Data for Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses (Study ST001289)

(Analysis AN002142)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
10Z-Heptadecenoic acid 2.2357 0.3848 1.2429 0.1366
11(12)-EpETE 0.6875 1.0938 NA 1.2188
11-HETE 0.6966 1.3034 1.0787 0.9213
11Z,14Z-Eicosadienoic acid 0.6460 1.8016 0.3965 1.1559
12-HETE 0.5422 1.8684 0.6326 0.9567
12-Oxo-ETE 0.8120 1.1053 NA 1.0526
13,16,19-Docosatrienoic acid 1.2527 1.2311 0.8207 0.6955
13Z,16Z-Docosadienoic acid 0.5571 1.9515 0.3486 1.1428
14(15)-EpETE 0.7471 0.9113 NA 1.3136
15-Deoxy-delta-12,14-PGD2 1.3462 0.9818 0.6731 0.9989
15-Deoxy-delta-12,14-PGJ2 1.8933 1.8984 0.0959 0.1124
15S-HETE 0.1748 1.2037 1.8732 0.7484
20-HETE 1.0675 1.1637 0.7735 0.9953
22R-Hydroxycholesterol 1.3070 0.6915 1.2656 0.6291
2,3-Dinor-TXB2 0.8699 1.6810 0.7928 0.5873
24,25-Epoxycholesterol 1.3854 1.2628 0.3167 1.0439
24S-Hydroxycholesterol 3.1457 0.3486 0.2002 0.1319
25-Hydroxycholesterol 1.6238 0.7600 0.6797 0.3824
27-Hydroxycholesterol 1.4010 0.8727 0.6774 0.8337
4beta-Hydroxy-cholesterol 0.9043 1.1242 0.9413 1.0303
5,8,11-Eicosatrienoic acid 1.1221 1.3255 0.8233 0.7290
5-HETE 0.5259 0.9211 1.7976 0.7554
7,10,13,16,19-Docosapentaenoic acid 1.8085 0.6158 1.2421 0.3335
7alpha-Hydroxy-cholesterol 1.7619 0.8906 0.8405 0.5070
7-Dehydrocholesterol NA NA NA NA
7-Oxo-cholesterol NA NA NA NA
8(9)-EpETE NA NA NA 1.0000
8-HETE 0.6787 0.9660 1.8449 0.5104
Adrenic acid 0.6497 1.8730 0.4230 1.0542
alpha-Linolenic acid 1.3968 1.1575 0.7424 0.7033
Arachidic acid 1.2795 1.0915 0.9446 0.6844
Arachidonic acid 0.9831 1.1153 1.0441 0.8576
Arachidonoyl-EA 0.9995 1.1764 0.9150 0.9100
Behenic acid 1.6054 1.0023 0.8462 0.5461
Bishomo-gamma-linolenic acid 1.6318 0.9337 0.9028 0.5318
CE(14:0) 2.8838 0.1171 0.7724 0.0197
CE(14:1) 1.5884 0.0294 0.5826 0.0147
CE(16:0) 2.2897 0.5646 0.9549 0.1907
CE(16:1) 2.3182 0.2757 1.3523 0.0538
CE(16:2) 2.3270 0.1756 1.4735 0.0238
CE(18:0) 2.0456 0.6251 1.1829 0.1465
CE(18:1) 2.0923 0.5425 1.2768 0.0884
CE(18:2) 1.8823 0.8199 1.2022 0.0956
CE(20:0) 1.2998 0.6298 1.8631 0.2074
CE(20:1) 1.9019 0.6277 1.3455 0.1248
CE(20:2) 1.9201 0.8362 1.1075 0.1362
CE(20:4) 1.2995 1.1591 1.4516 0.0898
CE(22:1) 1.9560 0.5653 1.3849 0.0938
CE(22:6) 2.1472 0.5391 1.2636 0.0501
Cer(d18:0/16:0) 1.4567 0.7952 1.0772 0.6709
