Metabolite_name RefMet_name Ab4 Ab5 Ab6 HC-HMA-Rag1KO+aIL-22 Ab #11 HC-HMA-Rag1KO+aIL-22 Ab #12 HC-HMA-Rag1KO+aIL-22 Ab #13 HC-HMA-Rag1KO+aIL-22 Ab #14 HC-HMA-Rag1KO+aIL-22 Ab #15 HC-Rag1KO+aIL-22l Ab #11 HC-Rag1KO+aIL-22l Ab #12 HC-Rag1KO+aIL-22l Ab #13 HC-Rag1KO+aIL-22l Ab #14 HC-Rag1KO+aIL-22l Ab #15 Ab1 Ab2 Ab3 HC-HMA-Rag1KO+Ctrl Ab #10 HC-HMA-Rag1KO+Ctrl Ab #6 HC-HMA-Rag1KO+Ctrl Ab #7 HC-HMA-Rag1KO+Ctrl Ab #8 HC-HMA-Rag1KO+Ctrl Ab #9 HC-Rag1KO+Ctrl Ab #10 HC-Rag1KO+Ctrl Ab #6 HC-Rag1KO+Ctrl Ab #7 HC-Rag1KO+Ctrl Ab #8 HC-Rag1KO+Ctrl Ab #9 Factors - Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody 1_3-Diaminopropane 1,3-Diaminopropane 11 9.5000 3.4000 23 6.7000 12 51 6.9000 6.7000 3.7000 6 34 55 5.7000 1-Methylhistamine 1-Methylhistamine 1.8000 0.4100 0.4000 0.7700 0.9300 2.3000 0.4200 0.6200 0.3300 0.3600 3.6000 3.7000 1-Methylnicotinamide 1-Methyl nicotinamide 9.8000 1.8000 6.1000 0.8700 1.6000 0.8200 1.1000 1.4000 0.9700 0.5100 3.3000 4.5000 1.1000 3-Aminoisobutyrate 3-Aminoisobutanoic acid 13 14 11 4.3000 6.1000 2.9000 5.7000 4.4000 38 30 17 20 28 18 12 5.9000 3.2000 7.8000 6.3000 4 9.1000 18 14 26 26 29 3-Indoxyl sulfate Indoxyl sulfate 24 87 146 204 11 3-Methylhistidine 3-Methylhistidine 7.6000 5.9000 5.6000 7.4000 8.3000 7 9.3000 6.8000 36 7.1000 8.7000 8.4000 7.7000 5.2000 7.5000 6.2000 6.3000 7.1000 8 9.3000 7.9000 6.8000 3.9000 21 20 8.3000 4-(beta-Acetylaminoethyl)imidazole N-Acetylhistamine 8.3000 12 6 12 15 8.5000 14 9.6000 11 22 20 19 22 7.4000 7.3000 9.3000 7.5000 8.5000 10 8.3000 9.6000 13 13 14 12 11 4-Hydroxymethylimidazole Imidazole-4-methanol 8 7.4000 6.3000 6 7 4.3000 6.6000 5.4000 4.9000 4.7000 4.2000 4.3000 4.4000 6.5000 7.7000 6 8.7000 8 6.1000 7.4000 6.3000 3.5000 2.9000 3.9000 4.3000 3.3000 5-Aminolevulinate 5-Amino-levulinic acid 25 28 20 21 20 19 26 17 25 19 19 21 28 13 16 12 13 12 16 14 10 14 9.2000 19 20 10 5-Aminovalerate 5-Aminopentanoic acid 3087 3083 2405 2450 2270 1886 3141 2001 5208 3888 2680 2458 3354 2613 3367 2182 2106 2427 2810 2147 2173 1347 1753 2135 2078 2850 5-Hydroxyindoleacetate 5-Hydroxyindoleacetic acid 1049 971 944 793 835 623 1007 610 889 1266 1202 1146 1558 808 886 738 928 847 901 836 820 898 802 1006 920 775 5-Hydroxylysine 5-Hydroxylysine 26 21 13 16 18 12 18 16 13 13 15 12 12 12 8.2000 11 86 15 16 14 14 11 7.7000 11 11 33 5-Methyl-2^-deoxycytidine 5-Methyl-2'-deoxycytidine 34 32 27 29 26 34 45 30 33 22 31 29 23 23 24 23 5-Methylcytosine 5-Methylcytosine 2.7000 2.1000 1.6000 3.2000 2.6000 3.1000 1.9000 5-Methylthioadenosine 5'-Methylthioadenosine 10 12 8.8000 14 11 15 