Metabolite_name RefMet_name S00031763 S00031764 S00031765 S00031766 S00031767 S00031768 S00031769 S00031770 S00031771 S00031772 S00031773 S00031774 S00031775 S00031776 S00031777 S00031778 S00031779 S00031780 S00031781 S00031782 S00031783 S00031784 S00031785 S00031786 S00031787 S00031788 S00031789 S00031790 S00031791 S00031792 S00031793 S00031794 S00031795 S00031796 S00031797 S00031798 Factors - Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Baseline Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 Time Point:Day 90 3a_7a_12a-trihydroxycholestanoic acid Coprocholic acid 0.1080 2.2370 0.0810 0.2240 0.0850 0.1720 0.1170 0.0890 0.0690 0.1730 0.0570 0.1210 0.1220 0.0770 0.0590 0.0760 0.0620 0.1250 0.2430 0.0820 0.0800 0.1270 0.1130 0.1220 0.0890 0.0810 a-Muricholic acid alpha-Muricholic acid 0.4530 3.0670 619.2010 268.7340 0.6560 0.5730 3.2360 4.2290 34.9920 3.0170 1.1150 0.8980 48.9620 28.7130 0.8270 97.8210 0.6060 27.1100 1.6390 5.4640 19.3970 610.0730 2.1350 0.9810 1.4050 10.7600 57.9360 1.2020 0.5930 1.0650 58.9430 103.0590 18.4030 99.6970 0.4160 1.2290 b-Muricholic acid beta-Muricholic acid 0.2140 1.0130 51.8330 27.4700 0.1820 0.4430 2.2700 2.7040 0.7590 3.1690 0.7430 1.0100 1.9790 0.5210 1.6460 0.4880 1.4750 1.8580 0.6670 66.3840 0.1420 0.6260 1.3160 3.8620 1.4220 1.3020 0.7150 0.8550 1.1120 2.5830 0.5560 1.2660 0.3710 1.2200 Chenodeoxycholic acidDeoxycholic acid 49.1230 194.6850 201.4450 135.0540 65.3510 161.5510 217.1760 175 99.3760 224.9520 94.3110 55.6790 269.8030 60.2380 198.5640 136.8560 82.6380 118.7680 129.1220 139.1130 172.6000 318.3070 15.3870 128.4110 153.2070 222.6960 212.0390 136.0370 38.8440 116.9130 201.6420 129.4640 181.2030 174.0020 34.5480 185.8900 Cholic acid Cholic acid 0.4140 3.4280 388.1750 166.8910 0.8540 1.4250 3.1060 5.2280 3.7080 13.0330 0.5810 1.6720 7.6700 14.2690 1.1770 6.6240 0.9870 14.2290 2.4010 3.4540 7.9690 307.9360 3.7010 4.2250 3.0150 9.0880 7.9100 2.8030 0.0360 2.2190 10.5220 17.6840 12.5170 20.7370 0.5620 8.1930 Glychocholic acid Glycocholic acid 0.1250 0.2740 1.9390 0.2940 0.6030 0.1370 2.1260 1.9800 0.4170 0.3750 0.4720 0.4360 1.1080 0.6820 8.9540 0.5800 0.4200 0.6100 0.9600 3.5920 0.7250 0.1210 1.2810 1.1650 0.1580 0.9170 0.2170 1.5170 0.4550 0.7470 0.3830 Glycochenodeoxycholic acid Glycochenodeoxycholic acid 0.3310 0.5850 1.2290 0.5470 0.1930 1.3790 1.8870 0.2690 12.4230 3.0720 1.0040 0.5180 0.9200 1.4140 0.0930 1.7080 1.1990 16.7220 1.1760 1.4030 1.2590 1.8970 3.6280 3.3670 0.4970 3.7690 1.8500 0.2860 1.7090 0.7710 6.5480 1.4530 2.0680 1.0400 Glycodeoxycholic acid Glycodeoxycholic acid 0.4480 0.2950 0.1800 0.3660 1.2680 1.0320 1.0710 4.1830 10.5360 3.9780 0.7520 3.6940 0.7770 0.3460 1.4640 0.9300 11.4580 1.8810 0.5500 0.2620 0.7790 3.7690 2.5660 1.9870 3.8580 4.1680 0.3590 5.9860 0.6180 7.9780 0.8790 0.2630 1.4680 Glycohyodeoxycholic acid Glycohyodeoxycholic acid 2.2190 0.0810 