Metabolite_name RefMet_name Ab4 Ab5 Ab6 HC-HMA-Rag1KO+aIL-22 Ab #11 HC-HMA-Rag1KO+aIL-22 Ab #12 HC-HMA-Rag1KO+aIL-22 Ab #13 HC-HMA-Rag1KO+aIL-22 Ab #14 HC-HMA-Rag1KO+aIL-22 Ab #15 HC-Rag1KO+aIL-22l Ab #11 HC-Rag1KO+aIL-22l Ab #12 HC-Rag1KO+aIL-22l Ab #13 HC-Rag1KO+aIL-22l Ab #14 HC-Rag1KO+aIL-22l Ab #15 Ab1 Ab2 Ab3 HC-HMA-Rag1KO+Ctrl Ab #10 HC-HMA-Rag1KO+Ctrl Ab #6 HC-HMA-Rag1KO+Ctrl Ab #7 HC-HMA-Rag1KO+Ctrl Ab #8 HC-HMA-Rag1KO+Ctrl Ab #9 HC-Rag1KO+Ctrl Ab #10 HC-Rag1KO+Ctrl Ab #6 HC-Rag1KO+Ctrl Ab #7 HC-Rag1KO+Ctrl Ab #8 HC-Rag1KO+Ctrl Ab #9 Factors - Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Anti-IL-22 antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody Factor:Control antibody 2_5-Dihydroxybenzoate Gentisic acid 14 31 22 19 15 38 24 53 48 26 33 52 15 34 17 23 28 30 29 32 19 18 40 29 22 2-Hydroxybutyrate 2-Hydroxybutyric acid 13 7.8000 12 28 16 35 34 29 28 23 11 12 35 2-Hydroxyglutarate 2-Hydroxyglutaric acid 142 122 165 247 82 68 104 62 1461 291 176 209 176 207 167 239 152 111 151 122 128 241 200 396 569 128 2-Isopropylmalate 2-Isopropylmalic acid 4.5000 2 4 30 4 12 15 4.6000 6.2000 13 4.2000 3.6000 2.5000 4.8000 3.3000 4.4000 6.1000 9.9000 8.5000 5.7000 2-Oxoglutarate 2-Oxoglutaric acid 83 100 70 87 81 136 78 115 123 96 3-(4-Hydroxyphenyl)propionate Desaminotyrosine 921 445 620 1130 701 2217 1501 1087 1384 2235 521 651 802 953 842 669 719 1135 1058 996 3-Methylbutanoate Isovaleric acid 185 306 86 208 235 111 185 101 284 174 161 158 129 176 168 38 78 151 281 178 84 196 116 139 210 135 3PG 3-Phosphoglyceric acid 45 48 42 13 12 8 24 19 26 57 34 41 33 78 83 155 27 18 19 18 13 27 18 45 18 12 3-Ureidopropionate Ureidopropionic acid 39 408 177 147 4-Acetylbutyrate 5-Ketocaproic acid 8.5000 8.6000 7.7000 13 8.1000 17 14 9.5000 7.7000 9.5000 8.7000 9.7000 7.9000 17 19 13 14 5-Oxoproline Pyroglutamic acid 82 80 65 66 55 63 57 53 100 56 44 64 48 80 98 73 59 64 76 60 59 159 31 45 41 63 Acetyl CoA Acetyl-CoA 21 16 18 18 35 34 49 48 3.3000 38 49 50 72 44 23 30 34 31 60 43 48 34 12 15 21 10 Adipate Adipic acid 33 24 15 48 20 45 48 49 22 18 19 17 28 ADP-ribose ADP-ribose 22 27 20 31 29 11 9.2000 13 19 20 20 28 24 14 12 11 10 11 AMP AMP 56 72 55 83 73 100 102 78 82 62 65 63 76 82 57 56 60 75 89 76 69 67 46 62 62 60 Argininosuccinate Argininosuccinic acid 16 9.4000 23 8.4000 8.5000 7 11 11 6.7000 11 5.5000 10 10 7.1000 Azelate Azelaic acid 72 58 65 62 74 38 89 40 89 136 140 98 150 63 77 51 78 70 83 75 86 57 64 90 81 84 Butyrate Butyric acid 1433 1888 1414 5014 2609 2651 6168 4522 9821 4246 5301 6536 6932 925 969 169 1679 3068 