Data for Identification of distinct metabolic perturbations and associated immunomodulatory events during intra-erythrocytic development stage of pediatric Plasmodium falciparum malaria (part-II) (Study ST001516)

(Analysis AN002516)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2
10-heptadecenoate (17:1n7) 1.0392 0.9604
10-undecenoate (11:1n1) 1.0369 0.9627
12,13-DiHOME 0.6882 1.3149
1,2,3-benzenetriol sulfate (2) 1.3720 0.7520
12-HETE 0.5820 1.4222
12-HHTrE 0.7026 1.2914
13-HODE + 9-HODE 0.8803 1.1209
14-HDoHE/17-HDoHE 0.6128 1.3598
1,5-anhydroglucitol (1,5-AG) 1.0398 0.9598
16a-hydroxy DHEA 3-sulfate 1.0983 0.8855
1,7-dimethylurate 0.8096 1.4880
1-carboxyethylisoleucine 0.9517 1.0496
1-carboxyethylleucine 1.2244 0.7547
1-carboxyethylphenylalanine 1.3481 0.6484
1-carboxyethyltyrosine 1.0570 0.9231
1-carboxyethylvaline 1.1964 0.8016
1-hydroxy-2-naphthalenecarboxylate 1.0789 0.9075
1-linoleoyl-GPG (18:2) 0.6586 1.2857
1-palmitoyl-GPG (16:0) 0.7819 1.1454
1-stearoyl-GPG (18:0) 1.0521 0.9596
21-hydroxypregnenolone disulfate 1.5128 0.3694
2,3-dihydroxy-2-methylbutyrate 0.8228 1.1314
2,3-dihydroxy-5-methylthio-4-pentenoate (DMTPA) 1.0509 0.9486
(2,4 or 2,5)-dimethylphenol sulfate 0.7262 1.2765
2,6-dihydroxybenzoic acid 0.7751 1.2272
2-aminoadipate 1.2210 0.7435
2-aminophenol sulfate 0.6872 1.2766
2^-deoxyuridine 0.8361 1.1059
2-ethylphenylsulfate 0.9522 1.0467
2-hydroxy-3-methylvalerate 1.1907 0.8073
2-hydroxyacetaminophen sulfate 1.0895 0.1305
2-hydroxybehenate 1.0140 0.9806
2-hydroxydecanoate 0.9498 1.0507
2-hydroxyfluorene sulfate 0.9586 1.0418
2-hydroxynervonate 0.9524 1.0502
2-hydroxyoctanoate 0.7650 1.2374
2-hydroxypalmitate 0.9935 1.0066
2-hydroxystearate 0.9627 1.0376
2-methoxyacetaminophen glucuronide 1.0247 0.2453
2-methoxyacetaminophen sulfate 1.0387 0.1864
2-methoxyresorcinol sulfate 0.9991 1.0006
2-methylcitrate/homocitrate 0.8340 1.1677
2-naphthol sulfate 0.7887 1.2135
2^-O-methyluridine 1.1069 0.8920
3-(3-amino-3-carboxypropyl)uridine 1.0366 0.9634
3-(3-hydroxyphenyl)propionate 0.9562 1.0372
3-(4-hydroxyphenyl)lactate 1.1955 0.8025
3-acetylphenol sulfate 1.0439 0.9770
3beta,7alpha-dihydroxy-5-cholestenoate 1.0790 0.9202
3beta-hydroxy-5-cholestenoate 0.9163 1.0846
3b-hydroxy-5-cholenoic acid 1.0216 0.9762
3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP) 0.9849 1.0152
3-carboxy-4-methyl-5-propyl-2-furanpropanoate (CMPF) 1.0652 0.9341
3-hydroxy-2-ethylpropionate 1.0319 0.9678
3-hydroxydecanoate 1.0282 0.9715
3-hydroxydodecanedioate 1.1500 0.8462
3-hydroxyhexanoate 1.2078 0.7901
3-hydroxyhippurate 0.8537 1.1208
3-hydroxylaurate 0.9707 1.0296
3-hydroxyoctanoate 1.0596 0.9398
3-hydroxyoleate 0.8966 1.1166
3-hydroxypyridine sulfate 0.9836 1.0166
3-indoxyl sulfate 1.0237 0.9761
3-methoxycatechol sulfate (1) 0.5786 1.3904
3-methoxytyramine sulfate 1.0254 0.9777
3-methyl-2-oxobutyrate 1.2476 0.7499
3-methyl-2-oxovalerate 1.0033 0.9967
3-methyl catechol sulfate (1) 0.9484 1.0526
3-(methylthio)acetaminophen sulfate 1.1222 0.0764
3-(N-acetyl-L-cystein-S-yl) acetaminophen 1.0744 0.0775
