Data for Metabolomics of patient-derived fibroblasts (Study ST001441)
(Analysis AN002408)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 |
---|---|---|---|---|
11^-Carboxy-alpha-chromanol | 2.1636 | 0.5213 | 0.9795 | 0.3356 |
12,13-epoxy-9-hydroperoxy-10E-octadecenoate | 1.5071 | 0.7349 | 0.9813 | 0.7766 |
13-carboxy-alpha-tocopherol | 2.2557 | 0.2847 | 1.3741 | 0.0856 |
15(S)-Hydroxyeicosatrienoic acid | 2.0911 | 0.3186 | 1.4388 | 0.1516 |
2-acetamido-5-oxopentanoate | 0.9536 | 0.9235 | 1.0160 | 1.1069 |
2-aminomuconate | 1.0967 | 0.4666 | 1.6144 | 0.8222 |
2-deoxy-D-ribose 5-phosphate/2-Deoxy-D-ribose 1-phosphate | 0.7624 | 0.8059 | 1.2813 | 1.1504 |
2-Hydroxyglutarate | 1.0545 | 0.7142 | 1.2770 | 0.9543 |
2-keto-3-deoxy-D-glycero-D-galactononic acid 9-phosphate | 0.9167 | 0.1003 | 2.9165 | 0.0664 |
2-methylglutaconic acid | 0.9809 | 1.0643 | 0.8718 | 1.0829 |
2-oxoadipate | 0.8462 | 0.8894 | 0.8259 | 1.4385 |
2-oxoglutarate | 0.9745 | 0.6334 | 1.3337 | 1.0584 |
3alpha-7alpha-12alpha-Trihydroxy-5beta-cholestanoate/3alpha-7alpha-12alpha-25-tetrahydroxy-5beta-cholestane-24-one | 2.1848 | 0.0257 | 1.7697 | 0.0198 |
3-dehydro-L-gulonate/D-glucuronate/L-iduronate | 1.0954 | 0.9425 | 1.0558 | 0.9063 |
3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid | 1.0008 | 0.9360 | 0.9257 | 1.1375 |
3-hydroxyanthranilate | 0.8598 | 1.0227 | 1.1175 | 1.0000 |
3-Keto-beta-D-galactose/L-Gulonolactone | 1.1899 | 0.8637 | 1.0900 | 0.8565 |
3-methyl-2-oxobutanoate | 0.9435 | 1.0673 | 0.9071 | 1.0821 |
3-methyl-2-oxopentanoate/4-methyl-2-oxopentanoate(ketoleucine) | 0.9792 | 0.9853 | 0.9939 | 1.0415 |
3(S)6(R)-dihydroxy-tetradec-8Z-enoate/3(S)6(S)-dihydroxy-tetradec-8Z-enoate | 2.2884 | 0.2576 | 1.2558 | 0.1983 |
4,6-Dihydroxyquinoline/quinoline-4,8-diol | 1.3212 | 0.7267 | 1.2701 | 0.6821 |
4-hydroperoxy-2-nonenal | 1.2451 | 0.9360 | 1.0808 | 0.7381 |
4-hydroxy-2-nonenal/3,4-epoxynonanal | 1.2126 | 0.9070 | 0.9677 | 0.9127 |
(4-hydroxy-3-methoxyphenyl)acetaldehyde | 1.6635 | 0.5036 | 1.3290 | 0.5040 |
4-hydroxybenzoate/Gentisate aldehyde | 1.2808 | 0.8911 | 1.1060 | 0.7221 |
4-Hydroxyphenylacetate/2-Hydroxyphenylacetate/3,4-Dihydroxyphenylacetaldehyde | 1.5140 | 0.9215 | 0.8288 | 0.7357 |
4-nitrophenolate | 1.1979 | 0.8147 | 1.0376 | 0.9498 |
4-pyridoxate | 1.8654 | 0.3571 | 1.4717 | 0.3058 |
4(R)-hydroxy-dodec-6Z-enoate/4(S)-hydroxy-dodec-6Z-enoate | 1.1792 | 0.9539 | 0.9896 | 0.8773 |
