Metabolite_name RefMet_name RBP42_KD_1 RBP42_KD_2 RBP42_KD_3 RBP42_KD_4 RBP42_WT_1 RBP42_WT_2 RBP42_WT_3 RBP42_WT_4 Factors - Treatment:Knockdown Treatment:Knockdown Treatment:Knockdown Treatment:Knockdown Treatment:Wild-type Treatment:Wild-type Treatment:Wild-type Treatment:Wild-type 1-Methylhistidine 1-Methylhistidine 51002.1500 33846.0500 31251.7300 31929.1000 31879.8300 45571.6700 32091.4500 34309.6300 2-Hydroxybutyric acid 2-Hydroxybutyric acid 194112.9000 176702 175361.3000 167680.1000 150850.4000 179933.2000 147999 128957 2-Hydroxyglutarate 2-Hydroxyglutaric acid 7453088 6762334 7011754 7044144 7989554 8830917 7076924 6649860 2-Ketoisovalerate Ketoisovaleric acid 17400000 14900000 13100000 12400000 16600000 17300000 15200000 13900000 2-Phenylbutyric acid 2-Phenylbutyric acid 20719.2100 34220.6100 30128.2700 23515.6300 30041.8600 16922.4400 21337.3900 19175.0800 3-Methyl-2-oxovaleric acid 3-Methyl-2-oxovaleric acid 69000000 58900000 50900000 48300000 59500000 68200000 53400000 52000000 3-Phosphoglycerate 3-Phosphoglyceric acid 106545.7000 97014.7400 95292.8400 119728.6000 91801.2200 120997.6000 115768.4000 108656.6000 3-Phosphoserine Phosphoserine 17816.8500 9420.6690 4029.9770 4785.1970 4397.5240 6547.0570 3507.3070 6300.9220 5-Phenylvaleric acid 5-Phenylvaleric acid 39148.8000 32125.8800 29044.3400 33848.8800 28172.2400 25434.1100 28059.3200 29041.8500 Acetoacetate Acetoacetic acid 8670611 7292994 5786530 6237162 6422912 8012040 5177302 5586044 Acetyl CoA Acetyl-CoA 16343.7200 14350.5400 17886.5100 13629.3300 15021.0700 20231.1800 22817.2900 9061.1440 Acetyl-Methionine N-Acetylmethionine 3105.3780 2603.5930 2399.6660 2101.2190 11058.9200 12825.3100 8480.8170 6943.6970 Aconitate trans-Aconitic acid 144302.9000 111863.3000 99474.9100 96348.5300 110624.5000 146461.5000 99157.6200 82848.2100 Adenine Adenine 717172.5000 1253348 902447.4000 676345.4000 1366010 1858975 1795065 1552054 ADP ADP 118954.9000 86932.7200 127250.6000 100538.4000 252503.1000 209117.4000 214665.2000 182544.5000 a-ketoglutarate 2-Oxoglutaric acid 3856420 3987198 3302137 2939210 1516307 2147187 1577918 1443166 Alanine Alanine 6167882 5235864 6083526 5691556 9166037 9051575 8745685 8242276 Aminoadipic acid Aminoadipic acid 40052.9300 35792.9700 27504.9400 32327.1200 30024.6300 35648.3000 27675.4700 25282.0500 AMP AMP 190204.5000 239497.8000 272481.1000 195031.8000 312294 369574.1000 314445.2000 313732 Arginine Arginine 4124895 3173367 2378299 2604921 2903843 4006551 2728691 2553868 Asparagine Asparagine 4757176 3429890 2863299 2782347 3887336 4948009 3460186 3019354 Aspartate Aspartic acid 5302538 3788934 2264893 2785946 3229949 5300042 2830144 2637400 ATP ATP 79692.8400 60516 69621.1300 75298.0900 121245.7000 105419.5000 122703.9000 95351.2500 Carbamoyl phosphate Carbamoylphosphate 6293.3910 10143.8300 4548.4170 4757.0800 5386.9630 11506.9000 8320.5710 5561.0540 Carnosine Carnosine 116509.2000 95354.5500 82329.9200 82605.0700 93352.9800 119142.4000 78983.2400 83937.0100 CDP-Choline (+HAc) Cytidine 