Data for Metabolomics of patient-derived fibroblasts (Study ST001441)

(Analysis AN002408)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3F4
11^-Carboxy-alpha-chromanol 2.1636 0.5213 0.9795 0.3356
12,13-epoxy-9-hydroperoxy-10E-octadecenoate 1.5071 0.7349 0.9813 0.7766
13-carboxy-alpha-tocopherol 2.2557 0.2847 1.3741 0.0856
15(S)-Hydroxyeicosatrienoic acid 2.0911 0.3186 1.4388 0.1516
2-acetamido-5-oxopentanoate 0.9536 0.9235 1.0160 1.1069
2-aminomuconate 1.0967 0.4666 1.6144 0.8222
2-deoxy-D-ribose 5-phosphate/2-Deoxy-D-ribose 1-phosphate 0.7624 0.8059 1.2813 1.1504
2-Hydroxyglutarate 1.0545 0.7142 1.2770 0.9543
2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate 0.9167 0.1003 2.9165 0.0664
2-methylglutaconic acid 0.9809 1.0643 0.8718 1.0829
2-oxoadipate 0.8462 0.8894 0.8259 1.4385
2-oxoglutarate 0.9745 0.6334 1.3337 1.0584
3alpha-7alpha-12alpha-Trihydroxy-5beta-cholestanoate/3alpha-7alpha-12alpha-25-tetrahydroxy-5beta-cholestane-24-one 2.1848 0.0257 1.7697 0.0198
3-dehydro-L-gulonate/D-glucuronate/L-iduronate 1.0954 0.9425 1.0558 0.9063
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid 1.0008 0.9360 0.9257 1.1375
3-hydroxyanthranilate 0.8598 1.0227 1.1175 1.0000
3-Keto-beta-D-galactose/L-Gulonolactone 1.1899 0.8637 1.0900 0.8565
3-methyl-2-oxobutanoate 0.9435 1.0673 0.9071 1.0821
3-methyl-2-oxopentanoate/4-methyl-2-oxopentanoate(ketoleucine) 0.9792 0.9853 0.9939 1.0415
3(S)6(R)-dihydroxy-tetradec-8Z-enoate/3(S)6(S)-dihydroxy-tetradec-8Z-enoate 2.2884 0.2576 1.2558 0.1983
4,6-Dihydroxyquinoline/quinoline-4,8-diol 1.3212 0.7267 1.2701 0.6821
4-hydroperoxy-2-nonenal 1.2451 0.9360 1.0808 0.7381
4-hydroxy-2-nonenal/3,4-epoxynonanal 1.2126 0.9070 0.9677 0.9127
(4-hydroxy-3-methoxyphenyl)acetaldehyde 1.6635 0.5036 1.3290 0.5040
4-hydroxybenzoate/Gentisate aldehyde 1.2808 0.8911 1.1060 0.7221
4-Hydroxyphenylacetate/2-Hydroxyphenylacetate/3,4-Dihydroxyphenylacetaldehyde 1.5140 0.9215 0.8288 0.7357
4-nitrophenolate 1.1979 0.8147 1.0376 0.9498
4-pyridoxate 1.8654 0.3571 1.4717 0.3058
4(R)-hydroxy-dodec-6Z-enoate/4(S)-hydroxy-dodec-6Z-enoate 1.1792 0.9539 0.9896 0.8773
5-Hydroxyisourate 2.0813 0.0044 1.9117 0.0026
5-Methoxyindoleacetate 2.1164 0.1139 1.6639 0.1057
5-oxoproline/L-1-Pyrroline-3-hydroxy-5-carboxylate 0.8377 1.2015 0.7777 1.1831
6-Phosphogluconic acid 1.7851 0.5982 1.2120 0.4048
6(S)-hydroxy-tetradeca-2E4E8Z-trienoate/6(R)-hydroxy-tetradeca-2E4E8Z-trienoate 1.7493 0.5027 1.2519 0.4962
7,9-dihydro-1H-purine-2688(3H)-trione 1.8949 0.1908 1.7549 0.1594