5-Hydroxyisourate | 2.0813 | 0.0044 | 1.9117 | 0.0026 |
5-Methoxyindoleacetate | 2.1164 | 0.1139 | 1.6639 | 0.1057 |
5-oxoproline/L-1-Pyrroline-3-hydroxy-5-carboxylate | 0.8377 | 1.2015 | 0.7777 | 1.1831 |
6-Phosphogluconic acid | 1.7851 | 0.5982 | 1.2120 | 0.4048 |
6(S)-hydroxy-tetradeca-2E4E8Z-trienoate/6(R)-hydroxy-tetradeca-2E4E8Z-trienoate | 1.7493 | 0.5027 | 1.2519 | 0.4962 |
7,9-dihydro-1H-purine-2688(3H)-trione | 1.8949 | 0.1908 | 1.7549 | 0.1594 |
8,11,14-Eicosatrienoic acid (DGLA) | 1.7172 | 0.4637 | 1.4619 | 0.3573 |
9(10)-EpOME/12(13)-EpOME | 1.1228 | 1.2410 | 0.8059 | 0.8303 |
9,10-hydroxyoctadec-12(Z)-enoate/12,13-hydroxyoctadec-9(Z)-enoate | 1.2888 | 0.8005 | 1.0040 | 0.9066 |
acetoacetate | 0.9644 | 0.9825 | 1.0804 | 0.9727 |
adipic acid | 1.3010 | 0.8925 | 1.1374 | 0.6691 |
ADP | 1.3192 | 0.9136 | 1.1307 | 0.6365 |
ADP-mannose/GDP-L-fucose/ADP alpha-D-glucoside | 0.9207 | 1.0938 | 1.0446 | 0.9409 |
ADP-ribose | 0.9984 | 0.8955 | 1.2560 | 0.8502 |
allantoate | 2.0594 | 0.0885 | 1.7622 | 0.0899 |
alpha-D-glucose | 0.9671 | 1.0776 | 0.8588 | 1.0964 |
AMP | 1.0508 | 1.0881 | 0.9618 | 0.8994 |
arachidonic acid | 1.6321 | 0.3380 | 1.6478 | 0.3822 |
arginine | 0.9955 | 1.0963 | 0.8216 | 1.0866 |
aspartate | 0.8789 | 2.1762 | 0.2729 | 0.6720 |
ATP | 1.3528 | 0.9109 | 1.0866 | 0.6497 |
Azelaic acid | 1.4154 | 0.7978 | 1.2400 | 0.5468 |
beta-D-Fructose 1,6-bisphosphate | 1.5147 | 0.4345 | 1.4804 | 0.5704 |
beta-hydroxy-beta-methylbutyrate | 1.5723 | 0.5119 | 1.5406 | 0.3751 |
C20H30O2(4) | 1.6329 | 0.3623 | 1.6225 | 0.3822 |
C20H30O3(6) | 1.6635 | 0.6065 | 1.2169 | 0.5131 |
C20H30O4(18) | 1.9614 | 0.4087 | 1.3385 | 0.2914 |
C20H32O3(12) | 1.7273 | 0.5525 | 1.3465 | 0.3737 |
C20H32O4(21) | 1.6811 | 0.4769 | 1.4535 | 0.3886 |
C20H34O4(4) | 1.8320 | 0.3394 | 1.6691 | 0.1596 |
C27H46O4(3) | 1.7849 | 0.8724 | 0.8686 | 0.4741 |
C4H8O3(3) | 1.4335 | 0.3376 | 1.9624 | 0.2665 |
C5H10O5(6) | 0.9951 | 1.0590 | 0.8669 | 1.0789 |
C6H12O6(5) | 0.5642 | 1.3264 | 0.6791 | 1.4303 |
caprate | 1.0240 | 0.9102 | 1.0941 | 0.9717 |
carnosine | 1.8644 | 0.1958 | 1.7381 | 0.2017 |
CDP | 1.5866 | 0.4717 | 1.5082 | 0.4335 |
cholesterol sulfate | 1.0588 | 0.1072 | 2.7160 | 0.1180 |
cis-aconitate | 1.3518 | 1.0175 | 0.9363 | 0.6944 |
citrate/isocitrate | 1.3420 | 1.0646 | 0.9170 | 0.6765 |
clupanodonic acid/docosa-4,7,10,13,16-pentaenoic acid | 1.9731 | 0.1194 | 1.7670 | 0.1406 |
