Metabolite_name	RefMet_name	20210522-C-3	20210522-C-4	20210522-C-5	20210522-C-6	20210522-C-7	20210522-C-8	20210522-CH-2	20210522-CH-3	20210522-CH-4	20210522-CH-5	20210522-CH-6	20210522-CH-8	20210522-CL-1	20210522-CL-3	20210522-CL-5	20210522-CL-6	20210522-CL-7	20210522-CL-8	20210522-CM-1	20210522-CM-2	20210522-CM-3-2	20210522-CM-4	20210522-CM-5	20210522-CM-6	20210522-AL-1-0524	20210522-AL-2	20210522-AL-4	20210522-AL-5	20210522-AL-6	20210522-AL-7	20210522-AH-1	20210522-AH-2	20210522-AH-3	20210522-AH-5	20210522-AH-6	20210522-AH-8
Factors	-	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 10% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 1% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil)	Treatment:3 times per week with 4 consecutive respectively intraperitoneal injection with 5% CCl4 (10 mL/kg of olive oil)	Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 1% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.	Treatment:Only intraperitoneally (i.p) injected with 5% CCl4 (10 mL/kg, dissolved in olive oil) at the 12th injection. During the previous 11 times they were treated the same as the healthy controls with an equal volume of olive oil.
Allantoin	Allantoin	0.7477	0.5099	0.6208	0.7860	0.6997	0.7461	1.2867	1.1727	1.9570	1.9806	1.5658	2.1959	1.0495	1.1053	0.9995	1.0404	0.7131	1.1387	1.6344	0.9620	1.3146	0.8860	1.7025	0.8565	0.5485	2.1113	1.3918	1.4874	2.3843	1.3612	2.7050	2.4871	2.8347	2.2279	3.1025	3.4405
Azelaic acid	Azelaic acid	3.6110	3.9013	7.0583	7.5526	5.0178	5.9411	2.0907	1.8938	2.0179	3.1994	3.4913	3.5513	3.9233	4.6361	3.9516	4.4218	3.1137	4.5468	3.9489	2.2976	3.0199	3.5475	3.0815	2.5420	9.3609	3.3659	3.0420	3.6108	3.4572	2.9147	7.0238	3.5704	2.5306	3.7033	2.9210	4.4019
Citraconic acid	Citraconic acid	0.8945	0.4650	1.2806	0.4742	0.4838	0.9209	14.2307	4.8966	4.5368	2.4395	4.5429	8.4405	5.1523	3.3305	3.0526	1.5076	3.3500	3.1568	4.4540	4.7039	7.7717	9.2259	9.7741	36.2685	0.5788	4.7799	10.3129	3.6497	3.5240	3.2696	3.0078	3.6184	6.5867	9.6155	8.3612	8.0025
Citrate	Citric acid	116.5455	138.7488	161.4963	53.6864	123.1577	132.7735	343.3869	114.1243	229.6039	133.6718	153.5666	231.1839	170.4761	161.5976	186.4571	173.1329	210.5614	167.9591	167.6351	217.3809	189.0428	211.0011	265.6898	398.5246	109.2126	278.6040	233.4653	263.0712	192.8029	245.7776	204.2574	202.7889	217.6900	494.6144	513.4307	576.8883
D-Fructose	Fructose	9.7777	9.9292	6.4408	6.4305	9.0942	10.0626	11.3944	9.9679	7.3819	9.8136	12.8169	13.5392	11.1489	11.6236	12.1206	7.3233	8.9837	7.4721	16.2718	12.8837	21.5735	11.6593	7.2563	6.4945	7.6821	8.1951	4.7400	9.0471	7.0367	5.8203	7.0002	7.3384	6.1713	5.4237	4.9259	7.4606
