Data for A Metabolomic Signature of Glucagon Action in Healthy Individuals with Overweight/Obesity Humans (Study ST001515)
(Analysis AN002512)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 | F4 | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 | F14 | F15 | F16 | F17 | F18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1-oleoyl-GPS (18:1) | 1.0374 | 0.9374 | 0.9599 | 0.9643 | 0.9382 | 0.9871 | 0.9688 | 1.0164 | 0.9543 | 1.0130 | 0.9231 | 1.0576 | 1.1570 | 0.9305 | 1.1113 | 0.9931 | 1.0075 | 1.0532 |
1-stearoyl-2-oleoyl-GPS (18:0/18:1) | 1.2590 | 1.2758 | 1.2552 | 1.6128 | 0.9442 | 1.1512 | 0.7183 | 0.9066 | 0.9515 | 0.9180 | 0.6983 | 0.8661 | 0.9023 | 0.8615 | 1.1991 | 0.8124 | 0.8303 | 0.8850 |
3-decenoylcarnitine | 1.3344 | 0.8787 | 0.7929 | 0.5911 | 0.9447 | 0.9761 | 1.0561 | 0.7761 | 0.7888 | 0.6923 | 0.9639 | 0.9113 | 1.4967 | 1.2225 | 1.2141 | 1.1975 | 1.2377 | 1.1322 |
3-hydroxydecanoylcarnitine | 1.3535 | 0.8775 | 0.9238 | 0.5738 | 1.1363 | 0.8831 | 1.1465 | 0.7257 | 0.8122 | 0.5563 | 1.0818 | 0.8791 | 1.4791 | 1.0674 | 1.0607 | 1.4285 | 1.1861 | 0.9949 |
3-hydroxyoleoylcarnitine | 1.0142 | 1.1219 | 1.1246 | 0.3878 | 1.1460 | 0.7448 | 1.0688 | 0.9553 | 1.2797 | 0.6208 | 1.2709 | 0.9720 | 1.2093 | 0.6433 | 0.7775 | 1.6649 | 1.0558 | 0.9165 |
4-cholesten-3-one | 0.7672 | 0.9004 | 0.7645 | 1.1961 | 0.9430 | 0.9776 | 0.8917 | 0.8787 | 1.2422 | 1.0680 | 0.9528 | 1.0905 | 0.6808 | 1.2273 | 1.0558 | 1.3712 | 0.9618 | 1.0746 |
4-methylnonanoylcarnitine | 1.5625 | 0.6541 | 0.7084 | 1.1384 | 0.6967 | 0.8665 | 1.2176 | 0.6497 | 0.7699 | 1.0133 | 0.5618 | 0.9956 | 1.3060 | 1.0749 | 1.2273 | 1.2639 | 1.2085 | 1.2145 |
5-dodecenoylcarnitine (C12:1) | 1.3631 | 0.7641 | 0.8067 | 0.5845 | 0.9825 | 0.9395 | 1.2987 | 0.7692 | 0.9858 | 0.7028 | 1.1668 | 0.9252 | 1.3598 | 0.8680 | 1.0056 | 1.4427 | 1.1138 | 0.9514 |
adrenoylcarnitine (C22:4)* | 1.2076 | 0.8972 | 0.9239 | 0.7719 | 1.0643 | 1.2147 | 1.1816 | 0.8333 | 0.9731 | 0.7823 | 0.8868 | 0.9875 | 1.1983 | 0.9192 | 0.9424 | 1.1070 | 1.1535 | 0.9688 |
alpha-tocopherol | 1.0234 | 0.9645 | 1.0724 | 0.9876 | 1.0229 | 0.9911 | 0.8425 | 0.9249 | 1.0130 | 0.8741 | 0.9733 | 0.9346 | 1.1252 | 1.1296 | 1.1075 | 1.0134 | 1.1038 | 1.0020 |
