Data for Core Functional Nodes and Sex-Specific Pathways in Human Ischemic and Dilated Cardiomyopathy (Study ST001364)
(Analysis AN002271)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 | F6 |
|---|---|---|---|---|---|---|
| 2-hydroxy-2-methylbutyrate | 0.8461 | 0.8545 | 1.1677 | 1.4262 | 0.9207 | 0.8150 |
| 2-hydroxyglutarate | 0.9940 | 0.8671 | 1.0566 | 1.2061 | 0.9464 | 0.9599 |
| 2-methylacetoacetate | 1.3068 | 1.1132 | 0.9211 | 0.6654 | 1.0285 | 1.0279 |
| 3-methyl-2-oxobutyrate | 1.2212 | 1.1358 | 0.9783 | 0.8611 | 0.7658 | 0.9989 |
| 3-methyl-4-hydroxyphenylglycine | 0.8839 | 1.5570 | 1.1681 | 0.4926 | 0.5486 | 1.0032 |
| 3-phosphoglycerate | 1.5633 | 0.9991 | 0.6488 | 0.9125 | 1.0913 | 1.0158 |
| 4-hydroxyphenylacetate | 2.0004 | 2.1140 | 0.5338 | 0.4023 | 0.4998 | 0.5387 |
| 5-hydroxyindoleacetic acid | 0.8852 | 0.7512 | 1.6741 | 1.0495 | 0.8667 | 0.7740 |
| Acetoacetic-acid | 0.9686 | 1.1230 | 1.0000 | 0.6611 | 0.7062 | 1.2891 |
| Acetyl-coA | 0.8138 | 0.9743 | 0.8868 | 1.3193 | 1.3515 | 0.8076 |
| ADP | 1.2729 | 0.8021 | 0.8904 | 1.1516 | 1.1540 | 0.9461 |
| Argininosuccinate | 0.8367 | 1.0467 | 1.1022 | 1.0156 | 0.9510 | 0.9714 |
| ATP | 0.9087 | 0.9900 | 0.6976 | 1.9059 | 0.9096 | 0.7076 |
| Biotin | 1.1576 | 1.0947 | 0.5893 | 0.3955 | 0.9277 | 1.6238 |
| cAMP | 1.0641 | 0.9955 | 0.7228 | 0.8900 | 1.3404 | 1.1006 |
| Cholesterol-sulfate | 0.8915 | 0.7571 | 1.0813 | 0.9842 | 1.3304 | 1.0537 |
| Citraconic-acid | 1.1018 | 0.8423 | 1.1338 | 0.9708 | 1.1534 | 0.9277 |
| Deoxycholic-Acid | 1.0275 | 0.9050 | 0.7278 | 1.2616 | 1.3938 | 0.9094 |
| Deoxyribose-5-phosphate | 1.0946 | 1.0093 | 0.7810 | 0.9164 | 1.0261 | 1.1649 |
| D-erythrose-4-phosphate | 0.7096 | 0.6468 | 1.9274 | 0.8856 | 1.4579 | 0.5723 |
| Fructose-1-6-bisphosphate | 1.4392 | 0.8496 | 0.6719 | 1.6788 | 1.1168 | 0.6446 |
| Fructose-6-phosphate | 0.6192 | 0.6368 | 1.9668 | 1.1986 | 0.8248 | 0.6923 |
| Glucose | 0.7532 | 1.1234 | 1.2298 | 1.0352 | 0.8332 | 0.8872 |
| Glucose-6-phosphate | 0.6949 | 0.6565 | 2.1392 | 1.0507 | 0.8343 | 0.5977 |
| Glutathione-oxidized-GSSG- | 1.0047 | 0.9210 | 0.8955 | 0.8943 | 1.2234 | 1.1147 |
| Glyceraldehyde | 1.3505 | 0.9963 | 0.9809 | 0.9545 | 0.7965 | 0.9768 |
| Glyceraldehyde-3-phosphate | 1.0517 | 1.0698 | 0.9464 | 1.0003 | 1.0778 | 0.9151 |
| Guanidoacetate | 1.3335 | 1.0914 | 0.8075 | 0.6159 | 1.2095 | 1.0692 |
| Homocysteate | 0.8545 | 1.1065 | 0.8880 | 0.5727 | 1.0870 | 1.3220 |
| Hydroxyisocaproate | 0.8129 | 1.4221 | 0.9377 | 0.9097 | 0.8613 | 0.8960 |
| Hypoxanthine | 0.9200 | 1.1744 | 0.9632 | 0.6748 | 0.6747 | 1.3029 |
