Metabolite_name	RefMet_name	KO_DW_1	KO_DW_2	KO_DW_3	KO_DW_4	KO_DW_5	KO_DW_6	KO_DW_7	KO_DW_8	KO_AZA_1	KO_AZA_2	KO_AZA_3	KO_AZA_4	KO_AZA_5	KO_AZA_6	KO_AZA_7	WT_DW_1	WT_DW_2	WT_DW_3	WT_DW_4	WT_DW_5	WT_DW_6	WT_DW_7	WT_DW_8	WT_AZA_1	WT_AZA_2	WT_AZA_3	WT_AZA_4	WT_AZA_5	WT_AZA_6	WT_AZA_7	WT_AZA_8
Factors	-	Genotype:Olfr544 KO mouse | Treatment:HFD	Genotype:Olfr544 KO mouse | Treatment:HFD	Genotype:Olfr544 KO mouse | Treatment:HFD	Genotype:Olfr544 KO mouse | Treatment:HFD	Genotype:Olfr544 KO mouse | Treatment:HFD	Genotype:Olfr544 KO mouse | Treatment:HFD	Genotype:Olfr544 KO mouse | Treatment:HFD	Genotype:Olfr544 KO mouse | Treatment:HFD	Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:Olfr544 KO mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:WT mouse | Treatment:HFD	Genotype:WT mouse | Treatment:HFD	Genotype:WT mouse | Treatment:HFD	Genotype:WT mouse | Treatment:HFD	Genotype:WT mouse | Treatment:HFD	Genotype:WT mouse | Treatment:HFD	Genotype:WT mouse | Treatment:HFD	Genotype:WT mouse | Treatment:HFD	Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)	Genotype:WT mouse | Treatment:HFD + Azelaic acid 0.05 % (w/w)
1-monopalmitin	MG 16:0/0:0/0:0	2550	21462	13904	1305	9352	9636	40572	8240	6640	14889	2111	6907	17820	12511	9191	10999	9891	18106	16440	22440	31919	25653	12120	17319	13026	20968	15335	29951	14860	10944	18396
2-(4-hydroxyphenyl)ethanol	Tyrosol	926	25711	18350	713	3399	15337	4744	5984	28574	9664	653	2684	1839	3546	1528	1059	1292	1064	1721	1725	2048	1323	1130	1147	1168	1712	1573	815	1435	1413	2062
2-hydroxyvalerate	2-Hydroxyvaleric acid	1702	9488	4784	1491	8969	4200	9497	5391	6405	3891	3423	6288	8584	6400	34830	3265	3612	4911	18835	12542	11062	14548	5570	6468	21097	23101	6567	10462	8723	14940	5980
2-ketoadipate	Oxoadipic acid	2683	6184	6499	2429	3742	6920	9131	3335	7680	5936	2638	7688	5718	13150	5175	3292	2709	1052	2634	3179	11273	1703	2908	2007	1196	1016	1247	1131	3099	3798	3532
2-ketoisocaproic acid	Ketoleucine	191	140	200	112	260	111	637	266	95	291	106	104	145	341	559	1281	2676	1386	3116	4285	1723	1201	2679	1309	6376	4199	1441	1111	7963	20701	1668
5-aminovalerate	5-Aminopentanoic acid	41987	104621	203094	2792	73603	272028	318102	381275	19262	120817	16222	106691	122097	228442	267849	22712	12568	43001	771555	418835	248250	1263386	74276	53031	899928	1735390	51599	151082	112367	151180	72418
adenosine	Adenosine	2298	11412	17983	424	12449	1702	3647	3213	6019	9838	2589	6223	11537	6082	247	7219	5191	5770	10251	8999	23128	12371	11531	6465	5467	11672	7731	17456	17976	10260	11678
alanine	Alanine	48455	89882	84797	10307	199958	139158	190679	168547	46246	33667	13069	42137	82447	241034	780295	43487	53567	145049	457904	380452	298525	378242	136457	160093	693882	751061	142124	291188	262101	386724	137586
arachidic acid	Arachidic acid	21777	49029	53225	6803	39268	16238	42889	47792	41719	52801	46199	60245	61348	35979	9671	81578	80454	85643	97799	112797	76586	95832	97500	98017	129484	100267	83905	96003	105560	115946	126200
aspartate	Aspartic acid	1946	2174	2258	802	3770	16618	5506	8553	2372	1811	396	1122	3085	7907	22523	258	237	603	915	1187	593	1159	271	349	1289	3244	428	435	538	583	494
azelaic acid	Azelaic acid	295	772	612	236	1106	709	934	635	2866	640	588	4565	3348	1725	369	290.8100	145.4050	145.4050	145.4050	145.4050	145.4050	145.4050	686.7500	1111.6000	3875	37432	876.1400	948.5300	840.6700	835.0600	1294.1000
cellobiose	Cellobiose	20458	334	1408	341	565	729	340	451	277	399	148	338	1211	449	188	3373	1451	1995	3712	2913	2911	6743	3631	2385	42607	6906	39726	4375	3054	65773	40216
