Metabolite_name RefMet_name 2831 2891 6541 5111 6914 6924 6991 7011 7021 7022 7001 7002 7003 7004 7005 Factors - diabetes:db/db | time of day:ZT17 diabetes:db/db | time of day:ZT17 diabetes:db/db | time of day:ZT17 diabetes:db/db | time of day:ZT5 diabetes:db/db | time of day:ZT5 diabetes:db/db | time of day:ZT5 diabetes:db/db | time of day:ZT5 diabetes:db/m | time of day:ZT17 diabetes:db/m | time of day:ZT17 diabetes:db/m | time of day:ZT17 diabetes:db/m | time of day:ZT5 diabetes:db/m | time of day:ZT5 diabetes:db/m | time of day:ZT5 diabetes:db/m | time of day:ZT5 diabetes:db/m | time of day:ZT5 1-palmitoyl-2-oleoyl-GPI (16:0/18:1) PI 16:0/18:1 1.8984 0.8926 1.0598 1.0260 0.7593 0.9323 0.8938 1.2196 1.1921 1.4993 1.1832 1.3470 1.3895 1.5966 1.9304 1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6) PE 18:0/22:6 2.0399 1.8785 2.3513 3.7080 1.4515 1.3381 0.9288 1.1732 1.0137 1.3957 1.2798 1.3121 1.3068 0.6544 0.9559 1-stearoyl-2-oleoyl-GPG (18:0/18:1) PG 18:0/18:1 0.8799 1.3288 1.0276 0.6516 0.8494 0.6647 1.1099 1.2231 1.3498 1.2935 0.9861 1.0127 1.0615 1.1918 0.9264 2_3-dihydroxyisovalerate 2,3-Dihydroxyisovaleric acid 0.9041 0.9394 1.0657 0.5327 0.8320 2.3105 2.3005 0.4710 2.7665 2.7948 0.6379 0.8295 1.3102 1.6195 1.6581 2-hydroxybutyrate/2-hydroxyisobutyrate 2-Hydroxybutyric acid/2-Hydroxyisobutyric acid 0.6401 1.2330 1.0943 1.2867 2.0844 1.5271 0.9107 0.7719 0.9595 1.0354 0.5893 0.4562 0.4873 0.6801 0.5798 2-hydroxyphenylacetate 2-Hydroxyphenylacetic acid 1.4529 1.0806 1.2437 0.6988 1.6106 0.1997 1 0.1997 0.5341 0.4689 0.1997 0.1997 0.1997 0.3323 0.2788 2-oxoadipate Oxoadipic acid 0.6201 1.7298 1.8035 0.5294 0.7362 1.1357 1.5121 1.4231 2.0846 1.5560 1.5617 1.3096 2.2542 0.7009 0.4810 3-hydroxy-3-methylglutarate 3-Hydroxymethylglutaric acid 1.2263 1.4424 1.8040 1.5449 1.0253 1.5451 0.9786 1.0214 0.8340 1.3791 0.6380 0.6329 0.8394 0.7906 0.6010 3-hydroxyadipate 3-Hydroxy-adipic acid 0.4332 1.2629 4.3784 0.4539 0.8547 4.8118 2.3705 0.4608 1.6940 1.6101 0.4007 0.3134 0.3440 0.4457 0.3548 3-hydroxybutyrate (BHBA) 3-Hydroxybutyric acid 1.2925 2.6369 0.9374 0.3529 0.9919 1.6000 0.2640 0.9312 1.0081 1.2100 0.3766 0.2610 0.2880 0.3704 0.3193 3-hydroxyisobutyrate 3-Hydroxyisobutyric acid 1.1250 1.7423 1.1860 0.4362 0.7271 1.3817 1.0084 0.5434 1.3054 1.5337 0.7562 0.6633 0.6610 0.6044 0.6503 3-methyl-2-oxobutyrate Ketoisovaleric acid 0.5960 1.3583 0.5817 0.4462 1.1361 0.9829 0.2996 0.8645 0.8651 1.2053 1.1688 1.1379 0.8909 0.4459 0.6305 3-methylglutaconate 3E-Methylglutaconic acid 0.9299 1.4751 1.2973 1.7170 1.0175 1.3092 1.1691 0.7905 1.0230 