16 13 5.5000 8.6000 12 11 8.2000 9.4000 10 9.6000 11 15 17 14 12 8.4000 4.3000 5.4000 6.3000 4.6000 7-Methylguanine 7-Methylguanine 28 27 19 37 24 27 15 27 29 20 25 30 26 29 34 39 37 Adenine Adenine 5.3000 10 6.5000 13 6.5000 9.9000 9.2000 8.8000 4.7000 10 9.5000 8.5000 9.7000 6.2000 4.2000 6.6000 11 10 11 8.8000 8.9000 15 6.7000 9.7000 5.6000 5.8000 Adenosine Adenosine 16 19 14 21 21 19 18 19 19 12 13 15 18 17 11 15 14 26 18 22 16 18 9.8000 13 17 20 ADMA Dimethylarginine 34 37 24 36 42 40 39 19 32 30 28 35 46 30 27 24 51 26 34 29 32 38 15 31 37 18 Agmatine Agmatine 10 7.7000 6.5000 10 20 11 15 13 6.1000 4.5000 7.9000 5.1000 7.8000 6.3000 8.6000 6 8.1000 8.4000 13 6.4000 8.6000 9 3.5000 3.7000 5.7000 3.1000 Ala Alanine 2571 2810 1709 1532 1425 1098 1759 1530 1965 1433 1547 1457 1406 1945 1978 1573 1039 1471 1617 1151 1152 934 350 519 629 574 Ala-Ala Ala-Ala 384 431 259 205 354 215 361 348 52 113 207 171 218 284 297 237 196 329 423 279 222 233 96 108 128 104 alpha-Aminoadipate Aminoadipic acid 43 42 27 19 32 24 32 27 14 43 33 27 55 38 30 26 26 35 37 26 28 21 15 25 16 27 Alpha-Methylserine Alpha-Methylserine 13 15 7.4000 11 8.2000 7.5000 8.1000 7.3000 11 9.8000 9.8000 9.9000 11 8.5000 7.2000 7.9000 5.1000 5.8000 9.7000 4.7000 5.7000 6.1000 Arg Arginine 918 917 513 768 1191 751 965 856 408 325 642 430 493 523 528 531 562 770 980 684 582 563 205 224 332 169 Asn Asparagine 216 242 119 421 830 657 917 678 154 239 430 337 427 98 106 146 400 523 872 650 478 347 94 142 221 159 Asp Aspartic acid 1997 2197 1078 1773 2075 1226 1817 1213 1976 1813 1884 2231 2361 846 872 731 2553 2345 3268 2657 1759 1116 525 929 1280 749 beta-Ala beta-Alanine 123 141 65 93 98 93 101 110 103 79 112 104 124 120 110 85 65 110 134 95 101 123 43 58 103 47 Betaine Betaine 28 26 39 40 20 30 39 55 126 130 130 121 106 43 34 51 35 30 32 28 23 711 21 69 27 24 Betaine aldehyde Betaine aldehyde 52 54 38 48 33 84 59 86 40 68 60 61 43 54 30 68 60 32 Cadaverine Cadaverine 22 15 12 15 14 11 24 8.5000 11 29 44 27 31 13 12 15 23 14 8.5000 12 12 27 19 22 19 13 Carnitine Carnitine 8.9000 13 6.7000 13 7.4000 14 8.1000 7.6000 22 36 16 51 28 18 8.2000 12 37 6.7000 6.2000 6.8000 8.3000 21 19 21 32 15 Carnosine Carnosine 1.8000 0.8800 1.2000 2.1000 0.6400 0.1100 1 1.5000 2.1000 0.9600 0.6900 Choline Choline 97 104 82 79 41 69 56 54 137 102 75 99 95 221 167 159 106 77 49 70 68 577 87 103 70 78 Citrulline Citrulline 177 220 100 342 86 115 129 73 154 50 34 39 33 100 110 95 142 93 55 49 49 40 41 66 72 56 Creatine Creatine 12 4.1000 5.3000 59 4 36 15 14 171 2.6000 6.8000 5.9000 14 6.3000 