Metabolite_name RefMet_name Blank001 Blank002 Blank003 MUT01 MUT02 MUT03 MUT04 MUT05 MUT06 MUT07 MUT08 MUT09 MUT10 V01 V02 V03 V04 V05 V06 V07 V08 V09 V10 WT01 WT02 WT03 WT04 WT05 WT06 WT07 WT08 WT09 WT10 CS31_WT01_48 CS32_WT02_48 CS33_WT03_48 CS34_WT04_48 CS35_WT05_48 CS36_WT06_48 CS37_WT07_48 CS38_WT08_48 CS39_WT09_48 CS40_WT10_48 CS41_MUT01_48 CS42_MUT02_48 CS43_MUT03_48 CS44_MUT04_48 CS45_MUT05_48 CS46_MUT06_48 CS47_MUT07_48 CS48_MUT08_48 CS49_MUT09_48 CS50_MUT10_48 CS51_V01_48 CS52_V02_48 CS53_V03_48 CS54_V04_48 CS55_V05_48 CS56_V06_48 CS57_V07_48 CS58_V08_48 CS59_V09_48 CS60_V10_48 HR_01_WT HR_02_WT HR_03_WT HR_04_WT HR_05_IDH2 HR_06_IDH2 HR_07_IDH2 HR_08_IDH2 HR_09_IDH1 HR_10_IDH1 HR_11_IDH1 HR_12_IDH1 QC002 QC003 QC004 QC005 QC007 QC008 QC009 QC010 QC011 QC06 Factors - Time Point:Blank | Sample Source:- Time Point:Blank | Sample Source:- Time Point:Blank | Sample Source:- Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-24h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:CS-48h | Sample Source:293T HEK cell line Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:HR | Sample Source:Peripheral blood mono-nuclear cells Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- Time Point:QC | Sample Source:- 2HG EIC Results 350 24.5685 277 149099.4184 113573.8189 193792 165613.6082 193454.2214 167596.3631 149553.5296 174699.2550 138357.9143 46323.9096 114.9891 153.6154 99.3462 147 217.5385 208 202 185 270 186.7153 208 229 106 269 227 293 191.0321 224.7784 309 188 416.0769 136 174.4615 140 88 219 187 202 229.4774 252 52373.7877 25699.3888 20168.7970 43709.2614 44661.9911 96216.0427 105992.4709 86368 91317.6108 50886.5411 100 95 97 101 79 172 111 214 139 39.2825 398.9231 412.2820 296.2180 2742.8999 15248.9196 229797.9352 152807.3429 514037.0952 621035.4005 8894.0178 23652.4308 10228.5396 247344.8571 313709.2498 237473.5094 310272 402789.2198 337960.5409 333160.3944 300712.5488 286699.1261 424871.6039 2HG TIC Results 5827.2469 5736.7937 4077.5625 1011826.0180 793902.9575 1280467.5620 1099299.6700 1295079.3480 1069168.2640 998440.9202 1145497.3680 929937.0141 345366.8361 1225.5366 1984.7715 2112.9777 1412.2163 1900.0145 2185.2231 1892.1134 1652.4659 2379.6125 2127.9625 1600.2927 1766.1031 1546.7734 1975.7625 2171.2354 1905.8134 1957.3213 1979.0335 3027.9209 1970.1469 2509.9754 2195.4000 1431.5223 1232.0876 1672.7827 1126.1250 1737.8172 939.9966 1573.5146 1059.4023 410910.7765 197697.5771 157407.1728 340394.3165 352363.9151 714603.4415 767532.3147 628545.7785 677076.7539 387689.2244 1516.8107 1086.6802 1329.5617 1295.8187 1131.4437 970.9440 1267.5000 3001.9595 1327.8438 1634.4500 4855.1883 5628.4594 7178.8016 11398.4318 110893.0043 1450304.2340 988477.7222 3029049.1970 3583177.5250 62002.6261 170291.5777 77559.8621 1622118.6820 2014774.8420 1557615.7140 2067240.8080 2501630.2350 2308320.5000 2295711.7720 2118710.2600 2056238.2250 2617796.4380 Asp EIC Results 34 25.9310 65 4778 5499.2428 11989.5002 4528.7211 3960.1957 4203.9231 4583.8137 4911.0152 4347.7872 1454 4072 12155.1151 4173.8885 3013.4254 3243 4002.4837 3918 3045 3662.3358 3994.7410 3674.6663 3334 6705.7972 2718.2968 4256.2849 3421.6446 3182 3085.1919 4013.7547 2236.2690 1005 1816.2509 1879 1220 1097 1151 1062 1221 1135 911 1327 1951 3313.7233 1042.2735 1009 951.2825 1194 1242 1165 1152 1441.9936 1103 2723 1234 1578 1411 1519 1264 1389.3187 1046 13213.9568 33519.6285 7797.9425 278317.2429 6254.0898 32259.5541 18889.7325 89508.5192 11823.0857 8699.0502 40897.8360 1287.3870 28168 33897.1563 27344 32648 54622.7651 36722.9884 34674.5544 31354.5028 29754.1646 58439.7285 Asp TIC Results 5306.8244 10665.6886 14472.8590 82785.9580 89576.9916 184595.3644 75943.9199 66255.5098 70801.5508 75371.3881 85047.2726 68997.3399 24718.9052 66367.8631 195115.1489 75550.2914 50766.0842 59880.8502 69381.2302 64545.0965 54247.9849 62067.0586 69226.8016 65546.0279 57925.8169 109874.8587 48154.7026 70498.5987 57527.1098 