Cer(d18:0/18:0) 1.5149 0.9396 0.7937 0.7518
Cer(d18:0/20:0) 1.5016 1.1343 0.7220 0.6421
Cer(d18:0/22:0) 1.7206 0.8914 0.7831 0.6048
Cer(d18:0/24:0) 1.6483 0.7843 1.0349 0.5325
Cer(d18:0/24:1) 1.5522 0.7578 1.0826 0.6073
Cer(d18:0/26:0) 1.8056 0.5833 0.8125 0.5937
Cer(d18:0/26:1) 1.2944 0.9972 1.0126 0.6972
Cer(d18:1/16:0) 1.2462 0.9117 0.9595 0.8826
Cer(d18:1/18:0) 1.2728 1.0056 0.7443 0.9774
Cer(d18:1/20:0) 1.3219 0.9519 0.8525 0.8737
Cer(d18:1/22:0) 1.3428 0.9229 0.9134 0.8208
Cer(d18:1/24:0) 1.4217 0.9192 0.8435 0.8156
Cer(d18:1/24:1) 1.1039 0.9415 0.9897 0.9649
Cer(d18:1/26:0) 1.3093 0.8282 0.9897 0.8729
Cer(d18:1/26:1) 1.6604 0.6979 0.9945 0.6472
Cerotic acid 1.4440 1.0108 0.8087 0.7365
Cholestenone 2.3936 NA 0.8936 0.7851
Cholesterol 1.9866 0.7769 0.6242 0.6123
cis-Erucic acid 1.4034 0.9956 0.9797 0.6212
CL(68:4) 0.9474 NA 1.0526 NA
CL(68:5) 1.1337 NA 0.9383 0.3519
CL(70:4) 1.0353 0.8471 1.3176 0.8000
CL(70:5) 1.4444 0.5000 1.6667 0.3889
CL(70:6) 1.3388 0.7107 1.1570 0.7934
CL(72:4) 1.0000 NA 1.0000 NA
CL(72:5) 0.7294 1.1059 1.1529 1.0118
CL(72:6) 1.1348 0.8652 1.0787 0.9213
CL(72:7) 0.7238 1.2286 0.6476 1.4000
CL(72:8) 0.4297 1.4322 0.3478 1.7903
CL(74:6) 0.8333 1.0185 0.8333 1.1111
CL(74:7) 0.4819 1.6386 0.5301 1.3494
CL(74:8) 0.7582 1.1242 0.7320 1.3856
CL(74:9) 0.6624 1.2994 0.5605 1.4777
Coenzyme Q9 0.5271 1.3664 0.9447 1.1618
Desmosterol 2.3632 0.4726 0.5217 0.5533
DHA 1.6911 0.8507 0.9860 0.4723
Dolichol-18 1.2523 0.8598 1.1682 0.7196
Dolichol-19 1.1010 0.9199 1.1847 0.7944
Dolichol-20 1.0120 1.0120 1.1566 0.8193
EPA 2.6756 0.2858 0.9152 0.1234
gamma-Linolenic acid 1.6803 0.8731 0.9124 0.5343
GlcCer(d18:0/16:0) 1.0959 1.0416 0.8584 0.9883
GlcCer(d18:0/18:0) 0.6558 1.1655 1.4628 0.8653
GlcCer(d18:0/20:0) 0.7138 0.7254 1.8939 0.6752
GlcCer(d18:0/22:0) 1.3354 0.6751 0.9675 0.9715
GlcCer(d18:0/24:0) 1.4804 0.2328 1.0452 0.9534
GlcCer(d18:0/24:1) 0.9505 0.9324 0.8639 1.2990
GlcCer(d18:0/26:0) 1.6364 0.2778 1.0343 0.3636
GlcCer(d18:0/26:1) 0.5159 0.9630 1.1349 1.2587
GlcCer(d18:1/16:0) 0.9380 1.0442 1.0384 0.9795
GlcCer(d18:1/18:0) 0.8510 0.9935 1.2227 0.9328
GlcCer(d18:1/20:0) 0.8953 1.1534 1.0616 0.8898
GlcCer(d18:1/22:0) 1.0337 1.0193 1.0345 0.9125
GlcCer(d18:1/24:0) 1.0344 1.1086 0.9332 0.9238
GlcCer(d18:1/24:1) 0.8665 1.0850 1.0281 1.0204
