Data for SS-31 and NMN: Two Paths to Improve Metabolism and Function in Aged Hearts (Study ST001329)

(Analysis AN002215)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5
1/3-Methylhistidine 1.1205 1.1373 1.0269 0.9911 0.7542
1-Methyladenosine 1.0145 0.9317 1.0661 0.8918 1.0496
1-methylguanidine 0.9836 0.8777 1.0735 0.9471 1.0786
1-Methylhistamine 1.0397 0.9266 1.0207 0.9735 1.0217
1-methylnicotinamide 1.5705 0.6898 0.6898 1.7279 0.5605
2/3-Phosphoglyceric Acid 1.0977 1.0519 0.9557 1.0400 0.8848
2-aminoisobutyric acid 0.9361 0.9510 1.1872 0.9678 0.9337
2^-deoxycytidine 0.9780 1.0246 1.0500 0.9436 0.9872
2-hydroxybutyrate 1.0427 0.9054 0.8796 1.2639 0.9841
2-Hydroxyglutarate 1.0023 1.0569 1.0696 1.0851 0.8242
3HBA 1.1126 0.8618 0.8759 1.0299 1.1161
3-hydroxyisovaleric acid 1.1297 0.8191 1.0392 1.0372 0.9680
3-Indoxyl Sulfate 1.3478 1.0386 0.8290 1.2588 0.6476
5-Aminovaleric Acid 1.0353 0.7298 1.0436 0.9811 1.1618
5-methylcytidine 0.8893 0.7883 1.2752 0.9708 1.0222
5^-methylthioadenosine 0.9115 0.9405 0.9103 0.9711 1.2397
6-Methyladenosine 0.9780 0.8707 1.2683 0.7307 1.0391
6-phosphogluconic acid 0.9758 1.0284 0.8584 1.1682 1.0281
7-methylguanine 1.0547 0.9297 1.0165 1.1444 0.8957
Acetylcarnitine 0.9514 0.8166 0.9745 1.1753 1.1060
Adenine 0.8964 0.8446 0.9110 1.0207 1.2995
Adenosine 1.5062 0.8363 0.7688 0.7845 1.0473
Adenylosuccinate 1.1546 1.0427 0.7469 1.0300 1.0558
ADP 0.9315 0.9187 0.9712 0.9380 1.2007
Alanine 0.9843 0.9692 0.9915 0.9966 1.0508
Allantoin 0.9790 1.0521 1.0417 0.9799 0.9476
Aminolevulinate 0.9909 0.9891 0.9853 0.9618 1.0575
AMP 1.0394 1.0217 0.7624 1.0919 1.1222
Anserine 0.8497 0.9516 0.7734 0.7797 1.5516
arabitol/xylitol 1.0575 1.0747 0.9714 0.9345 0.9573
Arachidonate 1.0528 1.0579 0.8184 1.0549 1.0484
Arginine 0.9638 0.9660 1.1082 0.9968 0.9554
Argininosuccinate 0.9214 0.9488 1.0851 0.9873 1.0380
Asparagine 0.9890 1.0435 1.0479 0.8901 0.9992
Aspartic Acid 0.9659 1.0193 0.9951 0.7813 1.1658
ATP 0.9551 0.9332 1.0264 1.0297 1.0505
beta alanine 0.9925 0.8116 0.7746 0.9119 1.4479
Betaine 1.0142 0.9885 0.9499 0.9318 1.0922
Betaine Aldehyde 0.9053 0.9529 1.0815 0.9622 1.0697
cAMP 1.1068 1.1914 0.8925 0.9432 0.8880
Carnitine 1.0067 0.9776 0.9619 1.0005 1.0502
Carnosine 0.7367 0.8946 0.7021 0.8270 1.7425
CDP 0.9759 0.9974 0.9854 0.9467 1.0744
Cholesteryl sulfate 0.9203 0.8672 0.9955 0.9344 1.2320
Choline 0.9176 0.9321 1.1094 0.9470 1.0580
