Metabolite_name RefMet_name 33_Chow_129Jax 34_Chow_129Jax 35_Chow_129Jax 36_Chow_129Jax 17_Chow_129Tac 18_Chow_129Tac 19_Chow_129Tac 20_Chow_129Tac 1_Chow_B6Jax 2_Chow_B6Jax 3_Chow_B6Jax 45_HFD Metronidazole_129Jax 46_HFD Metronidazole_129Jax 47_HFD Metronidazole_129Jax 48_HFD Metronidazole_129Jax 29_HFD Metronidazole_129Tac 30_HFD Metronidazole_129Tac 31_HFD Metronidazole_129Tac 32_HFD Metronidazole_129Tac 13_HFD Metronidazole_B6Jax 14_HFD Metronidazole_B6Jax 15_HFD Metronidazole_B6Jax 16_HFD Metronidazole_B6Jax 37_HFD Placebo_129Jax 38_HFD Placebo_129Jax 39_HFD Placebo_129Jax 40_HFD Placebo_129Jax 21_HFD Placebo_129Tac 22_HFD Placebo_129Tac 23_HFD Placebo_129Tac 24_HFD Placebo_129Tac 5_HFD Placebo_B6Jax 6_HFD Placebo_B6Jax 7_HFD Placebo_B6Jax 8_HFD Placebo_B6Jax 41_HFD Vancomycin_129Jax 42_HFD Vancomycin_129Jax 43_HFD Vancomycin_129Jax 44_HFD Vancomycin_129Jax 25_HFD Vancomycin_129Tac 26_HFD Vancomycin_129Tac 27_HFD Vancomycin_129Tac 28_HFD Vancomycin_129Tac 10_HFD Vancomycin_B6Jax 11_HFD Vancomycin_B6Jax 12_HFD Vancomycin_B6Jax 9_HFD Vancomycin_B6Jax Factors - Diet:Chow | Treatment:none | Strain:129Jax Diet:Chow | Treatment:none | Strain:129Jax Diet:Chow | Treatment:none | Strain:129Jax Diet:Chow | Treatment:none | Strain:129Jax Diet:Chow | Treatment:none | Strain:129Tac Diet:Chow | Treatment:none | Strain:129Tac Diet:Chow | Treatment:none | Strain:129Tac Diet:Chow | Treatment:none | Strain:129Tac Diet:Chow | Treatment:none | Strain:B6Jax Diet:Chow | Treatment:none | Strain:B6Jax Diet:Chow | Treatment:none | Strain:B6Jax Diet:HFD | Treatment:metronidazole | Strain:129Jax Diet:HFD | Treatment:metronidazole | Strain:129Jax Diet:HFD | Treatment:metronidazole | Strain:129Jax Diet:HFD | Treatment:metronidazole | Strain:129Jax Diet:HFD | Treatment:metronidazole | Strain:129Tac Diet:HFD | Treatment:metronidazole | Strain:129Tac Diet:HFD | Treatment:metronidazole | Strain:129Tac Diet:HFD | Treatment:metronidazole | Strain:129Tac Diet:HFD | Treatment:metronidazole | Strain:B6Jax Diet:HFD | Treatment:metronidazole | Strain:B6Jax Diet:HFD | Treatment:metronidazole | Strain:B6Jax Diet:HFD | Treatment:metronidazole | Strain:B6Jax Diet:HFD | Treatment:placebo | Strain:129Jax Diet:HFD | Treatment:placebo | Strain:129Jax Diet:HFD | Treatment:placebo | Strain:129Jax Diet:HFD | Treatment:placebo | Strain:129Jax Diet:HFD | Treatment:placebo | Strain:129Tac Diet:HFD | Treatment:placebo | Strain:129Tac Diet:HFD | Treatment:placebo | Strain:129Tac Diet:HFD | Treatment:placebo | Strain:129Tac Diet:HFD | Treatment:placebo | Strain:B6Jax Diet:HFD | Treatment:placebo | Strain:B6Jax Diet:HFD | Treatment:placebo | Strain:B6Jax Diet:HFD | Treatment:placebo | Strain:B6Jax Diet:HFD | Treatment:vancomycin | Strain:129Jax Diet:HFD | Treatment:vancomycin | Strain:129Jax Diet:HFD | Treatment:vancomycin | Strain:129Jax Diet:HFD | Treatment:vancomycin | Strain:129Jax Diet:HFD | Treatment:vancomycin | Strain:129Tac Diet:HFD | Treatment:vancomycin | Strain:129Tac Diet:HFD | Treatment:vancomycin | Strain:129Tac Diet:HFD | Treatment:vancomycin | Strain:129Tac Diet:HFD | Treatment:vancomycin | Strain:B6Jax Diet:HFD | Treatment:vancomycin | Strain:B6Jax Diet:HFD | Treatment:vancomycin | Strain:B6Jax Diet:HFD | Treatment:vancomycin | Strain:B6Jax 11-HETE 11-HETE 12754 54027 21804 7912 30891 21241 12613 49758 14824 6530 15471 6901 25173 5189 10549 15247 95003 87331 14128 23508 15615 16720 22051 38227 12S-HETE 12S-HETE 71289 150927 186823 118945 122733 94961 82347 105579 69048 73824 131080 33625 13881 