arachidonoylcarnitine (C20:4) | 1.1966 | 1.0302 | 0.9554 | 0.9054 | 1.0222 | 1.0496 | 1.0901 | 0.7986 | 0.9010 | 0.8018 | 0.8998 | 0.9484 | 1.1695 | 0.9581 | 0.9690 | 1.2100 | 1.1922 | 0.9623 |
arachidonoylcholine | 0.8065 | 0.8015 | 0.6948 | 1.2360 | 0.6492 | 0.6954 | 0.8276 | 1.0632 | 0.9466 | 1.2131 | 0.7161 | 0.8445 | 1.0715 | 1.2526 | 1.4782 | 1.2844 | 1.2056 | 1.3683 |
arachidoylcarnitine (C20)* | 1.0384 | 0.9351 | 1.0296 | 1.0018 | 1.0001 | 0.8687 | 0.9657 | 0.8947 | 0.8960 | 0.9642 | 0.8339 | 1.0334 | 1.0860 | 1.0362 | 1.0605 | 1.0308 | 1.2482 | 1.1580 |
behenoylcarnitine (C22)* | 1.0639 | 1.2504 | 1.0756 | 1.1587 | 1.0034 | 1.0116 | 0.8297 | 0.8969 | 0.8201 | 0.8528 | 0.8297 | 0.8344 | 1.1299 | 1.0035 | 1.1811 | 0.9248 | 1.3881 | 0.8681 |
beta-cryptoxanthin | 1.1992 | 1.0356 | 1.2672 | 1.1628 | 1.2437 | 1.1378 | 0.8741 | 0.9656 | 1.0931 | 0.9479 | 1.0045 | 0.9148 | 0.8804 | 0.8264 | 0.8732 | 0.7896 | 0.8732 | 0.8695 |
beta-sitosterol | 1.0309 | 1.1522 | 1.4389 | 1.0156 | 1.2772 | 0.9747 | 0.8177 | 0.8965 | 0.9884 | 0.8277 | 0.8617 | 0.8820 | 0.9543 | 1.1512 | 0.9354 | 0.8604 | 1.0536 | 1.0076 |
bilirubin (E,Z or Z,E)* | 1.0994 | 0.7370 | 0.8316 | 0.9947 | 0.8744 | 1.0039 | 1.0184 | 1.0016 | 1.2136 | 1.1636 | 1.1097 | 0.9204 | 1.1422 | 0.9449 | 0.9956 | 1.1205 | 0.9047 | 0.8676 |
biliverdin | 1.0386 | 0.4326 | 0.6352 | 0.6546 | 0.6348 | 0.7811 | 1.9954 | 0.7510 | 0.9190 | 1.3144 | 1.1499 | 1.4474 | 1.0380 | 0.6353 | 0.7890 | 1.3259 | 1.2171 | 0.9708 |
campesterol | 1.1389 | 1.0842 | 1.3051 | 0.9946 | 1.1925 | 1.0266 | 0.8213 | 0.7723 | 0.9646 | 0.8344 | 0.8898 | 0.8944 | 1.0182 | 1.2453 | 0.9764 | 0.8277 | 1.2269 | 0.9542 |
carotene diol (1) | 1.2366 | 1.0367 | 1.1565 | 1.1801 | 1.1623 | 1.1727 | 0.9104 | 0.8539 | 0.8790 | 0.9038 | 0.8829 | 0.9531 | 1.0265 | 1.0125 | 0.9294 | 0.8723 | 0.9622 | 0.9145 |
carotene diol (2) | 1.2617 | 1.1667 | 1.1485 | 1.2007 | 1.1771 | 1.1889 | 0.9184 | 0.8966 | 0.8152 | 0.8523 | 0.9040 | 0.9338 | 0.9973 | 0.8969 | 0.9424 | 0.9420 | 0.8987 | 0.8801 |
carotene diol (3) | 1.2165 | 1.0355 | 1.2129 | 1.1515 | 1.1580 | 1.2086 | 0.9449 | 0.9054 | 0.8373 | 0.9176 | 0.9628 | 1.0505 | 0.9620 | 0.9224 | 0.8526 | 0.8780 | 0.9124 | 0.8579 |
cerotoylcarnitine (C26)* | 1.1416 | 1.0548 | 1.1028 | 1.1301 | 1.0236 | 1.1247 | 0.8852 | 0.8329 | 0.8203 | 0.8988 | 0.7792 | 0.8708 | 1.1408 | 1.0602 | 1.0402 | 1.0742 | 1.0453 | 1.0844 |
