Metabolite_name RefMet_name AZ 16 AZ 33 BAL-AZ-01 BAL-AZ-33 AZ 10 AZ 13 AZ 45 BAL-AZ-02 BAL-AZ-19 BAL-AZ-34 AZ 07 AZ 30 AZ 36 BAL-AZ-04 BAL-AZ-09 BAL-AZ-10 AZ 03 AZ 06 AZ 32 BAL-AZ-07 BAL-AZ-18 AZ 22 AZ 29 AZ 38 BAL-AZ-12 BAL-AZ-22 BAL-AZ-26 AZ 01 AZ 24 AZ 39 BAL-AZ-13 BAL-AZ-14 BAL-AZ-17 AZ 21 AZ 26 AZ 15 AZ 23 AZ 43 AZ 02 AZ 37 AZ 44 AZ 08 AZ 17 AZ 40 AZ 09 AZ 25 AZ 31 AZ 14 AZ 18 BAL-AZ-06 BAL-AZ-11 BAL-AZ-24 BAL-AZ-05 BAL-AZ-25 BAL-AZ-35 BAL-AZ-08 BAL-AZ-23 BAL-AZ-28 BAL-AZ-03 BAL-AZ-27 BAL-AZ-30 BAL-AZ-20 BAL-AZ-21 BAL-AZ-31 BAL-AZ-15 BAL-AZ-29 BAL-AZ-32 Factors - Treatment:Control | Lung:Left Lung | Time point (day):- Treatment:Control | Lung:Left Lung | Time point (day):- Treatment:Control | Lung:Left Lung | Time point (day):- Treatment:Control | Lung:Left Lung | Time point (day):- Treatment:Control | Lung:Left Lung | Time point (day):12 Treatment:Control | Lung:Left Lung | Time point (day):12 Treatment:Control | Lung:Left Lung | Time point (day):12 Treatment:Control | Lung:Left Lung | Time point (day):12 Treatment:Control | Lung:Left Lung | Time point (day):12 Treatment:Control | Lung:Left Lung | Time point (day):12 Treatment:Control | Lung:Left Lung | Time point (day):8 Treatment:Control | Lung:Left Lung | Time point (day):8 Treatment:Control | Lung:Left Lung | Time point (day):8 Treatment:Control | Lung:Left Lung | Time point (day):8 Treatment:Control | Lung:Left Lung | Time point (day):8 Treatment:Control | Lung:Left Lung | Time point (day):8 Treatment:Control | Lung:Right Lung | Time point (day):- Treatment:Control | Lung:Right Lung | Time point (day):- Treatment:Control | Lung:Right Lung | Time point (day):- Treatment:Control | Lung:Right Lung | Time point (day):- Treatment:Control | Lung:Right Lung | Time point (day):- Treatment:Control | Lung:Right Lung | Time point (day):12 Treatment:Control | Lung:Right Lung | Time point (day):12 Treatment:Control | Lung:Right Lung | Time point (day):12 Treatment:Control | Lung:Right Lung | Time point (day):12 Treatment:Control | Lung:Right Lung | Time point (day):12 Treatment:Control | Lung:Right Lung | Time point (day):12 Treatment:Control | Lung:Right Lung | Time point (day):8 Treatment:Control | Lung:Right Lung | Time point (day):8 Treatment:Control | Lung:Right Lung | Time point (day):8 Treatment:Control | Lung:Right Lung | Time point (day):8 Treatment:Control | Lung:Right Lung | Time point (day):8 Treatment:Control | Lung:Right Lung | Time point (day):8 Treatment:Pravastatin | Lung:Left Lung | Time point (day):- Treatment:Pravastatin | Lung:Left Lung | Time point (day):- Treatment:Pravastatin | Lung:Left Lung | Time point (day):12 Treatment:Pravastatin | Lung:Left Lung | Time point (day):12 Treatment:Pravastatin | Lung:Left Lung | Time point (day):12 Treatment:Pravastatin | Lung:Left Lung | Time point (day):8 Treatment:Pravastatin | Lung:Left Lung | Time point (day):8 Treatment:Pravastatin | Lung:Left Lung | Time point (day):8 Treatment:Pravastatin | Lung:Right Lung | Time point (day):- Treatment:Pravastatin | Lung:Right Lung | Time point (day):- Treatment:Pravastatin | Lung:Right Lung | Time point (day):- Treatment:Pravastatin | Lung:Right Lung | Time point (day):12 Treatment:Pravastatin | Lung:Right Lung | Time point (day):12 Treatment:Pravastatin | Lung:Right Lung | Time point (day):12 Treatment:Pravastatin | Lung:Right Lung | Time point (day):8 Treatment:Pravastatin | Lung:Right Lung | Time point (day):8 Treatment:Simvastatin | Lung:Left Lung | Time point (day):- Treatment:Simvastatin | Lung:Left Lung | Time point (day):- Treatment:Simvastatin | Lung:Left Lung | Time point (day):- Treatment:Simvastatin | Lung:Left Lung | Time point (day):12 Treatment:Simvastatin | Lung:Left Lung | Time point (day):12 Treatment:Simvastatin | Lung:Left Lung | Time point (day):12 Treatment:Simvastatin | Lung:Left Lung | Time point (day):8 Treatment:Simvastatin | Lung:Left Lung | Time point (day):8 Treatment:Simvastatin | Lung:Left Lung | Time point (day):8 Treatment:Simvastatin | Lung:Right Lung | Time point (day):- Treatment:Simvastatin | Lung:Right Lung | Time point (day):- Treatment:Simvastatin | Lung:Right Lung | Time point (day):- Treatment:Simvastatin | Lung:Right Lung | Time point (day):12 Treatment:Simvastatin | Lung:Right Lung | Time point (day):12 Treatment:Simvastatin | Lung:Right Lung | Time point (day):12 Treatment:Simvastatin | Lung:Right Lung | Time point (day):8 Treatment:Simvastatin | Lung:Right Lung | Time point (day):8 Treatment:Simvastatin | Lung:Right Lung | Time point (day):8 11(12)-EpETre EA 11(12)-EpETrE-EA 15-HETE EA 15-HETE-EA 0.0001 0.0001 0.0003 0.0004 0.0003 0.0001 1-AG MG 20:4 0.4000 0.0890 0.0675 0.0502 0.0628 0.2360 0.1510 0.0311 0.0879 0.0707 0.0459 0.3550 0.1190 0.0195 0.0295 0.1200 0.3620 0.2840 0.0758 0.0167 0.0389 0.1640 0.1870 0.1440 0.1050 0.0553 0.0423 0.0336 0.0536 0.1160 0.0160 0.0187 0.0177 0.2910 0.1920 0.2300 0.0968 0.1400 0.5760 0.1110 0.1760 0.0859 0.2320 0.4090 0.1150 0.3650 0.4140 0.1310 0.2340 0.0365 0.0830 0.1450 0.0657 0.0800 