31888 12666 55024 33561 59139 60527 43256 168157 81230 41825 71636 63045 67972 120520 104269 89746 58357 89600 182860 215205 264683 217367 48076 53789 35725 14128 290281 47754 58116 46708 49350 12381 66136 142192 15S-HETE 15S-HETE 83445 118280 154470 95729 135384 109671 51324 92457 44919 76622 86100 28588 8535 40539 59292 51400 41814 48399 45750 127241 76635 47445 60013 30685 72195 75823 73198 81512 60565 68866 135932 211542 178731 199872 48305 87510 36952 18016 141922 58483 62737 40511 45527 35438 71632 118432 5-HETE 5-HETE 134589 146079 262063 181118 165064 134670 113185 149209 85238 114934 181785 9238 17022 30576 31979 23510 18771 16603 21433 72730 41175 26466 69067 46863 112069 107567 204715 57162 45303 60258 174481 180978 232457 159327 28660 21116 20112 7407 49189 36212 48454 31023 59939 27999 98454 107546 9-HETE 9-HETE 9617 76675 77093 38115 38281 39132 21964 30536 28877 22586 40941 3516 11618 12648 55078 16417 10190 25482 10341 10417 30886 37139 18856 10127 11181 55260 96917 108955 78188 6771 8264 4172 32433 6989 9461 21534 40296 32680 Adrenic Acid Adrenic acid 18487594 19392369 36595811 18107321 24722535 22963299 20089124 30491190 17904307 17079747 38241314 6571914 7433608 6366577 9990767 9675984 10721515 5907174 8645776 22857593 44817417 27093241 19077717 11331590 16462954 35524416 31223376 38426401 16702283 10975350 12094895 76953400 39299057 84269712 58625994 3525448 6401200 4489126 3956763 11101567 8511868 12197428 8818379 14557816 13259156 31919310 61940033 Alpha-muricholic acid alpha-Muricholic acid 27200793 53226385 51353183 45699448 21030722 5311508 12249352 7602768 19960334 17870581 10627110 179135 705912 113109 1055581 174588 154799 409621 932935 399728 513850 489479 387558 5871962 10132425 4966017 28808612 32072478 19755670 24694102 4158091 32866447 43952845 26412872 70818475 10690 3895 Arachidonic acid Arachidonic acid 102769610 161100217 221220739 82512539 187353445 106420169 86357519 115866143 79696741 67041806 204393357 75585677 86585835 105231547 62423519 149044140 140007595 87363464 112595118 201967209 346705579 238550685 251473315 113418547 112921483 224794865 189706804 286761364 165936025 148760790 90951272 474040795 274517604 550212641 492388388 71366556 93279807 62221639 61195640 150084914 103570419 135129591 106214154 222761445 203771207 279804855 394431520 Beta-muricholic acid beta-Muricholic acid 68456493 86083646 82015345 83691797 96956042 20738653 34951102 28325846 44366667 40731734 26730897 1737128 2373687 695526 4873246 2260334 1755515 7828195 38036106 3097667 4901838 2378267 2098135 42409957 42489672 28324415 86150615 106004435 88801022 74551846 16061729 117363455 108041563 84883840 141941370 247096 272158 300885 119813 792501 275241 595126 578897 765595 586105 1125238 1389091 Bishomo-gamma-linolenic acid Dihomo-gamma-linolenic acid 57962526 74521888 136364555 75551620 89203866 83555462 70347604 132902764 52166012 38895124 95015302 38199249 39265169 42118748 54773701 34803001 38641939 29231180 40183404 49780475 117220456 72336737 52935485 43926166 58141327 181247212 162894312 170925931 82864625 43762531 65121687 202997917 86219447 204909448 146363858 16702464 31102954 19451035 18022485 43215974 30928041 44046793 35013465 40070859 36219505 61522035 187280360 Chenodeoxycholic Acid Chenodeoxycholic acid 961730 726770 284386 383780 7082643 534683 659919 833926 392705 239427 289562 7197 13530 5615 5657 30883 40508 73720 328093 252875 548339 471591 1937211 401382 289277 2030379 364153 292434 111813 2288680 920584 1411302 1979532 