Data for Control of Topoisomerase II Activity and Chemotherapeutic Inhibition by TCA Cycle Metabolites (Study ST001658)

(Analysis AN002706)

Values for each metabolite have been scaled by dividing by the mean across all factors

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MetaboliteF1F2F3
1,1^-(2,5-Pyrazinediyl)di(1,2,3,4-butanetetrol) 0.0021 0.0100 2.9880
11-Aminoundecanoic acid 2.2019 0.4568 0.3413
1-[(3-Carboxypropyl)amino]-1-deoxy-beta-D-fructofuranose 0.0065 0.7484 2.2451
1-{[(3S,4S,5R)-2,3,4-Trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}-2-pyrrolidinecarboxylic acid (non-preferred name) 0.0012 1.2289 1.7699
1-(4-Amino-4-carboxybutanoyl)-2-piperidinecarboxylic acid 0.0214 0.0393 2.9393
1-(5-Decanoyl-4-nonyl-1,4-dihydro-3-pyridinyl)-1-dodecanone 2.8880 0.0371 0.0749
(15R,27R)-18,21,24-Trihydroxy-2,50-dimethyl-27-{[(9Z,11Z)-9,11-octadecadienoyloxy]methyl}-18,24-dioxido-12,29-dioxo-13,17,19,23,25,28-hexaoxa-18lambda~5~,24lambda~5~-diphosphadopentacontan-15-yl 22-methyltetracosanoate 0.0139 2.9527 0.0334
1H-Imidazol-2-ol 0.3948 1.1329 1.4724
1H-Imidazol-2-ol (2) 0.6432 1.4110 0.9459
2-[(2-Methylimidazo[1,2-a]pyridin-3-yl)carbonyl]hydrazine-1-carboxamide 0.0006 0.2183 2.7811
2,3-DIHYDRO-3,5-DIHYDROXY-6-METHYL-4H-PYRAN-4-ONE 0.1518 0.5254 2.3228
2,4,6-triaminotoluene 2.8603 0.0130 0.1266
2-Acetamido-2-deoxyglucose 0.0260 0.9085 2.0655
2-Amino-3-(1H-imidazol-4-yl)propan-1-ol 0.0292 0.0393 2.9315
2-Amino-4-[(4-aminobutyl)amino]butanoic acid 1.3660 0.6525 0.9815
2-Aminonicotinic acid 2.2665 0.3113 0.4222
2^-Deoxyadenosine 0.0005 0.6124 2.3871
2^-Deoxycytosine 1.5900 0.3377 1.0723
2^-deoxymugineic acid 0.0004 0.0136 2.9860
2-ETHYL-4,5-DIMETHYLOXAZOLE 1.2108 0.5065 1.2828
2-Hydroxyfelbamate 0.0368 2.8845 0.0788
2-Hydroxyhippuric acid 0.0012 0.6163 2.3825
(2R)-4-[(E)-2-{[(1S)-1-Carboxy-4-hydroxybutyl]amino}vinyl]-2,3-dihydro-2,6-pyridinedicarboxylic acid 0.0033 0.0029 2.9939
(2S)-2-Piperazinecarboxamide 0.8998 0.1996 1.9006
(2S)-3-Hydroxy-2-({[(3S,4S,5R)-2,3,4-trihydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]methyl}amino)butanoic acid (non-preferred name) 0.0005 0.0041 2.9953
3,4-Diaminopyridine 0.0132 0.0154 2.9714
3-amino-2,3-dideoxy-scyllo-inosose 2.2127 0.0577 0.7296
3-Aminopyrrolidine 0.6385 0.8111 1.5503
3-Pyrroline 0.0276 0.0107 2.9617
4-guanidinobutanal 0.0036 0.0056 2.9907
4-Hydroxyprolylalanine 0.0058 1.9036 1.0905
4-Hydroxyprolylleucine 1.2953 0.5437 1.1610
4-Hydroxyprolylthreonine 0.0013 0.0067 2.9920
4-Imidazolemethanol 0.7890 1.1759 1.0351
4-Imidazolemethanol (2) 1.9797 0.6333 0.3871
4-Morpholinylacetic acid 0.3282 0.0733 2.5985
4-Morpholinylacetic acid (2) 0.6561 0.4470 1.8969
(4R)-4-{[(4R)-4-Hydroxy-1-methyl-L-prolyl]oxy}-1-methyl-L-proline 0.4861 1.2780 1.2359
5-(4-Hydroxybutyl)-2,4-imidazolidinedione 0.0126 0.5100 2.4775
5-AMINO-3-HYDROXY-2-(2-OXO-AZETIDIN-1-YL)-PENTANOIC ACID 0.1027 0.1021 2.7952