3.8000 2.5000 4.8000 5.4000 6.6000 34 18 5 Creatinine Creatinine 18 13 7.4000 67 7.5000 9.6000 13 9.8000 504 13 11 10 8.3000 14 8.3000 14 11 6.7000 8.8000 7.5000 6.7000 65 6.8000 226 352 21 Cyclohexylamine Cyclohexylamine 3 2.5000 2.7000 54 46 46 115 17 2.6000 2.3000 2.8000 39 20 63 161 49 Cytidine Cytidine 34 43 41 20 22 19 23 19 38 8.1000 12 14 7.3000 42 45 47 28 40 16 29 30 12 8.8000 8.1000 10 9.4000 Cytosine Cytosine 4.8000 5.4000 6.4000 3.3000 9.6000 6.2000 12 3.4000 2.9000 3.9000 3.1000 6.7000 3.7000 4.6000 4.1000 3.1000 2.8000 4.8000 3.1000 3.6000 3.3000 2.4000 Diethanolamine Diethanolamine 51 15 15 18 7 44 16 11 4.9000 4.8000 30 13 16 92 20 111 12 21 14 7.8000 22 8 16 29 4.5000 4.6000 Ectoine Ectoine 5.3000 4.6000 4.7000 6.3000 5.3000 4.6000 8.8000 4.3000 19 14 15 15 16 3.5000 3.8000 11 5.5000 6.3000 4.6000 5.7000 19 9.3000 23 15 8.6000 GABA gamma-Aminobutyric acid 67 52 93 178 21 28 28 30 45 58 41 247 27 43 35 42 72 25 30 22 25 66 22 38 25 37 gamma-Butyrobetaine 3-Dehydroxycarnitine 163 214 109 122 99 191 108 85 107 215 175 301 231 130 110 132 257 61 67 93 131 186 96 87 125 66 gamma-Guanidinobutyrate 4-Guanidinobutanoic acid 7.6000 6.8000 4.3000 24 11 7.7000 15 15 66 9.3000 7.4000 7.3000 6.5000 6.8000 6.9000 8.2000 15 13 14 12 12 18 5.8000 59 43 11 Gln Glutamine 343 415 319 470 423 776 966 807 849 734 583 727 703 486 501 421 357 507 855 468 403 299 199 366 349 285 Glu Glutamic acid 8580 12323 5289 11565 13937 12224 13887 11311 5052 6130 5929 7044 7368 9084 7097 6972 7107 11965 15705 11600 13211 4055 2972 4617 5066 3780 Gly Glycine 813 807 709 1152 801 880 1538 1167 1891 1238 1153 1178 1044 687 834 805 1020 628 817 613 652 492 306 577 615 414 Gly-Gly Gly-Gly 17 17 18 15 6.1000 6.5000 12 7.3000 13 15 20 15 23 12 8.5000 7.3000 8.4000 5.4000 13 13 17 Guanidinoacetate Guanidoacetic acid 3.4000 8.8000 35 313 2.6000 124 155 21 Guanidinosuccinate Guanidinosuccinic acid 4.9000 5 3.5000 4.4000 4.8000 14 5.7000 14 8.5000 11 26 5.2000 7.3000 11 5.3000 5.3000 2.3000 6.5000 15 5.5000 Guanine Guanine 52 56 54 44 25 33 29 31 31 39 29 34 37 60 66 69 28 29 35 30 29 57 30 34 26 29 Guanosine Guanosine 47 57 45 8.7000 8.2000 11 7.6000 8.1000 25 5.8000 4.5000 6.7000 4.2000 44 53 44 5.9000 17 6.6000 8.5000 10 5.9000 6.9000 4.5000 6 His Histidine 419 406 222 282 466 313 469 332 129 165 255 198 223 208 227 223 278 245 372 254 209 213 90 111 147 88 Histamine Histamine 6.5000 5.4000 4.2000 23 13 11 20 14 14 27 32 27 22 2.3000 4.9000 4.2000 35 13 14 12 12 24 19 22 19 15 Homoserine Homoserine 45 44 35 23 27 14 26 23 42 51 64 51 54 39 37 33 18 23 25 