Data for Control of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle Metabolites (Study ST001658)
(Analysis AN002706)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this studyMetabolite | F1 | F2 | F3 |
---|---|---|---|
1,1^-(2,5-Pyrazinediyl)di(1,2,3,4-butanetetrol) | 0.0021 | 0.0100 | 2.9880 |
11-Aminoundecanoic acid | 2.2019 | 0.4568 | 0.3413 |
1-[(3-Carboxypropyl)amino]-1-deoxy-beta-D-fructofuranose | 0.0065 | 0.7484 | 2.2451 |
1-{[(3S,4S,5R)-2,3,4-Trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}-2-pyrrolidinecarboxylic acid (non-preferred name) | 0.0012 | 1.2289 | 1.7699 |
1-(4-Amino-4-carboxybutanoyl)-2-piperidinecarboxylic acid | 0.0214 | 0.0393 | 2.9393 |
1-(5-Decanoyl-4-nonyl-1,4-dihydro-3-pyridinyl)-1-dodecanone | 2.8880 | 0.0371 | 0.0749 |
(15R,27R)-18,21,24-Trihydroxy-2,50-dimethyl-27-{[(9Z,11Z)-9,11-octadecadienoyloxy]methyl}-18,24-dioxido-12,29-dioxo-13,17,19,23,25,28-hexaoxa-18lambda~5~,24lambda~5~-diphosphadopentacontan-15-yl 22-methyltetracosanoate | 0.0139 | 2.9527 | 0.0334 |
1H-Imidazol-2-ol | 0.3948 | 1.1329 | 1.4724 |
1H-Imidazol-2-ol (2) | 0.6432 | 1.4110 | 0.9459 |
2-[(2-Methylimidazo[1,2-a]pyridin-3-yl)carbonyl]hydrazine-1-carboxamide | 0.0006 | 0.2183 | 2.7811 |
2,3-DIHYDRO-3,5-DIHYDROXY-6-METHYL-4H-PYRAN-4-ONE | 0.1518 | 0.5254 | 2.3228 |
2,4,6-triaminotoluene | 2.8603 | 0.0130 | 0.1266 |
2-Acetamido-2-deoxyglucose | 0.0260 | 0.9085 | 2.0655 |
2-Amino-3-(1H-imidazol-4-yl)propan-1-ol | 0.0292 | 0.0393 | 2.9315 |
2-Amino-4-[(4-aminobutyl)amino]butanoic acid | 1.3660 | 0.6525 | 0.9815 |
2-Aminonicotinic acid | 2.2665 | 0.3113 | 0.4222 |
2^-Deoxyadenosine | 0.0005 | 0.6124 | 2.3871 |
2^-Deoxycytosine | 1.5900 | 0.3377 | 1.0723 |
2^-deoxymugineic acid | 0.0004 | 0.0136 | 2.9860 |
2-ETHYL-4,5-DIMETHYLOXAZOLE | 1.2108 | 0.5065 | 1.2828 |
2-Hydroxyfelbamate | 0.0368 | 2.8845 | 0.0788 |
2-Hydroxyhippuric acid | 0.0012 | 0.6163 | 2.3825 |
(2R)-4-[(E)-2-{[(1S)-1-Carboxy-4-hydroxybutyl]amino}vinyl]-2,3-dihydro-2,6-pyridinedicarboxylic acid | 0.0033 | 0.0029 | 2.9939 |
(2S)-2-Piperazinecarboxamide | 0.8998 | 0.1996 | 1.9006 |
(2S)-3-Hydroxy-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) | 0.0005 | 0.0041 | 2.9953 |
3,4-Diaminopyridine | 0.0132 | 0.0154 | 2.9714 |
3-amino-2,3-dideoxy-scyllo-inosose | 2.2127 | 0.0577 | 0.7296 |
3-Aminopyrrolidine | 0.6385 | 0.8111 | 1.5503 |
3-Pyrroline | 0.0276 | 0.0107 | 2.9617 |
4-guanidinobutanal | 0.0036 | 0.0056 | 2.9907 |
4-Hydroxyprolylalanine | 0.0058 | 1.9036 | 1.0905 |
