Data for Activation of ectopic olfactory receptor 544 induces GLP-1 secretion, alters gut microbiome, and improves intestinal permeability. (Study ST001399)

(Analysis AN002339)

Values for each metabolite have been scaled by dividing by the mean across all factors

Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

MetaboliteF1F2F3F4
1-monopalmitin 0.8910 0.6667 1.2285 1.1722
2-(4-hydroxyphenyl)ethanol 1.9903 1.4674 0.3009 0.2999
2-hydroxyvalerate 0.6146 1.0773 1.0037 1.3141
2-ketoadipate 1.1774 1.5778 0.8272 0.4899
2-ketoisocaproic acid 0.1114 0.1090 1.0663 2.6019
5-aminovalerate 0.6477 0.4669 1.3231 1.4957
adenosine 0.7658 0.7007 1.2174 1.2786
alanine 0.5241 0.7964 1.0652 1.5889
arachidic acid 0.4950 0.6289 1.3012 1.5285
aspartate 1.7265 1.8589 0.2166 0.3053
azelaic acid 0.2999 0.9121 0.1047 2.6723
cellobiose 0.3679 0.0514 0.3993 3.0629
chenodeoxycholic acid 1.0164 0.7533 0.8910 1.3085
cholic acid 1.0563 0.9622 0.7382 1.2385
decanoic acid 0.7204 0.7112 1.3217 1.2106
deoxycholic acid 0.3905 0.3455 1.6602 1.5220
dihydroxyacetone 1.2933 1.9246 0.5691 0.3286
DL-3-aminoisobutyrate 0.5084 0.3611 1.1202 1.9304
dodecanoic acid 1.0253 1.0190 0.8913 1.0667
fucose 1.8098 1.6972 0.2696 0.3105
fuculose 0.7081 0.6329 1.1542 1.4589
fumarate 1.5101 1.5803 0.3388 0.6433
glucose 0.5485 0.4954 1.5017 1.3913
glutamate 2.7043 1.0890 0.0716 0.1463
glycerate 1.4700 2.0775 0.2508 0.3365
glycerol 1.3045 1.2896 0.7799 0.6622
glycerol-1-phosphate 0.0000 0.0000 1.7855 2.0895
glycolate 1.6639 2.1605 0.1430 0.1777
guanine 0.6617 1.0431 1.1423 1.1583
guanosine 0.8233 0.5296 1.1467 1.4415
heptadecanoic acid 0.3040 0.3628 1.5412 1.7124
hypoxanthine 0.4334 0.5910 1.3435 1.5810
inosine 0.5821 0.5385 1.1616 1.6601
isoleucine 0.7720 0.9045 1.0604 1.2511
leucine 0.6971 0.7107 1.0940 1.4620
L-homoserine 1.9762 2.1234 0.0175 0.0234
lignoceric acid 0.5067 0.4407 1.3694 1.6133
linoleic acid 0.0000 0.0000 1.9585 1.9165
linolenic acid 0.0000 0.0000 2.0171 1.8579
lysine 0.3892 1.2477 0.9222 1.4718
lyxose 0.0000 0.0000 2.3358 1.5392
mannose 0.0837 0.0796 1.9349 1.7868
methionine 0.0000 0.0000 1.5881 2.2869
methionine sulfoxide 1.1282 1.6154 0.6447 0.6886
methylamine 0.0000 0.0000 2.1885 1.6865
myo-inositol 1.2806 0.8344 0.8281 1.0361
myristic acid 0.5338 0.4691 1.4617 1.4690
nonanoic acid 1.4019 1.4929 0.5443 0.6226
norvaline 1.8379 0.9006 0.2055 1.0437
oleic acid 0.2667 0.4289 1.6041 1.6290
O-phosphorylethanolamine 0.1602 0.1845 1.4407 2.1126
ornithine 1.9925 1.9469 0.0597 0.1193
oxoproline 1.7428 1.9718 0.1259 0.2809
palmitic acid 0.0031 0.0019 2.0890 1.7812
palmitoleic acid 1.7100 1.7925 0.3253 0.2713
pentadecanoic acid 0.2880 0.2323 1.4498 1.9339
phenylacetate 0.0000 0.0000 1.2840 2.5910
phenylalanine 0.4286 1.0597 1.0036 1.5156
phosphate 1.4218 0.9558 0.7232 0.8936
phosphogluconate 0.9801 0.7496 0.9784 1.2606
phytol 0.5102 0.2906 1.4856 1.6249
serine 0.7450 2.5049 0.3662 0.5720
spermidine 0.9157 0.7152 0.5994 1.7340
squalene 0.0000 0.0000 1.9428 1.9322
stearic acid 0.3616 0.2636 1.7730 1.5096
succinate 2.2347 1.7939 0.0234 0.0472
sucrose 0.0000 0.0000 3.5998 0.2752
tagatose 0.0000 0.0000 2.7608 1.1142
taurine 0.5078 0.4788 1.1765 1.7718
threonine 0.9181 1.8881 0.4526 0.8522
threose 0.8517 1.0058 1.0571 1.0862
thymine 0.0000 0.0000 1.6658 2.2092
trehalose 1.2757 1.0479 0.1171 1.5652
tyrosine 0.6926 1.3188 0.7472 1.2812
uracil 0.8347 0.8868 0.9822 1.2821
urea 0.8161 1.1175 1.8544 0.2267
uric acid 2.4531 1.2857 0.0999 0.1970
uridine 0.0000 0.0000 1.6372 2.2378
ursodeoxycholic acid 1.0093 0.6721 0.9460 1.3316
xanthurenic acid 0.0000 0.0000 2.0657 1.8093
xylose 0.1983 0.1478 1.8639 1.6836
β-alanine 0.4013 0.3570 1.5101 1.6512
γ-aminobutyrate 0.0000 0.0000 1.8509 2.0241
Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study

Factors:

F1Genotype:Olfr544 KO mouse | Treatment:HFD
F2Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)
F3Genotype:WT mouse | Treatment:HFD
F4Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)
  logo