5'-diphosphocholine 7828.6860 6313.0380 7892.0880 7784.7790 20807.0400 15894.2800 16345.6200 12791.5200 Cinnamic acid trans-Cinnamic acid 12692.8700 50538.3000 19862.9500 23684.9400 119100.2000 118122.7000 125886.9000 104581.6000 Citrate Citric acid 258642.7000 175882.7000 129274.9000 154640.4000 139280 227173.4000 133500.2000 117715.7000 Citrulline Citrulline 216978.1000 156338.6000 137088.3000 141126.7000 198629.2000 279729.9000 166108.8000 149473.5000 CMP CMP 1256.7820 2529.1560 3543.3550 1331.2680 5805.0610 4756.0840 5706.6550 5540.9320 Coenzyme A Coenzyme A 7487.9940 5009.9830 10836.3600 3934.4540 22945.7000 11400.8400 22002.9300 19754.3700 Creatine Creatine 38497.8800 12314.8300 10949.9500 24740.3300 26421.5800 17232 28778.4700 13044.1200 Creatinine Creatinine 779531.2000 699748.8000 518281.7000 582713.3000 611473.5000 791118.3000 530552.2000 539640.8000 Cresol 141213.7000 134699.4000 107491.8000 107521.2000 170542.3000 214248.5000 167115.2000 127792.3000 Cystathionine Cystathionine 19347.5900 17144.6000 22230.8400 21397.9600 43422.1800 47934.0200 65496.8100 52473.1100 Cystine Cystine 3393200 2568142 1774317 1919503 2029556 3222874 1939202 1770658 Cytidine Cytidine 24850.5000 21746.7900 16344.8900 21242.4900 14948.6700 24587.1300 17681.3500 16557.4300 Deoxycholylglycine Glycodeoxycholic acid 54799.2100 41910.5800 26149.7800 24338.4500 16187.0400 42831.6900 13956.3600 28161.5000 D-erythrose-4-phosphate Erythrose 4-phosphate 11961.3700 5796.0740 7746.1990 6110.9650 7019.1350 10992.2700 6326.3120 7498.8910 D-glucosamine-1 6-phosphate 26664.2600 19145.7300 25278.2800 18685.4900 28404.1200 27448.9900 21805.5900 20938.2200 Dihydroxyacetone phosphate Dihydroxyacetone phosphate 66692.8300 58729.2000 45140.7500 59073.3200 114063.3000 92611.9100 97431.7100 77022.7000 Dihydroxybenzeneacetic acid Dihydroxybenzeneacetic acid 35187.1000 51965.9300 61387.1200 53780.4100 40670.9900 32118.3300 42087.6900 57948.9200 Dimethylglycine Dimethylglycine 84680.6100 69603.3700 78784.3500 58863.9400 50457.5200 91962.0900 45547.7600 52813.0300 Folate Folic acid 177161 138486.7000 90424.3100 100566.8000 121438.4000 177388.8000 107836.5000 112534.8000 Fructose-1 6-bisphosphate Fructose 1,6-bisphosphate 25098.0700 21793.8500 21223.5500 15316.8500 57444.6900 49922.1800 40830.8300 40174.7800 Fructose-6-phosphate Fructose 6-phosphate 438763.8000 308984.2000 355363.9000 328880.7000 457864.1000 399711 344998.2000 333562.1000 GDP GDP 14975.1200 13102.3800 15006.2700 13352.3800 24125.7100 21407.5400 22120.4900 18875.1300 Glucose Glucose 80800000 68000000 50800000 55800000 59600000 74000000 48000000 49600000 Glucose-6-phosphate Glucose 6-phosphate 1376615 949872.5000 999239.8000 1013246 1217612 1106084 1047411 995284.5000 Glucuronic acid Glucuronic acid 84367.7700 58922.1400 53793.8400 57004.5400 49810.4000 74792.9700 54938.4900 50238.2700 Glutamate Glutamic acid 20700000 14500000 12000000 12100000 10800000 15900000 8770479 8605992 Glutamine Glutamine 79200000 65500000 46800000 50600000 58400000 84300000 53600000 50800000 