cetirizine | 0.8915 | 0.8915 | 0.8915 | 0.8915 | 0.8915 | 0.8915 | 1.6651 | 0.9370 | 0.9171 | 1.7241 | 0.8915 | 0.9845 | 0.8915 | 0.8915 | 0.8915 | 0.8915 | 0.8915 | 0.8915 |
cholesterol | 1.0656 | 0.8865 | 0.9901 | 1.0092 | 0.9636 | 0.9911 | 0.9841 | 0.8723 | 0.9230 | 0.9728 | 0.9034 | 0.9953 | 1.1675 | 1.0811 | 1.0445 | 1.0658 | 1.1010 | 1.0530 |
cis-4-decenoylcarnitine (C10:1) | 1.2181 | 0.7812 | 0.6691 | 0.5682 | 0.8515 | 0.8713 | 1.4309 | 0.8315 | 0.8386 | 0.7743 | 1.0672 | 0.9188 | 1.3242 | 1.3380 | 1.0693 | 1.3384 | 1.2472 | 0.9804 |
decanoylcarnitine (C10) | 1.5260 | 0.6541 | 0.6045 | 0.5080 | 0.9372 | 0.9611 | 1.5789 | 0.6265 | 0.8134 | 0.6413 | 1.0712 | 0.9310 | 1.5910 | 0.9229 | 1.1304 | 1.3675 | 1.1561 | 1.0430 |
delta-tocopherol | 0.9299 | 1.6034 | 0.7255 | 0.6917 | 1.0180 | 0.9167 | 1.0718 | 1.6744 | 0.7680 | 0.6405 | 1.0196 | 1.2996 | 0.8722 | 1.8002 | 0.8415 | 0.5565 | 0.7434 | 0.8885 |
dihomo-linolenoylcarnitine (C20:3n3 or 6)* | 1.2378 | 0.9853 | 0.9750 | 0.8262 | 0.9578 | 1.1926 | 1.1524 | 0.8498 | 0.9695 | 0.8983 | 0.9421 | 1.0622 | 1.1003 | 0.8917 | 0.9017 | 1.1142 | 0.9997 | 0.9223 |
dihomo-linolenoyl-choline | 1.0819 | 0.8829 | 0.5648 | 1.4563 | 0.4713 | 0.8896 | 0.9966 | 1.1234 | 0.8488 | 1.4779 | 0.5773 | 1.0843 | 0.9111 | 1.0447 | 1.2151 | 1.2705 | 0.8666 | 1.2100 |
dihomo-linoleoylcarnitine (C20:2)* | 1.0844 | 1.0675 | 1.0606 | 0.6324 | 1.1823 | 1.0479 | 1.0855 | 0.9289 | 0.9757 | 0.8067 | 0.9674 | 0.9815 | 1.0689 | 0.9220 | 0.9052 | 1.2562 | 1.0786 | 0.9793 |
docosahexaenoylcarnitine (C22:6)* | 1.3615 | 1.2497 | 0.8542 | 0.9226 | 0.9877 | 1.1004 | 0.8108 | 0.9704 | 0.7177 | 0.6117 | 0.7205 | 0.6274 | 1.1944 | 1.1108 | 1.1636 | 1.4950 | 1.3483 | 0.9654 |
docosahexaenoylcholine | 0.8965 | 0.8850 | 0.8944 | 1.3697 | 0.7653 | 0.6741 | 0.7342 | 0.9817 | 0.8818 | 1.1005 | 0.5850 | 0.7365 | 1.1735 | 1.2614 | 1.3732 | 1.3057 | 1.2110 | 1.3823 |
eicosenoylcarnitine (C20:1)* | 1.0080 | 1.0083 | 1.1757 | 0.6403 | 1.1551 | 0.8657 | 1.0503 | 0.8643 | 1.0271 | 0.8344 | 0.9815 | 0.9387 | 1.1748 | 0.8641 | 0.9733 | 1.3115 | 1.1557 | 1.0297 |
