Data for Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran (Study ST001299)
(Analysis AN002163)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 2,3-Dihydroxybenzoic acid | 1.0466 | 0.9172 | 1.0362 |
| 2-Aminooctanoic acid | 0.6369 | 0.7540 | 1.6091 |
| 2-Isopropylmalic acid | 1.4136 | 0.8922 | 0.6943 |
| 2-Keto-D-gluconate | 1.5385 | 0.7627 | 0.6988 |
| 2-Keto-isovalerate | 1.4632 | 0.9232 | 0.6136 |
| 3-Hydroxybutyric acid | 0.9097 | 1.0517 | 1.0386 |
| 3-Methylphenylacetic acid | 0.7726 | 0.8509 | 1.3765 |
| 3-Phosphoglycerate | 1.6882 | 0.6913 | 0.6205 |
| 3-Phospho-serine | 1.2569 | 0.9076 | 0.8026 |
| 3-S-Methylthiopropionate | 2.1499 | 0.5192 | 0.1078 |
| 4-Aminobutyrate | 0.9817 | 1.1200 | 0.8983 |
| 4-Hydroxyphenyllactate | 1.2958 | 0.8515 | 0.8527 |
| 4-Phosphopantothenate | 1.5466 | 0.6018 | 0.8219 |
| 4-Pyridoxic acid | 1.1774 | 0.9630 | 0.8596 |
| 5-Methoxytryptophan | 1.0293 | 0.9116 | 1.0710 |
| 6-Phospho-D-gluconate | 1.8106 | 0.3347 | 0.7821 |
| Acetoacetate | 1.0221 | 0.8992 | 1.0787 |
| Acetyl-aspartate | 1.2341 | 0.9999 | 0.7660 |
| Acetyl-glycine | 0.9780 | 1.1874 | 0.8346 |
| Acetyllysine | 1.2058 | 1.0401 | 0.7542 |
| Aconitate | 1.2749 | 0.8753 | 0.8498 |
| Adenosine | 1.0192 | 1.1104 | 0.8444 |
| Alanine/Sacrosine | 0.8785 | 1.1549 | 0.9666 |
| Alpha-ketoglutarate | 1.2614 | 1.0651 | 0.6735 |
| Aminoadipic acid | 1.0690 | 1.0097 | 0.9213 |
| AMP | 0.8872 | 0.7052 | 1.4076 |
| Anthranilate | 1.1006 | 0.8734 | 1.0260 |
| Ascorbic acid | 1.1239 | 1.0844 | 0.7917 |
| Asparagine | 0.7095 | 1.5933 | 0.6972 |
| Aspartate | 0.8249 | 1.1387 | 1.0364 |
| Asp-Leu-His (DLH) | 0.9002 | 1.1213 | 0.9742 |
| Asp-Leu/Ile-Ser (DLS) | 0.9640 | 1.0325 | 1.0042 |
| ATP | 1.1756 | 0.9043 | 0.9010 |
| CDP | 1.3740 | 0.7648 | 0.8333 |
| Chlorpropamide | 1.0003 | 1.0498 | 0.9399 |
| Citraconic acid | 0.9819 | 1.0281 | 0.9901 |
| Citrate/isocitrate | 1.0821 | 1.0100 | 0.9079 |
| Citrulline | 1.0824 | 1.3471 | 0.5705 |
| CMP | 1.0139 | 0.9082 | 1.0936 |
| CTP | NA | NA | 1.0000 |
| Cystathionine | 0.8695 | 1.1652 | 0.9584 |
| Cytosine | 1.2518 | 0.8486 | 0.8996 |
| dAMP | 0.6236 | 0.6472 | 1.8751 |
| dCMP | 0.7832 | 0.7350 | 1.4818 |
| Deoxyinosine | 2.0480 | 0.5689 | 0.1734 |
| Deoxyribose-phosphate | 0.9842 | 0.6210 | 1.3948 |
| dGDP | 1.2425 | 0.7588 | 0.9986 |
| Dihydroorotate | 0.6466 | 1.3504 | 1.0030 |
| Dihydroxy-acetone-phosphate | 1.5841 | 0.5411 | 0.8748 |
| D-Sedoheptulose-1/7-phosphate | 1.9304 | 0.3194 | 0.7502 |
| dTMP | 0.8736 | 0.6082 | 1.6219 |
| Erythrose-4-phosphate | 1.9955 | 0.3628 | 0.6417 |
| FMN | 1.8354 | 0.5080 | 0.5879 |
| Folate | 1.2421 | 0.8272 | 0.9168 |
| Fructose-1,6-bisphosphate | 1.4855 | 0.6852 | 0.5538 |
| Fructose-6-phosphate | 1.8823 | 0.4594 | 0.6583 |
| Fumarate | 0.6168 | 1.2404 | 1.1428 |
| GDP | 1.2886 | 0.8166 | 0.8948 |
| Glucarate | 1.2219 | 0.9300 | 0.8480 |
| Gluconate | 1.3584 | 0.9071 | 0.7345 |
| Glucono-_-lactone | 1.5767 | 0.9335 | 0.4898 |
| Glucose | 1.1923 | 1.0511 | 0.7566 |
| Glucose-1/6-phosphate | 1.9815 | 0.3356 | 0.6829 |
| Glutamate | 0.9833 | 1.0998 | 0.9169 |