Glutathione Glutathione 35605.1100 35154.3200 36711.6200 35939.6500 32339.9200 40119.4300 29691.4700 32653.2800 Glycerol-3-phosphate sn-Glycero-3-phosphate 3842234 3124696 4178787 3341963 7795268 6947658 6325724 5389911 Glycerophosphocholine (+HAc) sn-Glycero-3-phosphocholine 9293693 7691088 8632653 7835234 15700000 13800000 13600000 12100000 Glycine Glycine 1526534 1152698 1075352 1069920 1319209 1656321 1295202 1157357 Glycine-L-leucine 16088.4600 12360.2700 5338.5900 7894.7930 10612.4300 18624.9500 7552.3760 7711.5020 GMP GMP 11568.3700 8313.1320 10336.7200 8172.4390 17313.5400 17236.6900 17977.2200 13595.5500 GTP GTP 10899.0700 8328.8460 6834.8050 7292.3220 12222.9100 13064.9800 10953.7100 12151.3800 Guanine Guanine 46173.5800 28647.1700 33599.2700 29136.1600 81292.6200 81479.1600 84236.4300 61584.7200 Hippuric acid Hippuric acid 617244.2000 499052.2000 351685.8000 364980.8000 420825.5000 603496.1000 386617.2000 369366.2000 Hisidine 3940015 2521285 2187809 2103264 4145031 5142443 3811649 3197936 Homocitrulline Homocitrulline 8298.7960 7794.8310 4144.2420 5053.8260 4355.7980 6652.8110 6056.2930 5636.8650 Hydroxy-methoxycinnamic acid 19286.1500 32655.1000 47039.4900 20463.6400 43155.5700 38431.0600 39787.6800 41219.4400 Hydroxyphenyllactic acid Hydroxyphenyllactic acid 95714.7900 84108.8800 56704.1000 66518.4500 94466.0700 156674.2000 101643.9000 75736.2600 Hydroxyphenyl pyruvate 1602498 1332414 1248481 1163509 2058331 2421125 1825735 1632974 Hydroxyproline Hydroxyproline 125432.8000 118272.9000 98819.6500 105324.2000 134480.5000 122016 160552 139486.9000 Hypoxanthine Hypoxanthine 80000000 59800000 40900000 43600000 52900000 78200000 45500000 39800000 IMP IMP 25491.7200 26027.7300 36273.3600 30676.1200 35500.1300 41594.1200 49089.4500 37390.0700 Indole-3-carboxylic acid Indole-3-carboxylic acid 227809.5000 153470.5000 160132.4000 134471.3000 199485.2000 238491.4000 172410 148296.9000 Indolelactic acid Indolelactic acid 66380.2100 60788.7100 47693.5500 54234.6200 74203.6200 88401.5200 72576.6800 63840.4700 Inosine Inosine 330242.2000 313608.8000 149417.4000 237618.2000 252486.4000 244497.1000 216824.9000 166661.5000 Inositol Inositol 2526845 2026161 1603090 1711163 1868794 2502380 1633381 1599725 Isocitrate Isocitric acid 27856.0600 21838.0300 15648.2300 16279.3800 12697.6600 24046.3400 16568.2400 13824.4200 Isoleucine Isoleucine 40200000 31100000 21600000 24300000 28300000 38600000 24800000 23200000 Isovalerylglycine Isovalerylglycine 43405.6100 30990.9600 17686.3400 22408.1100 23835.1100 46302.1900 29209.0100 26350.6200 Kynurenic acid Kynurenic acid 10385.9500 7307.3500 4159.8090 2519.8370 5395.2730 7679.6810 2793.0280 5300.6240 Kynurenine Kynurenine 8168.6770 8718.1100 4773.4150 4236.3160 2845.6840 7467.2510 6649.6120 2983.3580 Lactate Lactic acid 87500000 68900000 51100000 54400000 63400000 85900000 53500000 49100000 Leucic acid Leucinic acid 596477.5000 759652.8000 693179.2000 640408.2000 3096091 3691697 3680286 3190583 Leucine Leucine 24400000 20100000 13800000 14800000 17000000 