5-AMINO-3-HYDROXY-2-(2-OXO-AZETIDIN-1-YL)-PENTANOIC ACID (2) 0.0036 0.0166 2.9798
5-Oxotetrahydrofuran-2-carboxylic acid 0.0110 0.0025 2.9865
6-(5-Hydroxy-2-methyl-4-oxo-1(4H)-pyridinyl)norleucine 2.9424 0.0405 0.0171
6-Oxolysine 0.2739 1.5479 1.1782
6-Oxo-pipecolinic acid 0.0181 0.0704 2.9115
6-Oxo-pipecolinic acid (2) 2.6669 0.0639 0.2693
(±)-Abscisic acid 2.6352 0.1224 0.2424
Aceturic acid 2.8135 0.0845 0.1020
Adipamide 1.8992 0.4317 0.6691
Alanylclavam 2.9485 0.0380 0.0136
ALA-PRO 1.7476 1.2020 0.0504
ala-ser 0.0201 0.0429 2.9370
aldehydo-D-glucosamine 6-phosphate 0.0130 2.9453 0.0418
Aminolevulinic acid 0.0272 0.3509 2.6218
APM 0.2994 2.6722 0.0285
arg-ala 0.0105 0.0241 2.9654
Benserazide 0.0094 0.0015 2.9891
Betaine 1.0469 1.7796 0.1735
Bicine 2.1499 0.5865 0.2636
Bis(methylbenzylidene)sorbitol 2.3268 0.2625 0.4107
Butoctamide semisuccinate 1.9432 0.6080 0.4488
Butoctamide semisuccinate (2) 2.2908 0.4306 0.2786
Cadaverine 0.0111 0.0115 2.9774
Caprolactam 2.6842 0.3099 0.0059
capuride 1.3492 0.5863 1.0645
carisoprodol 1.3221 0.6265 1.0514
Choline 2.9608 0.0197 0.0196
Cyclohexylamine 0.8911 1.0810 1.0279
Deanol 2.9282 0.0318 0.0399
Dehydroglycine 0.0190 0.0170 2.9640
D-Glucosamine 0.0082 0.0479 2.9439
D-(+)-Glucose 0.0302 0.3927 2.5771
D-(-)-Glutamine 0.0025 0.0014 2.9961
Diethylene glycol 0.9381 1.5058 0.5561
Dihydrothymine 1.0303 0.4012 1.5685
Dimethyl octanediimidate 1.2055 0.6075 1.1870
DL-Alanine 0.0707 2.1993 0.7300
DL-Arginine 0.0002 0.0003 2.9996
DL-Citrulline 0.0064 0.0114 2.9822
EJ4025000 1.1971 0.5303 1.2726
EJ4025000 (2) 1.4031 0.7401 0.8568
ethyl argininate 0.0040 0.0036 2.9925
Furfural 1.0097 0.1006 1.8897
g-Guanidinobutyrate 2.3657 0.0692 0.5651
glu-pro 2.9711 0.0134 0.0155
glutaral 2.8010 0.1643 0.0348
Gly-l-pro 2.4047 0.2487 0.3466
Gly-Lys 2.9881 0.0061 0.0059
Guvacine 0.9791 0.8193 1.2016
Hexitol 0.0053 2.4925 0.5022
HIDA 0.1328 0.0377 2.8295
Histamine 0.0644 0.0469 2.8887
Homocitrulline 2.8921 0.0982 0.0097
Imidazolelactic acid 0.0155 2.6819 0.3026
ISOXYL 0.0213 0.0058 2.9729
Kanosamine 0.0002 0.0002 2.9996
Kanosamine (2) 0.0029 0.0269 2.9702
L-(+)-Alanine 0.1007 1.7538 1.1455
L-Alanyl-L-proline 0.1682 2.8106 0.0212
L-(+)-Aspartic acid 0.0034 0.0033 2.9933
L-Aspartic acid 0.0044 2.7739 0.2218
lawsone 2.5276 0.2764 0.1961
Leu-Leu 1.3552 0.6758 0.9690
Leu-Val 1.1830 0.4970 1.3200
L-Glutamic acid 0.0097 0.0152 2.9751
l-Histidinal 1.0525 1.2113 0.7362
L-Histidine 0.0026 0.0033 2.9940
L-Proline 0.0612 0.0462 2.8926
L-Pyroglutamic acid 0.0462 1.6229 1.3309
L-Pyroglutamic acid (2) 0.0030 0.0012 2.9959
L-(-)-Serine 0.0019 0.0034 2.9947
L-Theanine 0.4967 0.2314 2.2718
LU3453000 0.0343 0.4840 2.4817
lys-leu 0.0049 0.0049 2.9902
Lysylvaline 0.0047 0.0250 2.9703
MA4000000 0.1247 0.1299 2.7454
Maleamic acid 0.0114 0.0092 2.9794
mebutamate 1.3455 0.5592 1.0953
melamine 2.0357 0.4462 0.5180