1.2482 0.6972 0.7706 0.7456 0.9110 0.7646 3-methylglutarate/2-methylglutarate Methylglutaric acid 1.9595 1.7308 1.5056 0.9813 1.2547 0.7778 1.0570 1.5392 1.4821 1.3630 0.3089 0.5848 0.1681 0.6817 0.1681 acetylphosphate Acetylphosphate 1.9150 2.1326 1.1435 0.5740 0.2901 3.4666 0.5704 1.9325 1.9293 2.3908 0.7201 0.7392 1.3785 0.6854 1.1333 adipate (C6-DC) Adipic acid 1.0065 1.2737 0.9459 1.0591 1.0477 1.5418 0.6605 0.8890 0.9566 0.8661 0.5377 0.6998 0.3646 0.9369 0.7393 alanine Alanine 1.0833 1.0057 0.8674 0.5192 1.0043 1.0031 2.0511 0.6584 1.1698 1.5871 0.8885 1.0601 0.8912 1.0375 0.8734 allantoic acid Allantoic acid 0.9952 1.2579 2.0842 1 1.3261 0.8214 0.3828 0.7784 0.8681 0.8282 0.3643 0.3643 0.3643 0.8310 0.9956 allantoin Allantoin 0.8849 0.9574 1.3714 0.8246 0.9824 1.1232 1.7481 0.7957 1.0840 1.1266 1.0291 1.2149 0.9752 0.9150 1.0088 alpha-ketoglutaramate 2-Keto-glutaramic acid 0.9956 1.2368 1.2753 2.7986 1.6527 1.9326 0.8850 0.7833 1.0175 0.9636 0.5606 0.3906 0.4574 2.0456 1.7123 alpha-ketoglutarate 2-Oxoglutaric acid 0.6663 1.8667 0.9347 0.7547 0.4775 1.4379 0.9440 1.1185 1.1760 1.0393 1.1158 0.9738 1.1230 0.4814 0.5319 arabitol/xylitol Arabitol 1.4088 1.0239 1.6261 2.1299 3.1447 2.0927 1.0020 0.9980 1.5562 1.6418 0.7023 0.7060 0.8371 4.2628 2.8504 arabonate/xylonate Arabinonic acid/Xylonic acid 3.3503 1.2791 3.8831 1.2097 2.4576 1.8139 2.1092 0.4582 1.0029 0.8908 0.3109 0.4325 0.9227 0.8434 0.9179 caffeic acid sulfate 6.2303 5.9436 7.7815 0.7735 2.3692 3.2483 3.9944 2.7070 2.5521 2.8743 0.7389 0.7165 0.6733 1.8770 2.0928 cysteine s-sulfate Cysteine-S-sulfate 2.7176 2.1044 2.3721 1.1905 0.9721 1.6345 1.5983 0.5985 1.5398 1.4744 1.0596 0.6659 0.3327 1.0279 0.7353 cystine Cystine 1.0696 0.9404 0.5699 1.3412 0.8627 0.4785 3.9068 1.0750 1.5211 1.7151 2.0389 2.4981 1.2302 0.9417 1.0020 dihydroorotate 4,5-Dihydroorotic acid 0.0821 0.0821 0.0821 1.1551 5.0895 0.0821 50.0082 0.0821 0.0821 0.0821 0.0821 0.0821 0.0821 2.9428 0.6125 erythritol Erythritol 0.8208 0.6732 1.4535 2.0460 2.4372 1.4378 1.7945 0.5813 0.8768 0.8157 0.6074 0.7039 0.7603 1.7992 1.3154 erythronate Erythronic acid 1.5800 1.5053 2.7237 1.7338 2.6898 1.7297 1.8783 0.6493 1.3248 1.0832 0.5493 0.5478 0.5768 1.0099 0.8333 ethylmalonate Ethylmalonic acid 1.3604 1.2547 2.3663 1.3805 1.2580 1.8185 0.9644 0.7526 0.5671 0.5764 0.7254 0.8091 0.6269 0.6574 0.6935 fructose Fructose 3.9162 5.2862 4.6752 2.3268 4.9851 1.3571 1.0807 0.5183 2.2204 0.7303 0.2943 0.2335 0.2323 0.7513 0.7228 fumarate Fumaric acid 0.6507 1.1137 0.7043 0.9988 0.9632 1.8202 2.5489 0.7381 0.9613 1.0525 1.0012 0.8545 0.9645 