4-Hydroxyprolylleucine | 1.2953 | 0.5437 | 1.1610 |
4-Hydroxyprolylthreonine | 0.0013 | 0.0067 | 2.9920 |
4-Imidazolemethanol | 0.7890 | 1.1759 | 1.0351 |
4-Imidazolemethanol (2) | 1.9797 | 0.6333 | 0.3871 |
4-Morpholinylacetic acid | 0.3282 | 0.0733 | 2.5985 |
4-Morpholinylacetic acid (2) | 0.6561 | 0.4470 | 1.8969 |
(4R)-4-{[(4R)-4-Hydroxy-1-methyl-L-prolyl]oxy}-1-methyl-L-proline | 0.4861 | 1.2780 | 1.2359 |
5-(4-Hydroxybutyl)-2,4-imidazolidinedione | 0.0126 | 0.5100 | 2.4775 |
5-AMINO-3-HYDROXY-2-(2-OXO-AZETIDIN-1-YL)-PENTANOIC ACID | 0.1027 | 0.1021 | 2.7952 |
5-AMINO-3-HYDROXY-2-(2-OXO-AZETIDIN-1-YL)-PENTANOIC ACID (2) | 0.0036 | 0.0166 | 2.9798 |
5-Oxotetrahydrofuran-2-carboxylic acid | 0.0110 | 0.0025 | 2.9865 |
6-(5-Hydroxy-2-methyl-4-oxo-1(4H)-pyridinyl)norleucine | 2.9424 | 0.0405 | 0.0171 |
6-Oxolysine | 0.2739 | 1.5479 | 1.1782 |
6-Oxo-pipecolinic acid | 0.0181 | 0.0704 | 2.9115 |
6-Oxo-pipecolinic acid (2) | 2.6669 | 0.0639 | 0.2693 |
(±)-Abscisic acid | 2.6352 | 0.1224 | 0.2424 |
Aceturic acid | 2.8135 | 0.0845 | 0.1020 |
Adipamide | 1.8992 | 0.4317 | 0.6691 |
Alanylclavam | 2.9485 | 0.0380 | 0.0136 |
ALA-PRO | 1.7476 | 1.2020 | 0.0504 |
ala-ser | 0.0201 | 0.0429 | 2.9370 |
aldehydo-D-glucosamine 6-phosphate | 0.0130 | 2.9453 | 0.0418 |
Aminolevulinic acid | 0.0272 | 0.3509 | 2.6218 |
APM | 0.2994 | 2.6722 | 0.0285 |
arg-ala | 0.0105 | 0.0241 | 2.9654 |
Benserazide | 0.0094 | 0.0015 | 2.9891 |
Betaine | 1.0469 | 1.7796 | 0.1735 |
Bicine | 2.1499 | 0.5865 | 0.2636 |
Bis(methylbenzylidene)sorbitol | 2.3268 | 0.2625 | 0.4107 |
Butoctamide semisuccinate | 1.9432 | 0.6080 | 0.4488 |
Butoctamide semisuccinate (2) | 2.2908 | 0.4306 | 0.2786 |
Cadaverine | 0.0111 | 0.0115 | 2.9774 |
Caprolactam | 2.6842 | 0.3099 | 0.0059 |
capuride | 1.3492 | 0.5863 | 1.0645 |
carisoprodol | 1.3221 | 0.6265 | 1.0514 |
Choline | 2.9608 | 0.0197 | 0.0196 |
Cyclohexylamine | 0.8911 | 1.0810 | 1.0279 |
Deanol | 2.9282 | 0.0318 | 0.0399 |
Dehydroglycine | 0.0190 | 0.0170 | 2.9640 |
D-Glucosamine | 0.0082 | 0.0479 | 2.9439 |
D-(+)-Glucose | 0.0302 | 0.3927 | 2.5771 |
D-(-)-Glutamine | 0.0025 | 0.0014 | 2.9961 |
Diethylene glycol | 0.9381 | 1.5058 | 0.5561 |
Dihydrothymine | 1.0303 | 0.4012 | 1.5685 |
Dimethyl octanediimidate | 1.2055 | 0.6075 | 1.1870 |
DL-Alanine | 0.0707 | 2.1993 | 0.7300 |
DL-Arginine | 0.0002 | 0.0003 | 2.9996 |
DL-Citrulline | 0.0064 | 0.0114 | 2.9822 |
EJ4025000 | 1.1971 | 0.5303 | 1.2726 |
EJ4025000 (2) | 1.4031 | 0.7401 | 0.8568 |