Citrulline 0.9531 0.9121 0.9207 1.0223 1.1807
CMP 0.9655 0.9823 0.9384 0.9734 1.1257
Creatine 0.9937 0.9913 1.0182 0.9898 1.0016
Creatinine 0.9916 1.0354 0.9832 0.9519 1.0270
CTP 1.0202 1.0689 0.9743 1.0327 0.9279
Cystathionine 0.7822 1.0506 1.0519 0.8726 1.1905
Cystine 0.9698 1.5752 1.1656 0.8319 0.4947
Cytidine 0.9971 1.0671 1.0212 0.9877 0.9338
DCMP 0.7925 1.0876 0.3718 2.2771 0.8940
Deoxycarnitine 0.9682 1.0285 0.9246 0.9914 1.0865
Deoxyguanosine 0.9578 1.1712 1.0255 0.9064 0.9330
D-GA3P 1.1616 1.2655 0.9233 0.9932 0.7119
DHAP 1.1547 1.2383 0.9050 1.0083 0.7491
dimethylarginine (A/SDMA) 1.0710 0.9731 0.9720 0.9684 1.0064
Dimethylglycine 1.0313 0.9848 1.1622 0.8463 0.9242
Epinephrine 1.0352 0.9866 1.0608 1.0337 0.8957
Ergocalciferol 1.2606 0.7451 1.0315 0.8289 1.0560
erythronic acid 1.1566 1.2520 0.8532 0.6823 1.0050
Erythrose-4-phosphate 1.0668 1.2137 0.9649 1.2302 0.6424
ethanolamine 0.9009 0.9050 1.1123 1.0035 1.0554
Ethylmalonic acid 1.1107 0.8764 0.8527 0.9528 1.1802
F16BP/F26BP/G16BP 1.3718 1.3637 0.8581 0.8456 0.6010
FAD 0.9682 1.0038 0.9602 0.9929 1.0706
Fumaric Acid 1.0150 0.9952 0.9282 0.9908 1.0681
G1P/G6P/F6P/F1P 1.0729 1.1907 0.9826 1.2489 0.6257
gamma-Aminobutyrate 0.9374 0.9221 1.1724 1.0218 0.9354
Glucoronate 1.0494 0.9520 1.1069 1.0519 0.8531
Glucose 1.0461 1.0816 0.7796 1.3405 0.8831
Glutamic acid 0.9342 0.9490 1.0437 0.8955 1.1288
Glutamine 0.9948 0.9991 1.0283 0.9938 0.9813
glutarylcarnitine 0.9592 1.0657 0.9439 0.9416 1.0778
Glycerate 1.0643 0.9985 0.9706 1.0079 0.9665
Glycerol-3-P 1.1849 1.0125 1.0053 0.9576 0.8431
Glycerophosphocholine 1.0168 0.9745 0.8963 1.1614 1.0019
Glycine 0.9239 1.0471 1.0288 0.9830 1.0130
GMP 1.0185 1.0468 0.8859 1.0087 1.0523
GTP 1.0279 0.9564 1.0137 1.0518 0.9626
Guanidinoacetate 1.0560 0.9470 0.8797 1.1285 1.0275
Guanine 1.0204 1.0495 1.0180 0.9746 0.9390
Guanosine 0.9606 1.0495 1.1109 0.9411 0.9233
Histamine 1.0072 0.9851 0.9821 0.9998 1.0238
Histidine 0.9960 0.9818 1.0451 0.9950 0.9771
homoarginine 0.9779 0.9609 0.9807 0.9860 1.0815
homocitrulline 1.2434 0.7846 1.2349 0.9377 0.7630
Hydroxyproline 0.9888 1.0340 0.9570 0.9638 1.0490
Hypotaurine 0.9023 0.7735 0.8587 0.9893 1.4267
Hypoxanthine 0.9348 0.9319 1.1733 0.9694 0.9636
IMP 0.9411 1.0458 0.9069 1.0585 1.0699
indole-3-carboxylic acid 0.8644 0.9719 1.1531 1.1261 0.9106
Indole-3-Lactate 1.1236 1.0645 0.9557 1.0651 0.8339
Inosine 0.9664 0.9852 1.0380 1.0022 1.0038