| Glutamine | 1.0126 | 0.9925 | 0.9950 |
| Glutathione | 0.7461 | 0.8665 | 1.3873 |
| Glycine | 0.8190 | 1.1739 | 1.0071 |
| GMP | 1.1619 | 0.7546 | 1.1002 |
| GTP | 1.4548 | NA | 0.5452 |
| Guanine | 0.9778 | 0.9493 | 1.0875 |
| Histidine | 0.9316 | 1.0653 | 1.0031 |
| Hydroxyisocaproic acid | 1.1272 | 0.7784 | 1.0943 |
| Hydroxyphenylacetic acid | 1.0904 | 0.8892 | 1.0204 |
| Hydroxyproline/Aminolevulinate | 1.3815 | 0.6523 | 0.9663 |
| Ile-Asp-Ser (IDS) | 1.2099 | 0.8706 | 0.9034 |
| IMP | 1.4181 | 0.7337 | 0.8179 |
| Indole-3-carboxylic acid | 1.1442 | 1.0034 | 0.8524 |
| Inosine | 1.2675 | 0.8867 | 0.8458 |
| Ketoleucine | 0.7771 | 0.8489 | 1.3740 |
| Lactate | 1.0671 | 0.9463 | 0.9866 |
| Leu-Asp (LD) | 1.0694 | 0.9347 | 0.9959 |
| Leucine/Isoleucine | 0.7172 | 1.2544 | 1.0284 |
| Lysine | 0.9193 | 1.1453 | 0.9354 |
| Malate | 0.9042 | 1.0919 | 1.0039 |
| Maleic acid | 1.1118 | 0.5684 | 1.3198 |
| Methionine | 1.8288 | 1.0222 | 0.1490 |
| N-Acetyl-glucosamine-1/6-phosphate | 1.6070 | 0.4629 | 0.9161 |
| N-Acetyl-glutamate | 1.0523 | 1.0622 | 0.8855 |
| N-Acetyl-glutamine | 1.1087 | 1.0778 | 0.8135 |
| N-Acetyl-L-ornithine | 0.6855 | 1.0101 | 1.3044 |
| N-Carbamoyl-L-aspartate | 1.0702 | 1.1086 | 0.8212 |
| Nicotinate | 1.1475 | 0.9702 | 0.8823 |
| O-Acetyl-serine | 1.2522 | 1.0304 | 0.7174 |
| Ornithine | 0.6149 | 1.7782 | 0.6069 |
| Orotate | 1.0785 | 1.1937 | 0.7278 |
| Oxaloacetate | 1.0683 | 0.9637 | 0.9679 |
| p-Aminobenzoate | 1.0355 | 1.0235 | 0.9410 |
| Pantothenate | 0.8810 | 1.2343 | 0.8847 |
| Phenyllactic acid | 0.9329 | 1.0281 | 1.0390 |
| Phenylpyruvate | 1.1539 | 1.0369 | 0.8092 |
| Phosphoenolpyruvate | 1.6334 | 0.7192 | 0.6474 |
| Pipecolic Acid | 0.8048 | 2.0970 | 0.0982 |
| Prephenate | 1.2060 | 0.7705 | 1.0235 |
| Pro-Glu (PE) | 0.9410 | 1.0757 | 0.9833 |
| Proline | 0.8137 | 1.1783 | 1.0080 |
| Pyridoxamine | 1.0857 | 0.8652 | 1.0491 |
| Pyridoxine | 0.9650 | 1.2770 | 0.7580 |
| Pyroglutamic acid | 0.9373 | 1.1262 | 0.9364 |
| Pyruvate | 1.2429 | 1.0801 | 0.6770 |
| Quinolinate | 1.1818 | 0.9421 | 0.8761 |
| Riboflavin | 1.0608 | 0.9707 | 0.9621 |
| Ribose | 1.0807 | 1.1254 | 0.7939 |
| Ribose-5-phosphate | 1.6355 | 0.5070 | 0.8575 |
| Ribulose-5-phosphate | 1.6623 | 0.3845 | 0.9438 |
| Ser-Asp (SD) | 0.9265 | 0.9411 | 1.1589 |
| Serine | 0.7888 | 1.2044 | 1.0068 |
| Ser-Leu/Ile-Asp (SID) | 1.0080 | 1.0895 | 0.9025 |
| sn-Glycerol-3-phosphate | 1.2948 | 0.6720 | 1.0332 |
| Succinate/Methylmalonic acid | 1.1492 | 0.9834 | 0.8674 |
| Taurine | 1.0736 | 0.9209 | 1.0055 |
| Thiamine | 0.8697 | 1.0708 | 1.0715 |
| Threonine/Homoserine | 0.9044 | 1.2010 | 0.8946 |
| Trehalose-6-Phosphate | 1.2881 | 0.8430 | 0.8427 |
| Trehalose/Sucrose | 1.3323 | 0.9134 | 0.7542 |
| Tryptophan | 0.7927 | 1.1989 | 1.0083 |
| UDP | 1.1879 | 0.8837 | 0.9140 |
| UDP-D-glucose | 1.4332 | 0.6720 | 0.8422 |
| UDP-N-acetyl-glucosamine | 1.4839 | 0.7519 | 0.6463 |
| UMP | 1.0845 | 0.8765 | 1.0468 |
Factors:
| F1 | Treatment:Control |
| F2 | Treatment:High Dose TCDF |
| F3 | Treatment:Low Dose TCDF |
