Metabolite_name	RefMet_name	2831	2891	6541	5111	6914	6924	6991	7011	7021	7022	7001	7002	7003	7004	7005
Factors	-	diabetes:db/db | time of day:ZT17	diabetes:db/db | time of day:ZT17	diabetes:db/db | time of day:ZT17	diabetes:db/db | time of day:ZT5	diabetes:db/db | time of day:ZT5	diabetes:db/db | time of day:ZT5	diabetes:db/db | time of day:ZT5	diabetes:db/m | time of day:ZT17	diabetes:db/m | time of day:ZT17	diabetes:db/m | time of day:ZT17	diabetes:db/m | time of day:ZT5	diabetes:db/m | time of day:ZT5	diabetes:db/m | time of day:ZT5	diabetes:db/m | time of day:ZT5	diabetes:db/m | time of day:ZT5
1-palmitoyl-2-oleoyl-GPI (16:0/18:1)	PI 16:0/18:1	1.8984	0.8926	1.0598	1.0260	0.7593	0.9323	0.8938	1.2196	1.1921	1.4993	1.1832	1.3470	1.3895	1.5966	1.9304
1-stearoyl-2-docosahexaenoyl-GPE (18:0/22:6)	PE 18:0/22:6	2.0399	1.8785	2.3513	3.7080	1.4515	1.3381	0.9288	1.1732	1.0137	1.3957	1.2798	1.3121	1.3068	0.6544	0.9559
1-stearoyl-2-oleoyl-GPG (18:0/18:1)	PG 18:0/18:1	0.8799	1.3288	1.0276	0.6516	0.8494	0.6647	1.1099	1.2231	1.3498	1.2935	0.9861	1.0127	1.0615	1.1918	0.9264
2_3-dihydroxyisovalerate	2,3-Dihydroxyisovaleric acid	0.9041	0.9394	1.0657	0.5327	0.8320	2.3105	2.3005	0.4710	2.7665	2.7948	0.6379	0.8295	1.3102	1.6195	1.6581
2-hydroxybutyrate/2-hydroxyisobutyrate	2-Hydroxybutyric acid/2-Hydroxyisobutyric acid	0.6401	1.2330	1.0943	1.2867	2.0844	1.5271	0.9107	0.7719	0.9595	1.0354	0.5893	0.4562	0.4873	0.6801	0.5798
2-hydroxyphenylacetate	2-Hydroxyphenylacetic acid	1.4529	1.0806	1.2437	0.6988	1.6106	0.1997	1	0.1997	0.5341	0.4689	0.1997	0.1997	0.1997	0.3323	0.2788
2-oxoadipate	Oxoadipic acid	0.6201	1.7298	1.8035	0.5294	0.7362	1.1357	1.5121	1.4231	2.0846	1.5560	1.5617	1.3096	2.2542	0.7009	0.4810
3-hydroxy-3-methylglutarate	3-Hydroxymethylglutaric acid	1.2263	1.4424	1.8040	1.5449	1.0253	1.5451	0.9786	1.0214	0.8340	1.3791	0.6380	0.6329	0.8394	0.7906	0.6010
3-hydroxyadipate	3-Hydroxy-adipic acid	0.4332	1.2629	4.3784	0.4539	0.8547	4.8118	2.3705	0.4608	1.6940	1.6101	0.4007	0.3134	0.3440	0.4457	0.3548
3-hydroxybutyrate (BHBA)	3-Hydroxybutyric acid	1.2925	2.6369	0.9374	0.3529	0.9919	1.6000	0.2640	0.9312	1.0081	1.2100	0.3766	0.2610	0.2880	0.3704	0.3193
3-hydroxyisobutyrate	3-Hydroxyisobutyric acid	1.1250	1.7423	1.1860	0.4362	0.7271	1.3817	1.0084	0.5434	1.3054	1.5337	0.7562	0.6633	0.6610	0.6044	0.6503
3-methyl-2-oxobutyrate	Ketoisovaleric acid	0.5960	1.3583	0.5817	0.4462	1.1361	0.9829	0.2996	0.8645	0.8651	1.2053	1.1688	1.1379	0.8909	0.4459	0.6305
3-methylglutaconate	3E-Methylglutaconic acid	0.9299	1.4751	1.2973	1.7170	1.0175	1.3092	1.1691	0.7905	1.0230	1.2482	0.6972	0.7706	0.7456	0.9110	0.7646
