.6919 | 1.2146 | 1.0934 |
ADP | 1.2613 | 0.8593 | 0.8794 |
ADP-glucose | 0.7522 | 1.2407 | 1.0071 |
AICAR | 1.2275 | 1.4700 | 0.3026 |
Allantoin | 0.8322 | 1.0819 | 1.0860 |
Alpha-ketoisovaleric acid | 0.7223 | 1.5835 | 0.6943 |
AMP | 0.3713 | 0.6170 | 2.0117 |
Anandamide | NA | NA | NA |
Argininosuccinic acid | 1.0570 | 1.2223 | 0.7207 |
ATP | 0.5324 | 0.8511 | 1.6166 |
Betaine | 0.8627 | 1.0014 | 1.1359 |
Carbamoyl phosphate | 0.8214 | 0.7231 | 1.3959 |
CDP | 1.1522 | 0.9731 | 0.8747 |
Choline | 0.7624 | 1.1137 | 1.1239 |
cis-Aconitic acid | 0.6695 | 1.1637 | 1.1669 |
Citric acid | 0.4694 | 1.2799 | 1.2507 |
Citrulline | 1.0663 | 1.0818 | 0.8520 |
Creatine | 0.9878 | 0.9932 | 1.0190 |
Creatinine | 0.7110 | 0.9739 | 1.3151 |
Cytidine | 0.7318 | 1.1473 | 1.1209 |
Cytidine monophosphate | 0.7764 | 1.1436 | 1.0800 |
Cytidine triphosphate | NA | NA | NA |
Cytosine | 1.0284 | 1.0361 | 0.9354 |
D-4^-Phosphopantothenate | NA | NA | NA |
dCDP | 1.1253 | 0.9435 | 0.9312 |
dCMP | NA | 1.0000 | NA |
dCTP | NA | NA | NA |
Deoxyadenosine monophosphate | NA | NA | NA |
Deoxyadenosine triphosphate | NA | NA | NA |
Deoxyguanosine | 1.0000 | NA | NA |
Deoxyuridine triphosphate | NA | NA | NA |
D-Erythrose 4-phosphate | 1.1195 | 1.2854 | 0.5951 |
dGDP | NA | NA | NA |
D-Glyceraldehyde 3-phosphate | 1.2920 | 1.4862 | 0.2218 |
dGTP | NA | NA | NA |
Dihydroxyacetone phosphate | 1.0906 | 1.3494 | 0.5600 |
DL-O-Phosphoserine | 0.8202 | 1.1545 | 1.0253 |
Dopamine | 1.1004 | 0.9836 | 0.9160 |
D-Ribulose 5-phosphate | 1.2232 | NA | 0.7768 |
D-Sedoheptulose 7-phosphate | 0.7460 | 1.7997 | 0.4543 |
dUMP | NA | NA | NA |
Epinephrine | 0.8753 | 1.0544 | 1.1055 |
FAD | 1.0277 | 1.0545 | 0.9178 |
Flavin Mononucleotide | 0.7786 | 1.1313 | 1.2007 |
Fructose 1,6-bisphosphate | 1.3134 | 1.3807 | 0.3059 |
Fructose 1-phosphate | 1.3721 | 1.4949 | 0.1330 |
Fructose 6-phosphate | 1.3098 | 1.4865 | 0.2036 |
Fumaric acid | 0.8359 | 1.0590 | 1.1051 |
Galactonic acid | 0.8387 | 1.3790 | 0.7823 |
Gamma-Aminobutyric acid | 0.9472 | 1.2244 | 0.8284 |
Gluconic acid | 1.0744 | 1.0858 | 0.8398 |
Gluconolactone | 0.7926 | 1.3257 | 0.8817 |
Glucosamine | NA | NA | NA |
Glucosamine-1P | 1.2156 | 1.3506 | 0.1508 |
Glucosamine 6-phosphate | 1.1845 | 1.2822 | 0.2999 |