1.0558 1.0043 gamma-glutamylthreonine gamma-Glutamylthreonine 0.8101 0.7142 0.9137 0.3303 1.0412 1.1370 0.7232 1.6155 2.4203 2.3411 0.9188 1.2088 1.1525 2.5215 2.5058 gentisate Gentisic acid 3.8414 4.1606 4.7926 0.3572 2.2226 0.9410 0.3572 0.9054 3.3972 3.4903 0.6330 0.3763 0.3572 1.6931 1.1473 gluconate Gluconic acid 2.0627 2.6537 1.8567 7.7458 3.2689 3.5191 1.4022 0.3579 1.5354 0.3973 0.4187 0.3917 0.6004 0.2315 0.2694 glucose Glucose 2.3209 2.6930 2.3635 1.6256 2.1897 2.7931 1.5324 0.8081 0.9500 0.9091 0.7491 0.7644 0.7286 0.1473 0.2969 glucuronate Glucuronic acid 1.8562 1.0364 1.6918 1.3774 1.2173 2.3717 1.4817 0.7251 0.8852 0.9917 0.9114 0.9358 0.9682 1.1295 1.2202 glutarate (C5-DC) Glutaric acid 1.0021 1.4611 0.7897 0.5955 1.0120 1.0645 0.6015 0.9979 1.2916 1.2756 0.5485 0.4621 0.7407 1.1715 1.4325 glycerate Glyceric acid 1.5020 1.3722 1.7486 1.2505 1.3058 1.1071 0.6534 0.7371 0.9229 0.8924 0.4800 0.5929 0.5348 0.6722 0.7825 glycerophosphoglycerol sn-Glycero-3-phosphoglycerol 1.1937 1.1491 0.8052 1.5923 0.6428 4.4014 1.5390 0.6598 0.7684 0.9999 0.6538 0.4668 0.8402 0.3191 0.6434 glycerophosphoinositol sn-Glycero-3-phosphoinositol 1.0134 0.8478 1.1119 0.9915 1.0085 1.7384 1.3350 0.6919 0.6122 1.2937 0.4996 0.5031 0.6589 1.4215 2.5806 glycolate (hydroxyacetate) Glycolic acid 3.5802 0.9276 1.3383 1.0959 1.7545 0.9554 0.3983 1.3217 1.1960 2.0799 0.2808 0.3529 0.4047 1.2334 1.1145 guanidinoacetate Guanidoacetic acid 0.7072 0.9781 0.2539 1.2337 0.4469 0.5918 1.6199 1.5488 0.7029 1.0505 1.5426 1.1289 1 1.6427 1.6522 gulonate Gulonic acid 1.2230 0.9970 2.3107 1.8847 0.4687 1.8623 0.7927 0.6796 1.5577 1.6502 0.9872 1.0030 1.1503 0.6468 0.7994 heptenedioate (C7:1-DC) 0.4180 0.8887 0.4180 1.3888 0.7623 0.7275 1.7506 0.4180 0.4180 0.4180 0.4180 0.4180 0.4180 0.4180 0.4180 hypotaurine Hypotaurine 0.5550 1.5629 0.6982 0.9662 0.7780 0.5442 0.5439 1.3168 1.2422 1.5780 0.9366 1.2783 1.1628 1.0115 1.2142 isocitric lactone Isocitric acid lactone 1.1686 1.3067 1.5491 1.0184 1.1350 2.0996 2.2087 0.6980 1.6215 1.4340 0.8408 1.0280 0.8304 0.8987 0.7692 itaconate Itaconic acid 2.6860 1.2166 3.6684 4.7817 1.6400 1.5138 4.0823 0.5788 0.8053 0.6234 0.6616 0.5193 0.8278 0.6490 0.5711 lactate Lactic acid 0.8418 0.8908 0.6065 1.1921 1.4326 1.2771 2.0717 0.7608 0.8266 0.8069 1.0698 0.9504 0.9558 1.4951 1.3326 maleate Maleic acid 1.3153 1.0286 1.1452 0.8115 0.7635 1.0302 1.0303 0.8918 1.0846 1.1498 1.1727 0.9075 0.8957 1.0893 1.3044 malonate Malonic acid 1.0015 0.9538 1.1820 0.9061 1.0424 0.8371 0.9020 1.1091 1.0915 1.0017 0.5232 0.7534 0.5217 1.2055 1.0252 mannitol/sorbitol