Data for Targeted Sphingolipid analysis of HeLa silenced for or overexpressing GOLPH3 or LCS (Study ST001673)
(Analysis AN002731)Values for each metabolite have been scaled by dividing by the mean across all factors Run Hierarchial cluster analysis on this study | Run Heatmap cluster analysis on this study| Metabolite | F1 | F2 | F3 | F4 | F5 |
|---|---|---|---|---|---|
| C14-Cer | 0.7479 | 1.4769 | 0.6991 | 1.1692 | 0.9069 |
| C14HexosylCer | 0.7618 | 1.1629 | 0.6181 | 1.8155 | 0.6418 |
| C14Lact-Cer | NA | NA | NA | 0.9587 | 1.0825 |
| C14-SM | 0.8490 | 1.3423 | 0.8770 | 0.9877 | 0.9439 |
| C16-Cer | 0.6323 | 1.2458 | 0.6241 | 1.6710 | 0.8268 |
| C16HexosylCer | 0.6375 | 0.8696 | 0.4691 | 2.5175 | 0.5063 |
| C16Lact-Cer | 1.1375 | 1.0537 | 1.5286 | 0.5204 | 0.7598 |
| C16-SM | 0.8542 | 1.1901 | 0.8813 | 1.1842 | 0.8901 |
| C18_1-Cer | 1.0322 | 1.2394 | 0.9374 | 0.7602 | 1.0307 |
| C18_1HexosylCer | 0.9982 | 1.0563 | 0.9712 | 1.0129 | 0.9613 |
| C18_1Lact-Cer | 0.9816 | 1.1790 | 1.2136 | 0.7764 | 0.8494 |
| C18_1-SM | 1.0390 | 1.0800 | 1.0244 | 0.8619 | 0.9947 |
| C18-Cer | 0.8918 | 1.2353 | 0.8865 | 1.0627 | 0.9237 |
| C18HexosylCer | 0.6964 | 0.7826 | 0.5555 | 2.4289 | 0.5366 |
| C18Lact-Cer | 1.0059 | 1.1844 | 1.5310 | 0.5040 | 0.7747 |
| C18-SM | 0.9476 | 1.1617 | 0.9503 | 1.0792 | 0.8612 |
| C20_1-Cer | 0.9663 | 1.5220 | 0.9059 | 0.7176 | 0.8883 |
| C20_1HexosylCer | 0.9262 | 1.3850 | 0.7894 | 1.1902 | 0.7092 |
| C20_1Lact-Cer | 0.9232 | 1.2303 | 1.3548 | 0.6310 | 0.8607 |
| C20_1-SM | 0.9831 | 1.4375 | 0.9773 | 0.7195 | 0.8826 |
| C20-Cer | 0.8333 | 1.4095 | 0.8876 | 1.1236 | 0.7459 |
| C20HexosylCer | 0.8307 | 0.9278 | 0.6437 | 1.9794 | 0.6183 |
| C20Lact-Cer | 0.9892 | 1.0322 | 1.5468 | 0.5852 | 0.8466 |
| C20-SM | 0.9731 | 1.3564 | 0.9118 | 0.9126 | 0.8461 |
| C22_1-Cer | 0.8378 | 1.7518 | 0.8399 | 0.6351 | 0.9353 |
| C22_1HexosylCer | 0.9207 | 1.6244 | 0.6994 | 1.1700 | 0.5855 |
| C22_1Lact-Cer | 0.8986 | 1.2796 | 1.5979 | 0.4549 | 0.7690 |
| C22_1-SM | 0.9949 | 1.5243 | 0.9525 | 0.5652 | 0.9631 |
| C22-Cer | 0.7878 | 1.5398 | 0.8298 | 1.1024 | 0.7402 |
| C22HexosylCer | 0.8292 | 1.1531 | 0.6540 | 1.6832 | 0.6806 |
| C22Lact-Cer | 0.9325 | 1.2661 | 1.5362 | 0.3573 | 0.9079 |
| C22-SM | 0.9829 | 1.3468 | 0.9235 | 0.7592 | 0.9876 |
| C24_1-Cer | 0.8187 | 1.5209 | 0.8797 | 1.1370 | 0.6437 |
| C24_1HexosylCer | 0.8808 | 1.2153 | 0.7351 | 1.5253 | 0.6435 |
| C24_1Lact-Cer | 0.9804 | 1.2614 | 1.5917 | 0.3986 | 0.7679 |
| C24_1-SM | 0.9405 | 1.4136 | 0.9054 | 0.8004 | 0.9402 |
| C24-Cer | 0.8785 | 1.3669 | 0.8487 | 1.0791 | 0.8269 |
| C24HexosylCer | 0.8389 | 1.1580 | 0.6586 | 1.5975 | 0.7470 |
| C24Lact-Cer | 1.0528 | 1.0475 | 1.5113 | 0.4504 | 0.9380 |
| C24-SM | 0.9403 | 1.3216 | 0.8185 | 0.8020 | 1.1175 |
| C26_1-Cer | 0.8759 | 1.5610 | 0.8689 | 0.9936 | 0.7006 |
| C26_1HexosylCer | 0.8612 | 1.3129 | 0.7192 | 1.2445 | 0.8622 |
| C26_1Lact-Cer | 0.9488 | 1.1648 | 1.2858 | 0.6511 | 0.9496 |
| C26_1-SM | 0.8202 | 1.6143 | 0.7636 | 0.7535 | 1.0484 |
| C26-Cer | 0.9405 | 1.3214 | 0.8791 | 1.1418 | 0.7172 |
| C26HexosylCer | 0.9768 | 1.0969 | 0.8524 | 1.1402 | 0.9337 |
| C26Lact-Cer | 0.9887 | 1.0891 | 1.0567 | 0.8976 | 0.9680 |
| C26-SM | 0.9340 | 1.1475 | 0.9290 | 0.9554 | 1.0341 |
Factors:
| F1 | Treatment:GOLPH3 overexpression |
| F2 | Treatment:GOLPH3 silencing |
| F3 | Treatment:LCS overexpression |
| F4 | Treatment:LCS silencing |
| F5 | Treatment:no treatment |