GlcCer(d18:1/26:0) 0.9087 0.9765 0.9222 1.1901
GlcCer(d18:1/26:1) 0.7965 1.0808 1.0010 1.1217
Lanosterol 1.8938 0.6284 0.8904 0.7861
Lauric acid 1.9316 0.3694 1.1101 0.5889
Lignoceric acid 1.5161 1.0506 0.8188 0.6145
Linoleic acid 1.0266 1.4298 0.6102 0.9333
LTE4 1.2218 0.8238 1.0079 0.9465
Margaric acid 1.6556 0.7336 1.0894 0.5214
Myristic acid 1.8385 0.5489 1.2018 0.4107
Nervonic acid 1.5544 1.0175 0.8212 0.6069
Oleic acid 1.1302 0.9622 1.0753 0.8324
PA(32:0) 0.8899 1.0492 0.7260 1.3348
PA(32:1) 1.6638 0.5719 1.2340 0.5303
PA(34:0) 1.0354 0.9663 0.6476 1.3508
PA(34:1) 1.0036 0.8034 1.0763 1.1167
PA(34:2) 1.0111 0.8557 1.0012 1.1319
PA(36:0) 0.8573 0.8950 1.2310 1.0167
PA(36:1) 0.9814 0.9328 0.9374 1.1484
PA(36:2) 0.7665 0.9715 0.9364 1.3256
PA(36:3) 0.9990 0.7799 1.0809 1.1402
PA(36:4) 0.8507 1.1013 0.9188 1.1292
PA(38:2) 0.8082 0.8855 1.2149 1.0914
PA(38:3) 1.0165 0.9432 1.0428 0.9974
PA(38:4) 0.8569 1.1831 0.7903 1.1696
PA(40:3) 0.6882 1.2611 0.6812 1.3694
PA(40:4) 0.4754 1.6114 0.4771 1.4362
PA(40:5) 1.0315 1.0197 1.0457 0.9031
PA(40:6) 1.2544 0.8408 1.0147 0.8901
Palmitic acid 1.4381 0.8213 1.1276 0.6131
Palmitoleic acid 2.0389 0.4595 1.2531 0.2485
PC(32:0) 0.9895 1.0994 0.8520 1.0591
PC(32:1) 1.4480 0.7652 1.1526 0.6342
PC(32:2) 1.5435 0.6012 1.2541 0.6012
PC(34:0) 1.0606 0.9468 1.0462 0.9463
PC(34:1) 1.1666 0.9686 0.9184 0.9465
PC(34:2) 1.0909 1.0529 0.7535 1.1027
PC(34:3) 1.2751 0.9231 0.9153 0.8866
PC(36:0) 1.1955 0.8234 1.2312 0.7499
PC(36:1) 1.2185 0.9445 1.0224 0.8147
PC(36:2) 0.4374 1.0840 1.1946 1.2840
PC(36:3) 1.0205 1.0828 0.7508 1.1459
PC(36:4) 1.0973 1.1828 0.6456 1.0743
PC(38:2) 1.0523 0.8256 1.0812 1.0409
PC(38:3) 0.9816 1.0488 0.8556 1.1141
PC(38:4) 1.0377 1.0246 0.7370 1.2007
PC(38:5) 1.2053 0.9189 1.0020 0.8737
PC(38:6) 1.2842 0.9551 0.9303 0.8304
PC(40:3) 0.7880 1.0175 0.8783 1.3161
PC(40:4) 0.6203 1.1875 0.6993 1.4930
PC(40:5) 0.8984 0.9355 0.9353 1.2308
PC(40:6) 1.2491 0.8076 1.1221 0.8212
PC(P-36:0)/PC(O-36:1) 1.2024 0.6570 1.3375 0.8031
PC(P-36:1)/PC(O-36:2) 1.1833 0.7457 1.1775 0.8935
PC(P-36:2)/PC(O-36:3) 1.0758 0.9804 0.9012 1.0427
PC(P-36:3)/PC(O-36:4) 1.1014 1.1330 0.7250 1.0406
PC(P-36:4)/PC(O-36:5) 1.2999 0.9687 0.9325 0.7989
PC(P-38:1)/PC(O-38:2) 1.0606 0.7430 1.2471 0.9493
PC(P-38:2)/PC(O-38:3) 0.9712 0.9057 1.0420 1.0811