CMP | 1.3166 | 0.8670 | 1.0993 | 0.7171 |
CTP | 1.5394 | 0.6684 | 1.3484 | 0.4438 |
cytidine | 1.5027 | 0.4364 | 1.4896 | 0.5713 |
Deoxyinosine | 0.5552 | 1.2561 | 1.0944 | 1.0943 |
Deoxyuridine | 1.7948 | 0.5920 | 1.2201 | 0.3932 |
D-Erythrose 4-phosphate | 1.3073 | 0.5613 | 1.3617 | 0.7697 |
D-Glucosamine 6-phosphate | 1.2040 | 0.7387 | 1.3220 | 0.7354 |
D-Glucuronate 1-phosphate | 1.0100 | 0.7048 | 1.3418 | 0.9434 |
D-glycerate | 1.9679 | 0.3383 | 1.4107 | 0.2831 |
D-Glycerate 3-phosphate/D-Glycerate 2-phosphate | 1.1237 | 0.7157 | 1.4439 | 0.7168 |
Dihydroxyacetone phosphate | 1.5716 | 0.3682 | 1.6585 | 0.4017 |
Diphosphate | 2.5894 | 0.1391 | 1.2115 | 0.0599 |
docosahexaenoate(DHA) | 1.9675 | 0.0852 | 1.8033 | 0.1440 |
docosanedioicacid | 1.4048 | 0.5824 | 1.0571 | 0.9557 |
Dodecanedioic acid | 1.3194 | 0.9673 | 1.0837 | 0.6296 |
dTTP | 2.4423 | 0.0099 | 1.5378 | 0.0099 |
dUDP | 0.5010 | 1.3990 | 0.5861 | 1.5139 |
dUMP | 0.5197 | 2.0303 | 0.5552 | 0.8948 |
Eicosenoic acid | 1.0956 | 1.0018 | 0.8801 | 1.0225 |
estrone 3-sulfate | 2.4008 | 0.0473 | 1.4903 | 0.0616 |
fructoseglycine | 1.1558 | 1.0425 | 0.9342 | 0.8674 |
fructoselysine 3-phosphate | 0.4681 | 1.7721 | 0.5039 | 1.2558 |
fructosyllysine | 1.1916 | 0.9357 | 1.0120 | 0.8607 |
fumarate | 1.3621 | 1.4000 | 0.7180 | 0.5199 |
G6P/F6P | 1.2177 | 0.8423 | 1.0343 | 0.9057 |
Galactosylglycerol | 2.2061 | 0.0668 | 1.6094 | 0.1176 |
gama-L-glutamyl-L-alpha-aminobutyrate | 1.3958 | 0.8230 | 1.1144 | 0.6668 |
GDP | 1.3328 | 0.6451 | 1.6047 | 0.4174 |
GDP-D-mannose | 0.8941 | 1.1231 | 1.0243 | 0.9584 |
Glycerol 3-phosphate | 1.0976 | 1.0934 | 0.9717 | 0.8373 |
glycochenodeoxycholate | 2.0727 | 0.1149 | 1.7178 | 0.0946 |
glycolithocholate | 2.0983 | 0.1481 | 1.6760 | 0.0776 |
Glycyl-phenylalanine | 1.9031 | 0.7835 | 0.8649 | 0.4484 |
GMP | 1.0110 | 1.1919 | 0.8866 | 0.9106 |
GTP | 1.4621 | 0.8164 | 1.1897 | 0.5319 |
guanosine | 0.7202 | 1.3023 | 0.7409 | 1.2366 |
gulonate | 1.4319 | 0.6579 | 1.3787 | 0.5315 |
Hexadecanedioic acid | 1.4219 | 0.6199 | 1.1574 | 0.8008 |
Hypotaurine | 0.7019 | 1.5950 | 0.6334 | 1.0697 |
Hypoxanthine | 1.4892 | 0.1164 | 2.2511 | 0.1433 |
inosine | 1.0176 | 0.8343 | 1.5214 | 0.6267 |
itaconate/Mesaconate | 1.2385 | 0.8301 | 1.1504 | 0.7810 |
kynurenate | 1.7154 | 0.3056 | 1.7547 | 0.2242 |
L-2-aminoadipate | 0.9723 | 1.2984 | 0.7841 | 0.9451 |