15 19 19 24 30 21 22 Homovanillate Homovanillic acid 96 218 157 101 86 80 130 79 165 199 291 155 270 82 86 95 114 90 47 94 78 163 Hydroxyproline Hydroxyproline 271 322 183 203 216 128 322 145 54 86 85 77 118 133 173 190 94 212 181 149 152 75 47 77 81 43 Hypoxanthine Hypoxanthine 141 153 96 42 37 24 15 12 28 106 101 89 128 62 17 30 29 Ile Isoleucine 166 158 135 150 78 67 214 153 245 136 151 107 138 139 149 95 79 143 183 117 101 74 37 58 63 60 Imidazole-4-acetate Imidazoleacetic acid 6.2000 3.4000 5.1000 34 14 13 13 23 5.4000 3.7000 5.8000 5.1000 6.4000 6.1000 8.1000 31 26 12 Indole-3-ethanol Tryptophanol 43 43 39 44 39 67 48 66 51 44 45 41 42 37 40 49 43 63 51 41 Inosine Inosine 381 472 395 171 270 160 161 57 244 48 42 46 71 368 386 289 201 553 113 233 258 101 77 58 81 54 Isoamylamine 3-Methyl-1-butylamine 0.9800 0.8500 1.8000 1.7000 1.2000 1.4000 1.5000 0.8100 0.7800 0.8300 0.6300 1.7000 0.8500 2.1000 2 1.3000 Isopropanolamine Isopropanolamine 10 19 12 12 5.6000 6.7000 12 8.8000 23 18 15 18 20 20 10 10 8.6000 7.2000 7.2000 7.9000 5.2000 11 10 12 11 7.6000 Leu Leucine 235 282 208 221 182 90 261 236 530 208 220 170 178 294 351 222 85 204 230 139 130 101 59 110 88 109 Lys Lysine 5126 5000 2324 2178 2592 2100 2465 1964 939 1461 2202 1851 1685 2815 2348 2417 1897 2087 2380 1630 1974 1803 1092 1151 1350 905 Mannosamine 2-Amino-2-deoxy-D-mannose 183 166 148 164 118 122 185 104 134 153 172 154 208 95 90 108 140 136 127 114 85 151 108 115 119 101 Met Methionine 170 183 148 155 127 115 169 102 234 196 235 178 171 132 145 136 156 131 146 118 116 644 73 123 95 84 Methionine sulfoxide Methionine sulfoxide 93 91 82 46 21 19 33 25 65 88 111 53 65 100 73 70 38 20 25 23 30 214 47 73 59 40 N1-Acetylspermidine N1-Acetylspermidine 363 292 196 185 297 185 162 163 55 303 363 380 393 218 163 147 240 100 125 109 105 351 121 100 129 48 N1_N12-Diacetylspermine N1,N12-Diacetylspermine 3.9000 2.9000 3.4000 5.1000 3.1000 2.4000 2.3000 1.4000 2.6000 7.3000 8.3000 9.6000 12 8.4000 4.1000 2.1000 8.6000 0.9100 1.5000 1.6000 1.9000 7.1000 2.3000 3.1000 2.8000 2.5000 N1_N8-Diacetylspermidine N1,N8-Diacetylspermidine 23 22 31 38 6.8000 16 21 8.6000 14 41 42 44 56 19 9.8000 10 40 4.7000 11 6.2000 11 19 12 17 17 21 N6_N6_N6-Trimethyllysine N-6-Trimethyllysine 22 22 13 12 13 12 11 8.2000 27 8.8000 12 14 13 15 16 8.8000 87 10 12 10 12 13 6.4000 14 18 9.8000 N8-Acetylspermidine N8-Acetylspermidine 13 16 14 22 9.7000 10 21 33 29 32 33 8.7000 10 8.1000 12 22 9.6000 9.2000 14 4.1000 N-Acetylglucosamine N-Acetylglucosamine 93 62 202 168 131 142 114 123 155 134 163 148 106 