0.0149 0.0393 0.0353 0.1290 0.0756 0.0264 0.0298 0.0868 0.0614 0.0269 0.0289 0.0723 0.0586 1-LG MG 18:2 1.3700 0.2270 0.3140 0.2490 0.2640 0.8640 0.8400 0.2470 0.3330 0.3760 0.3320 1.0400 0.5520 0.1400 0.1120 0.8410 0.9580 1.4400 0.4520 0.1280 0.1500 0.4510 1.9200 1.9100 0.4190 0.3340 0.4640 0.1930 0.3280 0.5100 0.0813 0.1170 0.1120 1.0700 0.7380 0.7130 0.4300 0.4300 1.4400 0.3000 1.7300 0.2910 1.2400 1.6100 0.4740 1.1900 0.8630 0.2960 0.6490 0.2910 0.3210 1.0700 0.2490 0.5370 0.1230 0.1680 0.1940 1.1400 0.3350 0.1850 0.2790 0.8370 0.5240 0.1650 0.2100 0.5990 0.3970 1-OG MG 18:1 0.2590 0.6830 0.6130 0.4000 0.9160 0.9300 0.3290 0.4540 1.3100 0.8170 0.7800 2.0600 1.0100 0.1680 0.3810 1.1100 1.6700 0.9950 0.5900 0.2510 0.2730 0.9990 3.4100 0.1460 0.4130 0.5710 0.8380 0.3140 0.6710 0.9480 0.2580 0.2860 0.2430 1.2400 1.6000 0.9140 0.5860 0.8170 1.1900 0.4380 0.4800 0.8780 0.9620 3.1200 0.7780 0.9500 0.5990 0.4510 0.6980 0.2900 0.2280 1.4700 0.3550 0.7850 0.3350 0.4090 0.8810 0.7110 0.2800 0.7020 0.6620 1.0200 1.2000 0.6420 0.2500 0.6310 0.8180 2-AG MG 20:4 1.2700 0.5730 1.4200 0.3490 1.0300 0.9910 0.9100 0.7800 1.4600 0.9270 0.5280 2.6500 0.9610 0.4420 1.3400 2.3500 1.1000 1.6200 0.7360 0.6950 1.1000 1.7400 1.0500 0.9300 1.0400 0.3880 0.3860 0.4920 0.6970 0.5150 0.5210 0.3320 0.4830 3.0900 1.1500 0.7770 1.0500 1.8300 2.0100 0.9890 0.6400 0.7480 0.4790 1.7700 1.1600 1.6300 2.2800 0.8160 1.4400 1.5700 0.6610 1.1900 1.3800 1.0900 0.3190 0.2490 0.4700 1.5400 1.1200 0.4080 0.6270 0.9950 0.7020 0.3830 0.3870 0.6320 2.1800 2-LG MG 18:2 2.2500 1.8500 3.5000 1.1100 3.0100 3.2600 3.1200 2.5500 6.1500 2.4300 1.9600 7.4600 2.2000 1.5700 5.8600 9.6400 2.6600 4.9000 2.4200 2.4000 1.7100 2.1900 6.4200 19.1000 3.7800 0.9750 4.0700 1.3400 1.8600 1.0300 0.8700 1.8400 0.6270 7.1000 3.2000 2.0300 1.4500 2.3400 3.7900 2.2600 4.1400 2.8500 2.4300 3.8500 2.3800 4.0700 3.5600 1.7400 3.5300 3.9700 1.7300 3.2100 3.4200 3.7200 1.0500 1.0300 1.5500 5.3000 1.7500 1.6200 2.6000 3.3300 1.9600 1.1300 1.2600 2.2700 8 2-OG MG 0:0/18:1(9Z)/0:0 0.6780 1.3400 4.1000 0.7390 2.9100 2.7300 0.8160 1.6700 3.2900 2.1800 1.4800 6.1400 3.5500 0.8240 3.7000 6.6700 3.5600 6.1200 1.2900 1.6400 0.7230 1.8000 6.9100 1.3400 1.7100 0.5010 2.8400 0.9420 1.5200 2.4600 0.5450 1.1000 0.7370 6.7700 2.8700 1.3700 0.7560 1.8300 3.2300 1.3000 3.5200 2.7700 1.4600 5.5400 1.6300 2.8700 1.6000 1.0100 2.3500 1.8000 0.7410 2.2900 1.6200 2.2800 0.6910 0.5260 1.4500 2.8700 1.0700 0.8590 1.3500 1.9500 1.1400 0.6060 0.5330 2.0900 5.5500 