chenodeoxycholic acid	Chenodeoxycholic acid	10135	53005	15103	8523	91554	56782	33713	31546	25989	7957	23442	59791	23621	51468	2531	21602	23512	36804	45689	21024	48839	36491	29353	33176	61971	45183	51553	42897	32378	102081	17462
cholic acid	Cholic acid	78848	156080	128234	14797	203608	209413	160139	171544	163805	160475	33474	199023	54445	212227	71367	22624	19473	114872	117474	64146	81495	325080	39456	89011	324885	503885	55012	194583	33676	57203	58107
decanoic acid	Capric acid	1412	3416	2888	1310	2249	1349	4046	2271	2274	2596	1430	3467	2611	2865	1118	3082	2690	4388	4728	5829	3615	6490	3926	4079	4622	3864	2354	4723	3234	3888	5063
deoxycholic acid	Deoxycholic acid	276784	212726	213451	246064	274208	194399	288030	271264	298027	209235	273387	195244	221468	291720	41271	974488	891629	1029659	1140588	1023914	1138933	1022260	1183313	1184570	907910	1149434	933400	1177622	1060658	444418	847524
dihydroxyacetone	Dihydroxyacetone	3681	8707	8593	565	15115	5950	9131	9649	7680	7634	2040	14964	26080	11384	10153	2695	2061	1095	2076	4028	11273	877	2908	1221	2583	2296	1968	1437	2315	838	2940
DL-3-aminoisobutyrate	3-Aminoisobutanoic acid	1819	2135	3318	1444	3643	2272	19921	1381	2045	2974	1926	3171	1867	6732	3616	8435	7186	9006	13495	11689	7484	12125	9753	53003	16450	17185	9980	10644	10038	10084	9047
dodecanoic acid	Lauric acid	2351	5634	4360	1795	4062	3703	8842	4217	3619	3443	2964	6861	6517	4183	2818	3578	3107	2976	3910	3990	5257	3381	4197	3650	3094	3880	2669	4365	5160	4673	8886
fucose	Fucose	147226	454447	444775	69669	746979	530408	682368	677506	271317	438061	213488	426528	494626	766843	469060	25067	24356	46172	102605	83080	101162	100531	76259	52444	111264	119049	45412	83310	52409	107413	72758
fuculose	L-Fuculose	787.5400	4042.5000	2188.2000	1081.5000	5634.5000	4237.3000	3441.4000	3896	2514.7000	1188	1759	2874.4000	4147.7000	5187.1000	2123.8000	1567	1588	2323	2431	957	2708	26872	2809	3381	2796	5300	1500	32519	896	2933	2821
fumarate	Fumaric acid	4362	9804	6933	3071	5887	8003	12406	5159	9409	2467	4521	7925	12049	11785	2778	565	746	1085	2015	3424	1584	2243	818	2847	4259	4395	826	5658	2940	1126	1646
glucose	Glucose	90263	98923	123133	15497	108801	92491	200609	60124	30192	181765	18008	41027	135844	191164	26162	185824	82777	197387	428999	343592	318873	320654	284370	114666	357954	355940	194715	295429	167533	349960	167341
glutamate	Glutamic acid	2613	5011	2478	2214	8068	84330	133087	6183	7137	1325	750	2363	10159	15587	48647	360	377	502	1445	2283	619	469	405	739	3168	4255	977	543	1189	1750	575
glycerate	Glyceric acid	730	4623	1397	661	4113	3401	4308	1636	4305	1872	1500	1844	7541	6736	2009	228	188	484	683	844	288	565	280	647	821	1006	520	622	453	232	476
glycerol	Glycerol	129126	269327	241895	68163	178619	150132	348092	266797	157902	171078	77220	225671	235785	267234	294230	57477	70769	71765	118720	120572	348752	117389	82327	97448	110697	114878	84091	103040	90181	128715	109573
glycerol-1-phosphate	sn-Glycero-3-phosphate	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	5298	4071	7479	12373	12560	11020	13625	8867	11988	10641	14661	3079	7864	9424	16000	14459
glycolate	Glycolic acid	3435	12808	8176	3586	15846	10982	17952	8511	13451	8673	6549	12266	23810	21599	6018	463	387	829	1317	1098	1006	1209	678	1122	1728	1576	534	1366	795	624	938
guanine	Guanine	5540	19859	5021	1424	13130	2885	14652	11107	8211	12540	8472	14845	13809	40396	3283	5512	4256	12573	37972	22820	15690	12194	16085	10761	25310	25359	11024	18350	14067	10045	13957