185 230 161 245 149 102 112 131 124 136 N-Acetylhistidine N-Acetylhistidine 11 15 7.5000 7.6000 6 49 9.7000 8.1000 10 11 12 11 8.6000 9.8000 6.6000 6.3000 18 21 5.1000 N-Acetylornithine N-Acetylornithine 68 73 36 48 22 17 22 21 19 27 30 25 26 32 36 31 30 31 23 19 22 20 14 19 17 N-Acetylputrescine N-Acetylputrescine 56 26 51 26 19 21 27 24 14 14 6.7000 5.7000 9.4000 257 333 166 151 9.6000 16 11 4.7000 14 9.5000 15 11 6.7000 N-Acetylvaline N-Acetylvaline 5.8000 205 9.1000 8.5000 9.7000 81 85 6.4000 N-alpha_N-alpha-Dimethylhistidine N,N-Dimethylhistidine 5.5000 5.7000 3.8000 4.4000 2.7000 N-epsilon-Acetyllysine N6-Acetyllysine 30 31 18 24 30 24 28 19 16 30 38 31 29 20 19 19 23 25 26 23 25 26 18 23 22 18 Nicotinamide Niacinamide 47 54 36 44 46 41 51 39 56 30 37 31 36 59 56 57 38 65 80 50 46 38 36 27 28 36 N-Methylalanine N-Methylalanine 4.6000 4.5000 2.7000 3 2.5000 2.7000 5.5000 5.6000 6.6000 9.9000 3.5000 2.8000 4.7000 3.1000 3.4000 3.5000 4.2000 5 3.9000 4.5000 N-Methylglutamate N-Methyl-glutamic acid 4.2000 3.6000 4.7000 4.9000 5.5000 5.7000 N_N-Dimethylglycine Dimethylglycine 5.3000 4.3000 4.6000 65 59 32 65 84 4.4000 4.3000 6.5000 26 14 O-Acetylserine O-Acetylserine 21 23 22 42 18 15 32 21 149 32 51 63 36 19 40 14 17 23 17 15 18 16 20 16 Ophthalmate Ophthalmic acid 19 16 31 41 42 29 47 24 3.7000 1.1000 1.2000 4.1000 0.9500 Ornithine Ornithine 392 455 181 1182 132 105 125 90 250 195 188 190 98 191 159 184 207 90 126 56 58 166 85 104 75 82 p-Aminobenzoate p-Aminobenzoic acid 6.1000 5.5000 2.3000 7.8000 6.7000 4.9000 2.9000 6.1000 5.2000 3.3000 3 4.5000 3.8000 Phe Phenylalanine 118 138 96 109 64 70 169 113 226 96 78 67 110 112 116 81 61 83 143 109 97 56 30 61 51 45 Pipecolate Pipecolic acid 71 65 57 30 18 24 37 20 149 115 120 116 156 57 52 45 27 21 20 17 16 56 51 105 100 89 Pro Proline 1652 1913 919 1133 2069 1288 1714 1203 183 394 672 560 834 1141 911 1485 1229 1525 1548 1387 1292 748 431 598 639 379 Putrescine(1_4-Butanediamine) Putrescine 11 7.6000 5.9000 14 13 9.7000 14 8.2000 19 7.2000 10 6 9 94 107 74 131 4.8000 5.4000 4.4000 7.8000 8.2000 4.7000 13 15 0.9400 Pyridoxamine Pyridoxamine 6.8000 5.9000 3.7000 9.1000 4.8000 2.5000 2.2000 1.9000 3.9000 5.4000 6.4000 7.3000 5.4000 2.5000 2.2000 2.7000 3 3.5000 2.2000 1.9000 2.8000 4.7000 2.7000 3.4000 3.5000 2.6000 Pyridoxamine 5^-phosphate Pyridoxamine 5'-phosphate 20 20 16 28 18 24 20 11 17 15 18 11 9.6000 9.5000 12 25 25 20 17 13 5.7000 7.9000 Saccharopine Saccharopine 16 16 16 17 14 18 40 50 50 39 22 24 19 18 30 25 26 28 20 SAM+ S-Adenosylmethionine 51 43 37 32 31 46 66 50 11 27 