Metabolite_name RefMet_name CarnsTG1 CarnsTG2 CarnsTG3 CarnsTG4 WT1 WT2 WT3 WT4 Factors - Genotype:CarnsTG Genotype:CarnsTG Genotype:CarnsTG Genotype:CarnsTG Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type 1-(2-Methoxyethoxy)-2-methyl-2-propanol_ TMS derivative 41552 19271 10106 10757 12467 1_3-Dihydro-1_3-dioxo-5-isobenzofurancarboxylic acid 45412 53629 34607 21753 61366 57328 61507 89971 1-Butanol_ TBDMS derivative 1-Butanol 2040435 2195037 2076864 2236466 2086849 2033440 1807911 1679078 1-Hexanol_ TMS derivative 1-Hexanol 12781 14607 12146 12424 13547 12134 12907 1-Methyl-1H-tetrazol-5-amine_ TMS derivative 3151841 3169463 2491074 1846127 2317258 3063767 3138475 363728 1-Octadecanoyl-2-(5Z_8Z_11Z_14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine 11074 11547 12381 14925 12369 12314 13288 11491 2_4_6(1H_3H_5H)-Pyrimidinetrione_ 5-ethyl-1_3-dimethyl-5-(1-methylpropyl)- 63289 56027 76531 208330 63776 53240 86068 31340 2-Bromotetradecane 11930 10169 7083 6502 2-Butenedioic acid_ 2TBDMS derivative Fumaric acid 38692 32151 33049 28257 35776 25378 52592 45000 2-Butenoic acid_ 2-[(trimethylsilyl)oxy]-_ trimethylsilyl ester Crotonic acid 2325 1335 1670 1828 1606 1730 2^-Deoxyguanosine 5^-monophosphate dGMP 53295 63793 39198 38833 40958 59342 55739 54224 2-Ethoxyethanol_ TMS derivative 18908 20425 19117 18639 18401 19261 19222 20920 2-(Ethylamino)ethanol_ tert-butyldimethylsilyl) ether 735245 817704 1103542 828401 719056 603716 2-Hydroxy-3-methylbutyric acid_ 2TBDMS derivative 2-Hydroxy-3-methylbutyric acid 4801 6711 11994 5199 3672 5386 2-Hydroxybutanoic acid_ 2TBDMS derivative 2-Hydroxybutyric acid 6537 7122 5329 5702 6458 2^-Methoxy-à-naphthoflavone 19490 17110 13216 12319 21976 4833 2-Methoxyethanol_ TBDMS derivative 2-Methoxyethanol 43330 47257 41619 44238 41263 41003 40520 43502 2-(Methylamino)ethanol_ tert-butyldimethylsilyl ether 14654 16453 16317 15608 11993 2-Pentanol_ TBDMS derivative 34197 43125 43835 38990 36771 37166 33609 35402 (2R)-Pyrrolidine-1_2-dicarboxylic acid_ bis(tert-butyldimethylsilyl) ester 39593 37984 92149 53183 48812 35911 42588 63643 2-Tridecen-1-ol_ (E)- 4120 4267 6169 5421 5772 5172 3_3-Dimethyl-2-butanol_ TBDMS derivative 17541 20745 20748 18633 16795 18332 11720 18254 3_4-Dihydroxyhydrocinnamic acid_ 3TMS derivative 3,4-Dihydroxyhydrocinnamic acid 54056 85077 72112 59468 3_4-hydroxyphenylpyruvic acid MTBSTFA Deri 2845443 2685942 3020573 3082536 2995567 2872074 2415158 3040883 3-Aminobutyric acid_ 2TBDMS derivative 3-Aminobutyric acid 49362 54970 58499 54560 65058 67360 56314 73327 3-Hydroxy-3-phenylpropionic acid_ 2TBDMS derivative 3-Hydroxy-3-phenylpropionic acid 37644 40264 38051 41115 43237 37187 41878 3-Hydroxybutyric acid_ (R)-_ 2TBDMS derivative 34828 15981 51836 55852 38900 19310 59513 42465 3-Pyridinol_ TBDMS derivative 3-Hydroxypyridine 44712 46240 26968 25135 30711 44469 37591 29765 5-Aminolevulinic acid 5-Amino-levulinic