guanosine	Guanosine	5848	16685	19047	764	39374	5592	58486	4851	8033	6380	2814	6122	55787	4919	739	8639	8830	10046	16950	47090	40006	61472	16795	16588	32034	44131	7781	61821	32894	31303	37213
heptadecanoic acid	Margaric acid	14463	36784	22860	6239	29502	13383	29714	29987	28103	29009	24632	37164	39160	25513	7462	110588	103199	105895	134317	125833	114750	99049	133919	153473	116112	108108	107219	111387	153592	119000	161689
hypoxanthine	Hypoxanthine	14680	94036	14404	17898	104747	55111	30402	50450	54863	25550	34917	71239	139451	102459	27014	62728	42553	133990	259766	223861	191938	84585	184046	187577	224124	166309	95420	126503	192189	177521	223001
inosine	Inosine	9184	40	38507	4473	267	42016	122096	386	27356	224	5964	10815	130920	132	219	23044	27918	25376	36376	93609	69228	106127	51257	57594	60222	78029	28203	99380	87622	101192	106500
isoleucine	Isoleucine	51491	63292	99876	7833	211650	85897	542250	278676	27128	64875	5674	48950	55748	287468	884847	50635	49495	91879	450039	306801	356755	418521	117831	107980	487416	567405	115584	256199	181538	359003	98038
leucine	Leucine	53699	68992	110819	8783	221942	87765	607690	307842	35099	62039	5647	47511	62447	295911	800537	60106	69031	123817	541067	350381	504234	514024	140533	122916	727251	837633	175842	359327	246031	474595	134271
L-homoserine	Homoserine	69257	106970	98878	22433	94658	60721	108163	60376	94365	80410	64179	147041	107286	62272	28719	121	100	621	1253	929	717	1169	599	838	1790	1854	662	690	344	500	666
lignoceric acid	Lignoceric acid	23458	37162	27708	13769	25401	31491	56759	31547	27631	23501	26769	29502	37219	19207	24366	55883	72194	86901	109881	106717	69297	87299	80233	97048	63180	78724	82433	111713	104999	143040	106305
linoleic acid	Linoleic acid	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	109884	110030	107524	136580	113166	191872	109830	132503	130128	123542	124929	103719	130034	133881	100282	143140
linolenic acid	Octadecatrienoic acid	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	4086	3693	3706	3953	3884	5704	3278	4151	4669	2592	4197	2417	4215	4162	3597	4045
lysine	Lysine	181	329	417	186	638	576	1568	436	140	257	101	115	191	1648	9696	180	212	712	2297	954	2449	2929	529	781	3828	6802	689	991	734	1929	623
lyxose	Lyxose	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	6012	51989	93503	122483	95368	2855	14485	142053	3819	52198	23937	75487	25636	8240	84808	74294
mannose	Mannose	1380	11337	7693	1827	8193	10575	12555	4560	11584	3074	5708	3453	10315	13011	1261	18011	60445	132835	157992	308949	161009	359381	145530	126940	237405	148962	117451	161688	113629	189049	146164
methionine	Methionine	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	7324	6348	27208	71917	75172	57262	67594	20061	15030	106256	148072	23182	41053	39653	83237	22904
methionine sulfoxide	Methionine sulfoxide	7952	8292	8938	1804	21907	9088	43922	13200	4525	7897	1570	5100	5378	15730	104014	1027	1066	6145	14175	7029	17521	15923	2893	4258	12867	24209	3671	9756	5479	3589	6428
methylamine	Methylamine	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	3009	2183	3442	4638	3858	21637	4412	3680	4018	5930	6577	2764	6357	3567	4105	2792
myo-inositol	Myo-inositol	13055	4652	13954	980	5073	46519	21987	44069	13602	16345	6299	11346	4552	22673	10869	1953	2033	47561	8020	7465	11621	14922	3608	9490	8306	35322	13723	31228	2850	10107	10573
myristic acid	Myristic acid	16693	85696	29066	8261	37380	20565	73419	38213	35945	31525	26594	44773	56266	33055	9654	92421	72277	95320	119711	108679	157682	75665	125185	106437	84950	84769	81463	76238	181057	79834	156441