PC(P-38:4)/PC(O-38:5) 1.1068 1.0344 0.8383 1.0205
PC(P-38:5)/PC(O-38:6) 1.4658 0.7571 1.0601 0.7170
PE(32:0) 1.0670 1.0328 0.8813 1.0189
PE(32:1) 1.7794 0.5323 1.1931 0.4952
PE(32:2) 1.4922 0.5873 1.3259 0.5946
PE(34:0) 1.0623 0.9515 1.0670 0.9192
PE(34:1) 1.1480 0.8877 1.0759 0.8885
PE(34:2) 1.1736 0.9182 0.9397 0.9684
PE(36:1) 1.1428 0.9751 0.8946 0.9876
PE(36:2) 1.0740 0.9796 0.9446 1.0018
PE(36:3) 1.1202 0.9377 0.9483 0.9938
PE(36:4) 1.1534 0.9849 0.8874 0.9743
PE(38:3) 1.0625 1.0580 0.7984 1.0811
PE(38:4) 1.0185 1.1455 0.6734 1.1625
PE(38:5) 1.5261 0.7454 1.0163 0.7122
PE(38:6) 1.4726 0.8489 0.8762 0.7740
PE(40:5) 1.0342 1.0823 0.8145 1.0690
PE(40:6) 1.3045 0.9328 0.8542 0.9085
Pentadecylic acid 2.0569 0.3860 1.2728 0.2844
PE(O-32:0) 1.4764 0.8301 0.8685 0.8251
PE(P-36:0)/PE(O-36:1) 1.2657 0.6578 1.3228 0.7537
PE(P-36:1)/PE(O-36:2) 1.1444 0.7007 1.2885 0.8664
PE(P-36:2)/PE(O-36:3) 1.0394 0.7472 1.2781 0.9353
PE(P-36:3)/PE(O-36:4) 0.8459 1.0342 1.0816 1.0383
PE(P-36:4)/PE(O-36:5) 0.8618 1.0765 0.9578 1.1039
PE(P-38:1)/PE(O-38:2) 1.2105 0.7024 1.2942 0.7929
PE(P-38:2)/PE(O-38:3) 1.0342 0.8557 1.1717 0.9385
PE(P-38:4)/PE(O-38:5) 0.8319 1.1065 0.9288 1.1328
PG(34:2) 2.4656 0.3991 0.6922 0.4430
PG(36:1) 2.1369 0.3700 0.8364 0.6566
PG(36:2) 1.3014 0.6844 1.2633 0.7508
PG(36:3) 1.2717 0.9326 0.7992 0.9966
PG(38:2) 1.7048 0.5143 0.9330 0.8478
PG(38:3) 1.6497 0.6017 0.8637 0.8848
PG(38:4) 1.7995 0.6753 0.7900 0.7352
PG(38:5) 1.6124 0.9630 0.5536 0.8710
PG(40:4) 1.3587 1.6577 0.3933 0.8085
PG(40:5) 0.9920 0.9241 0.7046 1.3793
PG(40:6) 1.4263 0.7610 0.8526 0.9601
PG(40:7) 2.0502 0.5769 0.6892 0.6836
PG(40:8) 1.5647 0.9179 0.5158 1.0016
PGD2 0.3278 1.3731 1.5604 0.7387
PGE2 0.2547 1.9494 1.0466 0.7493
PGJ2 1.1382 1.2969 0.2955 1.2695
PI(34:1) 1.0688 0.8927 1.1590 0.8795
PI(34:2) 0.9736 1.0115 1.0062 1.0086
PI(36:0) 1.0461 0.8325 1.2816 0.8398
PI(36:1) 0.9253 0.9775 1.1052 0.9920
PI(36:2) 0.8138 1.1601 0.9073 1.1188
PI(36:3) 0.8248 1.1384 0.8685 1.1683
PI(36:4) 1.0455 1.1460 0.8102 0.9984
PI(36:5) 1.3550 0.6588 1.3263 0.6600
PI(38:1) 0.3895 0.9179 1.4785 1.1378
PI(38:2) 1.1542 0.5556 1.7155 0.5747
PI(38:3) 1.1597 0.7654 1.3141 0.7608
PI(38:4) 0.9616 1.0938 0.8881 1.0566
PI(38:5) 1.2281 0.7730 1.2603 0.7385
PI(38:6) 1.2959 0.7494 1.3033 0.6514
PI(40:3) 0.8471 1.0673 0.8404 1.2452