acid 22517 21868 18136 18488 23946 17471 5-Nonanol_ TMS derivative 3-Nonanol 10085 8445 8799 7995 9834 11353 6-Hydroxy-7-methoxycoumarin 6-Hydroxy-7-methoxycoumarin 34016 31819 34257 37025 16911 26187 6-Methoxy-2-hexanol_ TMS derivative 126548 103694 100805 123035 91214 93684 70512 52180 9-Hexadecenoic acid_ (Z)-_ TBDMS derivative Palmitoleic acid 24319 33653 99881 119347 105500 37494 36260 48496 á-Alanine_ 2TBDMS derivative 3867 4679 7798 11574 8643 5372 11001 5475 Adenine_ 2TBDMS derivative Adenine 14668 7833 5955 4930 8016 8029 8077 7075 Alanylglycine_ 2TBDMS derivative Ala-Gly 18210 21068 13062 15361 19394 22399 17726 19289 (Aminooxy)acetic acid_ 2TBDMS derivative 1015646 1040729 910757 653449 1178562 1285733 1214331 1017974 Arachidonic Acid_ TBDMS derivative Arachidonic acid 120568 158304 114621 144805 140952 134065 139887 105728 Benzoic Acid_ TBDMS derivative Benzoic acid 5525 6118 6276 6012 6202 Butanedioic acid_ 2TBDMS derivative Succinic acid 4529 5353 5276 6090 6025 7178 Carbonic acid_ 2-dimethylaminoethyl 2-methoxyethyl ester 57524 70897 35803 16074 79428 86890 77881 111559 Cholesta-4_6-dien-3-one 4,6-Cholestadienone 939 848 771 793 Cholesterol_ TBDMS derivative Cholesterol 115874 85090 110014 90435 110794 126274 Citric acid_ 4TBDMS derivative Citric acid 1295932 671558 609507 549969 698407 948368 627269 1010913 Danthron 23205 20590 24139 21831 24052 26916 27349 Di-n-octyl phthalate Dioctyl phthalate 27231 28606 25104 26197 24674 25423 DL-Glyceraldehyde_ 2TBDMS derivative Glyceraldehyde 872897 825853 1253102 944032 952974 765261 793545 988399 Dodecanal_ O-methyloxime 2076 2420 1811 3276 3818 3178 2771 Dodecanoic acid_ TBDMS derivative Lauric acid 21683 16525 11126 16088 16188 15805 17968 19385 D-Pipecolic acid_ TBDMS derivative D-Pipecolic acid 13372 6776 19616 15097 D-Pyroglutamic acid_ 2TBDMS derivative 720176 621109 341084 311425 549439 650093 788416 552703 Erythrono-1_4-lactone_ 2TBDMS derivative Erythrono-1,4-lactone 663857 625590 684930 728802 801161 674108 724082 1065082 Ethanolamine_ 2TBDMS derivative Ethanolamine 35831 38318 42646 51302 43322 31008 42231 32789 Ethanone_ 1-(2-pyridinyl)- 46648 32433 58292 38646 33448 24142 Ethylene glycol_ 2TBDMS derivative Ethylene glycol 1314244 2010005 1483131 1511534 1919050 1869206 1864590 1416521 Ethyl (tert-butyldimethylsilyl)oxycarbamate 49900 43211 81309 28211 63651 31104 Glycerol_ 3TBDMS derivative Glycerol 252102 166485 409163 339841 390665 203877 285211 222842 Glycine_ 2TBDMS derivative Glycine 130618 132131 48270 35444 82570 128937 142702 97979 Glycolic acid_ 2TBDMS derivative Glycolic acid 29390 30613 33692 26497 27254 33135 26511 33360 Heptadecanoic acid_ TBDMS derivative Margaric acid 20818 23419 16664 16893 18355 21566 20396 18072 Hydroquinone_ TBDMS derivative Hydroquinone 19961 18615 25949 21794 25395 22623 29027 Hypoxanthine_ 2TBDMS derivative Hypoxanthine 163796 158747 180256 155381 191765 126169 187168 