nonanoic acid	Pelargonic acid	1388	2646	2604	1657	2044	1473	3312	2330	2241	1849	2574	2801	2713	2677	1408	662	701	692	938	1073	618	1204	888	1125	1061	898	653	1313	795	816	1090
norvaline	Norvaline	2418	2472	4638	716	4228	3055	71059	10748	2215	4529	1067	3537	9059	13658	8526	513	453	943	3418	2059	1609	1482	628	8636	5777	8195	8164	8009	781	9454	7393
oleic acid	Oleic acid	10874	151162	136076	12561	138226	17088	144062	56050	136466	130164	139409	143513	147763	136074	104058	600511	237628	607185	632583	609719	625854	61888	631632	643421	601552	597434	573910	167626	612123	229703	643452
O-phosphorylethanolamine	Phosphoethanolamine	140	679	780	232	1666	706	703	742	663	300	337	503	1255	882	1753	2098	1760	5551	6039	8833	8655	10612	7244	11224	10933	8451	3380	10995	8882	9365	11251
ornithine	Ornithine	228482	244631	190467	145168	363863	499131	545074	354162	288738	195902	127959	194416	657926	437972	295232	1638	2003	6159	22125	16049	10614	11382	7121	6990	47096	46906	7525	8765	10336	19143	7154
oxoproline	Oxoproline	660021	1261835	1003522	930204	688049	562467	1005825	385344	664325	1233088	1372354	574359	494618	826663	1266822	18891	21728	43847	101025	114893	62151	62006	44957	83618	296812	209154	51405	85509	99529	126496	94664
palmitic acid	Palmitic acid	3665	14150	3178	1923	7628	5537	21029	4993	6564	3977	4336	4311	5733	5755	2346	5421382	5248060	5453838	3194170	5511555	5366490	5650383	5603797	1518242	5593247	5602968	5525032	5726861	2930675	5529153	2917368
palmitoleic acid	Palmitoleic acid	58040	249065	138594	61603	346107	231428	220066	75109	358756	57091	136619	362151	119716	206938	24534	21909	20361	27066	36073	32067	66897	21511	36631	34016	644	24025	21189	17711	58380	15214	47739
pentadecanoic acid	Pentadecylic acid	39258	77275	51251	6221	143114	38509	215751	49300	49407	63384	18237	49688	75160	140005	42209	337397	260750	485178	371547	397707	501002	290072	480437	514011	343000	290912	535044	436021	822445	665572	560281
phenylacetate	Phenyl acetate	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	240145	6376	17893	56758	45624	54411	39620	23288	25456	88106	276962	249417	32642	241007	44570	18742
phenylalanine	Phenylalanine	11633	9220	15974	582	40707	19273	55557	61286	4465	11144	775	5506	6979	45826	388711	5930	6239	28789	112690	88796	69876	168117	21132	16114	153339	295043	30423	82189	40516	106135	33709
phosphate	Phosphoric acid	22272	75426	91595	36874	78676	88383	100568	61390	46227	37136	39198	18533	78697	66755	40004	30711	33607	34663	46130	48098	10950	46338	31910	42583	46481	46417	31587	46055	41952	48558	45302
phosphogluconate	6-Phosphogluconic acid	441	5969	10039	625	8845	2684	2376	3389	4990	1074	2322	3271	7032	4150	160	1302	1725	2956	3494	6431	3398	11913	3089	4791	5003	7445	4029	5528	4846	5615	6949
phytol	Phytol	3683	19925	5182	8367	16751	24092	17569	9017	10463	4166	3455	9311	12632	9273	2829	42637	22238	59304	41567	38735	33455	19492	47106	58277	31105	36067	41792	32259	41890	33041	58658
serine	Serine	4411	8191	4086	486	7813	5076	33568	13977	2995	3064	464	1750	5994	22584	191454	604	624	2169	12585	8084	5193	7456	1429	1723	17960	21842	2354	4663	3639	5729	1674
spermidine	Spermidine	9094	27032	8934	8500	9670	9317	26597	9552	9053	9053	9259	8628	25239	9111	3941	64112	94	573	1195	1936	849	2226	168	449	1897	3628	65360	804	979	68804	63901
squalene	Squalene	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	4208	4776	5968	8115	4604	4069	6041	5703	6915	3921	3504	3507	3447	7782	3051	11120
