Metabolite_name RefMet_name 20210522-C-3 20210522-C-4 20210522-C-5 20210522-C-6 20210522-C-7 20210522-C-8 20210522-CH-2 20210522-CH-3 20210522-CH-4 20210522-CH-5 20210522-CH-6 20210522-CH-8 20210522-CL-1 20210522-CL-3 20210522-CL-5 20210522-CL-6 20210522-CL-7 20210522-CL-8 20210522-CM-1 20210522-CM-2 20210522-CM-3-2 20210522-CM-4 20210522-CM-5 20210522-CM-6 20210522-AL-1-0524 20210522-AL-2 20210522-AL-4 20210522-AL-5 20210522-AL-6 20210522-AL-7 20210522-AH-1 20210522-AH-2 20210522-AH-3 20210522-AH-5 20210522-AH-6 20210522-AH-8 Factors - Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil) Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil) Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil. Allantoin Allantoin 0.7477 0.5099 0.6208 0.7860 0.6997 0.7461 1.2867 1.1727 1.9570 1.9806 1.5658 2.1959 1.0495 1.1053 0.9995 1.0404 0.7131 1.1387 1.6344 0.9620 1.3146 0.8860 1.7025 0.8565 0.5485 2.1113 1.3918 1.4874 2.3843 1.3612 2.7050 2.4871 2.8347 2.2279 3.1025 3.4405 Azelaic acid Azelaic acid 3.6110 3.9013 7.0583 7.5526 5.0178 5.9411 2.0907 1.8938 2.0179 3.1994 3.4913 3.5513 3.9233 4.6361 3.9516 4.4218 3.1137 4.5468 3.9489 2.2976 3.0199 3.5475 3.0815 2.5420 9.3609 3.3659 3.0420 3.6108 3.4572 2.9147 7.0238 3.5704 2.5306 3.7033 2.9210 4.4019 Citraconic acid Citraconic acid 0.8945 0.4650 1.2806 0.4742 0.4838 0.9209 14.2307 4.8966 4.5368 2.4395 4.5429 8.4405 5.1523 3.3305 3.0526 1.5076 3.3500 3.1568 4.4540 4.7039 7.7717 9.2259 9.7741 36.2685 0.5788 4.7799 10.3129 3.6497 3.5240 3.2696 3.0078 3.6184 6.5867 9.6155 8.3612 8.0025 Citrate Citric acid 116.5455 138.7488 161.4963 53.6864 123.1577 132.7735 343.3869 114.1243 229.6039 133.6718 153.5666 231.1839 170.4761 161.5976 186.4571 173.1329 210.5614 167.9591 167.6351 217.3809 189.0428 211.0011 265.6898 398.5246 109.2126 278.6040 233.4653 263.0712 192.8029 245.7776 204.2574 202.7889 217.6900 494.6144 513.4307 576.8883 D-Fructose Fructose 9.7777 9.9292 6.4408 6.4305 9.0942 10.0626 11.3944 9.9679 7.3819 9.8136 12.8169 13.5392 11.1489 11.6236 12.1206 7.3233 8.9837 7.4721 16.2718 12.8837 21.5735 11.6593 7.2563 6.4945 7.6821 8.1951 4.7400 9.0471 7.0367 5.8203 7.0002 7.3384 6.1713 5.4237 4.9259 7.4606 D-Glucose 6-phosphate Glucose 6-phosphate 2.6105 2.3015 2.8187 1.2552 2.1322 2.4365 6.0038 6.5171 3.4748 5.5261 5.6017 4.5964 3.7194 4.0809 6.2472 3.4393 5.0687 2.9874 4.1304 4.2181 5.3249 4.4447 6.4166 8.4934 2.3776 1.8115 1.4417 4.4843 1.4498 1.4014 2.0573 1.5226 1.3590 1.3404 1.2522 1.5040 Docosahexaenoic acid Docosahexaenoic acid 3.4451 3.4415 2.8546 3.5016 3.5150 2.9838 2.6615 2.6153 3.9637 3.7466 3.6409 3.6081 3.2971 3.3400 3.0375 3.2872 2.7170 3.0914 2.9192 3.0100 2.6530 3.4862 3.4047 2.9285 3.0325 3.5217 3.0645 3.3811 2.8600 2.9393 4.9177 3.6483 3.4391 3.8749 4.2813 3.7380 Flavin adenine dinucleotide FAD 76.8850 87.7328 84.3474 88.6973 83.2682 81.9725 57.2684 62.6794 57.9051 61.2542 61.7829 60.7930 59.6140 62.6322 61.2794 61.0184 62.8024 65.9333 65.8604 52.3073 54.8842 58.1357 60.4568 44.1542 87.3955 74.7717 77.7865 70.6715 64.8929 73.5149 75.3418 