gamma-tocopherol/beta-tocopherol | 1.0146 | 1.0513 | 0.7761 | 0.8498 | 0.9251 | 1.0110 | 0.8756 | 1.0393 | 0.7395 | 0.7588 | 0.9073 | 0.9889 | 1.2446 | 1.6030 | 1.0769 | 1.0632 | 1.1012 | 1.1938 |
heme | 0.5173 | 0.2773 | 0.2499 | 0.2513 | 0.2657 | 0.3160 | 4.2857 | 0.2491 | 0.2324 | 2.9464 | 0.6290 | 1.2011 | 0.3848 | 0.3569 | 0.3083 | 3.2209 | 0.7760 | 0.8695 |
laurylcarnitine (C12) | 1.3833 | 0.8142 | 0.7600 | 0.6282 | 1.0233 | 0.9577 | 1.3436 | 0.7287 | 0.9812 | 0.6835 | 1.1498 | 0.9343 | 1.4006 | 0.8540 | 0.9641 | 1.3912 | 1.0682 | 0.9535 |
lignoceroylcarnitine (C24)* | 1.1270 | 1.0926 | 1.0158 | 1.1358 | 0.9286 | 1.0829 | 0.9041 | 0.8162 | 0.7653 | 0.9050 | 0.7711 | 0.9051 | 1.1405 | 1.0877 | 1.0484 | 1.0708 | 1.1657 | 1.1593 |
linolenoylcarnitine (C18:3)* | 1.1142 | 1.2884 | 0.9336 | 0.5461 | 0.9231 | 0.9843 | 1.1015 | 1.1269 | 1.0266 | 0.6688 | 1.0462 | 0.9667 | 1.1779 | 1.1634 | 1.0036 | 1.0506 | 1.0534 | 0.8881 |
linoleoylcarnitine (C18:2)* | 1.0459 | 1.2164 | 0.9949 | 0.6529 | 1.1125 | 0.9631 | 1.0381 | 1.0053 | 0.9698 | 0.7939 | 1.0037 | 0.9556 | 1.1031 | 1.0762 | 0.9184 | 1.1764 | 1.0783 | 0.9600 |
linoleoylcholine* | 0.9189 | 1.0456 | 0.8692 | 1.2323 | 0.7652 | 0.7876 | 0.7470 | 1.0924 | 0.9767 | 1.0184 | 0.6707 | 0.8544 | 0.9785 | 1.3490 | 1.3829 | 1.1027 | 1.1454 | 1.2494 |
margaroylcarnitine (C17)* | 1.0618 | 0.8282 | 1.0871 | 0.6586 | 1.0671 | 0.9820 | 1.1949 | 0.7788 | 1.1093 | 0.8872 | 1.0565 | 1.0849 | 1.1731 | 0.7096 | 0.9754 | 1.1934 | 1.0641 | 1.0548 |
myristoleoylcarnitine (C14:1)* | 1.3135 | 1.2104 | 0.9002 | 0.5074 | 1.3166 | 0.9195 | 1.2183 | 0.8283 | 1.1014 | 0.6112 | 1.2606 | 0.8266 | 1.2226 | 0.7065 | 0.8262 | 1.4480 | 0.9908 | 0.7840 |
myristoylcarnitine (C14) | 1.1747 | 0.9340 | 1.0296 | 0.6908 | 1.0334 | 1.0445 | 1.1513 | 0.8464 | 1.0517 | 0.8528 | 1.0522 | 0.9873 | 1.1865 | 0.7258 | 0.9118 | 1.3107 | 0.9252 | 1.0601 |
nervonoylcarnitine (C24:1)* | 1.3006 | 0.9791 | 0.9674 | 1.0813 | 0.8841 | 1.1797 | 0.9584 | 0.7165 | 0.7404 | 0.8720 | 0.6656 | 0.7742 | 1.2960 | 0.9412 | 1.1004 | 1.3516 | 1.1509 | 1.1725 |
nonanoylcarnitine (C9) | 1.3030 | 0.6257 | 0.7105 | 0.6397 | 0.7361 | 0.9498 | 1.5235 | 0.7214 | 0.9448 | 0.7700 | 1.0449 | 1.0284 | 1.3866 | 1.0029 | 1.1357 | 1.2578 | 1.2015 | 1.0452 |
octadecanedioylcarnitine (C18-DC)* | 0.9547 | 1.1210 | 1.0597 | 1.0070 | 0.9392 | 0.7347 | 1.0730 | 1.2017 | 1.2302 | 1.1526 | 1.0794 | 0.8823 | 0.9733 | 0.9458 | 0.8764 | 0.9722 | 0.8959 | 0.8139 |