8,11,14-Eicosatrienoic acid (DGLA) 1.7172 0.4637 1.4619 0.3573
9(10)-EpOME/12(13)-EpOME 1.1228 1.2410 0.8059 0.8303
9,10-hydroxyoctadec-12(Z)-enoate/12,13-hydroxyoctadec-9(Z)-enoate 1.2888 0.8005 1.0040 0.9066
acetoacetate 0.9644 0.9825 1.0804 0.9727
adipic acid 1.3010 0.8925 1.1374 0.6691
ADP 1.3192 0.9136 1.1307 0.6365
ADP-mannose/GDP-L-fucose/ADP alpha-D-glucoside 0.9207 1.0938 1.0446 0.9409
ADP-ribose 0.9984 0.8955 1.2560 0.8502
allantoate 2.0594 0.0885 1.7622 0.0899
alpha-D-glucose 0.9671 1.0776 0.8588 1.0964
AMP 1.0508 1.0881 0.9618 0.8994
arachidonic acid 1.6321 0.3380 1.6478 0.3822
arginine 0.9955 1.0963 0.8216 1.0866
aspartate 0.8789 2.1762 0.2729 0.6720
ATP 1.3528 0.9109 1.0866 0.6497
Azelaic acid 1.4154 0.7978 1.2400 0.5468
beta-D-Fructose 1,6-bisphosphate 1.5147 0.4345 1.4804 0.5704
beta-hydroxy-beta-methylbutyrate 1.5723 0.5119 1.5406 0.3751
C20H30O2(4) 1.6329 0.3623 1.6225 0.3822
C20H30O3(6) 1.6635 0.6065 1.2169 0.5131
C20H30O4(18) 1.9614 0.4087 1.3385 0.2914
C20H32O3(12) 1.7273 0.5525 1.3465 0.3737
C20H32O4(21) 1.6811 0.4769 1.4535 0.3886
C20H34O4(4) 1.8320 0.3394 1.6691 0.1596
C27H46O4(3) 1.7849 0.8724 0.8686 0.4741
C4H8O3(3) 1.4335 0.3376 1.9624 0.2665
C5H10O5(6) 0.9951 1.0590 0.8669 1.0789
C6H12O6(5) 0.5642 1.3264 0.6791 1.4303
caprate 1.0240 0.9102 1.0941 0.9717
carnosine 1.8644 0.1958 1.7381 0.2017
CDP 1.5866 0.4717 1.5082 0.4335
cholesterol sulfate 1.0588 0.1072 2.7160 0.1180
cis-aconitate 1.3518 1.0175 0.9363 0.6944
citrate/isocitrate 1.3420 1.0646 0.9170 0.6765
clupanodonic acid/docosa-4,7,10,13,16-pentaenoic acid 1.9731 0.1194 1.7670 0.1406
CMP 1.3166 0.8670 1.0993 0.7171
CTP 1.5394 0.6684 1.3484 0.4438
cytidine 1.5027 0.4364 1.4896 0.5713
Deoxyinosine 0.5552 1.2561 1.0944 1.0943
Deoxyuridine 1.7948 0.5920 1.2201 0.3932
D-Erythrose 4-phosphate 1.3073 0.5613 1.3617 0.7697
D-Glucosamine 6-phosphate 1.2040 0.7387 1.3220 0.7354
D-Glucuronate 1-phosphate 1.0100 0.7048 1.3418 0.9434
D-glycerate 1.9679 0.3383 1.4107 0.2831
D-Glycerate 3-phosphate/D-Glycerate 2-phosphate 1.1237 0.7157 1.4439 0.7168
Dihydroxyacetone phosphate 1.5716 0.3682 1.6585 0.4017
Diphosphate 2.5894 0.1391 1.2115 0.0599
docosahexaenoate(DHA) 1.9675 0.0852 1.8033 0.1440
docosanedioicacid 1.4048 0.5824 1.0571 0.9557
Dodecanedioic acid 1.3194 0.9673 1.0837 0.6296
dTTP 2.4423 0.0099 1.5378 0.0099
dUDP 0.5010 1.3990 0.5861 1.5139
dUMP 0.5197 2.0303 0.5552 0.8948
Eicosenoic acid 1.0956 1.0018 0.8801 1.0225
estrone 3-sulfate 2.4008 0.0473 1.4903 0.0616
fructoseglycine 1.1558 1.0425 0.9342 0.8674
fructoselysine 3-phosphate 0.4681 1.7721 0.5039 1.2558
