Data for Examination of labeled glucose utilization in central carbon metabolism in HeLa cells post WNT stimulation (Study ST001320)

(Analysis AN002196)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
3-phosphogylcerate/2-phosphogylcerate 0.8075 1.0499 0.8339 1.3087
5^-methylthioadenosine 0.8938 1.1300 0.9563 1.0198
6-phosphogluconic-acid 1.0498 0.9703 1.0023 0.9776
acetyl-carnitine 0.9256 1.0192 0.9867 1.0684
ADP 0.9091 0.8997 1.0569 1.1344
AMP 1.1321 0.7813 1.1307 0.9560
carnitine 1.0559 0.9679 1.0254 0.9508
CDP 0.8220 0.8466 1.2597 1.0717
choline 0.7060 0.8756 1.0301 1.3882
citrate/isocitrate 0.7370 0.8658 1.0617 1.3355
citrulline 0.8054 0.9013 1.0536 1.2397
creatinine 0.8579 0.8083 1.2594 1.0744
CTP 1.0028 1.1256 0.8761 0.9956
cystathionine 1.1107 1.0575 0.9284 0.9035
dihydroxyacetone-phosphate 1.2102 0.7063 0.4983 1.5574
folic acid 0.5647 0.6255 1.2940 1.5158
fructose 0.7180 0.8336 1.0688 1.3797
fumarate 1.0001 0.9228 1.0468 1.0302
glucose 0.7087 0.8888 1.0468 1.3557
glycero-phospho-choline 0.9779 1.0288 0.9429 1.0503
glycine 0.9461 0.9891 0.9595 1.1052
GSH 1.0244 1.1486 0.9217 0.9053
GSSH 1.0096 0.9712 0.9303 1.0889
hexose-phosphate 1.0310 0.9214 1.0949 0.9526
hydroxyglutaric acid 0.4701 0.6261 1.3689 1.5348
hydroxyproline 0.8975 0.9681 0.9811 1.1532
hypotaurine 1.0623 1.0836 0.8770 0.9771
lactate 0.6784 0.8647 1.0639 1.3929
L-arginine 0.6807 0.8702 1.0599 1.3892
L-asparagine 1.2004 0.8691 1.0705 0.8600
L-aspartic acid 1.2638 0.8183 1.1797 0.7382
L-glutamic acid 1.0193 0.9936 1.0072 0.9799
L-glutamine 0.8694 0.9493 0.9930 1.1883
L-histidine 0.8362 0.9686 0.9706 1.2247
L-homocysteic acid 0.8745 0.9937 0.9889 1.1429
L-kynurenine NA 0.7687 1.0172 1.4455
L-leucine/ L-isoleucine 0.8470 0.9932 0.9806 1.1792
L-lysine 0.6826 0.8650 1.0709 1.3814
L-methionine 0.8266 0.9510 0.9746 1.2477
L-proline 0.9905 1.0288 0.9480 1.0327
L-serine 0.8761 0.9796 0.9678 1.1765
L-threonine 0.8861 0.9695 0.9804 1.1639
L-tryptophan 0.8416 0.9401 1.0027 1.2156
L-tyrosine 0.8474 0.9442 1.0052 1.2032
L-valine 0.8538 0.9595 0.9956 1.1910
malate 1.0204 0.8835 1.0846 1.0115
methyl-histidine 0.8066 0.9421 1.0254 1.2259
NAD+ 0.9977 1.0528 0.9249 1.0246
ornithine 0.7427 0.8680 1.0591 1.3302
phospho-choline 0.9900 1.0178 0.9685 1.0237
phosphocreatine 0.9542 1.0665 0.9098 1.0695
phosphorylethanolamine 0.7179 1.2140 0.8921 1.1760
phospho-serine 0.8412 1.0821 0.7606 1.3160
propionyl-carnitine 0.7655 1.1154 0.8521 1.2670
pyridoxine 0.6595 0.8285 1.1473 1.3647
ribose-5-phosphate NA 0.8937 1.7757 0.4369
S-adenosyl-methionine 0.8335 1.2478 0.7732 1.1455
sedoheptulose-7-phosphate 1.0510 1.0358 0.8071 1.1061
sorbitol / mannitol 0.7497 0.8910 1.0355 1.3238
stearic-acid 0.9244 0.8328 1.1422 1.1006
succinate 0.8021 1.0695 0.9415 1.1869
taurine 0.9930 1.0614 0.9159 1.0297
triflate 0.9411 1.0354 0.9637 1.0599
UDP-N-acetyl-glucosamine 1.1531 0.8753 1.0346 0.9370
uric acid 0.5695 0.8238 1.0753 1.5315
UTP 1.0814 1.0094 0.9295 0.9797
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Factors:

F1Treatment:vehicle | Treatment_Time(min):20
F2Treatment:vehicle | Treatment_Time(min):60
F3Treatment:wnt | Treatment_Time(min):20
F4Treatment:wnt | Treatment_Time(min):60
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