148404 Ibutilide Ibutilide 25401 35273 29324 21001 23474 23761 Isocitric acid lactone_ 2TBDMS derivative Isocitric acid lactone 51957 62891 79575 45721 72354 74163 32443 56970 Isoleucine_ 2TBDMS derivative Isoleucine 77825 49374 60868 60347 55081 44143 62753 56544 Isopropylamine_ N-tert-butyldimethylsilyl- 91434 114428 100315 119323 94812 80542 82778 87309 Itaconic acid_ 2TMS derivative Itaconic acid 16093 21548 24530 39706 27884 21992 21760 15303 Lactic acid_ 2TBDMS derivative Lactic acid 3430 2264 3165 2659 2947 5685 L-Alanine_ 2TBDMS derivative Alanine 700737 577106 660937 618116 615899 515352 728468 648104 L-Asparagine_ 3TBDMS derivative Asparagine 11286 10460 8337 7182 9208 10682 12058 11173 L-Aspartic acid_ 3TBDMS derivative Aspartic acid 861412 967279 417902 604015 636342 798224 781937 725064 L-Cysteine_ 3TBDMS derivative Cysteine 11107 18408 29040 30469 24168 L-Glutamic acid_ 3TBDMS derivative Glutamic acid 1704092 1553984 1194134 1212009 1463575 1470795 1567068 1366577 L-Glutamine_ 3TBDMS derivative Glutamine 425494 310051 114857 138211 255508 326584 381571 285847 L-Histidine_ N_1-bis(tert-butyldimethylsilyl)-_ tert-butyldimethylsilyl ester Histidine 47993 23155 15737 23005 Linoelaidic acid_ tert.-butyldimerthylsilyl ester Linoelaidic acid 374049 401817 425588 382325 392786 408445 386616 364943 L-Leucine_ 2TBDMS derivative Leucine 108959 80135 105166 99638 77641 66645 89503 93501 L-Lysine_ 3TBDMS derivative Lysine 141863 111442 130156 88240 142235 115227 129422 139252 L-Methionine_ 2TBDMS derivative Methionine 60249 58057 69849 43866 66608 60493 62902 91561 L-Ornithine_ 3TBDMS derivative Ornithine 29003 24455 27790 21240 26397 23051 25237 32991 L-Phenylalanine_ 2TBDMS derivative Phenylalanine 65213 48951 71205 56112 48442 52171 56864 65434 L-Proline_ 2TBDMS derivative Proline 15421 15128 18869 14479 18931 16281 16637 23296 L-Pyroglutamic acid_ 2TBDMS derivative Pyroglutamic acid 63550 46136 56500 35401 17522 18678 19457 32064 L-Serine_ 3TBDMS derivative Serine 364352 340200 383404 352428 369597 408589 397365 586398 L-Threonine_ 3TBDMS derivative Threonine 71094 123397 137209 175353 179271 135777 182707 165316 L-Tyrosine_ 3TBDMS derivative Tyrosine 102841 78357 112185 90602 110716 61024 106066 134004 L-Valine_ 2TBDMS derivative Valine 57276 44520 56915 53120 50355 46837 52814 54413 Malic acid_ 3TBDMS derivative Malic acid 608911 1006062 730804 642589 943665 1256162 1045251 1459135 Methanesulfonic acid_ TMS derivative Methanesulfonic acid 58763 73790 61089 39078 78925 70739 70636 110390 Metharbital Metharbital 9085 13319 26723 6075 6899 Methoxyacetic acid_ TBDMS derivative 8454 8113 9390 9145 9167 9101 10566 Methyl aminoacetate_ 2TMS derivative 77070 118496 41428 28246 42663 110834 56929 67008 Methyl lactate_ TBDMS derivative 22644 15375 37560 28498 30088 15398 19153 15660 Methylmalonic acid_ 2TBDMS derivative Methylmalonic acid 73721 43263 105560 89473 51037 70684 Methylmalonic