Data for Plasmodium falciparum increased time in circulation underlies persistent asymptomatic infection in the dry season (Study ST001384)

(Analysis AN002309)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4F5
1-Methyladenosine 1.3593 1.2218 0.9171 0.9310 1.0708
2,3-Diphosphoglyceric acid 1.0312 1.0984 1.0184 0.9803 1.0549
2-dehydro-D-gluconate 1.6289 1.5170 0.5842 0.5799 1.0506
2-Hydroxy-2-methylbutanedioic acid 1.2552 1.1779 0.9925 0.9565 1.1832
2-Isopropylmalic acid 0.9300 0.9046 1.2896 1.1798 1.0051
2-keto-isovalerate 1.4816 1.3308 0.7504 0.7199 1.0209
2-oxo-4-methylthiobutanoate 1.6518 0.8434 0.6741 0.6538 0.6340
3-phosphoglycerate 0.4474 0.4953 1.5923 1.6694 1.0097
3-S-methylthiopropionate 1.5471 1.3235 0.6492 0.5558 0.9901
4-aminobutyrate 0.9484 0.9178 1.3068 1.2790 1.1140
4-hydroxyphenyllactate 1.2529 1.1124 0.9767 0.9317 1.0373
4-phosphopantetheine 1.1491 1.3139 0.8208 0.7495 1.0571
4-phosphopantothenate 1.1109 0.9913 0.9249 0.9457 0.9198
4-Pyridoxic acid 0.9579 0.7726 1.3257 1.2381 0.9868
acetoacetate 1.5218 1.5863 0.6766 0.6895 1.2631
acetyl-aspartate 1.2248 1.1283 1.0428 1.0108 1.1214
Acetylcarnitine 1.3152 1.3693 0.9351 0.9237 1.0336
acetyl-CoA 0.2373 0.0388 1.3545 1.0605 0.6045
Acetyl-glycine 1.3649 1.2222 0.9333 0.8595 1.0400
Acetyllysine 1.3299 1.2075 0.9631 0.8461 1.1070
aconitate 1.1398 1.0334 1.1445 1.0934 1.0672
adenosine 0.8442 0.6964 1.2731 1.0846 1.0826
a-ketoglutarate 1.0458 0.9432 1.1722 1.1364 1.0460
alanine/sarcosine 1.0612 1.0315 1.1953 1.1884 1.0870
allantoate 0.7795 0.7208 1.3075 1.1856 1.0789
allantoin 0.8963 0.9165 1.3008 1.2258 1.0684
Aminoadipic acid 1.4028 1.3664 0.8668 0.7839 1.1043
arginine 0.6814 0.6437 1.5050 1.5148 0.9940
asparagine 0.9017 0.9055 1.3405 1.3377 1.1203
aspartate 1.2843 1.1962 0.9910 0.9478 1.0881
biotin 1.3071 1.2558 0.8564 0.7941 0.9612
CDP-ethanolamine 0.8268 0.9769 1.0469 1.2921 1.2366
Citraconic acid 1.1178 1.0218 1.1567 1.1108 1.0955
citrate/isocitrate 1.1988 1.0820 1.0899 1.0502 1.0461
citrulline 0.8610 0.8462 1.3880 1.3902 1.1011
creatine 1.3633 1.2698 0.6767 0.6331 0.9370
Creatinine 1.2949 1.1729 0.9862 0.9710 1.0648
cyclic-AMP 1.0958 0.7922 1.1002 0.8266 0.8854
cysteine 0.9226 0.6816 1.1680 1.2383 1.0507
Cystine 0.9159 0.9381 1.2654 1.2869 1.0448
cytidine 0.8434 0.7958 1.4433 1.3565 1.0257
dAMP 1.7627 0.9141 0.2657 0.3037 0.7242
dCDP 1.3205 1.2278 0.7078 0.5947 0.9668
deoxyribose-phosphate 1.2646 1.1816 0.9927 0.8768 1.0803
deoxyuridine 1.2579 0.7897 1.0960 0.9030 0.8884
D-erythrose-4-phosphate 0.8708 1.4431 0.9160 1.2131 1.5296