Glucose 6-phosphate | 1.4598 | 1.4218 | 0.1184 |
Glutathione | 1.1400 | 1.2605 | 0.5995 |
Glyceric acid | 1.3588 | 0.8789 | 0.7623 |
Glyceric acid 1,3-biphosphate | 1.1416 | 1.2503 | 0.6081 |
Glycerol 3-phosphate | 1.5056 | 1.1875 | 0.3069 |
Glycine | 0.9061 | 1.0161 | 1.0778 |
Guanine | 0.9201 | 0.9279 | 1.1521 |
Guanosine | 0.6708 | 0.9941 | 1.3351 |
Guanosine diphosphate | 0.9980 | 0.9770 | 1.0249 |
Guanosine monophosphate | 0.9116 | 1.1077 | 0.9807 |
Guanosine triphosphate | 1.1820 | 1.2424 | 0.5756 |
Histamine | 1.0835 | 0.8138 | 1.1027 |
Homocysteine | NA | 1.6565 | 0.5623 |
Hydroxypropionic acid | 1.1944 | 1.1021 | 0.7036 |
IDP | 0.5287 | 1.3142 | NA |
Inosine | 0.8771 | 1.0716 | 1.0513 |
Inosinic acid | 1.0212 | 0.9807 | 0.9982 |
Isocitric acid | NA | NA | NA |
L-2-Hydroxyglutaric acid | 0.6310 | 1.1575 | 1.2115 |
L-Alanine | 1.0215 | 1.0407 | 0.9378 |
L-Arginine | 1.0739 | 1.1310 | 0.7951 |
L-Asparagine | 0.7646 | 0.9688 | 1.2665 |
L-Aspartic acid | 0.8618 | 1.1264 | 1.0118 |
L-Carnitine | 0.5974 | 1.1820 | 1.2206 |
L-Cystathionine | 0.6071 | 1.0995 | 1.2934 |
L-Cysteine | 0.7570 | 2.0545 | 0.1885 |
L-Cystine | NA | NA | NA |
Levulinic acid | 0.7710 | 1.1397 | 1.0893 |
L-Glutamic acid | 1.4339 | 1.0733 | 0.4927 |
L-Glutamine | 1.1463 | 1.1402 | 0.7134 |
L-Histidine | 0.9884 | 0.9906 | 1.0210 |
L-Homoserine | 0.9344 | 1.0113 | 1.0543 |
L-Isoleucine | 1.7396 | 0.8589 | 0.4015 |
L-Kynurenine | 0.6808 | 1.1220 | 1.1972 |
L-Lactic acid | 0.6002 | 0.7916 | 1.6082 |
L-Leucine | 1.4848 | 1.0943 | 0.4209 |
L-Lysine | 0.9702 | 1.1117 | 0.9181 |
L-Methionine | 1.1497 | 1.0626 | 0.7877 |
L-Phenylalanine | 0.9651 | 1.1170 | 0.9179 |
L-Proline | 0.9328 | 1.1370 | 0.9302 |
L-Serine | 0.9231 | 1.0138 | 1.0630 |
L-Threonine | 0.9376 | 1.0132 | 1.0492 |
L-Tryptophan | 0.8068 | 1.2319 | 0.9614 |
L-Tyrosine | 0.9861 | 1.1117 | 0.9021 |
L-Valine | 1.4616 | 0.9876 | 0.5509 |
Maleic acid | 1.0824 | 1.0790 | 0.8387 |
Malic acid | 0.8508 | 1.0720 | 1.0772 |
Mevalonic acid | 0.8725 | 1.6095 | 0.5180 |
N-Acetylaspartylglutamic acid | 0.8946 | 0.5887 | 1.5167 |
N-Acetyl-b-D-galactosamine | NA | NA | 1.0000 |
N-Acetylgalactosamine | 0.5809 | 0.9977 | 1.2817 |
N-Acetylglucosamine 6-phosphate | 0.7923 | 1.4002 | 0.8076 |
N-Acetyl-L-alanine | 1.3504 | 0.9305 | 0.7190 |
