Data for Distinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis (Study ST001382)
(Analysis AN002303)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 |
|---|---|---|---|
| 2_3-dihydroxybenzoic acid | 1.0272 | 1.2664 | 0.0216 |
| 2-dehydro-D-gluconate | 1.6036 | 0.6747 | 0.0726 |
| 2-Isopropylmalic acid | 0.8170 | 1.4755 | 0.0252 |
| acetyl-CoA | 1.5388 | 0.7565 | 0.0156 |
| Acetyllysine | 0.7857 | 1.5141 | 0.0006 |
| adenosine | 0.6777 | 1.6223 | 0.0000 |
| adenosine 5--phosphosulfate | 1.4138 | 0.8862 | 0.0000 |
| a-ketoglutarate | 1.4410 | 0.8578 | 0.0040 |
| Aminoadipic acid | 1.2422 | 1.0576 | 0.0008 |
| arginine | 1.3762 | 0.9236 | 0.0006 |
| asparagine | 0.6213 | 1.6778 | 0.0032 |
| aspartate | 0.8315 | 1.4671 | 0.0047 |
| betaine | 0.1887 | 2.1104 | 0.0029 |
| biotin | 1.1012 | 1.1988 | 0.0000 |
| Cellobiose | 0.5407 | 1.7586 | 0.0023 |
| citrate/isocitrate | 1.3990 | 0.9004 | 0.0020 |
| citrulline | 1.6132 | 0.6868 | 0.0000 |
| CMP | 1.0004 | 1.2995 | 0.0001 |
| coenzyme A | 1.7470 | 0.5530 | 0.0001 |
| cyclic-AMP | 1.2997 | 1.0003 | 0.0000 |
| cyclic bis(3-->5-) dimeric GMP | 1.7986 | 0.5013 | 0.0000 |
| cystathionine | 0.9505 | 1.3494 | 0.0002 |
| Cystine | 2.1950 | 0.1049 | 0.0005 |
| cytidine | 1.5197 | 0.7803 | 0.0000 |
| dCDP | 1.1050 | 1.1950 | 0.0000 |
| deoxyadenosine | 1.9289 | 0.3711 | 0.0000 |
| deoxyinosine | 1.7805 | 0.5194 | 0.0000 |
| dephospho-CoA | 2.0318 | 0.2681 | 0.0003 |
| D-erythrose-4-phosphate | 1.7059 | 0.5874 | 0.0223 |
| D-gluconate | 1.5914 | 0.7076 | 0.0031 |
| D-glucosamine-6-phosphate | 1.8314 | 0.4605 | 0.0271 |
| dGMP | 1.2541 | 1.0436 | 0.0076 |
| D-sedoheptulose-1/7-phosphate | 1.2046 | 1.0954 | 0.0000 |
| dTMP | 1.7233 | 0.5767 | 0.0000 |
| FAD | 1.4617 | 0.8383 | 0.0001 |
| FMN | 0.2732 | 2.0256 | 0.0041 |
| fructose-1-6-bisphosphate | 0.2679 | 2.0320 | 0.0004 |
| fumarate | 0.0259 | 2.2724 | 0.0058 |
| Geranyl-PP | 0.2051 | 2.0948 | 0.0001 |
| glucono-δ-lactone | 1.5725 | 0.7263 | 0.0040 |
| glucosamine | 1.9660 | 0.3309 | 0.0101 |
| glucose-6-phosphate | 1.3119 | 0.9782 | 0.0330 |
| glutamine | 1.1521 | 1.1474 | 0.0017 |
| glutathione | 1.4598 | 0.8401 | 0.0002 |
| glutathione disulfide | 0.7938 | 1.5062 | 0.0000 |
| GMP | 0.3950 | 1.9050 | 0.0000 |
| guanine | 1.2010 | 1.0954 | 0.0118 |
| guanosine | 1.7718 | 0.5282 | 0.0001 |
| histidine | 1.5770 | 0.7230 | 0.0002 |
| homoserine | 0.5840 | 1.7150 | 0.0034 |
| hypoxanthine | 1.1055 | 1.1942 | 0.0011 |
| IMP | 0.7954 | 1.5045 | 0.0001 |
| inosine | 1.2989 | 0.9987 | 0.0082 |
| Kynurenine | 1.0232 | 1.2761 | 0.0022 |
| L-arginino-succinate | 1.7182 | 0.5818 | 0.0000 |
| lipoate | 1.4551 | 0.8449 | 0.0000 |
| lysine | 1.3993 | 0.9007 | 0.0000 |