L-4-hydroxyglutamate semialdehyde | 1.0069 | 0.9353 | 1.1679 | 0.8899 |
lactate | 1.5149 | 0.5345 | 1.4731 | 0.4775 |
L-arabinitol/xylitol/D-ribitol | 1.8548 | 0.2693 | 1.6123 | 0.2636 |
laurate | 1.1200 | 0.9191 | 1.0048 | 0.9562 |
L-cystathionine | 1.3265 | 0.7614 | 1.3078 | 0.6044 |
L-cysteate | 1.0420 | 1.2706 | 0.7215 | 0.9660 |
L-erythrulose | 0.9868 | 1.0682 | 0.8675 | 1.0775 |
L-fucose/L-Fuculose | 1.9974 | 0.0628 | 1.8382 | 0.1016 |
L-glutamate | 1.0108 | 0.9330 | 1.1691 | 0.8871 |
L-Iditol/D-glucitol/galactitol | 2.0045 | 0.0458 | 1.8547 | 0.0949 |
linoleic acid/linoelaidic acid (all trans C18:2)/octadecadienoate (n-C18:2) | 1.5922 | 0.6026 | 1.3436 | 0.4615 |
L-isoleucine/L-leucine | 1.0499 | 1.0491 | 0.8835 | 1.0175 |
lithocholate | 2.4693 | 0.5102 | 0.5102 | 0.5102 |
L-threonate | 1.9192 | 0.2796 | 1.5371 | 0.2641 |
L-tryptophan | 1.1110 | 0.9957 | 0.9079 | 0.9854 |
L-xylonate/L-lyxonate | 1.2765 | 0.7340 | 1.3317 | 0.6579 |
lysine | 1.0068 | 1.1047 | 0.8257 | 1.0628 |
malate | 1.2726 | 1.0916 | 0.9270 | 0.7089 |
margarate | 1.2246 | 0.8922 | 1.0856 | 0.7976 |
Methylisocitric acid/2-methylcitrate | 1.4808 | 1.0655 | 1.1263 | 0.3275 |
myo-inositol | 0.5623 | 1.3265 | 0.6792 | 1.4320 |
myristate | 1.1325 | 0.9579 | 1.0311 | 0.8786 |
N-acetyl-L-aspartate/2-Amino-3-oxoadipate | 0.9812 | 0.5691 | 1.7285 | 0.7212 |
N-acetyl-L-glutamate | 1.0076 | 0.7073 | 1.5298 | 0.7553 |
N-Acetylneuraminate 9-phosphate | 1.5174 | 0.8548 | 0.8319 | 0.7959 |
N-acetyl-seryl-aspartate | 1.2889 | 0.8980 | 1.2046 | 0.6085 |
NADH | 1.2236 | 1.1215 | 0.8763 | 0.7787 |
NADPH | 0.8057 | 1.4380 | 1.5918 | 0.1646 |
N-Carbamoyl-L-aspartate | 2.0893 | 1.0472 | 0.8483 | 0.0151 |
N-Formimidoyl-L-glutamate | 1.5143 | 0.9537 | 0.9434 | 0.5886 |
N(omega)-(L-Arginino)succinate | 1.8680 | 1.4947 | 0.4286 | 0.2087 |
nonanoate | 0.8725 | 1.4770 | 0.9559 | 0.6946 |
N-phosphocreatinate | 1.4148 | 0.7241 | 1.2687 | 0.5924 |
oleic acid/elaidate/trans-vaccenate | 1.4469 | 0.6937 | 1.2644 | 0.5950 |
omega hydroxy dodecanoate (n-C12:0) | 1.2908 | 1.1803 | 0.7055 | 0.8233 |
omega hydroxy hexadecanoate (n-C16:0) | 1.2616 | 0.8464 | 0.8936 | 0.9984 |
omega hydroxy tetradecanoate (n-C14:0) | 1.1451 | 1.2012 | 0.7832 | 0.8705 |
O-Phospho-L-serine | 1.0715 | 1.3815 | 0.8306 | 0.7164 |
oxalatosuccinate | 2.8313 | 0.2924 | 0.3212 | 0.5550 |
palmitate | 1.1651 | 0.9147 | 1.0729 | 0.8473 |
palmitoleate | 1.3400 | 0.8741 | 1.1461 | 0.6398 |