AEA AEA 0.0115 0.0013 0.0115 0.0012 0.0078 0.0059 0.0048 0.0019 0.0089 0.0049 0.0017 0.0108 0.0072 0.0003 0.0040 0.0107 0.0049 0.0241 0.0039 0.0015 0.0043 0.0045 0.0029 0.0052 0.0024 0.0009 0.0031 0.0006 0.0019 0.0060 0.0002 0.0018 0.0026 0.0140 0.0130 0.0096 0.0068 0.0037 0.0057 0.0072 0.0029 0.0061 0.0060 0.0150 0.0054 0.0071 0.0030 0.0049 0.0043 0.0030 0.0024 0.0083 0.0035 0.0080 0.0022 0.0035 0.0042 0.0032 0.0024 0.0028 0.0032 0.0033 0.0039 0.0026 0.0021 0.0025 0.0024 aLEA alpha-Linolenoyl-EA 0.0003 0.0002 0.0002 0.0004 0.0003 0.0002 0.0002 0.0004 0.0001 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0004 0.0003 0.0008 0.0004 0.0005 0.0002 0.0002 0.0003 0.0004 0.0004 0.0004 0.0003 0.0004 0.0004 0.0002 0.0002 0.0003 0.0002 DEA Adrenoyl-EA 0.0048 0.0048 0.0048 0.0009 0.0045 0.0009 0.0023 0.0011 0.0043 0.0018 0.0047 0.0010 0.0005 0.0025 0.0058 0.0031 0.0070 0.0009 0.0011 0.0012 0.0032 0.0021 0.0040 0.0013 0.0007 0.0020 0.0003 0.0009 0.0003 0.0011 0.0016 0.0034 0.0043 0.0030 0.0007 0.0030 0.0042 0.0018 0.0003 0.0027 0.0041 0.0087 0.0023 0.0025 0.0021 0.0014 0.0012 0.0018 0.0010 0.0028 0.0020 0.0029 0.0012 0.0015 0.0022 0.0018 0.0010 0.0016 0.0013 0.0019 0.0021 0.0005 0.0008 0.0020 0.0019 DHEA Dehydroepiandrosterone 0.0107 0.0014 0.0116 0.0033 0.0090 0.0071 0.0073 0.0053 0.0102 0.0066 0.0059 0.0182 0.0081 0.0027 0.0039 0.0218 0.0058 0.0129 0.0048 0.0021 0.0067 0.0075 0.0029 0.0060 0.0043 0.0041 0.0042 0.0029 0.0062 0.0049 0.0020 0.0027 0.0040 0.0153 0.0267 0.0162 0.0100 0.0145 0.0127 0.0133 0.0043 0.0063 0.0103 0.0201 0.0100 0.0078 0.0074 0.0069 0.0062 0.0106 0.0045 0.0136 0.0127 0.0109 0.0041 0.0067 0.0094 0.0104 0.0047 0.0049 0.0071 0.0121 0.0082 0.0059 0.0049 0.0077 0.0091 Dihomo GLA EA Dihomo-gamma-linolenoyl-EA 0.0047 0.0003 0.0046 0.0005 0.0055 0.0021 0.0009 0.0009 0.0034 0.0020 0.0016 0.0031 0.0028 0.0002 0.0011 0.0058 0.0010 0.0015 0.0007 0.0006 0.0014 0.0019 0.0012 0.0021 0.0008 0.0005 0.0016 0.0007 0.0002 0.0021 0.0001 0.0009 0.0011 0.0036 0.0040 0.0024 0.0006 0.0013 0.0010 0.0018 0.0011 0.0015 0.0007 0.0002 0.0012 0.0022 0.0011 0.0006 0.0002 0.0017 0.0006 0.0032 0.0014 0.0023 0.0005 0.0009 0.0017 0.0013 0.0009 0.0011 0.0013 0.0015 0.0013 0.0006 0.0005 0.0007 0.0012 LEA Linoleoyl-EA 0.0222 0.0134 0.0147 0.0039 0.0152 0.0116 0.0113 0.0077 0.0155 0.0099 0.0121 0.0224 0.0196 0.0036 0.0090 0.0231 0.0126 0.0395 0.0164 0.0048 0.0101 0.0105 0.0123 0.0149 0.0064 0.0041 0.0068 0.0034 0.0112 0.0151 0.0018 0.0060 0.0049 0.0237 0.0292 0.0209 0.0155 0.0117 