| malate | 1.3432 | 0.9568 | 0.0002 |
| methionine | 1.3021 | 0.9979 | 0.0000 |
| Methylcysteine | 1.6561 | 0.5889 | 0.1832 |
| myo-inositol | 1.6160 | 0.6838 | 0.0008 |
| N-acetyl-glucosamine-1/6-phosphate | 1.3691 | 0.9309 | 0.0000 |
| N-acetyl-glutamate | 1.3109 | 0.9890 | 0.0002 |
| N-acetyl-glutamine | 1.1809 | 1.1191 | 0.0000 |
| N-Acetyl-L-alanine | 0.9717 | 1.3244 | 0.0130 |
| N-acetyl-L-ornithine | 0.7246 | 1.5753 | 0.0004 |
| N-Acetylputrescine | 0.1760 | 2.1240 | 0.0001 |
| NAD+ | 1.8971 | 0.4029 | 0.0000 |
| NADH | 2.1168 | 0.1832 | 0.0000 |
| NADP+ | 1.7846 | 0.5154 | 0.0001 |
| N-carbamoyl-L-aspartate | 1.2045 | 1.0955 | 0.0001 |
| O-acetyl-L-serine | 1.4779 | 0.8219 | 0.0007 |
| Octoluse 8/1P | 1.0385 | 1.2615 | 0.0002 |
| Octoluse Bisphosphate | 0.3913 | 1.9087 | 0.0000 |
| ornithine | 1.3644 | 0.9356 | 0.0000 |
| orotidine-5--phosphate | 0.0943 | 2.2057 | 0.0001 |
| pantothenate | 1.0326 | 1.2674 | 0.0001 |
| Phenylpropiolic acid | 1.6068 | 0.6887 | 0.0149 |
| p-hydroxybenzoate | 0.9785 | 1.2346 | 0.2898 |
| prephenate | 2.1798 | 0.1201 | 0.0001 |
| proline | 0.7250 | 1.5680 | 0.0233 |
| pyridoxine | 1.4077 | 0.8923 | 0.0001 |
| Pyroglutamic acid | 0.9373 | 1.3624 | 0.0011 |
| Pyrophosphate | 2.1258 | 0.1742 | 0.0000 |
| riboflavin | 1.1038 | 1.1962 | 0.0000 |
| ribose-phosphate | 1.0088 | 1.2212 | 0.2332 |
| S-adenosyl-L-homoCysteine | 2.2997 | 0.0002 | 0.0002 |
| Sedoheptoluse bisphosphate | 1.1108 | 1.1336 | 0.1853 |
| shikimate-3-phosphate | 1.3138 | 0.9178 | 0.2279 |
| S-methyl-5--thioadenosine | 0.7089 | 1.5910 | 0.0001 |
| sn-glycerol-3-phosphate | 1.3536 | 0.9453 | 0.0036 |
| S-ribosyl-L-homocysteine-nega | 1.6106 | 0.6894 | 0.0000 |
| succinate | 0.0338 | 2.2655 | 0.0022 |
| succinyl-CoA/methylmalonyl-CoA | 1.7945 | 0.5054 | 0.0003 |
| thiamine | 1.0863 | 1.2137 | 0.0001 |
| thiamine-phosphate | 0.1581 | 2.1419 | 0.0001 |
| Thiamine pyrophosphate | 1.0251 | 1.2749 | 0.0001 |
| thymidine | 1.3090 | 0.9908 | 0.0006 |
| trehalose-6-Phosphate | 1.7863 | 0.5136 | 0.0001 |
| trehalose/sucrose | 0.5406 | 1.7586 | 0.0027 |
| tryptophan | 0.2837 | 2.0160 | 0.0007 |
| tyrosine | 1.3351 | 0.9625 | 0.0078 |
| UDP | 0.4543 | 1.8457 | 0.0000 |
| UDP-D-glucose | 1.1420 | 1.1580 | 0.0000 |
| UDP-N-acetyl-glucosamine | 1.2774 | 1.0226 | 0.0000 |
| UMP | 0.0747 | 2.2205 | 0.0162 |
| Uric acid | 2.1292 | 0.1642 | 0.0218 |
| uridine | 1.3927 | 0.9069 | 0.0012 |
| valine | 1.0358 | 1.2640 | 0.0006 |
| xanthine | 1.3909 | 0.9091 | 0.0001 |
| xanthosine | 0.9110 | 1.3890 | 0.0000 |
| xanthosine-5-phosphate | 0.8607 | 1.4393 | 0.0000 |
Factors:
| F1 | Grown in presence of NaCl (mM):- |
| F2 | Grown in presence of NaCl (mM):350 |
| F3 | Grown in presence of NaCl (mM):N/A |