3-methylglutarate/2-methylglutarate	Methylglutaric acid	1.9595	1.7308	1.5056	0.9813	1.2547	0.7778	1.0570	1.5392	1.4821	1.3630	0.3089	0.5848	0.1681	0.6817	0.1681
acetylphosphate	Acetylphosphate	1.9150	2.1326	1.1435	0.5740	0.2901	3.4666	0.5704	1.9325	1.9293	2.3908	0.7201	0.7392	1.3785	0.6854	1.1333
adipate (C6-DC)	Adipic acid	1.0065	1.2737	0.9459	1.0591	1.0477	1.5418	0.6605	0.8890	0.9566	0.8661	0.5377	0.6998	0.3646	0.9369	0.7393
alanine	Alanine	1.0833	1.0057	0.8674	0.5192	1.0043	1.0031	2.0511	0.6584	1.1698	1.5871	0.8885	1.0601	0.8912	1.0375	0.8734
allantoic acid	Allantoic acid	0.9952	1.2579	2.0842	1	1.3261	0.8214	0.3828	0.7784	0.8681	0.8282	0.3643	0.3643	0.3643	0.8310	0.9956
allantoin	Allantoin	0.8849	0.9574	1.3714	0.8246	0.9824	1.1232	1.7481	0.7957	1.0840	1.1266	1.0291	1.2149	0.9752	0.9150	1.0088
alpha-ketoglutaramate	2-Keto-glutaramic acid	0.9956	1.2368	1.2753	2.7986	1.6527	1.9326	0.8850	0.7833	1.0175	0.9636	0.5606	0.3906	0.4574	2.0456	1.7123
alpha-ketoglutarate	2-Oxoglutaric acid	0.6663	1.8667	0.9347	0.7547	0.4775	1.4379	0.9440	1.1185	1.1760	1.0393	1.1158	0.9738	1.1230	0.4814	0.5319
arabitol/xylitol	Arabitol	1.4088	1.0239	1.6261	2.1299	3.1447	2.0927	1.0020	0.9980	1.5562	1.6418	0.7023	0.7060	0.8371	4.2628	2.8504
arabonate/xylonate	Arabinonic acid/Xylonic acid	3.3503	1.2791	3.8831	1.2097	2.4576	1.8139	2.1092	0.4582	1.0029	0.8908	0.3109	0.4325	0.9227	0.8434	0.9179
caffeic acid sulfate		6.2303	5.9436	7.7815	0.7735	2.3692	3.2483	3.9944	2.7070	2.5521	2.8743	0.7389	0.7165	0.6733	1.8770	2.0928
cysteine s-sulfate	Cysteine-S-sulfate	2.7176	2.1044	2.3721	1.1905	0.9721	1.6345	1.5983	0.5985	1.5398	1.4744	1.0596	0.6659	0.3327	1.0279	0.7353
cystine	Cystine	1.0696	0.9404	0.5699	1.3412	0.8627	0.4785	3.9068	1.0750	1.5211	1.7151	2.0389	2.4981	1.2302	0.9417	1.0020
dihydroorotate	4,5-Dihydroorotic acid	0.0821	0.0821	0.0821	1.1551	5.0895	0.0821	50.0082	0.0821	0.0821	0.0821	0.0821	0.0821	0.0821	2.9428	0.6125
erythritol	Erythritol	0.8208	0.6732	1.4535	2.0460	2.4372	1.4378	1.7945	0.5813	0.8768	0.8157	0.6074	0.7039	0.7603	1.7992	1.3154
erythronate	Erythronic acid	1.5800	1.5053	2.7237	1.7338	2.6898	1.7297	1.8783	0.6493	1.3248	1.0832	0.5493	0.5478	0.5768	1.0099	0.8333
ethylmalonate	Ethylmalonic acid	1.3604	1.2547	2.3663	1.3805	1.2580	1.8185	0.9644	0.7526	0.5671	0.5764	0.7254	0.8091	0.6269	0.6574	0.6935
fructose	Fructose	3.9162	5.2862	4.6752	2.3268	4.9851	1.3571	1.0807	0.5183	2.2204	0.7303	0.2943	0.2335	0.2323	0.7513	0.7228
fumarate	Fumaric acid	0.6507	1.1137	0.7043	0.9988	0.9632	1.8202	2.5489	0.7381	0.9613	1.0525	1.0012	0.8545	0.9645	1.0558	1.0043
