Data for Activation of ectopic olfactory receptor 544 induces GLP-1 secretion, alters gut microbiome, and improves intestinal permeability. (Study ST001399)
(Analysis AN002339)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 |
---|---|---|---|---|
1-monopalmitin | 0.8910 | 0.6667 | 1.2285 | 1.1722 |
2-(4-hydroxyphenyl)ethanol | 1.9903 | 1.4674 | 0.3009 | 0.2999 |
2-hydroxyvalerate | 0.6146 | 1.0773 | 1.0037 | 1.3141 |
2-ketoadipate | 1.1774 | 1.5778 | 0.8272 | 0.4899 |
2-ketoisocaproic acid | 0.1114 | 0.1090 | 1.0663 | 2.6019 |
5-aminovalerate | 0.6477 | 0.4669 | 1.3231 | 1.4957 |
adenosine | 0.7658 | 0.7007 | 1.2174 | 1.2786 |
alanine | 0.5241 | 0.7964 | 1.0652 | 1.5889 |
arachidic acid | 0.4950 | 0.6289 | 1.3012 | 1.5285 |
aspartate | 1.7265 | 1.8589 | 0.2166 | 0.3053 |
azelaic acid | 0.2999 | 0.9121 | 0.1047 | 2.6723 |
cellobiose | 0.3679 | 0.0514 | 0.3993 | 3.0629 |
chenodeoxycholic acid | 1.0164 | 0.7533 | 0.8910 | 1.3085 |
cholic acid | 1.0563 | 0.9622 | 0.7382 | 1.2385 |
decanoic acid | 0.7204 | 0.7112 | 1.3217 | 1.2106 |
deoxycholic acid | 0.3905 | 0.3455 | 1.6602 | 1.5220 |
dihydroxyacetone | 1.2933 | 1.9246 | 0.5691 | 0.3286 |
DL-3-aminoisobutyrate | 0.5084 | 0.3611 | 1.1202 | 1.9304 |
dodecanoic acid | 1.0253 | 1.0190 | 0.8913 | 1.0667 |
fucose | 1.8098 | 1.6972 | 0.2696 | 0.3105 |
fuculose | 0.7081 | 0.6329 | 1.1542 | 1.4589 |
fumarate | 1.5101 | 1.5803 | 0.3388 | 0.6433 |
glucose | 0.5485 | 0.4954 | 1.5017 | 1.3913 |
glutamate | 2.7043 | 1.0890 | 0.0716 | 0.1463 |
glycerate | 1.4700 | 2.0775 | 0.2508 | 0.3365 |
glycerol | 1.3045 | 1.2896 | 0.7799 | 0.6622 |
glycerol-1-phosphate | 0.0000 | 0.0000 | 1.7855 | 2.0895 |
glycolate | 1.6639 | 2.1605 | 0.1430 | 0.1777 |
guanine | 0.6617 | 1.0431 | 1.1423 | 1.1583 |
guanosine | 0.8233 | 0.5296 | 1.1467 | 1.4415 |
heptadecanoic acid | 0.3040 | 0.3628 | 1.5412 | 1.7124 |
hypoxanthine | 0.4334 | 0.5910 | 1.3435 | 1.5810 |
inosine | 0.5821 | 0.5385 | 1.1616 | 1.6601 |
isoleucine | 0.7720 | 0.9045 | 1.0604 | 1.2511 |
leucine | 0.6971 | 0.7107 | 1.0940 | 1.4620 |
L-homoserine | 1.9762 | 2.1234 | 0.0175 | 0.0234 |
lignoceric acid | 0.5067 | 0.4407 | 1.3694 | 1.6133 |
linoleic acid | 0.0000 | 0.0000 | 1.9585 | 1.9165 |
linolenic acid | 0.0000 | 0.0000 | 2.0171 | 1.8579 |
lysine | 0.3892 | 1.2477 | 0.9222 | 1.4718 |
lyxose | 0.0000 | 0.0000 | 2.3358 | 1.5392 |