octadecenedioylcarnitine (C18:1-DC)* | 0.8892 | 1.4301 | 1.0750 | 0.7763 | 0.9087 | 0.7059 | 0.9747 | 1.2636 | 1.1855 | 0.9752 | 1.0992 | 0.9346 | 0.9469 | 0.9604 | 0.8614 | 1.2198 | 0.9401 | 0.8163 |
octanoylcarnitine (C8) | 1.3572 | 0.6492 | 0.6491 | 0.4847 | 0.8237 | 0.9512 | 1.5817 | 0.6633 | 0.8849 | 0.7049 | 1.0938 | 0.9946 | 1.5004 | 1.0369 | 1.0675 | 1.3474 | 1.2227 | 1.0405 |
oleoylcarnitine (C18) | 1.1242 | 0.9858 | 1.0990 | 0.6079 | 1.1537 | 0.9603 | 1.1216 | 0.8658 | 1.0792 | 0.8047 | 1.1078 | 1.0010 | 1.1339 | 0.7810 | 0.9125 | 1.2761 | 1.0336 | 0.9460 |
oleoylcholine | 1.0083 | 0.9731 | 0.7809 | 1.3260 | 0.6374 | 0.7459 | 0.8203 | 1.0185 | 0.9183 | 1.1542 | 0.6436 | 0.8344 | 1.0383 | 1.1702 | 1.3962 | 1.2370 | 1.1104 | 1.3309 |
palmitoleoylcarnitine (C16:1)* | 1.1699 | 0.9321 | 0.9768 | 0.5302 | 1.1429 | 0.9323 | 1.2025 | 0.8165 | 1.1544 | 0.7612 | 1.1852 | 1.0287 | 1.1826 | 0.7172 | 0.8612 | 1.4321 | 1.0084 | 0.9325 |
palmitoylcarnitine (C16) | 1.1326 | 0.9083 | 1.0700 | 0.7200 | 1.0506 | 1.0401 | 1.1281 | 0.8512 | 1.0554 | 0.9109 | 0.9929 | 1.0941 | 1.0997 | 0.7929 | 0.9394 | 1.1790 | 0.9744 | 1.0356 |
palmitoylcholine | 0.9082 | 0.9255 | 0.7512 | 1.2535 | 0.6791 | 0.7580 | 0.7672 | 1.1100 | 0.9718 | 1.1555 | 0.6963 | 0.8949 | 1.0476 | 1.2654 | 1.3575 | 1.1940 | 1.1025 | 1.3022 |
palmitoyl-sphingosine-phosphoethanolamine (d18:1/16:0) | 1.0631 | 0.8648 | 0.8941 | 0.9966 | 0.9696 | 0.9946 | 1.0091 | 0.9380 | 0.9158 | 1.0370 | 1.0144 | 1.0161 | 1.0463 | 1.0742 | 1.0777 | 1.0441 | 1.0235 | 1.0566 |
piperine | 0.6238 | 0.7903 | 0.3818 | 0.7592 | 0.4906 | 1.1174 | 0.7317 | 0.8094 | 0.3763 | 0.8144 | 0.4693 | 1.3120 | 1.7209 | 1.7376 | 1.1053 | 1.2944 | 1.3045 | 2.5261 |
retinal | 1.0490 | 0.9243 | 0.9016 | 0.9333 | 0.7742 | 0.8514 | 1.2007 | 0.9111 | 0.8515 | 0.9326 | 1.0299 | 0.9324 | 1.1648 | 1.1803 | 1.1756 | 1.1016 | 1.0698 | 1.0942 |
retinol (Vitamin A) | 0.9965 | 0.8603 | 0.9005 | 1.0268 | 0.8297 | 0.9764 | 0.9733 | 0.9305 | 0.9723 | 1.0386 | 0.8922 | 0.9893 | 1.1571 | 1.1635 | 1.1209 | 1.0497 | 1.1072 | 1.0898 |
solanidine | 2.0729 | 1.7107 | 1.2538 | 1.7594 | 1.4560 | 1.4240 | 0.8524 | 0.8444 | 0.9532 | 0.8974 | 0.5449 | 0.6164 | 0.6039 | 0.7525 | 0.6724 | 0.4560 | 0.5271 | 0.5612 |