fructosyllysine 1.1916 0.9357 1.0120 0.8607
fumarate 1.3621 1.4000 0.7180 0.5199
G6P/F6P 1.2177 0.8423 1.0343 0.9057
Galactosylglycerol 2.2061 0.0668 1.6094 0.1176
gama-L-glutamyl-L-alpha-aminobutyrate 1.3958 0.8230 1.1144 0.6668
GDP 1.3328 0.6451 1.6047 0.4174
GDP-D-mannose 0.8941 1.1231 1.0243 0.9584
Glycerol 3-phosphate 1.0976 1.0934 0.9717 0.8373
glycochenodeoxycholate 2.0727 0.1149 1.7178 0.0946
glycolithocholate 2.0983 0.1481 1.6760 0.0776
Glycyl-phenylalanine 1.9031 0.7835 0.8649 0.4484
GMP 1.0110 1.1919 0.8866 0.9106
GTP 1.4621 0.8164 1.1897 0.5319
guanosine 0.7202 1.3023 0.7409 1.2366
gulonate 1.4319 0.6579 1.3787 0.5315
Hexadecanedioic acid 1.4219 0.6199 1.1574 0.8008
Hypotaurine 0.7019 1.5950 0.6334 1.0697
Hypoxanthine 1.4892 0.1164 2.2511 0.1433
inosine 1.0176 0.8343 1.5214 0.6267
itaconate/Mesaconate 1.2385 0.8301 1.1504 0.7810
kynurenate 1.7154 0.3056 1.7547 0.2242
L-2-aminoadipate 0.9723 1.2984 0.7841 0.9451
L-4-hydroxyglutamate semialdehyde 1.0069 0.9353 1.1679 0.8899
lactate 1.5149 0.5345 1.4731 0.4775
L-arabinitol/xylitol/D-ribitol 1.8548 0.2693 1.6123 0.2636
laurate 1.1200 0.9191 1.0048 0.9562
L-cystathionine 1.3265 0.7614 1.3078 0.6044
L-cysteate 1.0420 1.2706 0.7215 0.9660
L-erythrulose 0.9868 1.0682 0.8675 1.0775
L-fucose/L-Fuculose 1.9974 0.0628 1.8382 0.1016
L-glutamate 1.0108 0.9330 1.1691 0.8871
L-Iditol/D-glucitol/galactitol 2.0045 0.0458 1.8547 0.0949
linoleic acid/linoelaidic acid (all trans C18:2)/octadecadienoate (n-C18:2) 1.5922 0.6026 1.3436 0.4615
L-isoleucine/L-leucine 1.0499 1.0491 0.8835 1.0175
lithocholate 2.4693 0.5102 0.5102 0.5102
L-threonate 1.9192 0.2796 1.5371 0.2641
L-tryptophan 1.1110 0.9957 0.9079 0.9854
L-xylonate/L-lyxonate 1.2765 0.7340 1.3317 0.6579
lysine 1.0068 1.1047 0.8257 1.0628
malate 1.2726 1.0916 0.9270 0.7089
margarate 1.2246 0.8922 1.0856 0.7976
Methylisocitric acid/2-methylcitrate 1.4808 1.0655 1.1263 0.3275
myo-inositol 0.5623 1.3265 0.6792 1.4320
myristate 1.1325 0.9579 1.0311 0.8786
N-acetyl-L-aspartate/2-Amino-3-oxoadipate 0.9812 0.5691 1.7285 0.7212
N-acetyl-L-glutamate 1.0076 0.7073 1.5298 0.7553
N-Acetylneuraminate 9-phosphate 1.5174 0.8548 0.8319 0.7959
N-acetyl-seryl-aspartate 1.2889 0.8980 1.2046 0.6085
NADH 1.2236 1.1215 0.8763 0.7787
NADPH 0.8057 1.4380 1.5918 0.1646
N-Carbamoyl-L-aspartate 2.0893 1.0472 0.8483 0.0151
N-Formimidoyl-L-glutamate 1.5143 0.9537 0.9434 0.5886
N(omega)-(L-Arginino)succinate 1.8680 1.4947 0.4286 0.2087
nonanoate 0.8725 1.4770 0.9559 0.6946
N-phosphocreatinate 1.4148 0.7241 1.2687 0.5924