Sorbitol 0.7459 0.8371 0.5136 2.4983 3.7876 1.5602 3.1929 0.2851 0.2969 0.3897 0.7298 0.8314 0.7963 2.0698 1.8504 mannose Mannose 2.3755 0.9207 2.3283 1.8920 1.4361 1.3496 1.1480 1.0522 0.7984 0.9910 0.7163 0.8914 0.5518 0.2212 0.2924 methylmalonate (MMA) Methylmalonic acid 1.0292 0.8471 1.1112 1.5304 1.1793 1.1983 2.5491 1.0448 0.9734 1.0858 0.9175 0.9028 0.7779 1.1712 1.0080 methylsuccinate Methylsuccinic acid 2.7799 1.6999 1.4879 2.0319 1.1907 1.1799 2.3973 0.7942 0.9524 0.9519 0.9243 0.6096 0.6492 0.8999 0.7178 myo-inositol Myo-inositol 0.9209 1.0579 1.0510 1.1212 0.8566 2.1097 0.9944 1.0205 1.0738 0.9654 0.5995 0.7944 0.7833 0.9984 0.8055 N2-acetyllysine N(2)-Acetyllysine 1.3363 0.6266 1.3322 0.7914 1.0118 1.5277 1.9742 1.1247 2.4134 2.4739 0.9241 1.4809 1.3043 2.6553 2.5414 N6-acetyllysine N6-Acetyllysine 1.1947 0.7351 1.3917 0.9382 0.8577 1.1801 1.9204 1.0571 2.6023 2.4752 0.7799 1.0336 1.0894 2.1749 1.6792 N-acetylalanine N-Acetylalanine 1.5353 1.2786 1.3727 0.8470 0.8730 1.2340 1.5622 1.0484 1.1849 1.2434 0.9199 1.0890 0.9936 0.9970 1.1608 N-acetylaspartate (NAA) N-Acetylaspartic acid 0.6298 0.9549 0.7252 0.5926 0.6079 0.7253 0.9469 1.0088 1.0453 1.4481 0.7966 1.0791 1.3913 1.4487 1.4460 N-acetylglutamate N-Acetylglutamic acid 2.7940 1.0785 3.0394 1.1203 0.5563 1.2353 1.0829 0.9065 2.2684 1.7985 0.7708 0.4890 0.7264 0.9306 0.7934 N-acetylglutamine N-Acetylglutamine 1.2698 0.5646 1.3431 1.4798 0.5424 0.9017 0.8355 0.9585 1.1920 1.0305 1.1532 1.0185 1.1773 0.9815 0.8637 N-acetylglycine N-Acetylglycine 0.7377 1.2954 0.9890 0.4517 0.4545 0.7114 0.7094 0.9586 1.1430 1.5009 1.3520 1.3583 1.0110 0.5997 0.7442 N-acetylneuraminate N-Acetylneuraminic acid 1.2464 1.1090 1.3208 1.0925 0.8490 1.9077 1.2157 1.0140 1.0303 1.1827 0.8045 0.9507 1.2383 0.7961 1.1256 N-acetylserine N-Acetylserine 1.3758 0.7798 1.2491 0.6262 0.6837 0.9618 2.3690 1.1650 1.8984 1.9128 1.0984 1.4279 1.2320 1.4421 1.4435 N-carbamoylaspartate N-Carbamoylaspartic acid 0.5944 0.5008 0.5336 0.9703 1.5161 1.3892 32.0616 0.3523 0.3060 0.2975 0.4900 0.5469 0.7551 1.3747 1.9800 N-formylanthranilic acid Formylanthranilic acid 0.5288 1.5730 1.1493 0.7347 0.5429 0.5524 1.0905 0.6603 1.5529 1.1814 0.5126 1.0078 1.0305 0.7725 0.8026 N-glycolylneuraminate N-Glycoloylneuraminic acid 0.6020 0.6875 1.0215 1.6295 0.5393 5.1695 1.5454 0.6772 0.5104 0.6787 0.9240 1.2589 1.2488 0.5364 1.2223 orotate Orotic acid 0.8409 0.3729 0.6314 1.2567 1.1807 0.7248 13.9244 0.7377 0.4931 0.4301 0.5679 0.5832 0.6110 0.9432 1.2402 orotidine Orotidine 1.5052 1.3022 1.5017 1.0293 0.8946 1.5505 1.8255 1.0406 