mannose | 0.0837 | 0.0796 | 1.9349 | 1.7868 |
methionine | 0.0000 | 0.0000 | 1.5881 | 2.2869 |
methionine sulfoxide | 1.1282 | 1.6154 | 0.6447 | 0.6886 |
methylamine | 0.0000 | 0.0000 | 2.1885 | 1.6865 |
myo-inositol | 1.2806 | 0.8344 | 0.8281 | 1.0361 |
myristic acid | 0.5338 | 0.4691 | 1.4617 | 1.4690 |
nonanoic acid | 1.4019 | 1.4929 | 0.5443 | 0.6226 |
norvaline | 1.8379 | 0.9006 | 0.2055 | 1.0437 |
oleic acid | 0.2667 | 0.4289 | 1.6041 | 1.6290 |
O-phosphorylethanolamine | 0.1602 | 0.1845 | 1.4407 | 2.1126 |
ornithine | 1.9925 | 1.9469 | 0.0597 | 0.1193 |
oxoproline | 1.7428 | 1.9718 | 0.1259 | 0.2809 |
palmitic acid | 0.0031 | 0.0019 | 2.0890 | 1.7812 |
palmitoleic acid | 1.7100 | 1.7925 | 0.3253 | 0.2713 |
pentadecanoic acid | 0.2880 | 0.2323 | 1.4498 | 1.9339 |
phenylacetate | 0.0000 | 0.0000 | 1.2840 | 2.5910 |
phenylalanine | 0.4286 | 1.0597 | 1.0036 | 1.5156 |
phosphate | 1.4218 | 0.9558 | 0.7232 | 0.8936 |
phosphogluconate | 0.9801 | 0.7496 | 0.9784 | 1.2606 |
phytol | 0.5102 | 0.2906 | 1.4856 | 1.6249 |
serine | 0.7450 | 2.5049 | 0.3662 | 0.5720 |
spermidine | 0.9157 | 0.7152 | 0.5994 | 1.7340 |
squalene | 0.0000 | 0.0000 | 1.9428 | 1.9322 |
stearic acid | 0.3616 | 0.2636 | 1.7730 | 1.5096 |
succinate | 2.2347 | 1.7939 | 0.0234 | 0.0472 |
sucrose | 0.0000 | 0.0000 | 3.5998 | 0.2752 |
tagatose | 0.0000 | 0.0000 | 2.7608 | 1.1142 |
taurine | 0.5078 | 0.4788 | 1.1765 | 1.7718 |
threonine | 0.9181 | 1.8881 | 0.4526 | 0.8522 |
threose | 0.8517 | 1.0058 | 1.0571 | 1.0862 |
thymine | 0.0000 | 0.0000 | 1.6658 | 2.2092 |
trehalose | 1.2757 | 1.0479 | 0.1171 | 1.5652 |
tyrosine | 0.6926 | 1.3188 | 0.7472 | 1.2812 |
uracil | 0.8347 | 0.8868 | 0.9822 | 1.2821 |
urea | 0.8161 | 1.1175 | 1.8544 | 0.2267 |
uric acid | 2.4531 | 1.2857 | 0.0999 | 0.1970 |
uridine | 0.0000 | 0.0000 | 1.6372 | 2.2378 |
ursodeoxycholic acid | 1.0093 | 0.6721 | 0.9460 | 1.3316 |
xanthurenic acid | 0.0000 | 0.0000 | 2.0657 | 1.8093 |
xylose | 0.1983 | 0.1478 | 1.8639 | 1.6836 |
β-alanine | 0.4013 | 0.3570 | 1.5101 | 1.6512 |
γ-aminobutyrate | 0.0000 | 0.0000 | 1.8509 | 2.0241 |
Factors:
F1 | Genotype:Olfr544 KO mouse | Treatment:HFD |
F2 | Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w) |
F3 | Genotype:WT mouse | Treatment:HFD |
F4 | Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w) |