5330 4904 6322 9687 Cholic acid Cholic acid 107878056 47036947 19457681 10370189 431065028 26965781 16458337 13109445 6742642 5744143 4580451 22689746 12845081 18202420 16380067 29337929 16769333 34751940 83021029 40382913 19313152 40420183 23670162 188356915 12664526 91488754 68398578 336225585 92133283 51067554 7730979 172721365 36489920 56980907 275844929 71577 52348 36761 890392 196863 455628 237012 18363 3445 33882 109261 Deoxycholic acid Deoxycholic acid 134799316 222893117 241450057 238464493 252224144 185592251 171869449 173342937 126789006 198609613 97683139 172155 146974 7217 74441 52704 94849 208107 73659 328093 252875 548339 471591 125039003 135963556 184750840 272316224 440226572 438240584 361296579 82257487 340122352 262482603 285516059 476881239 63050 142042 49223 25625 298240 212418 101096 43849 40417 94949 79981 285284 DHA DHA 123320705 133452578 280945360 150570866 311723053 216740358 185077326 274808140 156212362 138341624 308682992 18762860 31782084 32782759 20835926 40544416 42081764 21119624 29533661 64101022 123089930 76041860 75460934 29534840 22579741 45267944 44627294 80258461 57664877 42355451 23098933 199054850 65370129 239915341 138588861 13156018 19688446 12189167 11564855 39708957 35006950 33442708 29801282 61668103 55708584 69448003 137904615 DPA DPA 35166307 31200796 94545286 42870173 65631139 60968775 53260691 102674832 44626201 37580651 62675244 2536249 3473832 3097622 3373339 3946464 4773812 2693570 4961630 8264443 22695025 13774268 7110872 5354505 8034753 19426650 19063132 19672878 12722704 5999633 5219385 64631451 14118146 78646533 36998663 1455625 2686591 1915148 1718217 4247726 3780103 4336575 3293372 5673347 5368135 10941616 38290341 Eicosapentaenoic acid Eicosapentaenoic acid 101819205 82743118 182019358 79467092 215623885 107718061 105291420 139614727 69863453 62603159 148169781 3550475 4389157 5534462 3901826 6959314 7352615 4504210 4776669 8549381 16706230 11205101 8623522 4289836 5017866 10790506 8934700 12012797 7182183 6222163 5099547 30999770 7123689 36754544 18740990 3296041 3931632 3081468 2851864 8464703 5778696 5885239 4536919 6808632 5862380 8699755 26855485 Gamma-linolenic acid gamma-Linolenic acid 294764859 305282578 725932435 241766128 368452233 207613242 173928087 232179848 106987709 133983185 286354633 62354224 20704642 43483004 108634755 27762251 31527361 35408332 47422397 18557757 165993378 107049078 26853423 56447358 72531447 671305647 642501405 477094520 101171778 66637043 164800112 474116480 44515596 475456391 224165767 22661742 47284992 23355442 16730660 68014724 18157857 94627466 63526307 20989214 15493491 39436618 360316197 Glycocholic Acid Glycocholic acid 170545 8951 733622 3163 13127 2934 5477 132489 3516 135879 119483 88116 108591 78192 79324 257840 73546 151704 245004 459070 5241 298236 212716 5142882 1429219 478314 156802 694065 139650 271754 2422430 15129 18219 7205 8771 159185 46631 7942 91844 50102 10700 53947 105250 Glycodeoxycholic acid Glycodeoxycholic acid 8527 53866 84810 41460 35042 2055 10040 5809 11594 2070 3237 136104 97814 358726 522496 457078 261103 60509 144987 63949 73490 318112 2474 Linoleic acid Linoleic acid 1990559416 2148810234 5128614150 1599919719 2173786116 1568545404 1337520712 1672331132 1046995092 1235928438 2074123458 836456942 392733861 663563403 1084773140 548693585 648791801 644719656 746443494 479834098 1683082335 1217455764 634349913 793284601 971094907 5529457366 5195578336 4150270049 1301424202 849225428 1554265781 3969040633 711057688 3596912629 1822023719 