PI(40:4) 0.5539 1.3941 0.6116 1.4405
PI(40:5) 0.9283 0.9032 1.2207 0.9477
PI(40:6) 1.0750 0.8545 1.2569 0.8135
PI(40:7) 1.0058 0.8353 1.3560 0.8029
PS(32:0) 0.6860 1.2179 0.8058 1.2903
PS(32:1) 1.3139 0.6660 1.4083 0.6118
PS(34:0) 0.6943 1.2167 0.8369 1.2521
PS(34:1) 1.0345 0.9050 1.1011 0.9593
PS(34:2) 1.0057 0.9307 1.0317 1.0318
PS(36:0) 0.8013 1.0275 1.2517 0.9194
PS(36:1) 0.9484 1.0391 0.9971 1.0153
PS(36:2) 0.7971 1.1396 0.8079 1.2554
PS(36:3) 1.1374 0.7891 1.2360 0.8375
PS(36:4) 0.9948 1.0653 0.8894 1.0506
PS(38:0) 0.8356 1.0001 1.2526 0.9117
PS(38:1) 0.9823 1.0058 1.0058 1.0061
PS(38:2) 0.7320 1.0372 1.1258 1.1049
PS(38:3) 0.9391 1.0298 1.1051 0.9260
PS(38:4) 0.7851 1.3353 0.7634 1.1162
PS(38:5) 1.1764 0.7522 1.3412 0.7301
PS(40:2) 0.7847 1.0509 1.2909 0.8734
PS(40:3) 0.5739 1.5801 0.8044 1.0416
PS(40:4) 0.3378 1.8036 0.4678 1.3908
PS(40:5) 0.8413 1.0343 1.2467 0.8776
PS(40:6) 1.0018 0.9553 1.2109 0.8320
PS(40:7) 1.1666 0.6823 1.5512 0.5998
SM(d18:0/16:0) 1.0975 0.9694 0.9561 0.9769
SM(d18:0/18:0) 1.1184 0.9048 1.0416 0.9352
SM(d18:0/20:0) 1.1281 1.0130 0.9304 0.9285
SM(d18:0/22:0) 1.2915 0.9459 0.8597 0.9029
SM(d18:0/24:0) 1.1994 1.0242 0.8664 0.9100
SM(d18:0/24:1) 1.0970 1.0313 0.8714 1.0003
SM(d18:0/26:0) 1.0126 1.1357 0.8112 1.0406
SM(d18:0/26:1) 0.9404 1.1024 0.8706 1.0866
SM(d18:1/16:0) 1.0609 1.0393 0.9376 0.9622
SM(d18:1/18:0) 1.1267 0.9468 1.0100 0.9164
SM(d18:1/20:0) 1.2797 0.9380 0.9133 0.8690
SM(d18:1/22:0) 1.2364 0.9763 0.9125 0.8748
SM(d18:1/24:0) 1.0779 1.0623 0.8660 0.9939
SM(d18:1/24:1) 0.9795 1.1095 0.8827 1.0283
SM(d18:1/26:0) 0.9688 1.0999 0.8398 1.0915
SM(d18:1/26:1) 0.9797 1.0967 0.8505 1.0730
Sphinganine 1.4905 0.6651 1.1909 0.6162
Sphinganine-1-phosphate 1.0365 0.9532 1.2004 0.8048
Sphingosine 1.1786 0.8764 1.1383 0.7930
Sphingosine-1-phosphate 0.9710 0.9960 1.0869 0.9457
Stearic acid 1.2373 1.0542 0.9264 0.7820
Stearidonic acid 1.9679 0.4685 1.0776 0.4217
Tricosanoic acid 1.8102 0.7942 0.9051 0.4905
TXB2 0.3745 0.9527 1.5474 1.1254
Zymosterol 3.1288 0.3786 0.1536 0.1738
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Factors:

F1Genotype:LDLR-KO | Diet:High fat
F2Genotype:LDLR-KO | Diet:Normal
F3Genotype:Wild type | Diet:High fat
F4Genotype:Wild type | Diet:Normal
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