dGDP/ADP 1.0159 1.0716 1.1601 1.1426 1.0808
D-glucarate 0.5188 0.4958 1.6505 1.6636 1.1634
D-gluconate 1.3432 1.4917 0.8494 0.9198 1.1510
dGMP/AMP 1.1800 1.1842 1.0744 1.0486 1.0809
dGTP/ATP 0.9078 0.8907 1.2188 1.0044 0.9317
dihydroxy-acetone-phosphate 0.4543 0.3057 1.8459 2.0220 0.7165
Dithioerythritol 0.3345 0.2564 1.4966 1.3078 1.2241
DL-Pipecolic Acid 1.0454 0.9678 1.0896 1.0348 1.1241
DLS 1.1907 1.0452 0.8742 0.7862 0.9091
D-sedoheptulose-1/7-phosphate 1.1071 0.9247 0.9499 0.9203 0.9268
dTDP 1.3086 1.1768 0.7005 0.7786 1.0083
EV 0.7895 0.7212 1.2564 1.2000 0.8950
FAD 1.0146 1.0686 1.0373 1.0088 1.0446
folate 1.2212 0.8201 1.1386 NA NA
fructose-1-6-bisphosphate 0.1146 0.1401 1.4418 0.6779 0.4317
fumarate 1.3410 1.2274 0.9032 0.8722 1.1163
GDP 1.0012 1.1816 0.9635 0.9646 0.9947
glutamate 0.9712 0.9429 1.2840 1.2712 1.0982
glutamine 0.9257 0.9487 1.2541 1.2584 1.0735
glutathione 0.8858 0.7297 1.1643 1.1935 1.0045
glutathione disulfide 0.5393 0.4457 1.5034 1.4436 0.9397
glycerate 0.8621 0.8474 1.3708 1.3767 1.1774
GMP 1.1280 1.2854 1.0113 1.0181 1.1241
Hexose 1.3083 1.2218 0.9608 0.9555 1.0795
hexose-phosphate 1.2964 1.3809 0.7604 0.5953 1.1292
histidine 1.0052 0.9471 1.2615 1.2394 1.0787
homocysteic acid 0.8662 0.7551 1.3938 1.4022 1.0962
Hydroxyisocaproic acid 1.4460 1.2328 0.8613 0.8102 1.0383
Hydroxyphenylacetic acid 2.1225 1.3785 0.2906 0.2526 0.9422
hydroxyproline/Aminolevulinate 0.8895 0.8991 1.3575 1.3452 1.0995
IDP 1.1579 1.3022 0.8147 0.9482 1.1915
IDS 1.0376 0.9223 1.0074 1.0098 0.8876
IMP 0.5358 0.5620 1.6387 1.6095 1.1282
indole 1.0621 0.9844 0.9717 0.9355 0.9449
Indole-3-carboxylic acid 1.4038 1.1597 0.8246 0.8190 1.0965
inosine 1.1897 1.0329 1.0942 1.0646 1.0989
isoleucine 1.0256 0.9244 1.1979 1.1263 1.0554
Ketoleucine 1.3445 1.1199 0.9456 0.8742 1.1759
Kynurenic acid 1.7097 1.4503 0.6009 0.5470 1.0542
Kynurenine 1.4404 1.1887 0.8900 0.8175 1.0051
lactate 1.1973 1.0795 1.0773 1.0372 1.0777
L-arginino-succinate 1.1388 1.0952 0.9477 0.8953 0.9966
leucine 1.2779 1.1471 1.0140 0.9510 1.0679
lysine 0.9367 0.8953 1.3044 1.2853 1.0536
malate 1.3457 1.2154 0.9376 0.8489 1.1186
methionine 0.8418 0.7758 1.4458 1.3178 1.0890
Methylcysteine 1.1616 0.9765 0.8974 0.8281 0.9594
myo-inositol 1.7540 0.9763 0.6643 0.6811 0.8889
N-acetyl-glucosamine 1.4186 1.2469 0.8667 0.8392 1.1048
N-acetyl-glucosamine-1/6-phosphate 0.7334 0.7482 1.2752 1.2180 0.9992
N-acetyl-glutamate 1.2398 1.1395 1.0427 0.9834 1.0537
N-acetyl-glutamine 1.2739 1.1385 1.0256 0.9794 1.0112