3-phenylpropionate (hydrocinnamate) 1.0830 0.9170
4-acetamidobutanoate 1.0005 0.9995
4-acetamidophenol 1.1102 0.0772
4-acetamidophenylglucuronide 1.0987 0.0690
4-acetaminophen sulfate 1.1272 0.0969
4-acetylphenol sulfate 1.0382 0.9632
4-allylphenol sulfate 0.5811 1.4189
4-ethylphenylsulfate 0.8354 1.1663
4-hydroxycoumarin 1.1616 0.8267
4-hydroxyhippurate 1.5893 0.4048
4-hydroxyphenylacetate 1.0299 0.9671
4-hydroxyphenylacetylglutamine 0.9470 1.0457
4-hydroxyphenylpyruvate 1.1448 0.8552
4-methyl-2-oxopentanoate 1.2404 0.7572
4-methylcatechol sulfate 0.8267 1.1751
4-methylguaiacol sulfate 0.9849 1.0161
4-vinylguaiacol sulfate 1.0056 0.9939
4-vinylphenol sulfate 0.8488 1.1528
5,6-dihydrothymine 1.0164 0.9835
5,6-dihydrouracil 1.0075 0.9933
5,6-dihydrouridine 1.0100 0.9899
5alpha-pregnan-3beta,20alpha-diol disulfate 1.4818 0.5182
5alpha-pregnan-3beta,20alpha-diol monosulfate (2) 1.5878 0.2841
5-dodecenoate (12:1n7) 1.1085 0.8833
5-hydroxyhexanoate 0.6621 1.3345
5-hydroxyindoleacetate 0.9840 1.0135
5-hydroxyindole sulfate 1.0671 0.9297
5-methyluridine (ribothymidine) 0.8817 1.1195
5-oxoproline 1.0290 0.9707
6-bromotryptophan 0.8322 1.1678
6-hydroxyindole sulfate 1.0442 0.9554
6-oxopiperidine-2-carboxylate 1.2857 0.7114
7-alpha-hydroxy-3-oxo-4-cholestenoate (7-Hoca) 0.8727 1.1286
7-hydroxyindole sulfate 0.9107 1.0915
8-hydroxyoctanoate 0.2935 1.2329
9,10-DiHOME 1.0730 0.9247
acesulfame 0.7348 1.1515
acisoga 1.0150 0.9848
aconitate [cis or trans] 1.1014 0.8976
adrenate (22:4n6) 1.0494 0.9495
alpha-hydroxycaproate 0.8325 1.1589
alpha-hydroxyisocaproate 1.2942 0.7028
amoxicillin 0.5551 2.7797
androstenediol (3alpha, 17alpha) monosulfate (3) 1.2710 0.6784
androstenediol (3beta,17beta) disulfate (1) 0.9816 1.0188
androstenediol (3beta,17beta) disulfate (2) 1.2005 0.7863
androsterone sulfate 1.1981 0.7604
arachidate (20:0) 1.0491 0.9504
arachidonate (20:4n6) 0.9872 1.0129
azelate (C9-DC) 0.1025 1.9066
benzoate 1.1379 0.8607
beta-citrylglutamate 0.6450 1.3550
beta-hydroxyisovalerate 1.2267 0.7710
caprate (10:0) 1.0482 0.9513
caproate (6:0) 0.9961 1.0039
caprylate (8:0) 1.0447 0.9548
catechol sulfate 0.6780 1.3253
C-glycosyltryptophan 0.9576 1.0428
cholate 1.5372 0.4628
cinnamoylglycine 0.8734 1.1280
cis-4-decenoate (10:1n6) 1.0773 0.9219
corticosterone 1.4621 0.5136
cortisol 1.3680 0.6282
cortisone 1.1842 0.8140
dehydroepiandrosterone sulfate (DHEA-S) 1.1801 0.8199
diclofenac 1.0000 NA
dihomo-linoleate (20:2n6) 1.0786 0.9206
dihomo-linolenate (20:3n3 or n6) 0.9893 1.0108
docosadienoate (22:2n6) 1.1405 0.8581
docosahexaenoate (DHA; 22:6n3) 1.0204 0.9794
docosapentaenoate (n3 DPA; 22:5n3) 1.0829 0.9154
docosapentaenoate (n6 DPA; 22:5n6) 0.9413 1.0541
dodecadienoate (12:2) 0.9006 1.1004
dodecanedioate (C12-DC) 0.8952 1.1016
dodecenedioate (C12:1-DC) 1.0219 0.9779
dopamine 3-O-sulfate 0.8900 1.1111
dopamine 4-sulfate 0.9490 1.0499
eicosanedioate (C20-DC) 0.9376 1.0630
eicosapentaenoate (EPA; 20:5n3) 1.0540 0.9454
eicosenedioate (C20:1-DC) 0.9129 1.0871
eicosenoate (20:1) 1.1484 0.8501
erucate (22:1n9) 1.0786 0.9206