0.1730 Glycoursodeoxycholic acid Glycoursodeoxycholic acid 0.0560 0.2010 0.0660 0.1150 0.3150 0.4940 0.1780 1.8830 0.0700 0.1380 0.1540 0.4910 0.7560 0.1210 0.1320 0.0790 0.5660 0.2010 0.1060 0.1940 0.0740 0.1910 1.0860 0.0810 g-Muricholic acid (hyocholic acid) Hyocholic acid 3.2470 4.0180 0.9100 0.8030 1.4890 1.2660 24.5730 14.7630 3.9980 73.0870 26.7910 18.6000 38.0310 5.9070 99.6130 3.0350 1.8650 7.7870 68 15.4180 0.8500 1.0680 3.5480 4.5660 28.9660 11.9390 64.0140 15.7100 19.6150 31.6490 5.5770 52.7270 3.3910 0.3980 47.9850 Hyodeoxycholic acid Hyodeoxycholic acid 3.8390 155.5790 1.4980 1.0450 23.3840 47.4520 344.5020 165.1100 36.6580 349.0160 14.0710 59.1150 2.7620 45.9020 93.7890 76.5340 26.9780 48.0060 141.9580 106.1760 42.6600 3.3230 0.6490 86.2600 104.0850 525.0210 90.0090 252.3760 13.3090 49.7570 30.6570 39.9060 33.6890 38.5750 14.3820 214.2630 Tauro-alpha-muricholic acidTauro-beta-muricholic acid Tauromuricholic acid 0.0520 0.3380 150.0970 0.0790 0.0830 0.5350 0.1240 0.2060 0.1200 0.2450 0.0660 0.0780 0.1160 0.1680 0.0560 1.9500 13.1310 0.1070 0.1030 0.1040 1.0170 0.0960 0.0810 2.8810 1.1230 0.1590 0.0810 0.1380 Taurochenodeoxycholic acid Taurochenodeoxycholic acid 0.1680 0.3510 4.1340 0.1460 0.1170 0.4670 0.3250 0.1250 0.8950 0.4230 0.0770 0.1960 0.3120 1.1390 0.0500 0.4260 1.1990 5.4880 0.4930 0.3190 0.2070 0.2900 1.8720 0.5540 0.1700 0.3790 0.2130 0.1720 0.2590 0.3130 0.7590 0.3120 1.5600 0.2480 Taurocholic acid Taurocholic acid 0.1230 0.2180 59.0960 0.0960 0.1520 0.3330 0.2310 0.1640 0.5120 0.3070 0.1000 0.1480 0.1700 0.4200 0.0600 0.2160 0.7710 3.8160 0.3200 0.3410 0.8840 0.1570 0.0750 1.5960 0.1740 0.1590 0.3010 0.1250 0.0410 0.2020 0.2720 0.3460 0.2390 0.1360 0.4690 0.2000 Taurodeoxycholic acid Taurodeoxycholic acid 0.1850 0.1410 0.3580 0.0580 0.1320 0.3360 0.2280 0.1760 3.9140 0.8350 0.0730 0.1810 0.4830 0.5230 0.0500 0.1400 0.4390 1.6620 0.4350 1.7050 5.5640 0.0790 1.1130 0.1690 0.2770 10.6900 0.2450 0.1930 0.3280 1.0540 0.4430 0.1310 0.1290 0.3140 Taurolithocolic acid Taurolithocholic acid 0.1670 0.6040 0.1380 0.2030 0.4740 0.1460 0.8540 0.5210 Tauroursodeoxycholic acid/Tauro-hyodeoxycholic acid Tauroursodeoxycholic acid 0.0540 0.1330 0.1580 0.0570 0.0810 0.2560 0.0780 0.0850 0.0950 0.0620 0.0730 0.0800 0.0540 0.1010 0.1210 0.0590 0.1160 0.0640 0.0700 0.0510 0.1100 0.1260 0.0820 0.0720 0.1020 0.0540 0.1090 0.0770 Ursodeoxycholic acid Ursodeoxycholic acid 0.8450 7.6100 8.4000 10.2620 6.6840 5.0510 1.3160 1.4280 33.3260 1.2780 46.4230 7.8190 83.5870 1.7410 12.6980 3.4810 5.4750 126.0500 3.7390 3.3180 w-Muricholic acid omega-Muricholic acid 0.3300 3.2080 725.0260 314.2350 0.4080 0.3480 3.4380 4.6490 39.1190 3.2010 1.8430 0.7750 57.2200 28.9000 0.7930 106.2840 0.5060 28.9350 1.6820 5.8800 21.2520 664.4100 2.2210 0.9950 1.3440 12.3490 62.9600 1.1560 0.3260 0.9820 65.3980 115.7800 21.6930 110.0420 0.2610 1.0820