402690665 765348507 424988229 384808077 852234232 468439889 1051620766 934698541 520408256 430399106 823366788 3093217563 Lipoxin A4 Lipoxin A4 413073 373635 337662 394512 171987 257469 123476 159833 232060 318431 261430 133239 74838 56581 45689 29621 74018 73938 35328 178892 65771 363081 57489 58862 142124 355155 352396 300992 315133 62234 66136 30321 47871 Lithocholic acid Lithocholic acid 9108526 7991214 11887628 9551747 5004814 11011198 8850513 12839906 11092715 13956392 11494303 1987 1077036 3098152 2011434 4778601 6127636 4224166 4860702 2494472 10212325 11516557 17451833 9830551 2907 LTB4 LTB4 65149 71919 62339 103733 47748 66394 Myristic acid Myristic acid 104040188 124691361 372701961 118661610 104537709 74960430 67803473 82069940 61591569 73969980 121022764 49873994 33383184 38928526 74001011 33087486 37594991 38774163 42348532 29894399 88723783 56780077 32308918 46487655 59689638 331179266 331737566 218420349 61370123 40757204 116684205 184177998 52137816 234456544 91631155 25757465 41161968 29542700 28233222 51136988 29781014 59578216 45805963 29536316 25707252 38067381 154388042 Myristoleic acid Myristoleic acid 4268761 4923063 25312161 4735754 2989838 1678125 1514404 1895868 1224988 1502871 4008403 1480693 322971 833326 2349956 400500 541011 513678 340445 188265 3175327 1325635 123070 934357 1573297 21069418 20357429 9906580 1938248 1140533 5228150 6982894 247050 12449857 1427273 436579 784561 148298 219885 1362931 304459 1907068 1179992 161028 78902 303171 5522218 Oleic acid Oleic acid 1745817381 2039049045 4021546847 1693623690 1682449181 1294073519 1178392184 1475702344 1071096182 1274167969 2086816769 1078887646 658375372 887930602 1748744021 798182697 887936999 886139907 1121109555 971032245 2070426033 1566489001 955895226 1115522232 1240685164 4965687464 5138383410 3576621408 1460228695 908503387 1929390820 3939763123 1443477914 3588018408 2009961194 550950120 1010633147 712964821 687141792 1059758429 698710747 1279999474 1140233148 845316180 664033457 1374410371 3342673990 Palmitic acid Palmitic acid 1116354219 1285347194 2973399769 1170527326 1095344353 959166428 802826587 1018193624 788902139 1155350805 1204563010 755420901 683278010 652372974 1286054463 696634524 740945766 832842740 1046960873 642576522 1201927191 975459030 677954891 975515921 839445961 2849752394 2859486714 2115779500 942900569 585086488 1227927415 2029011122 1321776123 2408734567 1070942493 482043705 806617346 670178647 613329021 874334361 631080002 849129163 809384643 592970510 534917365 748181173 1767464734 Palmitoleic acid Palmitoleic acid 351480158 445226161 1276026350 480912383 231212364 141949384 117440509 159521439 110166298 116854704 380152037 239042207 40598385 152890968 329302831 71306054 66063370 81902935 38243458 21424414 435550210 209888444 21641802 150204884 271700950 1651879462 1646732311 1053689917 293339636 187535506 603491729 817374507 45286494 1086212340 204477402 68454171 141733367 26266996 26573163 193084526 35336418 280057870 183785477 16342175 12713691 39856104 677297376 PGD2 PGD2 46604 163602 128481 304172 225193 12659 80364 36479 38562 52917 40928 29594 22361 29996 378737 37450 52599 282242 159064 112452 44752 141483 71565 26067 22321 26057 93709 PGE1 PGE1 17257 68705 72526 162891 97992 40225 19560 14931 115138 204911 133987 210744 49516 29275 104270 56798 97544 129145 163918 66909 388096 141185 259556 65909 74635 185364 40832 130372 104222 205967 136073 33638 6893 10130 PGE2-d4 (Internal Standard) 8261566 6972565 7525933 7224573 7782570 7880620 