23300000 14700000 14400000 Lysine Lysine 7964018 6030420 4376668 4505898 4982784 7385096 4325626 4227810 Malate Malic acid 3584550 2481703 2054221 2388351 4213098 4952305 3808662 3214329 Mannose-6-phosphate Mannose 6-phosphate 286405.9000 189194 229377.2000 225113 272365.8000 255585.8000 212872 209779.8000 Methionine Methionine 5435460 4178261 3065839 3252741 3595853 5081370 3145631 3177078 Methionine sulfoxide Methionine sulfoxide 45941.0300 28989.3800 19697.9000 21472.6100 30010.0500 35956.9400 22651.9100 17217.5500 Methylphenyllactate 63386.4500 55830.6100 72629.2600 59711.4600 52145.6200 57118.1000 63617.4300 51705.4700 Methylsuccinic acid Methylsuccinic acid 464894.4000 380956.1000 398090 415821.8000 497220.2000 535595.8000 503771.7000 429843.3000 N-Acetylaspartate N-Acetylaspartic acid 24393.0300 16029.7900 13571.7700 15018.1800 17456.3100 20400.0500 10184.4600 12035.9900 N-acetyl-glutamate N-Acetylglutamic acid 11613.7100 6635.7830 6977.4830 6533.3400 10583.3000 12527.3300 5781.4280 5862.9780 NAD+ NAD 59971.7900 54857.5500 71423.7300 67679.4200 126351.8000 112505.8000 119284 104335.2000 NADP+ NADP 876.6451 780.7767 1247.0390 3863.7210 6354.9410 4305.3420 5823.9040 NG-dimethyl-L-arginine 8298.3750 6056.5950 6822.4240 4222.0930 5913.2970 9200.6630 4385.2010 1752.7950 N-octanoylglycine Capryloylglycine 131542.6000 152420.6000 158733.1000 154619.7000 161038.7000 136524.7000 176919.8000 153100.3000 O-Butanoylcarnitine CAR 4:0 185819.4000 157048.1000 72427.3200 141234.5000 103522.9000 65581.6200 205798.8000 77585.8000 O-Decanoyl-L-carnitine CAR 10:0 75586.5600 64370.6200 43833.7000 53748.3400 38153.6200 40652.1000 53467.4300 50781.9500 O-Propanoylcarnitine CAR 3:0 901562.3000 709560.2000 419929.9000 714805.5000 571712.4000 497399.2000 977661.5000 426655.8000 Ornithine Ornithine 681605.7000 509261.2000 459931.8000 453612.8000 503273.9000 667685.7000 500428.8000 428277.8000 Orotate Orotic acid 36441.0600 34106.9100 21562.5900 10909.7500 30927.9000 33311.2500 28128.1000 19399.5300 Oxaloacetate Oxaloacetic acid 4940.5880 1965.5170 3082.2170 2874.2440 6164.0960 8639.1870 5245.6240 1975.2480 Pantothenate Pantothenic acid 2341719 1423773 922306.6000 959123.2000 1265767 2023711 1112474 1022858 p-coumaric acid cis-p-Coumaric acid 6690070 5547260 5172710 5170858 9147668 9944337 7839418 7497660 Phenylacetylglycine Phenylacetylglycine 87545.9600 67064.1600 44463.9900 44703.7800 66623.1600 85738.1300 55973.7600 50861.5200 Phenylalanine Phenylalanine 19600000 16500000 11300000 11800000 11000000 15900000 9798566 9740857 Phenylethanolamine 2-Hydroxyphenethylamine 19757.2800 12927.4400 23342.3500 25419.7300 22450.3200 24358.7400 24969.7500 20094.5300 Phosphocholine (+HAc) Choline phosphate 740284.3000 571426.5000 622360.1000 554436.6000 1198495 1139701 1073472 956525.8000 Phosphoenolpyruvate Phosphoenolpyruvic acid 33141.1200 32227.6200 33266.8500 38361.0500 36294.4600 39700.8900 42211.7600 38842.5900 Proline Proline 7164228 6073848 5187998 4970484 7922842 8660395 7059220 6267546 Pyridoxic acid