Methionine sulfoxide 0.0025 0.0021 2.9953
Methylimidazoleacetic acid 0.0045 0.0942 2.9013
Methylol Dimethylhydantoin 0.0022 0.2090 2.7887
MFCD00037215 0.0053 0.0069 2.9878
MFCD01664827 0.0023 2.9911 0.0066
Miglitol 0.0236 0.0660 2.9104
Muramic acid 0.0003 0.2694 2.7302
Muscimol 0.5766 0.6043 1.8191
N-(4-Amino-1-carboxybutyl)glutamic acid 0.0589 0.4879 2.4532
N-((4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL)FORMAMIDE 2.9915 0.0035 0.0050
N6-METHYLLYSINE 0.0340 0.0426 2.9233
N~6~,N~6~-Dimethyllysine 0.0170 0.0185 2.9645
N-Acetylleucylleucine 1.2598 0.4278 1.3124
N-Acetylneuraminic acid 0.0023 0.0074 2.9903
N-Acetylputrescine 2.6798 0.3133 0.0070
NI3400000 0.7150 0.0593 2.2258
Nicotinamide 0.1367 2.7009 0.1624
NJ5000000 0.0564 0.0743 2.8693
N-methylethanolamine phosphate 0.4833 2.4920 0.0247
N-methylethanolamine phosphate (2) 1.5314 1.2801 0.1885
N,N-diacetyllegionaminic acid 0.0037 0.0156 2.9807
N,N-diacetyllegionaminic acid (2) 0.0009 0.0029 2.9962
N,N-Diethylethanolamine 1.9847 0.4527 0.5625
NPYR 0.0668 0.0300 2.9032
nylon cyclic dimer 0.3825 0.7462 1.8712
nylon cyclic dimer (2) 1.2324 0.7011 1.0665
Ofloxacin ethyl ester 0.0015 0.0025 2.9959
Oxaceprol 0.0180 0.0188 2.9632
pentobarbital 2.6571 0.3322 0.0107
pentobarbital (2) 1.8257 1.1694 0.0049
pentobarbital (3) 2.9976 0.0012 0.0011
Pioglitazone 0.0047 0.0058 2.9895
Piracetam 2.8501 0.0870 0.0628
Piracetam (2) 2.5403 0.2895 0.1702
PPG n10 0.9542 0.8044 1.2414
PPG n10 (2) 0.5290 0.5490 1.9220
PPG n8 1.2590 0.6337 1.1073
PPG n9 1.1906 0.6021 1.2073
pro-gln 0.0060 0.0129 2.9811
pro-gln (2) 0.0325 0.0717 2.8958
Pro-Glu 0.1688 1.3617 1.4695
Pro-Glu (2) 0.0627 1.2157 1.7215
Proline 0.2307 2.7451 0.0243
Pyridoxamine 1.5592 1.2016 0.2392
Pyrimidine 0.5278 1.4413 1.0309
Pyrimidine (2) 1.1341 0.9473 0.9186
Reduced Glutathione 0.0058 0.0038 2.9903
RV0540000 2.9263 0.0204 0.0532
spinacine 0.0347 0.0414 2.9238
Streptamine 0.0230 0.0511 2.9259
Succinyl proline 0.0018 0.1841 2.8140
Sulfuric acid 2.4713 0.2335 0.2953
Tetraacetylethylenediamine 0.0125 0.1145 2.8729
Threonine 0.0047 0.0023 2.9929
tiapride 0.0308 0.0335 2.9357
Tiformin 2.9253 0.0311 0.0436
Timonacic 2.0224 0.9724 0.0052
Triethanolamine 2.1876 0.6834 0.1289
Triethylamine 2.1722 0.3785 0.4494
Triisopropanolamine 2.2284 0.5058 0.2658
trimethadione 1.0077 1.2773 0.7151
UB6600000 2.1601 0.3453 0.4946
UB6600000 (2) 2.9622 0.0188 0.0189
val-arg 0.0116 0.0063 2.9821
val-asn 0.0098 0.0284 2.9618
Veronal 2.9422 0.0538 0.0040
Veronal (2) 2.9489 0.0033 0.0478
Veronal (3) 2.8775 0.0423 0.0802
Viloxazine 2.9457 0.0220 0.0322
(Z)-dehydrobutyrine 0.0318 0.0377 2.9305
(Z)-dehydrobutyrine (2) 0.3629 0.3078 2.3292
Υ-Aminobutyric acid (GABA) 0.3573 2.5075 0.1352
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Factors:

F1Treatment:HPLC fraction 4
F2Treatment:HPLC fraction 5
F3Treatment:HPLC fraction 6
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