N-Acetyl-L-alanine 1.2766 1.1139 1.0343 0.9273 1.0469
N-acetyl-L-ornithine 1.2444 1.2502 1.0022 0.9720 1.1242
NAD+ 0.7454 0.2275 1.3398 1.1707 0.8367
N-carbamoyl-L-aspartate 0.9940 0.9192 1.0824 1.0944 1.0131
Octulose Bisphosphate 0.6562 0.6262 1.3254 1.3861 1.0613
ornithine 0.8099 0.8338 1.4295 1.4012 1.1230
orotate 1.0178 0.9076 1.0252 0.9885 0.9317
orotidine-5^-phosphate 0.5360 0.5264 1.4649 1.3834 1.0868
oxaloacetate 1.0449 0.8128 1.2157 1.1368 0.9567
p-aminobenzoate 1.1571 0.8369 0.9620 1.2146 0.8047
pantothenate 0.9335 0.9392 1.3215 1.2410 1.1242
Phenol Red 0.5636 0.5966 0.4711 0.5019 0.5988
phenylalanine 1.4804 1.3243 0.8085 0.7775 1.0758
Phenyllactic acid 1.6977 1.4232 0.6181 0.6046 1.0413
phenylpyruvate 1.6472 1.4279 0.6563 0.6460 1.0395
phosphoenolpyruvate 0.7351 0.7392 1.5094 1.4944 1.0700
p-hydroxybenzoate 1.1364 0.9226 1.1370 1.0491 1.0065
proline 0.9482 0.8871 1.3259 1.2601 1.0883
pyridoxine 1.1289 1.2906 0.8720 1.2660 0.5657
Pyroglutamic acid 1.0719 1.0246 1.0689 1.0445 1.0289
Pyrophosphate 1.0376 0.9938 1.2105 0.9844 1.0250
pyruvate 1.2530 1.1363 1.0277 0.9902 1.0825
quinolinate 1.3023 1.3135 0.7962 0.7386 1.2132
ribose 1.3252 1.2204 0.9486 0.9338 1.0832
Ribose-5-phosphate 1.1249 0.9935 1.0481 0.9731 1.0071
SD 1.1777 0.9313 1.1164 0.9421 0.9499
serine 0.9693 1.0083 1.2646 1.2805 1.1076
sn-glycerol-3-phosphate 0.9554 0.7460 1.3548 1.2536 1.0895
succinate/Methylmalonic acid 1.1399 1.0780 1.0034 0.9403 1.0372
taurine 1.0399 1.0723 1.1319 1.1590 1.0817
Tetrahydrobiopterin 0.8724 0.8319 1.0921 1.7024 0.5724
thiamine NA NA NA NA NA
thiamine-phosphate 0.8791 0.3412 1.2976 1.0644 0.7264
threonine/homoserine 0.9950 1.0005 1.2536 1.2307 1.1077
trehalose/sucrose 1.5549 1.5596 0.7256 0.5486 1.0893
tryptophan 1.1795 1.0916 1.0998 1.0503 1.0736
tyrosine 1.0446 1.0278 1.2101 1.1729 1.1138
UDP 1.0833 1.0915 1.1772 1.1910 0.9992
UDP-D-glucose 0.8339 0.7213 1.2657 0.9107 1.1038
UDP-D-glucuronate 0.8265 0.8831 1.1438 1.2598 0.9758
UDP-N-acetyl-glucosamine 0.7063 1.0345 1.0901 1.2783 1.5016
UMP 0.9115 0.9246 1.1814 1.2370 1.1329
Uric acid 1.0968 1.0361 1.0536 0.9972 1.0320
uridine 1.1401 1.0431 1.0916 0.9804 1.0496
valine 1.3245 1.2070 0.9575 0.9023 1.0960
xanthine 1.2350 1.2006 0.9594 0.9515 1.0699
xanthosine 0.9914 0.7946 1.1090 0.8561 0.9478
Xanthurenic acid 1.6267 1.5021 0.6768 0.5789 1.0301
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Factors:

F1Genotype:MAL
F2Genotype:MAL Pool
F3Genotype:May
F4Genotype:May Pool
F5Genotype:Pool
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