pentadecanoate | 1.1800 | 0.9116 | 1.0905 | 0.8179 |
Perillic acid | 1.2705 | 0.9493 | 0.8806 | 0.8997 |
phenylacetate/(4-hydroxyphenyl)acetaldehyde | 1.2149 | 0.7304 | 0.8074 | 1.2473 |
Phosphoenolpyruvate | 0.8797 | 0.8137 | 1.4080 | 0.8986 |
phytanic acid/arachidic acid | 1.1935 | 0.8482 | 1.1555 | 0.8027 |
pristanic acid | 1.2273 | 0.8325 | 1.0065 | 0.9336 |
pyruvate | 1.0076 | 0.8779 | 0.8700 | 1.2445 |
quinolinate | 2.1400 | 0.0971 | 1.6577 | 0.1052 |
(R)-2-hydroxy-4-methylpentanoate | 1.2250 | 0.7980 | 1.2352 | 0.7418 |
ribose-phosphate | 1.2509 | 0.7205 | 1.4654 | 0.5632 |
(R)-Pantothenate | 1.0690 | 0.9558 | 0.9656 | 1.0096 |
(R)-S-lactoylglutathionate | 0.9653 | 1.2768 | 0.7198 | 1.0381 |
S-[2-carboxy-1-(1 H-imidazol-4-yl)ethyl]-L-cysteine | 1.2880 | 0.6889 | 1.2586 | 0.7645 |
(S)-dihydroorotate | 1.1218 | 1.1216 | 0.7843 | 0.9723 |
Sedoheptulose 7-phosphate | 0.5716 | 1.1801 | 0.6692 | 1.5791 |
stearate | 1.2317 | 0.9279 | 1.0387 | 0.8017 |
succinate(2-) | 1.7419 | 0.3597 | 1.6233 | 0.2752 |
sulfoglycolithocholate | 2.4288 | 0.0215 | 1.5326 | 0.0172 |
Taurine | 1.1456 | 0.9022 | 1.0952 | 0.8570 |
Taurodeoxycholic acid/taurochenodeoxycholate | 2.1902 | 0.0798 | 1.6619 | 0.0681 |
taurolithocholate | 2.0875 | 0.0656 | 1.7733 | 0.0736 |
tetradecenoate (n-C14:1) | 0.8263 | 1.4502 | 0.7550 | 0.9685 |
thiosulfate | 1.0718 | 0.9026 | 1.0670 | 0.9585 |
Thymidine | 1.8376 | 0.4526 | 1.3471 | 0.3627 |
trans-4,5-epoxy-2(E)-decenal | 1.2779 | 0.7105 | 1.3685 | 0.6431 |
UDP | 1.1848 | 0.9186 | 1.1636 | 0.7329 |
UDP-alpha-D-xylose | 0.8086 | 1.4138 | 0.7161 | 1.0615 |
UDP-D-glucose/UDP-D-galactose | 0.9779 | 1.0120 | 1.0532 | 0.9568 |
UDP-D-glucuronate | 1.0118 | 1.1064 | 1.0561 | 0.8257 |
UDP-N-acetyl-alpha-D-glucosamine/UDP-N-acetyl-alpha-D-galactosamine | 0.7884 | 1.3123 | 0.6982 | 1.2011 |
UMP | 0.9818 | 0.7812 | 1.3929 | 0.8441 |
uracil | 1.1718 | 0.8973 | 1.1569 | 0.7740 |
uridine | 0.8561 | 0.9872 | 1.1594 | 0.9973 |
UTP | 1.4217 | 0.7652 | 1.2431 | 0.5700 |
Valine | 1.0323 | 1.0603 | 0.8805 | 1.0269 |
w-hydroxydecanoicacid | 1.3143 | 0.8052 | 1.2197 | 0.6608 |
Xanthine | 1.9476 | 0.1092 | 1.8238 | 0.1193 |
Factors:
F1 | Sample Source:Control | Treatment Duration:Day0 |
F2 | Sample Source:Control | Treatment Duration:Day5 |
F3 | Sample Source:Patient | Treatment Duration:Day0 |
F4 | Sample Source:Patient | Treatment Duration:Day5 |