4604 4693 2311 2263 1735 2081 3252 2317 Cholate Cholic acid 63 87 154 119 51 646 221 92 485 214 285 242 407 259 223 144 70 135 58 133 98 403 717 494 2026 594 cis-Aconitate cis-Aconitic acid 38 2.3000 2.2000 2.6000 6.1000 198 4.8000 2 3.3000 2.9000 8.9000 46 60 7.7000 Citraconate Citraconic acid 6.9000 3.8000 5.2000 6.3000 3.7000 3.2000 7 4.8000 21 4.7000 3.7000 1.8000 3.6000 4.5000 3.9000 6 9.6000 3.5000 3.7000 4.2000 5.1000 3.3000 3.7000 8.3000 5.5000 7.7000 Citramalate Citramalic acid 20 14 23 19 13 11 25 12 62 34 29 26 27 14 12 23 14 14 13 23 16 36 63 53 57 Citrate Citric acid 41 104 79 396 38 23 115 155 7101 222 71 78 86 76 73 111 44 72 63 57 36 936 41 1859 2361 197 CMP CMP 11 11 6.7000 11 11 13 11 12 39 14 16 17 17 13 9.4000 8.4000 14 11 10 10 12 10 7.1000 9.9000 16 14 Cysteate Cysteic acid 101 138 62 9.8000 11 12 10 14 17 22 24 29 24 77 65 48 67 92 102 91 104 15 17 15 17 43 DCA Deoxycholic acid 25 37 20 56 76 12 30 57 42 78 53 114 8.3000 303 Dodecanedioate Dodecanedioic acid 5.2000 8.7000 9.5000 12 9.9000 5.7000 15 7.8000 32 37 19 20 49 12 17 9.7000 11 12 9.7000 14 15 15 20 34 32 32 dTMP dTMP 28 30 21 14 16 14 14 11 14 14 22 18 26 22 19 24 19 19 20 18 27 13 13 17 21 15 F6P Fructose 6-phosphate 47 64 59 13 19 23 29 16 33 21 36 29 54 60 61 32 23 16 25 15 32 15 14 10 11 Fumarate Fumaric acid 34 110 51 35 19 24 11 23 20 31 11 52 G1P Glucose 1-phosphate 23 34 42 8.1000 11 15 28 11 27 36 20 48 42 52 56 62 19 18 11 11 16 30 15 27 20 26 G6P Glucose 6-phosphate 200 254 257 54 91 114 165 83 49 126 87 131 109 249 317 267 143 118 97 111 94 97 48 66 43 43 Glutarate Glutaric acid 442 186 223 373 187 202 845 399 495 308 838 195 469 167 140 121 380 253 230 293 254 193 134 279 265 108 Glycerate Glyceric acid 112 124 114 205 63 76 1438 499 304 148 358 118 176 Glycolate Glycolic acid 275 299 459 352 260 133 208 180 746 517 202 212 491 352 352 304 198 316 264 300 162 266 472 330 357 Isethionate 2-Hydroxyethanesulfonate 27 8.5000 7.2000 8.4000 224 103 62 41 194 51 46 73 44 123 200 18 Isocitrate Isocitric acid 25 7 7.4000 217 12 72 126 12 Lactate Lactic acid 790 1063 911 1019 438 166 2181 1903 2393 1411 325 295 371 1018 1134 927 2899 4932 2132 1295 1665 901 3068 5173 600 23196 Malate Malic acid 128 94 172 189 85 71 103 139 456 251 172 145 118 121 144 109 146 88 92 88 100 293 95 181 110 122 Malonate Malonic acid 279 188 382 202 59 81 383 260 724 818 675 608 1129 390 233 269 274 267 366 473 637 464 519 N-Acetylaspartate N-Acetylaspartic acid 59 75 35 307 658 360 411 283 190 126 168 120 175 51 43 43 359 107 330 159 99 86 88 155 179 100 N-Acetylglucosamine 