77.4912 75.7995 78.9849 81.1987 84.9067 Gluconic acid Gluconic acid 15.9683 9.2744 12.8320 11.9269 21.2919 14.6919 8.7252 9.4061 12.1732 14.2637 11.1548 11.3283 9.2762 8.2002 8.4654 8.1224 8.1455 12.6551 10.3635 8.3001 10.3977 10.0640 10.7308 4.9030 14.9649 16.2517 16.3279 12.8890 14.4007 15.6075 10.1805 8.9097 12.3330 11.9309 8.3728 14.4805 Glucose Glucose 12.8829 14.2778 8.8639 8.6810 12.9459 13.3394 14.9554 14.5499 11.0358 13.0383 15.5150 17.9542 14.9659 14.6928 14.9942 8.7746 12.9681 11.1306 22.3453 15.3071 27.6988 13.2574 9.9977 10.1380 9.7459 10.9803 6.4737 11.5462 9.7325 7.6136 9.1666 10.0030 8.5024 8.7366 6.5102 11.2936 Glutaric acid Glutaric acid 14.8043 9.6057 3.8686 13.2397 6.7491 8.8479 18.5323 17.6940 12.8759 20.2932 20.2991 17.8532 28.8424 15.4297 9.8444 15.8220 17.5646 18.0613 15.2780 10.7477 26.6629 28.5518 13.2068 16.4622 18.7378 24.7606 26.0647 33.1350 18.4327 33.3068 12.0430 11.9740 11.5448 12.7323 4.9092 16.7665 Glycocholic acid Glycocholic acid 1.1456 0.8447 0.3576 1.2954 1.1266 0.7664 0.6243 0.8119 1.1459 0.6543 0.9137 0.8068 0.8677 1.3426 0.9913 1.2296 1.5228 0.7103 1.5235 0.9638 1.0928 0.7788 0.2239 0.0882 1.1085 0.5396 0.8283 1.0600 0.7547 0.2801 0.8922 0.2195 0.5273 0.7625 0.5005 0.5516 Indoxyl sulfate Indoxyl sulfate 4.9585 6.0676 2.8829 2.1743 3.5449 7.3200 9.1585 6.1027 3.1499 6.9038 4.7576 3.6427 3.3369 3.7790 6.2425 7.6451 5.8332 10.0045 3.1871 3.6156 5.8933 8.2658 7.0762 13.0689 6.9144 2.8024 4.8845 4.2861 3.2779 4.8712 2.9943 5.2482 2.5264 2.3287 2.9762 3.3850 Isocitric acid Isocitric acid 81.9556 89.5298 163.3977 48.2876 83.0627 104.4906 237.1691 95.4166 176.6636 129.0676 139.7226 199.5531 148.6065 134.4457 154.4042 142.7747 178.7220 136.3122 111.2036 187.1680 158.9826 130.1283 221.2947 299.0326 91.2244 211.4479 184.3114 198.8609 192.6799 209.6886 137.0125 173.5182 165.7734 391.5044 385.9784 422.3388 L-Lactate Lactic acid 48.2818 53.7160 40.9074 39.1760 50.8068 49.1325 68.3696 56.8923 55.9006 57.8437 66.5780 70.3829 59.6967 61.9322 56.8854 39.1054 48.5501 46.1914 82.8453 64.1373 91.9993 60.9022 46.6279 50.5139 45.4391 46.4681 33.5094 48.1733 48.1354 37.9833 41.8029 46.8383 41.7078 37.4368 34.1675 50.9756 Malic acid Malic acid 105.2871 122.4102 94.3479 99.4120 109.5893 123.2148 415.4620 230.7087 386.4865 265.6866 272.7201 410.4503 204.8083 209.1098 258.9057 207.4941 219.9265 201.1323 308.2885 253.5419 270.8039 241.4677 282.9169 284.9887 129.5479 315.3657 200.7840 311.8864 369.5949 197.4287 351.8182 351.6140 297.7758 402.6532 386.2249 494.1172 Malonic acid Malonic acid 33.5195 22.9878 47.8677 55.8393 46.3670 35.3752 21.6850 16.4451 14.3792 18.9363 23.3917 19.6341 31.4640 23.2540 24.9872 35.4118 25.6466 35.0168 19.1755 16.5502 38.5984 33.9653 47.1672 29.8731 46.0604 48.9919 31.6118 29.8024 32.0869 28.2819 37.2317 36.2133 35.0866 43.1734 54.8856 61.2559 Methylmalonic acid Methylmalonic acid 167.9215 172.9768 95.6717 163.8627 161.3883 177.7999 169.1637 161.4386 124.4822 145.2088 136.3872 154.9958 213.3916 176.7340 158.2283 115.1594 160.1514 173.6224 172.9264 