gamma-glutamylthreonine	gamma-Glutamylthreonine	0.8101	0.7142	0.9137	0.3303	1.0412	1.1370	0.7232	1.6155	2.4203	2.3411	0.9188	1.2088	1.1525	2.5215	2.5058
gentisate	Gentisic acid	3.8414	4.1606	4.7926	0.3572	2.2226	0.9410	0.3572	0.9054	3.3972	3.4903	0.6330	0.3763	0.3572	1.6931	1.1473
gluconate	Gluconic acid	2.0627	2.6537	1.8567	7.7458	3.2689	3.5191	1.4022	0.3579	1.5354	0.3973	0.4187	0.3917	0.6004	0.2315	0.2694
glucose	Glucose	2.3209	2.6930	2.3635	1.6256	2.1897	2.7931	1.5324	0.8081	0.9500	0.9091	0.7491	0.7644	0.7286	0.1473	0.2969
glucuronate	Glucuronic acid	1.8562	1.0364	1.6918	1.3774	1.2173	2.3717	1.4817	0.7251	0.8852	0.9917	0.9114	0.9358	0.9682	1.1295	1.2202
glutarate (C5-DC)	Glutaric acid	1.0021	1.4611	0.7897	0.5955	1.0120	1.0645	0.6015	0.9979	1.2916	1.2756	0.5485	0.4621	0.7407	1.1715	1.4325
glycerate	Glyceric acid	1.5020	1.3722	1.7486	1.2505	1.3058	1.1071	0.6534	0.7371	0.9229	0.8924	0.4800	0.5929	0.5348	0.6722	0.7825
glycerophosphoglycerol	sn-Glycero-3-phosphoglycerol	1.1937	1.1491	0.8052	1.5923	0.6428	4.4014	1.5390	0.6598	0.7684	0.9999	0.6538	0.4668	0.8402	0.3191	0.6434
glycerophosphoinositol	sn-Glycero-3-phosphoinositol	1.0134	0.8478	1.1119	0.9915	1.0085	1.7384	1.3350	0.6919	0.6122	1.2937	0.4996	0.5031	0.6589	1.4215	2.5806
glycolate (hydroxyacetate)	Glycolic acid	3.5802	0.9276	1.3383	1.0959	1.7545	0.9554	0.3983	1.3217	1.1960	2.0799	0.2808	0.3529	0.4047	1.2334	1.1145
guanidinoacetate	Guanidoacetic acid	0.7072	0.9781	0.2539	1.2337	0.4469	0.5918	1.6199	1.5488	0.7029	1.0505	1.5426	1.1289	1	1.6427	1.6522
gulonate	Gulonic acid	1.2230	0.9970	2.3107	1.8847	0.4687	1.8623	0.7927	0.6796	1.5577	1.6502	0.9872	1.0030	1.1503	0.6468	0.7994
heptenedioate (C7:1-DC)		0.4180	0.8887	0.4180	1.3888	0.7623	0.7275	1.7506	0.4180	0.4180	0.4180	0.4180	0.4180	0.4180	0.4180	0.4180
hypotaurine	Hypotaurine	0.5550	1.5629	0.6982	0.9662	0.7780	0.5442	0.5439	1.3168	1.2422	1.5780	0.9366	1.2783	1.1628	1.0115	1.2142
isocitric lactone	Isocitric acid lactone	1.1686	1.3067	1.5491	1.0184	1.1350	2.0996	2.2087	0.6980	1.6215	1.4340	0.8408	1.0280	0.8304	0.8987	0.7692
itaconate	Itaconic acid	2.6860	1.2166	3.6684	4.7817	1.6400	1.5138	4.0823	0.5788	0.8053	0.6234	0.6616	0.5193	0.8278	0.6490	0.5711
lactate	Lactic acid	0.8418	0.8908	0.6065	1.1921	1.4326	1.2771	2.0717	0.7608	0.8266	0.8069	1.0698	0.9504	0.9558	1.4951	1.3326
maleate	Maleic acid	1.3153	1.0286	1.1452	0.8115	0.7635	1.0302	1.0303	0.8918	1.0846	1.1498	1.1727	0.9075	0.8957	1.0893	1.3044
malonate	Malonic acid	1.0015	0.9538	1.1820	0.9061	1.0424	0.8371	0.9020	1.1091	1.0915	1.0017	0.5232	0.7534	0.5217	1.2055	1.0252