ethyl argininate | 0.0040 | 0.0036 | 2.9925 |
Furfural | 1.0097 | 0.1006 | 1.8897 |
g-Guanidinobutyrate | 2.3657 | 0.0692 | 0.5651 |
glu-pro | 2.9711 | 0.0134 | 0.0155 |
glutaral | 2.8010 | 0.1643 | 0.0348 |
Gly-l-pro | 2.4047 | 0.2487 | 0.3466 |
Gly-Lys | 2.9881 | 0.0061 | 0.0059 |
Guvacine | 0.9791 | 0.8193 | 1.2016 |
Hexitol | 0.0053 | 2.4925 | 0.5022 |
HIDA | 0.1328 | 0.0377 | 2.8295 |
Histamine | 0.0644 | 0.0469 | 2.8887 |
Homocitrulline | 2.8921 | 0.0982 | 0.0097 |
Imidazolelactic acid | 0.0155 | 2.6819 | 0.3026 |
ISOXYL | 0.0213 | 0.0058 | 2.9729 |
Kanosamine | 0.0002 | 0.0002 | 2.9996 |
Kanosamine (2) | 0.0029 | 0.0269 | 2.9702 |
L-(+)-Alanine | 0.1007 | 1.7538 | 1.1455 |
L-Alanyl-L-proline | 0.1682 | 2.8106 | 0.0212 |
L-(+)-Aspartic acid | 0.0034 | 0.0033 | 2.9933 |
L-Aspartic acid | 0.0044 | 2.7739 | 0.2218 |
lawsone | 2.5276 | 0.2764 | 0.1961 |
Leu-Leu | 1.3552 | 0.6758 | 0.9690 |
Leu-Val | 1.1830 | 0.4970 | 1.3200 |
L-Glutamic acid | 0.0097 | 0.0152 | 2.9751 |
l-Histidinal | 1.0525 | 1.2113 | 0.7362 |
L-Histidine | 0.0026 | 0.0033 | 2.9940 |
L-Proline | 0.0612 | 0.0462 | 2.8926 |
L-Pyroglutamic acid | 0.0462 | 1.6229 | 1.3309 |
L-Pyroglutamic acid (2) | 0.0030 | 0.0012 | 2.9959 |
L-(-)-Serine | 0.0019 | 0.0034 | 2.9947 |
L-Theanine | 0.4967 | 0.2314 | 2.2718 |
LU3453000 | 0.0343 | 0.4840 | 2.4817 |
lys-leu | 0.0049 | 0.0049 | 2.9902 |
Lysylvaline | 0.0047 | 0.0250 | 2.9703 |
MA4000000 | 0.1247 | 0.1299 | 2.7454 |
Maleamic acid | 0.0114 | 0.0092 | 2.9794 |
mebutamate | 1.3455 | 0.5592 | 1.0953 |
melamine | 2.0357 | 0.4462 | 0.5180 |
Methionine sulfoxide | 0.0025 | 0.0021 | 2.9953 |
Methylimidazoleacetic acid | 0.0045 | 0.0942 | 2.9013 |
Methylol Dimethylhydantoin | 0.0022 | 0.2090 | 2.7887 |
MFCD00037215 | 0.0053 | 0.0069 | 2.9878 |
MFCD01664827 | 0.0023 | 2.9911 | 0.0066 |
Miglitol | 0.0236 | 0.0660 | 2.9104 |
Muramic acid | 0.0003 | 0.2694 | 2.7302 |
Muscimol | 0.5766 | 0.6043 | 1.8191 |
N-(4-Amino-1-carboxybutyl)glutamic acid | 0.0589 | 0.4879 | 2.4532 |
N-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)FORMAMIDE | 2.9915 | 0.0035 | 0.0050 |
N6-METHYLLYSINE | 0.0340 | 0.0426 | 2.9233 |
N~6~,N~6~-Dimethyllysine | 0.0170 | 0.0185 | 2.9645 |
N-Acetylleucylleucine | 1.2598 | 0.4278 | 1.3124 |
N-Acetylneuraminic acid | 0.0023 | 0.0074 | 2.9903 |
N-Acetylputrescine | 2.6798 | 0.3133 | 0.0070 |
NI3400000 | 0.7150 | 0.0593 | 2.2258 |
Nicotinamide | 0.1367 | 2.7009 | 0.1624 |
NJ5000000 | 0.0564 | 0.0743 | 2.8693 |