1.0686 0.9889 0.8077 0.8314 1.3199 1.1038 1.4515 perfluorooctanesulfonic acid (PFOS) Perfluorooctanesulfonic acid 1.2193 0.8679 1.0643 0.6118 1.8750 0.6532 1.3684 0.8863 0.9882 1.0118 0.8309 0.6787 0.9215 0.7203 0.5708 pimelate (C7-DC) Pimelic acid 1.4104 1.6206 1.3662 0.4037 1.2122 1.1300 0.9528 0.7213 0.6932 0.6592 0.2340 0.3302 0.5030 0.2340 0.2340 pyruvate Pyruvic acid 1.2708 1.7747 1.1657 0.3820 0.5785 0.9867 2.9363 1.1760 1.2730 1.2622 3.8771 3.3467 2.8825 0.3700 0.2965 quinate Quinic acid 5.9136 3.0347 2.8898 0.9981 1.8771 1.9882 6.0709 1.3795 2.8105 4.1866 0.4454 0.4536 0.5391 0.9868 1.7979 quinolinate Quinolinic acid 0.8392 1.7147 2.3846 0.4525 0.6524 1.6050 0.4796 0.8192 5.9760 5.2184 0.9941 1.6056 3.2049 1.2698 1.1121 ribitol Ribitol 0.6649 0.3334 0.3539 6.9787 12.1545 3.0837 1.7612 0.5884 0.3664 0.6952 0.5034 0.4520 0.3715 11.2434 8.8977 ribonate Ribonic acid 2.2431 0.2423 3.2121 0.2423 2.5841 0.2423 1.2708 0.7213 1.1434 0.9170 0.5631 0.7924 0.5531 0.2423 0.4148 ribose Ribose 8.5339 7.0674 9.9333 1.0017 1.5498 5.0240 0.5039 2.6773 3.0206 2.2424 0.2249 0.1759 0.1455 0.8535 0.2999 ribose 1-phosphate Ribose 1-phosphate 1.3629 4.3855 0.3172 0.0640 0.0640 8.3274 1.2605 2.3376 1 4.7298 0.2791 0.0640 0.4178 0.0640 0.0640 ribulonate/xylulonate 2.1084 2.0437 2.2506 1.6737 1.5868 1.6264 1.6374 0.8271 0.9840 0.9529 0.4729 0.7114 0.5124 0.8292 0.9113 ribulose/xylulose 5-phosphate Ribulose 5-phosphate 6.3614 5.2750 1.1133 0.1144 0.1144 10.3485 1.0622 5.2571 4.0826 11.7851 1.6514 1 2.6671 0.1144 0.4171 salicylate Salicylic acid 1.6909 1.8024 1.8812 0.6258 1.2653 1.2803 1.5958 1.0678 2.0220 1.9617 0.5044 1.2063 1 0.9179 0.7298 sedoheptulose Glucoheptulose 2.6526 2.1205 1.5626 0.5412 1.3515 3.7734 0.7079 0.6380 1.9784 0.5594 0.4562 0.5773 0.2058 0.2798 1.1614 sphingosine 1-phosphate Sphingosine 1-phosphate 1.9286 1.0181 1.6709 1.1094 1.3022 0.8414 2.5268 1.4629 1.0418 1.2963 0.2809 0.4277 0.4833 0.8009 1.1809 succinate Succinic acid 0.6996 1.3185 0.8400 1.4985 1.2419 1.8637 6.9027 0.7562 0.8325 0.8073 0.7875 0.6813 0.7599 1.2180 1.3415 sucrose Sucrose 4.3104 40.0715 6.2366 0.7932 1.6984 0.3606 2.8875 116.2993 15.2754 6.4934 0.4753 0.8667 0.4050 1.0404 0.9749 threonate Threonic acid 1.3764 1.0623 1.3058 1.5075 0.7941 1.1461 1.2002 0.7376 0.9385 0.9435 0.6002 0.6889 0.9195 0.7699 0.7982 tricarballylate 1,2,3-Propanetricarboxylic acid 2.2403 2.5871 2.2130 1.2777 2.9995 1.9160 1.0930 2.3866 3.0041 4.3524 0.4418 0.3165 0.5198 0.6549 1.5390 xylose Xylose 0.2171 0.2171 0.2171 0.2171 1.5935 0.6390 0.2171 0.2171 0.2171 2.6227 0.5422 0.3829 0.2952 1 2.9890