Inositol 0.9630 0.9694 0.9969 1.0301 1.0424
iso-Leucine /allo-isoleucine 1.0343 0.9326 1.0647 1.0190 0.9473
isoValeric Acid /4-oxobutanoate/acetoacetate 0.8966 0.9175 0.8640 1.1499 1.1997
isovalerylcarnitine 1.1149 0.8730 1.0953 0.9832 0.9163
lactate 0.9861 0.9994 0.9842 1.0520 0.9944
Lactose/Trehalose 1.0948 1.1400 0.9931 1.2589 0.6307
Leucine /D-norleucine 1.0373 0.9543 1.0739 1.0500 0.8967
Linoleic Acid 1.1348 0.9869 0.8717 1.0414 0.9881
Linolenic Acid 1.1593 0.9632 0.8604 1.0446 0.9945
L-Kynurenine 1.1718 0.8130 1.0818 1.3025 0.7149
Lysine 1.0012 0.9681 1.0804 0.9869 0.9538
Malate 1.0076 0.9813 0.9628 0.9962 1.0484
Malondialdehyde 0.9834 0.7014 0.9248 0.9985 1.3402
mannitol 1.1694 0.8492 1.0665 0.8710 0.9899
Mannose 1.1348 1.1102 0.8585 1.2266 0.7750
Methionine 0.9987 0.7332 1.2438 1.0055 0.9761
methionine sulfoxide 1.0835 1.1914 1.4215 0.5428 0.6473
Methylmalonate 0.8467 1.0546 0.7567 1.3073 1.1335
Mevalonate 0.9235 0.9538 0.9999 0.9332 1.1532
N2,N2-Dimethylguanosine 1.1383 0.6269 1.2005 0.9655 1.0067
N6-Acetyl-lysine 0.9950 0.9855 1.0811 0.9704 0.9553
N6-Trimethyllysine 0.9433 0.9527 1.0306 0.9973 1.0627
N-Ac-Alanine 0.9904 0.9680 1.0799 1.0325 0.9339
N-Acetyl-aspartyl-glutamate (naag) 0.7784 1.3175 0.9346 0.9608 1.0300
N-AcetylGlycine 1.0991 0.8703 0.7713 1.3705 0.9989
N-Acetylneuraminate 1.0452 1.0053 0.9689 1.0898 0.9254
N-Ac-L-Glutamine 1.0589 0.9403 0.9343 1.0344 1.0386
N-Ac-Methionine 0.9615 0.6177 1.3557 1.0623 0.9567
NAD 1.0010 0.9621 0.9544 1.0464 1.0454
NADH 1.0036 1.0336 0.8792 0.9327 1.1344
NADP 1.1710 0.9050 0.9028 0.8825 1.0980
NADPH 0.9906 1.1230 0.8713 1.1532 0.9327
N-Carbamoyl-B-Alanine 1.0436 0.8796 1.0795 1.0653 0.9374
n-formylmethionine 0.9968 0.7209 1.0399 1.0712 1.1481
n-glycylproline 1.1061 0.8837 1.0283 1.0859 0.9141
Niacinamide 1.0097 0.9856 0.9181 1.0432 1.0562
n-isobutyrylglycine 0.8753 1.0675 0.8277 1.2815 1.0427
n-isovalerylglycine 0.9705 0.7334 0.9826 1.0107 1.2595
o-phosphoethanolamine 1.0564 0.9701 1.0004 1.1436 0.8771
Ornithine 0.9239 0.9567 1.1521 0.9311 0.9997
Orotate 1.0806 1.0750 1.0959 0.9229 0.8191
Oxidized glutathione 0.9306 0.9520 1.1789 0.8875 0.9998
Palmitic Acid 1.0792 1.0198 0.9325 0.9674 1.0002
Pentothenate 0.9755 1.0993 1.0719 0.9328 0.9126
PGE 1.0466 0.7589 1.1971 0.9267 1.0100
Phenylalanine 1.0268 0.9715 1.0899 1.0313 0.8884
Phosphoadenosine phosphosulfate 0.9521 0.9094 1.0260 1.0701 1.0466
phosphocreatine 0.8961 0.8657 1.1582 1.1062 0.9781