N-methylethanolamine phosphate | 0.4833 | 2.4920 | 0.0247 |
N-methylethanolamine phosphate (2) | 1.5314 | 1.2801 | 0.1885 |
N,N-diacetyllegionaminic acid | 0.0037 | 0.0156 | 2.9807 |
N,N-diacetyllegionaminic acid (2) | 0.0009 | 0.0029 | 2.9962 |
N,N-Diethylethanolamine | 1.9847 | 0.4527 | 0.5625 |
NPYR | 0.0668 | 0.0300 | 2.9032 |
nylon cyclic dimer | 0.3825 | 0.7462 | 1.8712 |
nylon cyclic dimer (2) | 1.2324 | 0.7011 | 1.0665 |
Ofloxacin ethyl ester | 0.0015 | 0.0025 | 2.9959 |
Oxaceprol | 0.0180 | 0.0188 | 2.9632 |
pentobarbital | 2.6571 | 0.3322 | 0.0107 |
pentobarbital (2) | 1.8257 | 1.1694 | 0.0049 |
pentobarbital (3) | 2.9976 | 0.0012 | 0.0011 |
Pioglitazone | 0.0047 | 0.0058 | 2.9895 |
Piracetam | 2.8501 | 0.0870 | 0.0628 |
Piracetam (2) | 2.5403 | 0.2895 | 0.1702 |
PPG n10 | 0.9542 | 0.8044 | 1.2414 |
PPG n10 (2) | 0.5290 | 0.5490 | 1.9220 |
PPG n8 | 1.2590 | 0.6337 | 1.1073 |
PPG n9 | 1.1906 | 0.6021 | 1.2073 |
pro-gln | 0.0060 | 0.0129 | 2.9811 |
pro-gln (2) | 0.0325 | 0.0717 | 2.8958 |
Pro-Glu | 0.1688 | 1.3617 | 1.4695 |
Pro-Glu (2) | 0.0627 | 1.2157 | 1.7215 |
Proline | 0.2307 | 2.7451 | 0.0243 |
Pyridoxamine | 1.5592 | 1.2016 | 0.2392 |
Pyrimidine | 0.5278 | 1.4413 | 1.0309 |
Pyrimidine (2) | 1.1341 | 0.9473 | 0.9186 |
Reduced Glutathione | 0.0058 | 0.0038 | 2.9903 |
RV0540000 | 2.9263 | 0.0204 | 0.0532 |
spinacine | 0.0347 | 0.0414 | 2.9238 |
Streptamine | 0.0230 | 0.0511 | 2.9259 |
Succinyl proline | 0.0018 | 0.1841 | 2.8140 |
Sulfuric acid | 2.4713 | 0.2335 | 0.2953 |
Tetraacetylethylenediamine | 0.0125 | 0.1145 | 2.8729 |
Threonine | 0.0047 | 0.0023 | 2.9929 |
tiapride | 0.0308 | 0.0335 | 2.9357 |
Tiformin | 2.9253 | 0.0311 | 0.0436 |
Timonacic | 2.0224 | 0.9724 | 0.0052 |
Triethanolamine | 2.1876 | 0.6834 | 0.1289 |
Triethylamine | 2.1722 | 0.3785 | 0.4494 |
Triisopropanolamine | 2.2284 | 0.5058 | 0.2658 |
trimethadione | 1.0077 | 1.2773 | 0.7151 |
UB6600000 | 2.1601 | 0.3453 | 0.4946 |
UB6600000 (2) | 2.9622 | 0.0188 | 0.0189 |
val-arg | 0.0116 | 0.0063 | 2.9821 |
val-asn | 0.0098 | 0.0284 | 2.9618 |
Veronal | 2.9422 | 0.0538 | 0.0040 |
Veronal (2) | 2.9489 | 0.0033 | 0.0478 |
Veronal (3) | 2.8775 | 0.0423 | 0.0802 |
Viloxazine | 2.9457 | 0.0220 | 0.0322 |
(Z)-dehydrobutyrine | 0.0318 | 0.0377 | 2.9305 |
(Z)-dehydrobutyrine (2) | 0.3629 | 0.3078 | 2.3292 |
Υ-Aminobutyric acid (GABA) | 0.3573 | 2.5075 | 0.1352 |
Factors:
F1 | Treatment:HPLC fraction 4 |
F2 | Treatment:HPLC fraction 5 |
F3 | Treatment:HPLC fraction 6 |