sphingadienine | 1.0157 | 0.8498 | 0.9827 | 1.4501 | 0.8114 | 1.1683 | 1.0918 | 1.0514 | 0.9840 | 1.2408 | 0.7525 | 0.9856 | 1.1539 | 0.9147 | 0.9277 | 0.7408 | 0.7218 | 1.0459 |
sphinganine | 1.1156 | 0.9944 | 1.0304 | 1.1227 | 0.8711 | 1.0717 | 1.0815 | 0.9463 | 1.0232 | 1.0231 | 0.7859 | 1.0465 | 1.1045 | 0.9280 | 1.0568 | 0.8965 | 0.8199 | 1.0605 |
sphingosine | 1.1487 | 1.0017 | 1.0713 | 1.1424 | 0.8763 | 1.1284 | 1.1493 | 0.9825 | 0.9410 | 1.0766 | 0.7272 | 1.0409 | 1.1212 | 0.8434 | 1.0049 | 0.8444 | 0.7650 | 1.0719 |
stearoylcarnitine (C18) | 1.0686 | 0.9329 | 1.1575 | 0.8430 | 1.1985 | 1.0075 | 1.1250 | 0.8200 | 1.0484 | 0.9853 | 0.9764 | 1.0162 | 1.0552 | 0.7347 | 0.8848 | 1.0985 | 1.0166 | 0.9893 |
stearoylcholine* | 0.9258 | 0.9206 | 0.7462 | 1.3458 | 0.6692 | 0.7266 | 0.7775 | 1.0797 | 0.9067 | 1.1865 | 0.6494 | 0.8711 | 0.9992 | 1.2700 | 1.4381 | 1.1979 | 1.1470 | 1.3007 |
undecenoylcarnitine (C11:1) | 1.3372 | 0.6676 | 0.5079 | 1.0857 | 0.7426 | 1.0531 | 1.1115 | 0.6472 | 0.6604 | 1.1865 | 0.7468 | 1.0057 | 1.4205 | 0.9696 | 1.1626 | 1.3351 | 1.1805 | 1.2642 |
ximenoylcarnitine (C26:1)* | 1.1956 | 1.0628 | 1.0617 | 1.1944 | 0.9719 | 1.1256 | 0.9042 | 0.8147 | 0.7941 | 0.9615 | 0.7520 | 0.8617 | 1.1133 | 1.0775 | 1.0262 | 1.0890 | 1.0849 | 1.0142 |
Factors:
F1 | Group:High-Dose | TIMEPOINT:-0.5HR |
F2 | Group:High-Dose | TIMEPOINT:+23HR POST INFUSION |
F3 | Group:High-Dose | TIMEPOINT:+47HR POST INFUSION |
F4 | Group:High-Dose | TIMEPOINT:+4HR POST INFUSION |
F5 | Group:High-Dose | TIMEPOINT:+71HR POST INFUSION |
F6 | Group:High-Dose | TIMEPOINT:BASELINE |
F7 | Group:Low-Dose | TIMEPOINT:-0.5HR |
F8 | Group:Low-Dose | TIMEPOINT:+23HR POST INFUSION |
F9 | Group:Low-Dose | TIMEPOINT:+47HR POST INFUSION |
F10 | Group:Low-Dose | TIMEPOINT:+4HR POST INFUSION |
F11 | Group:Low-Dose | TIMEPOINT:+71HR POST INFUSION |
F12 | Group:Low-Dose | TIMEPOINT:BASELINE |
F13 | Group:Placebo | TIMEPOINT:-0.5HR |
F14 | Group:Placebo | TIMEPOINT:+23HR POST INFUSION |
F15 | Group:Placebo | TIMEPOINT:+47HR POST INFUSION |
F16 | Group:Placebo | TIMEPOINT:+4HR POST INFUSION |
F17 | Group:Placebo | TIMEPOINT:+71HR POST INFUSION |
F18 | Group:Placebo | TIMEPOINT:BASELINE |