Phosphotyrosine 0.9482 1.0268 0.9648 0.9436 1.0980
Pipecolate 0.9727 1.1824 1.1447 1.0210 0.7144
Proline 0.9636 1.0389 1.1603 0.9719 0.8594
pseudouridine 0.9889 0.9970 1.0487 1.0647 0.9207
Putrescine 1.0624 1.1554 1.1303 1.0175 0.6713
Pyridoxal-5-P 1.0072 0.9744 0.9545 1.0615 1.0193
Pyridoxamine 0.9910 1.0751 1.1016 0.8693 0.9312
Pyroglutamic Acid 1.0248 0.9535 1.0044 0.8508 1.1111
Pyruvate 0.9542 0.6619 1.2891 1.1587 0.9288
Reduced glutathione 0.7549 0.8793 0.4456 2.3612 0.9722
riboflavin 1.0490 1.1474 0.9761 0.8337 0.9670
Ribose-5-P 1.0137 1.0249 0.9804 0.9977 0.9879
Ribulose 5-phosphate 1.0398 1.0179 1.0382 0.9978 0.9119
S-adenosylmethionine (SAM) 0.9235 0.9977 0.9171 0.9471 1.1902
SAH 0.9498 0.9739 1.0872 0.8756 1.0635
Sedoheptulose 7-phosphate 0.9428 1.0236 1.2112 1.0613 0.7808
Serine 0.9636 1.0688 1.1349 0.9610 0.8671
Serotonin 0.5796 0.4250 0.6325 3.7327 0.4102
Sorbitol 1.1736 0.9149 1.0299 0.8073 1.0103
succinylcarnitine 0.9603 1.0111 0.9405 1.0348 1.0634
Sucrose 0.8791 0.8831 1.3663 0.9629 0.8667
Taurine 0.9959 1.0002 1.0079 0.9793 1.0095
Taurocyamine 1.0625 0.9581 1.0204 1.0420 0.9292
Tetrahydrobiopterin 1.2057 0.8893 0.8131 1.0047 1.0875
Thiamine 1.0101 0.9702 0.9951 0.9362 1.0630
Thiamine pyrophosphate 0.8760 1.0268 0.9078 1.0971 1.1188
threonic acid 1.1854 1.2508 0.8274 0.6154 1.0501
Threonine 0.9530 1.0417 1.1126 0.9344 0.9395
Thymine 0.9235 0.9952 1.3030 0.7797 0.9180
trigonelline 0.9944 1.0434 1.2636 0.8814 0.7844
Trimethylamine-N-oxide (TMAO) 1.1134 1.0414 1.3446 1.0699 0.4704
Tryptophan 1.0141 0.9405 1.0484 0.9893 0.9954
Tyrosine 1.0466 0.9705 1.0205 0.9642 0.9853
UDP-GlcNAc 0.9398 0.9928 1.0477 1.0781 0.9615
UDP-Glucose 0.8177 0.8408 1.2127 0.7554 1.2501
UMP 1.0290 1.1122 0.8592 0.9761 1.0367
Uracil 0.9922 1.0310 1.1447 0.9291 0.8839
Urate 1.1120 0.8482 1.0856 1.0517 0.9038
Uridine 0.9712 1.0698 0.8473 1.0345 1.0979
Valine 1.0016 0.9673 1.0820 1.0233 0.9283
Xanthine 1.0111 0.9533 1.1320 1.0313 0.8758
Xanthosine 0.9483 1.0630 1.1194 0.9210 0.9281
xylonate 0.9866 1.0553 1.1027 1.0003 0.8633
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Factors:

F1Age (Months):26 | Treatment:NMN (300 mg/kg/day)
F2Age (Months):26 | Treatment:None
F3Age (Months):26 | Treatment:SS-31 (3 mg/kg/day)
F4Age (Months):26 | Treatment:SS-31 (3 mg/kg/day) + NMN (300 mg/kg/day)
F5Age (Months):5-6 | Treatment:None
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