oleic acid/elaidate/trans-vaccenate 1.4469 0.6937 1.2644 0.5950
omega hydroxy dodecanoate (n-C12:0) 1.2908 1.1803 0.7055 0.8233
omega hydroxy hexadecanoate (n-C16:0) 1.2616 0.8464 0.8936 0.9984
omega hydroxy tetradecanoate (n-C14:0) 1.1451 1.2012 0.7832 0.8705
O-Phospho-L-serine 1.0715 1.3815 0.8306 0.7164
oxalatosuccinate 2.8313 0.2924 0.3212 0.5550
palmitate 1.1651 0.9147 1.0729 0.8473
palmitoleate 1.3400 0.8741 1.1461 0.6398
pentadecanoate 1.1800 0.9116 1.0905 0.8179
Perillic acid 1.2705 0.9493 0.8806 0.8997
phenylacetate/(4-hydroxyphenyl)acetaldehyde 1.2149 0.7304 0.8074 1.2473
Phosphoenolpyruvate 0.8797 0.8137 1.4080 0.8986
phytanic acid/arachidic acid 1.1935 0.8482 1.1555 0.8027
pristanic acid 1.2273 0.8325 1.0065 0.9336
pyruvate 1.0076 0.8779 0.8700 1.2445
quinolinate 2.1400 0.0971 1.6577 0.1052
(R)-2-hydroxy-4-methylpentanoate 1.2250 0.7980 1.2352 0.7418
ribose-phosphate 1.2509 0.7205 1.4654 0.5632
(R)-Pantothenate 1.0690 0.9558 0.9656 1.0096
(R)-S-lactoylglutathionate 0.9653 1.2768 0.7198 1.0381
S-[2-carboxy-1-(1 H-imidazol-4-yl)ethyl]-L-cysteine 1.2880 0.6889 1.2586 0.7645
(S)-dihydroorotate 1.1218 1.1216 0.7843 0.9723
Sedoheptulose 7-phosphate 0.5716 1.1801 0.6692 1.5791
stearate 1.2317 0.9279 1.0387 0.8017
succinate(2-) 1.7419 0.3597 1.6233 0.2752
sulfoglycolithocholate 2.4288 0.0215 1.5326 0.0172
Taurine 1.1456 0.9022 1.0952 0.8570
Taurodeoxycholic acid/taurochenodeoxycholate 2.1902 0.0798 1.6619 0.0681
taurolithocholate 2.0875 0.0656 1.7733 0.0736
tetradecenoate (n-C14:1) 0.8263 1.4502 0.7550 0.9685
thiosulfate 1.0718 0.9026 1.0670 0.9585
Thymidine 1.8376 0.4526 1.3471 0.3627
trans-4,5-epoxy-2(E)-decenal 1.2779 0.7105 1.3685 0.6431
UDP 1.1848 0.9186 1.1636 0.7329
UDP-alpha-D-xylose 0.8086 1.4138 0.7161 1.0615
UDP-D-glucose/UDP-D-galactose 0.9779 1.0120 1.0532 0.9568
UDP-D-glucuronate 1.0118 1.1064 1.0561 0.8257
UDP-N-acetyl-alpha-D-glucosamine/UDP-N-acetyl-alpha-D-galactosamine 0.7884 1.3123 0.6982 1.2011
UMP 0.9818 0.7812 1.3929 0.8441
uracil 1.1718 0.8973 1.1569 0.7740
uridine 0.8561 0.9872 1.1594 0.9973
UTP 1.4217 0.7652 1.2431 0.5700
Valine 1.0323 1.0603 0.8805 1.0269
w-hydroxydecanoicacid 1.3143 0.8052 1.2197 0.6608
Xanthine 1.9476 0.1092 1.8238 0.1193
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Factors:

F1Sample Source:Control | Treatment Duration:Day0
F2Sample Source:Control | Treatment Duration:Day5
F3Sample Source:Patient | Treatment Duration:Day0
F4Sample Source:Patient | Treatment Duration:Day5
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