165.0676 207.1497 168.5814 137.1373 95.4687 164.7119 170.8068 178.3686 91.4287 186.8343 189.0484 115.4916 159.1807 177.8026 130.6345 76.3636 190.9438 N-Acetylglutamic acid N-Acetylglutamic acid 80.2269 63.6798 43.9942 69.4756 50.0219 57.6454 59.8393 84.5930 55.9800 89.4462 112.0923 83.3981 89.8400 74.8117 59.8374 75.1578 80.5002 72.4764 49.0842 46.5558 97.4380 110.2130 59.1513 67.1409 82.9731 77.4706 90.4201 81.3391 52.8890 71.2519 65.7389 76.5783 61.8205 55.7549 44.5386 68.1377 Oxalic acid Oxalic acid 8.0560 8.2712 5.8498 5.7218 7.3383 8.2923 9.2687 8.9231 7.7002 9.8498 9.1397 10.7654 9.2933 8.3029 7.8374 6.4896 7.7773 6.4518 10.6627 9.1939 13.0951 8.2987 7.3035 6.7949 7.0998 7.6595 5.2163 7.6605 5.9262 5.5981 5.7117 7.0801 6.6078 5.6707 5.0362 8.4930 p-Hydroxyphenylpropionic acid 10.2270 10.2930 11.7976 9.8899 10.0903 9.3970 13.4029 14.3593 14.2165 14.6248 12.1033 14.1438 11.6650 13.1994 13.2984 11.6553 12.1870 12.2149 10.5601 10.5102 11.3441 11.4073 14.2323 14.1276 10.5804 9.8447 11.1328 11.5800 10.1759 9.9276 11.0536 11.4205 9.6477 9.6270 13.0347 13.0218 Succinic acid Succinic acid 162.4978 180.0732 94.9399 142.4400 154.0553 189.0683 154.0386 154.8296 125.1063 142.7655 122.0281 155.3676 208.5175 156.0138 147.2414 111.0106 166.6679 174.6178 163.8578 155.7812 183.3161 168.6923 139.7294 88.2937 162.7897 153.3641 157.0228 91.4495 176.4993 193.0358 109.9764 154.6210 154.0529 125.9616 74.0466 178.8955 Taurochenodeoxycholic acid Taurochenodeoxycholic acid 60.1890 43.9188 22.5127 41.1059 58.2893 51.2675 18.6381 6.4420 17.0519 8.5418 14.1213 16.1864 23.7813 13.4780 19.0400 21.7192 18.4344 17.8741 14.1171 14.1215 14.5746 18.6964 21.4105 6.8793 47.2469 29.1447 26.1948 38.9206 31.7882 39.3757 50.2258 31.4238 35.6199 27.9848 22.5612 31.0097 Taurocholic acid Taurocholic acid 17.8543 25.0512 11.7575 26.6432 39.0248 19.8942 23.2482 20.4221 21.9432 21.2991 19.7055 21.3835 26.6438 21.9221 20.3846 26.5932 22.8679 18.4104 19.1901 14.9576 20.6530 22.3716 9.9149 18.6929 24.2354 11.6411 16.2032 24.5468 16.6015 8.1208 27.3332 10.9773 22.6359 21.5182 18.9547 18.0134 Taurodeoxycholic acid Taurodeoxycholic acid 60.1890 43.9188 22.5127 41.1059 58.2893 51.2675 18.5135 6.4420 17.0367 8.5089 14.5937 16.2815 23.7675 13.7187 18.9360 21.7192 19.1403 18.4888 14.0769 14.5650 15.0164 18.6740 20.8702 6.8793 47.2469 29.1447 26.1948 38.9206 31.7882 39.3757 50.2258 31.4238 35.6199 27.9848 22.5612 31.0097 Tauroursodeoxycholic acid Tauroursodeoxycholic acid 28.1244 22.1059 10.4299 18.3617 29.6625 25.1281 8.7407 3.2985 7.3665 4.0546 6.9445 7.3826 10.8561 7.1967 8.3764 10.2857 8.9700 8.5865 7.2812 7.3906 7.4689 9.2941 10.3993 3.1863 22.7716 13.3191 13.1742 18.5987 14.9004 19.4636 24.4848 15.1890 18.3402 14.4453 10.5726 13.4817 Uridine Uridine 20.6180 21.6947 23.0105 18.0230 23.1103 27.8522 20.0712 17.2062 12.7518 18.5245 20.3046 19.3599 21.6621 21.8910 23.1419 19.7414 15.6695 20.8143 28.9013 18.6853 19.0500 26.2186 21.4997 20.5988 20.3090 19.8129 16.1660 20.8534 18.3120 19.2073 22.8966 17.1656 15.2693 8.7655 13.3612 9.5922