mannitol/sorbitol	Sorbitol	0.7459	0.8371	0.5136	2.4983	3.7876	1.5602	3.1929	0.2851	0.2969	0.3897	0.7298	0.8314	0.7963	2.0698	1.8504
mannose	Mannose	2.3755	0.9207	2.3283	1.8920	1.4361	1.3496	1.1480	1.0522	0.7984	0.9910	0.7163	0.8914	0.5518	0.2212	0.2924
methylmalonate (MMA)	Methylmalonic acid	1.0292	0.8471	1.1112	1.5304	1.1793	1.1983	2.5491	1.0448	0.9734	1.0858	0.9175	0.9028	0.7779	1.1712	1.0080
methylsuccinate	Methylsuccinic acid	2.7799	1.6999	1.4879	2.0319	1.1907	1.1799	2.3973	0.7942	0.9524	0.9519	0.9243	0.6096	0.6492	0.8999	0.7178
myo-inositol	Myo-inositol	0.9209	1.0579	1.0510	1.1212	0.8566	2.1097	0.9944	1.0205	1.0738	0.9654	0.5995	0.7944	0.7833	0.9984	0.8055
N2-acetyllysine	N(2)-Acetyllysine	1.3363	0.6266	1.3322	0.7914	1.0118	1.5277	1.9742	1.1247	2.4134	2.4739	0.9241	1.4809	1.3043	2.6553	2.5414
N6-acetyllysine	N6-Acetyllysine	1.1947	0.7351	1.3917	0.9382	0.8577	1.1801	1.9204	1.0571	2.6023	2.4752	0.7799	1.0336	1.0894	2.1749	1.6792
N-acetylalanine	N-Acetylalanine	1.5353	1.2786	1.3727	0.8470	0.8730	1.2340	1.5622	1.0484	1.1849	1.2434	0.9199	1.0890	0.9936	0.9970	1.1608
N-acetylaspartate (NAA)	N-Acetylaspartic acid	0.6298	0.9549	0.7252	0.5926	0.6079	0.7253	0.9469	1.0088	1.0453	1.4481	0.7966	1.0791	1.3913	1.4487	1.4460
N-acetylglutamate	N-Acetylglutamic acid	2.7940	1.0785	3.0394	1.1203	0.5563	1.2353	1.0829	0.9065	2.2684	1.7985	0.7708	0.4890	0.7264	0.9306	0.7934
N-acetylglutamine	N-Acetylglutamine	1.2698	0.5646	1.3431	1.4798	0.5424	0.9017	0.8355	0.9585	1.1920	1.0305	1.1532	1.0185	1.1773	0.9815	0.8637
N-acetylglycine	N-Acetylglycine	0.7377	1.2954	0.9890	0.4517	0.4545	0.7114	0.7094	0.9586	1.1430	1.5009	1.3520	1.3583	1.0110	0.5997	0.7442
N-acetylneuraminate	N-Acetylneuraminic acid	1.2464	1.1090	1.3208	1.0925	0.8490	1.9077	1.2157	1.0140	1.0303	1.1827	0.8045	0.9507	1.2383	0.7961	1.1256
N-acetylserine	N-Acetylserine	1.3758	0.7798	1.2491	0.6262	0.6837	0.9618	2.3690	1.1650	1.8984	1.9128	1.0984	1.4279	1.2320	1.4421	1.4435
N-carbamoylaspartate	N-Carbamoylaspartic acid	0.5944	0.5008	0.5336	0.9703	1.5161	1.3892	32.0616	0.3523	0.3060	0.2975	0.4900	0.5469	0.7551	1.3747	1.9800
N-formylanthranilic acid	Formylanthranilic acid	0.5288	1.5730	1.1493	0.7347	0.5429	0.5524	1.0905	0.6603	1.5529	1.1814	0.5126	1.0078	1.0305	0.7725	0.8026
N-glycolylneuraminate	N-Glycoloylneuraminic acid	0.6020	0.6875	1.0215	1.6295	0.5393	5.1695	1.5454	0.6772	0.5104	0.6787	0.9240	1.2589	1.2488	0.5364	1.2223
orotate	Orotic acid	0.8409	0.3729	0.6314	1.2567	1.1807	0.7248	13.9244	0.7377	0.4931	0.4301	0.5679	0.5832	0.6110	0.9432	1.2402
orotidine	Orotidine	1.5052	1.3022	1.5017	1.0293	0.8946	1.5505	1.8255	1.0406	1.0686	0.9889	0.8077	0.8314	1.3199	1.1038	1.4515
