Data for Liver metabolomics in old liver-specific SIRT6 overexpressing mice (Study ST001508)
(Analysis AN002499)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 |
|---|---|---|---|---|
| Acetoacetate | 1.0512 | 0.9838 | 0.9362 | 1.0288 |
| Acetyl CoA | 0.9280 | 1.0430 | 1.0098 | 1.0192 |
| aKG | 1.0809 | 1.0112 | 0.8400 | 1.0680 |
| Arginine | 1.0746 | 1.0706 | 0.9622 | 0.8926 |
| Asparagine | 0.9589 | 0.9986 | 1.1191 | 0.9234 |
| Aspartate | 0.8791 | 1.1023 | 0.9625 | 1.0561 |
| cis-aconitate | 1.0872 | 0.9575 | 1.0105 | 0.9448 |
| Citrate | 1.0385 | 0.9507 | 1.0099 | 1.0009 |
| Cysteine | 0.8972 | 0.9904 | 1.3383 | 0.6645 |
| Cystine | 0.7401 | 1.0842 | 1.4207 | 0.7550 |
| dihydroxyacetone phosphate (DHAP) | 0.9079 | 1.0719 | 1.1105 | 0.9098 |
| Fructose | 0.9937 | 0.9292 | 1.1462 | 0.9308 |
| fructose 1,6-diphosphate | 1.0856 | 0.9144 | NA | NA |
| Fructose-6-phosphate | 0.9191 | 0.9949 | 1.0160 | 1.0700 |
| G6P | 0.9150 | 1.0285 | 1.0204 | 1.0361 |
| Glucose | 1.0995 | 0.9619 | 0.9316 | 1.0071 |
| Glutamate | 0.8638 | 1.0571 | 1.0061 | 1.0730 |
| Glutamine | 0.9333 | 0.9834 | 1.0670 | 1.0164 |
| Glyceraldehyde 3-phosphate | 1.0675 | 0.9374 | 1.0231 | 0.9720 |
| Glycerol | 1.1336 | 0.9586 | 0.9477 | 0.9601 |
| Glycine | 1.0952 | 1.0058 | 0.9890 | 0.9100 |
| Histidine | 1.1171 | 1.0403 | 0.9672 | 0.8754 |
| IsoLeucine | 1.0935 | 0.9778 | 1.0223 | 0.9065 |
| Lactate | 1.1457 | 0.9456 | 0.9478 | 0.9609 |
| Leucine | 1.0556 | 0.9804 | 1.0232 | 0.9408 |
| Lysine | 0.9889 | 1.0053 | 1.0310 | 0.9748 |
| Malate | 1.0772 | 1.0055 | 0.8971 | 1.0203 |
| Methionine | 1.1521 | 0.9068 | 0.9797 | 0.9614 |
| NAD+ | 1.0947 | 0.9610 | 0.8081 | 1.1363 |
| NADH | 1.1259 | 0.8376 | 0.9776 | 1.0589 |
| NADP+ | 0.9529 | 0.9315 | 1.0262 | 1.0895 |
| NADPH | 1.0547 | 0.8214 | 1.1079 | 1.0160 |
| PEP | 0.9734 | 1.1183 | 0.9383 | 0.9701 |
| Phenylalanine | 1.0426 | 0.9559 | 1.0404 | 0.9611 |
| Proline | 1.0031 | 1.0272 | 1.0828 | 0.8869 |
| Pyruvate | 1.0494 | 1.0523 | 0.9320 | 0.9663 |
| Serine | 1.0965 | 0.9329 | 1.0676 | 0.9031 |
| Succinic Acid | 1.1666 | 0.9504 | 0.9243 | 0.9587 |
| Threonine | 1.0133 | 1.0355 | 1.0276 | 0.9237 |
| Tryptophan | 0.9874 | 0.9432 | 1.0446 | 1.0248 |
| Tyrosine | 1.0692 | 0.9205 | 1.0665 | 0.9437 |
| Valine | 1.1277 | 0.9959 | 0.9416 | 0.9348 |
Factors:
| F1 | Genotype:Albumin Cre control |
| F2 | Genotype:Flox control |
| F3 | Genotype:Liver specific SIRT6 overexpression |
| F4 | Genotype:Wild-type |