stearic acid	Stearic acid	1134041	261915	1247643	1288976	1258340	1066305	312688	384362	685462	53993	682757	1218533	1109946	337208	347875	2456982	4251778	4941058	4936046	4899496	2894749	4743980	4970593	23743	3864891	2896338	4770019	4972227	4532262	3208820	4761319
succinate	Succinic acid	3046	199218	130490	3766	289191	51743	16780	5692	193213	5302	100847	129047	37058	22205	3949	661	809	859	1117	1632	462	1115	683	1972	2473	3024	1443	1656	1227	1991	993
sucrose	Sucrose	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	508320	3035	5161	6701	15093	3809	4929	5530	7045	1786	7143	5721	2421	5406	6617	6113
tagatose	D-Tagatose	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	250127	31329	84677	126399	153870	61920	76657	399175	66337	83104	89501	24578	39945	44901	59892	69642
taurine	Taurine	959	1671	1541	1106	4523	4853	4319	2504	2339	1148	1054	1767	3776	5261	2374	734	257	11533	10095	2398	5141	17966	1635	3774	6001	44150	1377	7809	1949	5261	4615
threonine	Threonine	3620	6199	3595	561	9512	4094	40007	27815	2436	2768	624	2190	6303	26323	131033	881	856	3409	14071	8723	6743	10442	1910	2210	26724	29967	3471	8099	5987	9472	2622
threose	Threose	279	486	186	439	349	260	2890	264	380	838	434	268	823	1646	936	678	549	739	887	778	758	1099	908	1154	913	1022	888	796	500	624	675
thymine	Thymine	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	31206	30724	18422	45523	35744	23377	16779	57529	53172	21087	25620	53718	31805	57021	30516	70936
trehalose	Trehalose	16750	42258	31703	3187	77273	15374	9004	6864	21140	6684	27802	22292	48166	18226	1179	1613	2075	2611	1438	4020	4000	637	2183	4504	53268	2466	48702	4375	3838	81461	49737
tyrosine	Tyrosine	47037	19575	51045	2620	105828	45351	210198	117170	5628	48255	3802	15546	24003	153916	746567	4785	4304	30062	176256	56920	172253	176940	24542	28702	262961	427632	49127	103034	57954	151991	26336
uracil	Uracil	81733	426863	71084	58541	331316	214576	207367	157880	322094	66445	111308	226981	343720	353556	16132	165855	157056	190559	353761	329214	211647	82308	332731	312946	234578	168784	282514	189806	458278	216424	516399
urea	Urea	1715	1826	4164	2227	6564	4029	9387	126682	5399	1280	1087	3145	24802	3501	148401	6515	4371	9376	3901	7065	313496	4741	6348	5432	7807	5938	4779	4056	5987	5640	3852
uric acid	Uric acid	918	11062	12414	563	23807	5755	21594	7142	5233	4305	1257	7147	15890	3415	934	57	362	753	465	929	338	326	159	586	931	629	631	785	1251	590	1284
uridine	Uridine	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	4867	3757	2427	9761	20491	10601	20254	10564	7321	10038	16106	3677	19391	10268	20423	25843
ursodeoxycholic acid	Ursodeoxycholic acid	1568	2425	2245	694	3282	9872	5856	7730	3197	2949	1190	6010	1242	4625	407	3361	2368	4916	5334	1207	4450	7787	2138	2912	13878	8986	3316	6492	610	5427	2804
xanthurenic acid	Xanthurenic acid	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	65	133	235	262	1005	343	162	164	146	261	408	117	357	339	269	178
xylose	Xylose	3126	43947	6221	6448	39142	21259	49843	9888	22729	4168	10118	19629	49322	8419	2909	195749	134865	238722	316856	243432	117596	85971	357720	257785	125404	131369	195679	82233	296250	232637	205984
β-alanine	beta-Alanine	7166	8610	6350	7493	8857	11203	17852	10004	8633	5503	7801	10552	11053	8255	8550	35782	29728	36429	43724	42504	23894	42186	37489	41155	43995	45763	35156	38965	39481	40057	34418
γ-aminobutyrate	gamma-Aminobutyric acid	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	185	198	708	575	634	465	522	367	419	707	822	468	394	561	331	294