0.0156 0.0172 0.0185 0.0161 0.0147 0.0473 0.0191 0.0178 0.0099 0.0121 0.0141 0.0110 0.0082 0.0219 0.0144 0.0200 0.0068 0.0095 0.0130 0.0145 0.0087 0.0092 0.0091 0.0138 0.0136 0.0073 0.0066 0.0108 0.0119 LTE4 LTE4 0.0647 0.0161 0.0299 0.0998 0.0356 0.0403 0.0639 0.0043 0.0899 0.0449 0.0958 0.1180 0.0333 0.0740 0.0420 0.0136 0.0283 0.0752 0.1310 0.0106 0.0983 0.0073 NA-Gly N-Arachidonoyl glycine NO-Gly N-Oleoyl glycine 0.0070 0.0031 0.0050 0.0020 0.0057 0.0028 0.0026 0.0038 0.0025 0.0025 0.0063 0.0057 0.0438 0.0015 0.0023 0.0044 0.0072 0.0116 0.0054 0.0025 0.0025 0.0048 0.0137 0.0051 0.0036 0.0020 0.0015 0.0018 0.0089 0.0049 0.0036 0.0019 0.0031 0.0029 0.0061 0.0146 0.0061 0.0047 0.0067 0.0021 0.0109 0.0084 0.0079 0.0204 0.0074 0.0031 0.0038 0.0042 0.0063 0.0020 0.0039 0.0059 0.0044 0.0055 0.0021 0.0037 0.0051 0.0027 0.0032 0.0020 0.0026 0.0068 0.0059 0.0026 0.0023 0.0057 0.0032 OEA Oleoyl-EA 0.0480 0.0205 0.0671 0.0156 0.0325 0.0252 0.0306 0.0400 0.0590 0.0298 0.0318 0.0519 0.0369 0.0238 0.0317 0.0967 0.0419 0.0819 0.0415 0.0204 0.0286 0.0185 0.0271 0.0353 0.0265 0.0288 0.0233 0.0085 0.0362 0.0243 0.0119 0.0260 0.0298 0.0599 0.0671 0.0424 0.0307 0.0386 0.0326 0.0402 0.0414 0.0397 0.0337 0.0609 0.0462 0.0416 0.0249 0.0277 0.0421 0.0497 0.0235 0.0734 0.0621 0.0499 0.0295 0.0442 0.0593 0.0540 0.0358 0.0251 0.0370 0.0631 0.0440 0.0274 0.0323 0.0374 0.0486 PEA Palmitoyl-EA 0.7570 1.2500 3.6600 3.6100 0.5460 0.5820 0.7980 3.6000 6.0900 3.3300 1.4500 0.5010 0.7110 9.2600 9.4400 4.3300 1.8800 0.6280 0.5990 8.8900 3.2700 0.7240 0.5070 0.4500 9.8700 9.1000 2.6600 0.6080 1.4800 0.4520 4.7700 7.9700 7.0400 0.6730 0.7590 0.8020 0.6930 0.6620 0.6310 0.8690 0.6320 0.4930 0.6620 0.8780 0.5370 0.6380 0.7700 0.7920 0.4780 6.3400 5 7.8100 8.1200 1.2800 3.9500 7.6100 7.3000 1.3500 9.5000 4.1000 5.9400 8.9900 11.2000 6.9200 11.5000 6.2400 8.7200 PGD2 EA PGD2-EA PGE2 1G 1-Glyceryl-PGE2 PGE2 EA PGE2-EA PGE3 PGE3 PGF2a 1G 1(3)-Glyceryl-PGF2alpha PGF2a EA PGF2alpha-EA 0.0011 0.0007 0.0004 0.0016 0.0010 PGF3a PGF3alpha SEA Stearoyl-EA 0.1610 0.5690 7.4200 1.4000 0.4570 0.6130 0.1490 7.5400 10.5000 3.9200 0.6100 0.5890 0.4210 4.4300 6.3700 4.7000 1.7700 0.1320 0.3720 4.5600 5.2100 0.8820 0.6580 0.0800 3.6500 5.0400 1.1600 0.2900 1.4200 0.3990 3.0600 8.7600 9.5900 0.3910 0.3940 1.0800 0.2180 0.7600 0.4130 0.1940 0.1490 0.4580 0.4640 0.2140 0.5350 0.6240 0.4410 0.3780 0.2820 10.3000 4.2100 9.9000 5.2200 4.9600 3.4500 3.8600 1.0300 4.6800 0.5790 5.9000 15.6000 7.3400 2.4600 14.9000 7.3500 8.0700