Data for Disruption of Redox Balance Enhances the Effects of BRAF-inhibitors in Melanoma (Study ST001339)
(Analysis AN002233)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| Adenosine | 1.1892 | 1.5459 | 0.7025 | 0.5624 |
| ADP | 1.0998 | 0.7887 | 1.3330 | 0.7785 |
| AMP | 0.6417 | 1.3484 | 1.1568 | 0.8531 |
| ATP | 1.3192 | 0.6577 | 1.2976 | 0.7256 |
| GDP | 1.3683 | 0.5775 | 1.4257 | 0.6284 |
| GMP | 0.4090 | 0.7083 | 1.1470 | 1.7357 |
| GSH | 1.3986 | 1.2659 | 1.2082 | 0.1273 |
| GSSG | 0.7201 | 1.0506 | 1.0924 | 1.1370 |
| GTP | 1.7676 | 0.4378 | 1.2262 | 0.5685 |
| L-Cysteine | 0.2550 | 0.6923 | 0.8113 | 2.2415 |
| L-Cystine | NA | 0.0583 | NA | 1.9417 |
| L-Serine | 1.2450 | 1.6263 | 0.7565 | 0.3721 |
| NAD | 1.7428 | 1.4103 | 0.4822 | 0.3647 |
| NADH | NA | NA | 1.6561 | 0.3439 |
| NADP | 1.2665 | 0.9169 | 1.1068 | 0.7097 |
| UDP | 1.4010 | 0.4562 | 1.6826 | 0.4602 |
| UMP | 0.3544 | 1.1590 | 1.4251 | 1.0615 |
| UTP | 1.5182 | 0.4351 | 1.5862 | 0.4605 |
Factors:
| F1 | genotype:resistant | treatment:DMSO |
| F2 | genotype:resistant | treatment:PLX4720 |
| F3 | genotype:sensitive | treatment:DMSO |
| F4 | genotype:sensitive | treatment:PLX4720 |