54193.4024 52567.2186 68731.6365 42896.0822 19136.3901 31039.5341 33477.1042 20106.6476 24558.9413 23075.7592 21037.2237 23649.2834 22287.0271 20638.8375 23392.7082 31661.4361 55695.2869 15504.2958 20797.2545 18890.3854 22634.3023 22521.5209 22127.0749 20365.9857 24803.5116 22427.6143 48423.5534 23241.5012 29344.7689 27501.0992 30064.9036 24947.4044 26826.7331 22522.2380 207144.2845 498470.7185 135569.8079 3450604.4330 114465.8525 493269.6016 294486.5884 1251014.1260 199059.4260 148462.0829 609124.4604 30251.6896 447866.2448 517862.6181 429798.3593 508958.2916 788290.8294 620218.6602 586575.8508 513001.8396 498748.7566 830592.7041 Glu EIC Results 173.1178 52.3146 129 379383.6661 553716.6715 509222.1630 375655.6020 344749.4315 351267.1984 327978.7070 411560.9846 275121.6334 36423.1178 934035.5617 1121221.9640 967320.9254 796064.9075 827220.0986 1096147.9000 958285.8009 856029.8588 990626.1800 767966.1044 863701.3527 775707.6208 1010130.5760 820832.6422 948702.1825 779101.1062 718882.7063 786260.5234 1025686.7120 354539.6253 110601.1028 68351.4036 72772.8563 49911.8227 102053.4034 81988.5512 93037.5076 88845.6680 74874.4818 102408 59903.2821 35286.0440 104180.3391 23784.7766 47240.1566 30213.9525 38941.8200 47686.8242 43606.3178 28334.9063 161903.8392 52460.3983 98985.3852 56981.7013 120836.1069 103251.6172 159346.2915 68263.0158 89995.7474 122740.3042 493847.4982 1052077.0600 423002.6766 2735000.7160 338847.0227 1211303.9610 879267.2920 1228190.7060 830819.2785 410022.5336 837782.4800 131308.0108 56331.9583 69132.4660 57421.8218 68298.6427 107096.0611 85587.2989 79924.0880 68413.2501 66061.1803 114711.7821 Glu TIC Results 2445.5757 3341.7363 2820.9994 2773219.4820 3911635.8270 3618888.4130 2824469.4600 2628371.8450 2636272.7340 2428900.6250 3010281.9620 2105616.6300 325767.9230 6177417.3330 7399968.0040 6304200.4310 5388128.6700 5635202.7650 7130334.2990 6210461.4250 5752449.5060 6571665.0970 5235173 5883039.8720 5319126.7590 6710379.3620 5720729.8380 6259518.7600 5446163.3080 4913475.0680 5277603.5000 6774789.1040 2744293.7930 981691.4646 629705.2325 667199.7068 479408.5638 906725.4161 749449.6118 820508.4048 811977.5594 684639.2191 912840.1011 545835.1978 335738.4797 917124.0403 229728.4523 442350.3798 296481.0148 371541.9572 448996.3810 402768.3020 276934.2842 1423014.7120 480477.1016 896398.7647 523768.2465 1048159.7370 916524.7667 1373593.6760 627541.9594 801784.0505 1078039.9360 3486475.5730 6700558.6370 2983100.0950 15857911.8200 2476359.8790 7513739.8610 5688185.0370 7693632.9840 5421979.0810 2886950.2900 5657123.8970 1022163.6210 492659.6078 598050.7795 494130.8833 608088.0796 861844.5374 782679.0936 716686.8442 639601.1459 611840.7043 899682.6277 Ratio of 2HG/Glu EIC 2.0217 0.4696 2.1473 0.3930 0.2051 0.3806 0.4409 0.5611 0.4771 0.4560 0.4245 0.5029 1.2718 0.0001 0.0001 0.0001 0.0002 0.0003 0.0002 0.0002 0.0002 0.0003 0.0002 0.0002 0.0003 0.0001 0.0003 0.0002 0.0004 0.0003 0.0003 0.0003 0.0005 0.0038 0.0020 0.0024 0.0028 0.0009 0.0027 0.0020 0.0023 0.0031 0.0025 0.8743 0.7283 0.1936 1.8377 0.9454 3.1845 2.7218 1.8112 2.0941 1.7959 0.0006 0.0018 0.0010 0.0018 0.0007 0.0017 0.0007 0.0031 0.0015 0.0003 0.0008 0.0004 0.0007 0.0010 0.0450 0.1897 0.1738 0.4185 0.7475 0.0217 0.0282 0.0779 4.3908 4.5378 4.1356 4.5429 3.7610 3.9487 4.1685 4.3955 4.3399 3.7038 Ratio of 2HG/Glu TIC 2.3828 1.7167 1.4454 0.3649 0.2030 0.3538 0.3892 0.4927 0.4056 0.4111 0.3805 0.4416 1.0602 0.0002 0.0003 0.0003 0.0003 0.0003 0.0003 0.0003 0.0003 0.0004 0.0004 0.0003 0.0003 0.0002 0.0003 0.0003 0.0003 0.0004 0.0004 0.0004 0.0007 0.0026 0.0035 0.0021 0.0026 0.0018 0.0015 0.0021 0.0012 0.0023 0.0012 0.7528 0.5888 0.1716 1.4817 0.7966 2.4103 2.0658 1.3999 1.6811 1.3999 0.0011 0.0023 0.0015 0.0025 0.0011 0.0011 0.0009 0.0048 0.0017 0.0015 0.0014 0.0008 0.0024 0.0007 0.0448 0.1930 0.1738 0.3937 0.6609 0.0215 0.0301 0.0759 3.2926 3.3689 3.1522 3.3996 2.9026 2.9493 3.2032 3.3125 3.3607 2.9097