7593167 7734474 7980356 7748543 8460655 8968514 8777717 8613069 7782226 8766864 9137875 9349478 9408042 8579939 9543776 7785005 9055769 6841973 7858233 7758470 7493960 7516307 8477558 6818912 7726269 7106908 6731912 6897189 6216742 7806395 8798204 7732039 9145181 8424621 9364844 8943083 9226887 8332133 8112777 8270774 9100735 Sphingosine-1-phosphate Sphingosine 1-phosphate 1899 7301 3646 2215 2484 6016 15091 6303 4774 2875 Stearic acid Stearic acid 897498841 793134145 1238812617 772892941 897752711 921045732 736406413 978823655 1012447385 1146064257 1247505499 1384575142 1754021527 1297320484 2055513401 1474999038 1493640298 1742831436 2377047470 1272314411 1199635541 1533715149 1496187776 1866007309 1500267296 1139131089 1407680400 1149973102 1218966583 798986518 1255651999 954372776 2341067728 1363555089 1072809999 994960085 1452316599 1706880949 1560366681 1451613716 1492641925 1488557665 1390874867 1187191176 1167995993 1290529004 1389566182 Tauro-beta-muricholic acid Tauro-beta-muricholic acid 961465707 267198263 101173752 108425352 481369705 38485518 39038838 29318703 13601855 7160905 7944243 10080732678 3005689011 6082113819 8229290488 4400528981 3954862357 3712463790 1562865342 11028641741 4714676904 7248182290 6973087435 7209675543 266926645 8076040263 3946300784 3179208675 1642044530 2091599250 273098274 5163373799 180656848 1315490701 3878305596 6168828366 4875508182 3187018407 1810004740 8127565853 3333828217 3337093609 6041063531 9183495504 4779103461 10335520119 10855700884 Taurochenodeoxycholic acid Taurochenodeoxycholic acid 11313911 559568 364802 679078 1005198 190435 615532 618599 426738 199950 266259 10472711 3920781 15423958 11141021 8094107 10820372 3741281 2035022 39359170 17300742 30743452 54085359 25782720 2275289 11029510 3372109 17455256 2829249 4971752 1868672 12189735 2773477 3846925 4095965 4970908 6005277 2338903 4131084 17786480 4411663 3917412 11927516 31307916 13681868 27404831 19331987 Taurocholic acid Taurocholic acid 333636237 15136364 6982639 10343603 15039522 1262084 4544096 3800250 1711763 2576978 2248371 2718425567 676082860 2573010055 2311023512 1839690842 1632501546 1375111161 618145154 1738277117 520088431 808050760 1055602680 4326766305 38206461 2999555860 569903231 1000874418 291223033 349201027 89193391 870463293 26158139 97341027 461806876 1494917568 1046223484 611064455 503203128 3822428982 1186470807 1020592157 2197763981 932921277 475222120 1000488674 1156662848 Taurodeoxycholic acid Taurodeoxycholic acid 20101193 13177182 22831377 17591652 1170667 105498 251472 245401 2046395 650367 1338613 18259 37156 24932 24994 24022 10307 2487 37108 49552281 18647086 40364379 177226080 148258280 142190436 174137799 7866449 150249983 18338285 78288045 442997127 2667 16855 231509 55157 39121 58114 8338 Taurohyodeoxycholate/Tauroursodeoxycholate 75863489 11133321 5143350 7548217 14176069 1994291 3044969 2488869 1353104 741485 839271 91500183 21846618 75876513 94697160 64616873 71737732 37617950 22470984 134358475 39121589 82019564 88625574 267865970 8325453 137256211 58238893 164706358 63847165 53621814 13366992 129385966 15508283 24096140 75828941 37390748 37635956 20372765 21074837 114190355 29993819 23164070 76373483 83398307 32715138 67205491 95528995 Taurolithocholic acid Taurolithocholic acid 565879 306996 465799 389404 99809 18714 4857 75071 14546 29194 4331 7866 2321 4425 16573 6796 535136 406171 694416 2658855 1315770 1301985 2218029 325747 2965464 389503 4851794 4590983 2652 4002 87819 29089 21891 3143 4299 12551