1-phosphate N-Acetylglucosamine 1-phosphate 25 35 31 20 26 44 41 27 88 36 29 30 39 47 38 40 25 31 32 33 30 25 30 40 47 31 N-Acetylglucosamine 6-phosphate N-Acetyl-glucosamine 6-phosphate 43 55 23 20 23 20 33 19 34 46 35 36 44 88 72 73 31 27 31 26 29 36 30 43 43 29 N-Acetylglutamate N-Acetylglutamic acid 64 82 57 266 259 238 464 279 304 276 542 289 399 142 82 118 263 271 212 199 296 76 85 139 138 145 NAD+ NAD 436 492 166 485 482 522 828 568 76 364 669 575 732 373 270 337 365 414 821 549 522 414 148 217 291 185 NADP+ NADP 18 23 9.1000 27 30 27 40 25 25 24 28 36 19 15 13 20 28 41 30 31 17 9.6000 13 16 10 Nicotinate Nicotinic acid 182 239 186 313 105 102 58 81 127 420 202 313 194 298 263 148 98 122 84 123 114 197 136 225 91 65 O-Phosphoserine Phosphoserine 9.1000 13 6 8.6000 9.1000 4.9000 11 6.2000 8.6000 16 17 18 23 12 6.4000 20 12 10 15 12 12 13 22 17 9.3000 Pentanoate Valeric acid 136 150 125 202 190 56 195 73 137 266 460 355 545 71 72 36 92 229 256 158 106 164 155 163 226 149 Phenaceturate Phenylacetylglycine 27 270 141 262 23 Phthalate Phthalic acid 4.2000 2.8000 3.2000 5.7000 5.8000 4.4000 7.2000 5 3.3000 3.5000 3.6000 2.7000 3.9000 5.1000 4.7000 2 6 6.1000 5.7000 5.8000 5.6000 2.6000 3.2000 3.9000 3 3.6000 Pimelate Pimelic acid 24 22 15 23 26 13 25 16 42 27 36 23 30 16 13 8.9000 21 27 23 30 26 19 14 27 26 13 Proline betaine Proline betaine 5.7000 12 6.7000 23 2.1000 1.6000 8 3.1000 191 9.4000 4.6000 5.2000 4.2000 5 8.3000 8.3000 14 2.5000 2.5000 3.5000 1.3000 44 2.6000 128 89 11 Propionate Propionic acid 6228 6606 4778 7621 5532 3752 9707 3198 26691 20005 22160 13948 29508 6364 5528 1899 7024 7419 7317 6445 5797 11774 9881 15355 18603 23281 Ru5P Ribulose 5-phosphate 27 65 41 12 26 19 22 17 26 19 31 24 51 70 61 21 44 26 35 30 22 7.4000 S7P Sedoheptulose 7-phosphate 53 49 35 16 32 26 39 33 94 62 84 90 68 65 58 51 52 46 42 49 49 33 46 31 42 Sebacate Sebacic acid 7.3000 7.4000 8.1000 7.2000 7.4000 4.8000 9.6000 4.2000 12 16 13 11 24 10 17 7.2000 6.8000 6.7000 8.1000 8.2000 9.4000 7.2000 9.5000 13 12 13 Succinate Succinic acid 1513 1108 1273 1918 720 502 2558 716 24309 1828 3816 1002 4598 602 349 245 969 624 616 639 691 671 804 2217 3114 3629 Taurocholate Taurocholic acid 16 23 27 42 29 85 45 69 243 130 71 84 131 320 232 105 230 281 161 433 186 85 161 149 626 265 UDP UDP 20 30 22 17 25 20 33 14 24 26 27 37 22 15 15 17 21 24 20 18 25 8.7000 17 21 15 UMP UMP 26 30 14 30 35 47 31 32 83 41 41 44 43 41 20 19 47 33 35 39 34 43 37 46 60 55 Urate Uric acid 22 32 36 49 30 30 38 33 23 82 26 32 32 54 47 91 46 44 68 43 50 48 82 101 57 50