48 39 33 37 36 38 40 35 45 37 37 32 14 16 18 9.9000 Sarcosine Sarcosine 88 93 86 39 70 61 75 68 479 142 108 141 86 62 52 88 52 57 60 47 62 66 49 181 130 79 SDMA Symmetric dimethylarginine 17 18 14 11 8.4000 17 13 5.2000 9.4000 6.6000 5.6000 6.2000 8 15 14 9.6000 24 6.2000 11 5 3.4000 7.4000 4.1000 10 13 11 Ser Serine 764 679 458 463 288 334 491 319 604 420 398 333 418 845 612 804 484 374 376 372 336 284 206 328 306 390 Serotonin Serotonin 10 5.3000 6.6000 10 5.4000 3.7000 11 9.5000 10 7.6000 11 20 8.3000 8.1000 21 9.5000 7.8000 6.7000 9.8000 11 11 14 10 Spermidine Spermidine 225 208 106 109 186 110 192 92 50 85 153 100 124 135 96 107 169 157 166 116 151 85 64 71 87 62 Taurine Taurine 81 108 77 138 45 111 59 60 1558 928 1011 680 933 902 1168 983 1550 430 1413 158 Thiamine Thiamine 14 11 7.7000 18 6.5000 6.6000 11 11 9.3000 25 14 24 12 12 6.8000 8.3000 10 6.8000 8 7.5000 7.5000 17 11 13 6.8000 4.2000 Thr Threonine 472 509 431 367 357 572 963 670 168 336 417 394 419 397 455 315 507 398 504 394 335 372 152 189 250 176 Thymidine Thymidine 198 208 185 109 129 105 107 77 298 477 364 493 155 119 171 165 232 163 182 162 149 280 430 277 403 445 Thymine Thymine 223 217 189 76 64 64 75 81 191 191 108 153 106 149 177 164 117 79 68 72 59 673 149 145 115 169 Trigonelline Trigonelline 5.1000 7.5000 4.2000 15 2.1000 3.4000 7.8000 5.8000 100 9.3000 6.7000 2.9000 4.2000 3.5000 39 98 54 9.8000 Trimethylamine N-oxide Trimethylamine N-oxide 15 1.7000 2 354 355 320 390 295 361 189 717 570 147 Trp Tryptophan 71 96 44 85 96 81 116 70 126 55 67 48 60 78 61 67 74 73 102 70 52 85 26 33 42 27 Tyr Tyrosine 281 351 226 328 309 318 552 441 322 145 173 135 152 201 325 220 162 286 454 284 208 134 53 109 88 99 Tyramine Tyramine 12 11 10 4.7000 3.9000 4.2000 4.5000 2.4000 2.1000 0.9400 2.7000 1.7000 2.4000 38 7.8000 10 8.4000 4.5000 5 6.8000 4.2000 1.5000 2.9000 Uracil Uracil 394 429 132 43 37 86 77 103 131 141 215 170 140 30 107 82 74 40 Urea Urea 158 3351 65 59 142 7157 307 439 520 264 282 403 55 406 161 30872 33103 842 Uridine Uridine 306 322 255 158 182 123 150 110 215 124 123 141 200 227 219 303 223 157 145 150 132 114 131 143 107 Urocanate Urocanic acid 8.9000 11 8.7000 24 9.6000 8.7000 10 7.4000 8.4000 30 13 7.7000 12 12 15 10 11 12 7.5000 7.2000 7 9.2000 9.6000 18 Val Valine 493 479 422 388 299 195 479 454 757 451 440 354 408 394 425 329 202 402 533 263 243 219 143 208 191 261 Xanthine Xanthine 234 269 151 54 147 112 193 150 167 58 95 Xanthurenate Xanthurenic acid 5.9000 7.1000 4.3000 5.4000 6 63 9.7000 24 12 28 22 6.8000 9.6000 13 8.4000 10 9.8000 30 34 17