perfluorooctanesulfonic acid (PFOS)	Perfluorooctanesulfonic acid	1.2193	0.8679	1.0643	0.6118	1.8750	0.6532	1.3684	0.8863	0.9882	1.0118	0.8309	0.6787	0.9215	0.7203	0.5708
pimelate (C7-DC)	Pimelic acid	1.4104	1.6206	1.3662	0.4037	1.2122	1.1300	0.9528	0.7213	0.6932	0.6592	0.2340	0.3302	0.5030	0.2340	0.2340
pyruvate	Pyruvic acid	1.2708	1.7747	1.1657	0.3820	0.5785	0.9867	2.9363	1.1760	1.2730	1.2622	3.8771	3.3467	2.8825	0.3700	0.2965
quinate	Quinic acid	5.9136	3.0347	2.8898	0.9981	1.8771	1.9882	6.0709	1.3795	2.8105	4.1866	0.4454	0.4536	0.5391	0.9868	1.7979
quinolinate	Quinolinic acid	0.8392	1.7147	2.3846	0.4525	0.6524	1.6050	0.4796	0.8192	5.9760	5.2184	0.9941	1.6056	3.2049	1.2698	1.1121
ribitol	Ribitol	0.6649	0.3334	0.3539	6.9787	12.1545	3.0837	1.7612	0.5884	0.3664	0.6952	0.5034	0.4520	0.3715	11.2434	8.8977
ribonate	Ribonic acid	2.2431	0.2423	3.2121	0.2423	2.5841	0.2423	1.2708	0.7213	1.1434	0.9170	0.5631	0.7924	0.5531	0.2423	0.4148
ribose	Ribose	8.5339	7.0674	9.9333	1.0017	1.5498	5.0240	0.5039	2.6773	3.0206	2.2424	0.2249	0.1759	0.1455	0.8535	0.2999
ribose 1-phosphate	Ribose 1-phosphate	1.3629	4.3855	0.3172	0.0640	0.0640	8.3274	1.2605	2.3376	1	4.7298	0.2791	0.0640	0.4178	0.0640	0.0640
ribulonate/xylulonate		2.1084	2.0437	2.2506	1.6737	1.5868	1.6264	1.6374	0.8271	0.9840	0.9529	0.4729	0.7114	0.5124	0.8292	0.9113
ribulose/xylulose 5-phosphate	Ribulose 5-phosphate	6.3614	5.2750	1.1133	0.1144	0.1144	10.3485	1.0622	5.2571	4.0826	11.7851	1.6514	1	2.6671	0.1144	0.4171
salicylate	Salicylic acid	1.6909	1.8024	1.8812	0.6258	1.2653	1.2803	1.5958	1.0678	2.0220	1.9617	0.5044	1.2063	1	0.9179	0.7298
sedoheptulose	Glucoheptulose	2.6526	2.1205	1.5626	0.5412	1.3515	3.7734	0.7079	0.6380	1.9784	0.5594	0.4562	0.5773	0.2058	0.2798	1.1614
sphingosine 1-phosphate	Sphingosine 1-phosphate	1.9286	1.0181	1.6709	1.1094	1.3022	0.8414	2.5268	1.4629	1.0418	1.2963	0.2809	0.4277	0.4833	0.8009	1.1809
succinate	Succinic acid	0.6996	1.3185	0.8400	1.4985	1.2419	1.8637	6.9027	0.7562	0.8325	0.8073	0.7875	0.6813	0.7599	1.2180	1.3415
sucrose	Sucrose	4.3104	40.0715	6.2366	0.7932	1.6984	0.3606	2.8875	116.2993	15.2754	6.4934	0.4753	0.8667	0.4050	1.0404	0.9749
threonate	Threonic acid	1.3764	1.0623	1.3058	1.5075	0.7941	1.1461	1.2002	0.7376	0.9385	0.9435	0.6002	0.6889	0.9195	0.7699	0.7982
tricarballylate	1,2,3-Propanetricarboxylic acid	2.2403	2.5871	2.2130	1.2777	2.9995	1.9160	1.0930	2.3866	3.0041	4.3524	0.4418	0.3165	0.5198	0.6549	1.5390
xylose	Xylose	0.2171	0.2171	0.2171	0.2171	1.5935	0.6390	0.2171	0.2171	0.2171	2.6227	0.5422	0.3829	0.2952	1	2.9890