| Inosine | 0.8394 | 1.1275 | 0.7897 | 0.9127 | 0.8311 | 1.2793 |
| Isocitrate | 0.6129 | 0.8378 | 1.1706 | 1.1179 | 1.3462 | 0.9474 |
| Kynurenic-acid | 0.8365 | 2.2684 | 0.5960 | 0.5528 | 0.6207 | 0.7660 |
| Kynurenine | 1.3187 | 1.3248 | 0.7025 | 0.6654 | 0.7604 | 1.1403 |
| Lactate | 0.8723 | 1.0695 | 1.0925 | 1.1444 | 0.8590 | 0.8967 |
| Malonate | 1.0103 | 0.9136 | 0.6797 | 0.8631 | 1.3937 | 1.2278 |
| Malonyl-coA | 1.0369 | 0.9747 | 1.0477 | 0.9427 | 1.3064 | 0.8530 |
| Mevalonate | 0.4784 | 1.1875 | 1.4732 | 1.7107 | 0.4652 | 0.4833 |
| N-Acetyl-L-Alanine | 0.9551 | 0.7973 | 1.3020 | 1.1695 | 1.0443 | 0.8225 |
| N-carbomyl-aspartate | 0.8509 | 1.1835 | 0.5741 | 0.3829 | 1.0157 | 1.6742 |
| Niacinamide | 0.8108 | 0.8945 | 1.3141 | 1.2069 | 0.8767 | 0.8550 |
| Oxaloacetate | 0.8837 | 1.0694 | 1.0350 | 1.0664 | 0.9332 | 0.9547 |
| p-aminobenzoate-p-AB | 1.0512 | 1.0569 | 0.9380 | 0.7074 | 0.6604 | 1.3474 |
| Phenyllactic | 0.6639 | 1.6837 | 0.8692 | 1.1166 | 0.5721 | 0.7897 |
| Phenylpyruvate | 0.9921 | 0.7909 | 0.7291 | 0.9908 | 1.3465 | 1.2420 |
| Pyroglutamic-acid | 1.0447 | 0.9933 | 0.9145 | 0.8963 | 1.0785 | 1.0854 |
| Pyruvate | 1.1306 | 0.8398 | 0.9887 | 1.0883 | 0.9660 | 1.0432 |
| Quercetin | 1.1179 | 0.9764 | 1.0732 | 0.8244 | 1.2695 | 0.8919 |
| Riboflavin-5-MonoPhosphate | 0.5192 | 0.3366 | 2.2250 | 1.6905 | 0.6384 | 0.5549 |
| S-adenosyl-L-homocysteine | 1.0067 | 1.2180 | 1.1482 | 0.7571 | 0.8290 | 0.9375 |
| Succinate | 1.0999 | 0.7811 | 0.9246 | 0.9032 | 0.7874 | 1.3815 |
| Taurine | 1.3380 | 1.0694 | 0.7106 | 0.7662 | 0.8771 | 1.2253 |
| Taurodeoxycholate | 0.1728 | 1.6062 | 1.1109 | 0.3908 | 0.4935 | 1.4589 |
| Thiamine-Pyrophosphate | 0.9671 | 0.7541 | 1.0104 | 1.1170 | 1.4540 | 0.9205 |
| Thymidine | 0.9822 | 1.2680 | 0.6631 | 0.6013 | 0.8460 | 1.3934 |
| Tropisetron | 0.9232 | 0.9700 | 1.1952 | 1.0616 | 0.7383 | 0.9969 |
| Uracil | 0.6673 | 1.1311 | 1.3159 | 0.5657 | 0.3941 | 1.4026 |
| Ureidopropionic-acid | 0.9220 | 0.7847 | 1.3942 | 1.1047 | 1.0492 | 0.8195 |
| Uridine | 1.1826 | 1.0823 | 0.6002 | 0.3879 | 0.9537 | 1.6060 |
| Uridine-5-diphosphate | 1.1082 | 0.9008 | 1.3419 | 1.2467 | 0.8766 | 0.6507 |
| Xanthine | 0.5678 | 1.4577 | 1.2313 | 0.5454 | 0.5144 | 1.1802 |
| Xanthosine | 1.1348 | 1.4282 | 0.5828 | 0.4666 | 0.7476 | 1.3806 |
| Xanthurenate | 1.0710 | 1.1193 | 0.8831 | 0.6836 | 0.9309 | 1.2067 |
Factors:
| F1 | Condition:DCM | Gender:F |
| F2 | Condition:DCM | Gender:M |
| F3 | Condition:Donor | Gender:F |
| F4 | Condition:Donor | Gender:M |
| F5 | Condition:ICM | Gender:F |
| F6 | Condition:ICM | Gender:M |