acid_ 2TMS derivative Methylmalonic acid 11417 13665 10480 11772 12922 Myristic acid_ TBDMS derivative Myristic acid 12776 12274 26530 29888 24867 13989 14393 17207 Naphtho[2_3-b]furan-4_9-dione 15055 24490 30501 22717 37219 Neopentyl alcohol_ TBDMS derivative 8124 7389 7902 7442 7005 Niacinamide_ TBDMS derivative Niacinamide 317721 313037 224293 205082 278074 329190 368321 277898 Nizatidine Nizatidine 29338 40612 117273 101417 86357 57068 42659 59799 N-Methyldodecanamide 8996 7042 8725 7180 6888 N_N^-Bis(tert-butyldimethylsilyl)acetamidine 2838142 1601202 2529695 2588729 1626151 2744498 1552623 2921222 Nonanoic acid_ TBDMS derivative Pelargonic acid 6748 10185 7642 7002 6852 5825 8032 Nonanoyl chloride 11832 13539 8254 7267 10183 12434 12502 9690 Oleamide_ TBDMS derivative Oleamide 28381 27225 23135 39436 22284 19802 Oleic Acid_ (E)-_ TBDMS derivative 269133 321352 426556 391122 396500 344515 322088 307342 Palmitic Acid_ TBDMS derivative Palmitic acid 886509 1002090 933112 1096470 942557 962561 1002395 859595 Pentadecanoic acid_ TBDMS derivative Pentadecylic acid 5685 6019 5393 6966 6754 5564 4743 5187 Pentanedioic acid_ 2-[(tert-butyldimethylsilyl)oxy]-_ bis(tert-butyldimethylsilyl) ester Glutaric acid 21772 15017 15482 18448 20452 30672 17674 Phosphoric acid_ tris(tert-butyldimethylsilyl) ester Phosphoric acid 1266385 645129 1239495 1420191 1481795 1437524 1203259 1819480 Phthalic acid_ hept-3-yl isohexyl ester 44671 356964 357088 371904 Pipecolic acid_ 2TBDMS derivative Pipecolic acid 37336 39002 22301 44618 31610 36609 28584 23536 Propanedioic acid_ 2TMS derivative Malonic acid 453890 511668 402998 449065 366899 436046 342640 Propanoic acid_ 3-[methyl[2-oxo-2-[(trimethylsilyl)oxy]ethyl]amino]-3-oxo-_ trimethylsilyl ester Propionic acid 30774 41686 22646 24290 18989 28056 49233 Propanoic acid_ 3-[(tert-butyldimethylsilyl)oxy]-2-methyl-_ tert-butyldimethylsilyl ester Propionic acid 17484 8666 33971 26335 21449 10361 21910 21106 Propanoic acid_ TBDMS derivative Propionic acid 118147 117749 98937 127904 127129 136475 146791 158029 Propargyl alcohol_ TBDMS derivative 73261 80361 53985 62057 74731 74454 60423 Stearic acid_ TBDMS derivative Stearic acid 880103 997638 830587 821693 849467 959665 915407 856349 Sulfurous acid_ 2-ethylhexyl hexyl ester 4533 3754 3997 4037 3307 4369 Taurine_ 2TBDMS derivative Taurine 3647183 3437993 2225259 711325 2990833 3515210 2519055 3488839 Thymol_ TBDMS derivative Thymol 64031 82769 31385 17446 44219 74180 88722 58316 Tianeptine 53221 60796 54874 60317 52186 66502 48022 trans-1-Chloro-2-trimethylsilyloxycyclohexane 39511 37388 41627 40090 42499 46932 Tris(tert-butyldimethylsilyloxy)arsane 21518 21354 20296 22645 24991 21378 Undecanamide_ 11-bromo- 66094 82385 60665 55696 Uracil_ 2TBDMS derivative Uracil 9302 8527 15519 18429 21782 13222 17271 13921 Urea_ 2TBDMS derivative Urea 1235549 1342446 1507491 1398797 1317407 1187888 1115703 1277275