Pyridoxic acid 133574.8000 91759.1000 68487.1500 71686.4100 85940.8200 137349.3000 82010.2400 72586.5900 Pyridoxine Pyridoxine 14389.8500 11778.2900 3305.5350 7042.3030 15029.2800 19228.4900 17588.0400 12855.3100 Pyruvate Pyruvic acid 54600000 43000000 40200000 39600000 57200000 62400000 49900000 45900000 Quinaldic acid Quinaldic acid 23543.4300 11027.8800 12202.2700 7328.6590 16255.3900 16852.4600 9454.1270 10192.3300 Ribitol Ribitol 430251.9000 304452.3000 249621.5000 287552.8000 298532.3000 408034.5000 260915.9000 275997.7000 Ribose phosphate Ribose 5-phosphate 86812.3000 67291.8600 107511.5000 77400.2300 236709.4000 202256.6000 217086.7000 180404.1000 S-adenosyl-L-methionine S-Adenosylmethionine 3382.0710 1442.4840 1370.7450 1995.6180 6614.5660 10064.5800 7127.5330 9544.0220 Serine Serine 10900000 8199488 7182162 7063338 9735769 11700000 8811733 7691286 Shikimate Shikimic acid 161535.5000 124668.5000 137164.1000 126008.6000 124562.6000 159315.9000 138558.1000 130586.7000 Sorbitol Sorbitol 6233604 5346120 4180838 4184576 5088598 6287040 4613870 4164071 Succinate Succinic acid 36800000 29300000 29700000 29000000 71100000 68400000 65500000 62300000 Taurine Taurine 612896.2000 509181.9000 388084 380370.5000 629329.2000 680871.2000 513252.2000 474246.1000 Thiamine Thiamine 13600000 9971077 7312740 7503942 9694098 13200000 8876337 7943272 Thiamine pyrophosphate Thiamine diphosphate 1595.5720 1206.9390 829.0129 987.8527 3925.9440 4499.2780 2885.2870 1346.5450 Threonic acid Threonic acid 2515443 2114169 1688692 1619997 1786427 2205308 1769120 1636220 Threonine Threonine 16000000 10100000 6649126 7052088 10400000 17900000 8369434 7776822 Thymidine Thymidine 18200000 15400000 14100000 14300000 14000000 17000000 13200000 12200000 Thymine Thymine 125912.6000 111586.2000 90457.1500 89590.6300 92760.8800 141982 95045.5100 90497.4600 Tryptophan Tryptophan 3794321 3121507 2162076 2298896 2337712 3440983 2196678 2107242 Tyrosine Tyrosine 10500000 8024352 5959964 6286144 6502492 9816421 5770568 5764534 UDP UDP 16464.9000 5981.7110 17646.0700 13664.4200 38353.3900 32091.7200 41273.9100 35396.7700 UDP-D-Glucose UDP-glucose 456773.7000 349137.9000 471837.1000 448897.6000 569654.8000 466188.6000 529500.6000 432908 UDP-N-acetyl-glucosamine UDP-N-acetylglucosamine 97360.3200 68105.2100 93830.1800 67401.9100 116958.5000 84790.3500 125880.2000 101534.7000 UMP UMP 64256.0500 56921.8600 94577.4300 76783.8800 149424.9000 167334.4000 159443.8000 149219.4000 Uracil Uracil 1283227 1422128 1265028 1217795 1661226 2243890 2059851 1862544 Uric acid Uric acid 663736.8000 503047.8000 369329.6000 434126 466247.6000 589116.5000 394883.8000 385199.4000 Uridine Uridine 272422.9000 237671.3000 191321.4000 209275.1000 201537.8000 274378 205102.8000 192487.3000 UTP UTP 13539.6500 9998.1500 18785.4200 16546.9400 25369.2200 23201.3700 27254.8500 25879.8400 Valine Valine 22000000 16500000 13000000 12800000 16200000 22100000 14600000 13400000 Xanthine Xanthine 3381169 2682985 2184134 2129372 3813580 5214220 4097098 3414511