eugenol sulfate 1.1963 0.8037
Fibrinopeptide A (2-15) 1.4403 0.5959
Fibrinopeptide A (3-15) 1.5364 0.5869
Fibrinopeptide A (3-16) 1.7764 0.4631
Fibrinopeptide A (4-15) 1.4265 0.4603
Fibrinopeptide A (5-16) 1.7965 0.4373
Fibrinopeptide A (7-16) 1.3922 0.5026
Fibrinopeptide A (8-16) 1.2189 0.7171
Fibrinopeptide A, des-ala(1) 1.5958 0.4832
Fibrinopeptide B (1-11) 0.9800 1.0202
Fibrinopeptide B (1-12) 0.9353 1.0654
Fibrinopeptide B (1-13) 1.3817 0.6954
gamma-CEHC 0.8699 1.1315
gamma-glutamyltyrosine 1.0086 0.9913
gamma-glutamylvaline 1.1417 0.8569
glucuronide of C12H22O4 (1) 0.4972 1.3053
glucuronide of C14H26O4 (1) 0.3660 1.4191
glu-gly-asn-val 0.9483 1.0475
glycerol 1.2325 0.7651
glyco-alpha-muricholate 1.1360 0.8478
glyco-beta-muricholate 1.1755 0.8188
glycochenodeoxycholate 1.1010 0.8980
glycochenodeoxycholate 3-sulfate 1.3053 0.6885
glycochenodeoxycholate glucuronide (1) 1.3478 0.6377
glycocholate 1.1989 0.7991
glycocholenate sulfate 1.0583 0.9411
glycodeoxycholate 3-sulfate 1.3461 0.6270
glycohyocholate 1.1037 0.8894
glycolithocholate 0.9284 1.0771
glycolithocholate sulfate 1.1387 0.8599
glycoursodeoxycholate 1.1620 0.8347
guaiacol sulfate 0.7590 1.2434
heneicosapentaenoate (21:5n3) 0.9763 1.0274
heptanoate (7:0) 0.6688 1.3345
hexadecadienoate (16:2n6) 1.0937 0.9054
hexadecanedioate (C16-DC) 1.3388 0.6578
hexadecenedioate (C16:1-DC) 1.2263 0.7690
hexanoylglutamine 1.4209 0.5704
hexanoylglycine 1.1129 0.8743
hippurate 0.9261 1.0747
histidine 0.9131 1.0878
homovanillate (HVA) 1.0677 0.9323
hydroquinone sulfate 1.0769 0.9063
hydroxy-CMPF 1.1376 0.8610
hypoxanthine 0.8246 1.1771
indole-3-carboxylate 1.0937 0.9042
indoleacetate 0.9120 1.0889
indolelactate 1.1461 0.8524
indolepropionate 0.6147 1.3892
indolepropionylglycine 0.7159 1.1527
inosine 0.9390 1.0616
isobutyrylglycine 1.1349 0.8699
isoeugenol sulfate 1.0710 0.9127
isoleucylglycine 0.8999 1.0657
isoursodeoxycholate 1.0728 0.9288
isovalerate (i5:0) 1.0131 0.9868
isovalerylglycine 1.1695 0.8034
kynurenate 1.4760 0.5192
linoleate (18:2n6) 1.0248 0.9749
linolenate [alpha or gamma; (18:3n3 or 6)] 1.0382 0.9615
lithocholate sulfate (1) 1.4197 0.5712
malate 1.0152 0.9846
margarate (17:0) 1.0280 0.9717
methyl-4-hydroxybenzoate sulfate 1.7491 0.2667
methyl glucopyranoside (alpha + beta) 0.7110 1.2919
methylnaphthyl sulfate (1) 0.9067 1.0951
methylnaphthyl sulfate (2) 0.9334 1.0673
metronidazole 1.0000 NA
myristate (14:0) 1.0327 0.9670
myristoleate (14:1n5) 1.1285 0.8702
N-(2-furoyl)glycine 0.6798 1.2836
N2,N5-diacetylornithine 1.1321 0.8679
N4-acetyl-5-hydroxysulfamethoxazole 1.0125 0.9800
N4-acetylcytidine 1.0985 0.9015
N4-acetylsulfamethoxazole 1.6015 0.3384
N6-acetyllysine 1.1479 0.8506
N6-carbamoylthreonyladenosine 1.0795 0.9197
N6-succinyladenosine 1.0279 0.9771
N-acetyl-2-aminooctanoate 0.7451 1.2575
N-acetylaspartate (NAA) 0.9801 1.0201
N-acetyl-aspartyl-glutamate (NAAG) 1.0003 0.9997
N-acetyl-beta-alanine 1.1338 0.8635
N-acetylcarnosine 0.9934 1.0067
N-acetylisoleucine 0.9666 1.0337
N-acetylleucine 1.0678 0.9315
N-acetylmethionine 0.7752 1.2248