N-Acetyl-L-aspartic acid | 1.0156 | 0.9229 | 1.0615 |
NAD | 0.3780 | 0.8306 | 1.7914 |
NADH | 0.7800 | 1.1307 | 1.0893 |
NADP | 0.9572 | 1.1565 | 0.8862 |
NADPH | NA | NA | 1.0000 |
Niacinamide | 0.9284 | 1.0013 | 1.0704 |
N-Methyltryptamine | 1.0696 | 0.9949 | 0.9355 |
Norepinephrine | 0.8712 | 1.0242 | 1.1046 |
Ornithine | 1.2022 | 1.0791 | 0.7188 |
Orotic acid | 0.9674 | 1.4478 | 0.5848 |
Orotidylic acid | NA | NA | NA |
Oxalacetic acid | 0.4957 | 0.7632 | 1.7411 |
Oxidized glutathione | 0.9226 | 1.0422 | 1.0352 |
Oxoglutaric acid | 0.5927 | 0.9290 | 1.4783 |
Pantothenic acid | 0.9312 | 0.9587 | 1.1101 |
Phenylethylamine | 1.0003 | 1.0611 | 0.9385 |
Phosphocreatine | 0.4654 | 0.9535 | 1.5811 |
Phosphoenolpyruvic acid | 1.0762 | 1.3013 | 0.6225 |
Phosphohydroxypyruvic acid | NA | 1.0000 | NA |
Phosphoribosyl pyrophosphate | NA | NA | NA |
Phosphorylcholine | 0.8572 | 1.3698 | 0.7731 |
p-Octopamine | 1.0368 | 1.0272 | 0.9361 |
p-Synephrine | 0.6424 | 1.2352 | 1.1224 |
Putrescine | 1.3251 | 1.1576 | 0.5173 |
Pyruvic acid | 0.6874 | 0.7615 | 1.5511 |
Ribose 1,5-bisphosphate | 0.9313 | 1.2594 | 0.8093 |
S-Adenosylhomocysteine | NA | NA | NA |
S-Adenosylmethionine | 1.0204 | 1.1698 | 0.8099 |
Serotonin | 0.9842 | 1.3142 | 0.7016 |
Spermidine | 0.2594 | 1.9627 | 0.7778 |
Spermine | 0.9861 | 1.0276 | 0.9863 |
Succinic acid | 0.8534 | 0.9804 | 1.1662 |
Succinic acid semialdehyde | 0.8280 | 1.1933 | 0.9787 |
Thiamine | 1.2187 | 1.1937 | 0.5876 |
Thymidine | 0.5945 | 1.2040 | 1.2015 |
Thymidine 5^-triphosphate | NA | NA | NA |
Thymine | NA | 1.1861 | 0.4417 |
total iron content | 0.9986 | 1.0203 | 0.9811 |
Tryptamine | 0.9441 | 1.1224 | 0.9335 |
Tyramine | 0.9962 | 0.9048 | 1.0990 |
Uracil | 0.5180 | 1.4849 | 0.9971 |
Ureidosuccinic acid | 0.8476 | 1.3758 | 0.6649 |
Uric acid | 1.3634 | 0.8537 | 0.7829 |
Uridine | 0.8637 | 1.1326 | 1.0037 |
Uridine 5^-diphosphate | 1.2217 | 0.9581 | 0.8202 |
Uridine 5^-monophosphate | 0.8232 | 1.2558 | 0.9210 |
Uridine diphosphate glucose | 0.6856 | 1.3063 | 1.0081 |
Uridine diphosphate-N-acetylglucosamine | 0.8080 | 1.3694 | 0.8226 |
Uridine triphosphate | 1.2596 | 1.1276 | 0.4192 |
Xanthine | 0.8304 | 1.2551 | 0.9145 |
Factors:
F1 | Treatment:daily prednisone |
F2 | Treatment:vehicle |
F3 | Treatment:weekly prednisone |