N-acetylphenylalanine 1.2146 0.7832
N-acetyltaurine 0.8514 1.1501
N-acetylthreonine 1.0637 0.9357
N-acetyltyrosine 1.1859 0.8889
N-acetylvaline 1.0971 0.9019
N-delta-acetylornithine 1.0464 0.9532
N-formylanthranilic acid 1.5464 0.4309
N-formylmethionine 0.9863 1.0139
N-formylphenylalanine 1.2322 0.7655
N-linoleoylserine 0.8496 1.1204
N-linoleoyltaurine 0.7899 1.1289
N-oleoylserine 0.8986 1.0855
nonadecanoate (19:0) 1.0361 0.9635
N-palmitoylglycine 0.8597 1.1357
N-palmitoylserine 0.8412 1.1002
N-stearoylserine 0.7418 1.2243
N-stearoyltaurine 0.7669 1.1529
o-cresol sulfate 0.6551 1.3484
octadecadienedioate (C18:2-DC) 1.2232 0.7745
octadecanedioate (C18-DC) 1.2271 0.7659
octadecenedioate (C18:1-DC) 1.2880 0.7091
oleate/vaccenate (18:1) 1.0625 0.9368
oleoyl ethanolamide 1.0896 0.9095
O-sulfo-L-tyrosine 0.9685 1.0319
oxalate (ethanedioate) 0.5423 1.4623
palmitate (16:0) 1.0209 0.9789
palmitoleate (16:1n7) 1.0738 0.9254
pantothenate 0.9228 1.0780
p-cresol glucuronide 1.2593 0.7183
p-cresol sulfate 1.0697 0.9296
perfluorooctanoate (PFOA) 1.0258 0.9728
phenol glucuronide 1.0572 0.9662
phenol sulfate 1.0072 0.9927
phenylacetate 1.1958 0.7979
phenylacetylglutamate 1.1297 0.8578
phenylacetylglutamine 1.1544 0.8441
phenyllactate (PLA) 1.4059 0.5900
pregnenediol disulfate (C21H34O8S2) 1.4527 0.5428
pregnenediol sulfate (C21H34O5S) 1.7037 0.2891
pregnenetriol disulfate 1.5217 0.4730
pregnenetriol sulfate 1.6431 0.3504
pregnenolone sulfate 1.7298 0.2467
propionylglycine 0.8520 1.1496
propyl 4-hydroxybenzoate sulfate 1.2486 0.4157
pseudouridine 1.0447 0.9549
pyridoxate 0.7587 1.2438
pyrraline 0.6569 1.2912
saccharin 1.2600 0.1912
S-adenosylhomocysteine (SAH) 1.0042 0.9973
salicyluric glucuronide 1.9728 0.0272
S-methylcysteine 0.9178 1.0831
stearate (18:0) 1.0388 0.9608
stearidonate (18:4n3) 0.9254 1.0754
sucrose 1.6724 0.3057
sulfate 1.0713 0.9280
syringol sulfate 1.1957 0.6860
tartronate (hydroxymalonate) 0.7678 1.1146
tauro-beta-muricholate 1.1921 0.7860
taurochenodeoxycholate 1.3099 0.6805
taurochenodeoxycholic acid 3-sulfate 1.3177 0.6358
taurocholate 1.3111 0.6722
taurocholenate sulfate 1.3727 0.6235
taurodeoxycholic acid 3-sulfate 1.3771 0.4840
taurohyocholate 1.0843 0.8744
taurolithocholate 3-sulfate 1.3434 0.6530
tauroursodeoxycholate 1.1943 0.6172
tetradecadienedioate (C14:2-DC) 1.0783 0.9160
tetradecadienoate (14:2) 1.0975 0.9015
tetradecanedioate (C14-DC) 1.1648 0.8335
tetrahydrocortisol sulfate (1) 1.3055 0.2844
threonylphenylalanine 1.0698 0.9562
thromboxane B2 0.7304 1.2586
thymol sulfate 0.8572 1.1060
thyroxine 0.9868 1.0134
tridecenedioate (C13:1-DC) 1.0490 0.9505
tyramine O-sulfate 1.4898 0.5325
undecanedioate (C11-DC) 0.0685 1.8563
urate 0.9911 1.0090
uridine 0.8742 1.1270
valerate (5:0) 1.1546 0.8422
valylglycine 0.9930 1.0044
vanillactate 1.1178 0.8810
vanillylmandelate (VMA) 1.0415 0.9581
xanthosine 0.8061 1.1236
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Factors:

F1INFECTION:Infected
F2INFECTION:Non-infected
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