D-Glucose 6-phosphate	Glucose 6-phosphate	2.6105	2.3015	2.8187	1.2552	2.1322	2.4365	6.0038	6.5171	3.4748	5.5261	5.6017	4.5964	3.7194	4.0809	6.2472	3.4393	5.0687	2.9874	4.1304	4.2181	5.3249	4.4447	6.4166	8.4934	2.3776	1.8115	1.4417	4.4843	1.4498	1.4014	2.0573	1.5226	1.3590	1.3404	1.2522	1.5040
Docosahexaenoic acid	Docosahexaenoic acid	3.4451	3.4415	2.8546	3.5016	3.5150	2.9838	2.6615	2.6153	3.9637	3.7466	3.6409	3.6081	3.2971	3.3400	3.0375	3.2872	2.7170	3.0914	2.9192	3.0100	2.6530	3.4862	3.4047	2.9285	3.0325	3.5217	3.0645	3.3811	2.8600	2.9393	4.9177	3.6483	3.4391	3.8749	4.2813	3.7380
Flavin adenine dinucleotide	FAD	76.8850	87.7328	84.3474	88.6973	83.2682	81.9725	57.2684	62.6794	57.9051	61.2542	61.7829	60.7930	59.6140	62.6322	61.2794	61.0184	62.8024	65.9333	65.8604	52.3073	54.8842	58.1357	60.4568	44.1542	87.3955	74.7717	77.7865	70.6715	64.8929	73.5149	75.3418	77.4912	75.7995	78.9849	81.1987	84.9067
Gluconic acid	Gluconic acid	15.9683	9.2744	12.8320	11.9269	21.2919	14.6919	8.7252	9.4061	12.1732	14.2637	11.1548	11.3283	9.2762	8.2002	8.4654	8.1224	8.1455	12.6551	10.3635	8.3001	10.3977	10.0640	10.7308	4.9030	14.9649	16.2517	16.3279	12.8890	14.4007	15.6075	10.1805	8.9097	12.3330	11.9309	8.3728	14.4805
Glucose	Glucose	12.8829	14.2778	8.8639	8.6810	12.9459	13.3394	14.9554	14.5499	11.0358	13.0383	15.5150	17.9542	14.9659	14.6928	14.9942	8.7746	12.9681	11.1306	22.3453	15.3071	27.6988	13.2574	9.9977	10.1380	9.7459	10.9803	6.4737	11.5462	9.7325	7.6136	9.1666	10.0030	8.5024	8.7366	6.5102	11.2936
Glutaric acid	Glutaric acid	14.8043	9.6057	3.8686	13.2397	6.7491	8.8479	18.5323	17.6940	12.8759	20.2932	20.2991	17.8532	28.8424	15.4297	9.8444	15.8220	17.5646	18.0613	15.2780	10.7477	26.6629	28.5518	13.2068	16.4622	18.7378	24.7606	26.0647	33.1350	18.4327	33.3068	12.0430	11.9740	11.5448	12.7323	4.9092	16.7665
Glycocholic acid	Glycocholic acid	1.1456	0.8447	0.3576	1.2954	1.1266	0.7664	0.6243	0.8119	1.1459	0.6543	0.9137	0.8068	0.8677	1.3426	0.9913	1.2296	1.5228	0.7103	1.5235	0.9638	1.0928	0.7788	0.2239	0.0882	1.1085	0.5396	0.8283	1.0600	0.7547	0.2801	0.8922	0.2195	0.5273	0.7625	0.5005	0.5516
Indoxyl sulfate	Indoxyl sulfate	4.9585	6.0676	2.8829	2.1743	3.5449	7.3200	9.1585	6.1027	3.1499	6.9038	4.7576	3.6427	3.3369	3.7790	6.2425	7.6451	5.8332	10.0045	3.1871	3.6156	5.8933	8.2658	7.0762	13.0689	6.9144	2.8024	4.8845	4.2861	3.2779	4.8712	2.9943	5.2482	2.5264	2.3287	2.9762	3.3850
Isocitric acid	Isocitric acid	81.9556	89.5298	163.3977	48.2876	83.0627	104.4906	237.1691	95.4166	176.6636	129.0676	139.7226	199.5531	148.6065	134.4457	154.4042	142.7747	178.7220	136.3122	111.2036	187.1680	158.9826	130.1283	221.2947	299.0326	91.2244	211.4479	184.3114	198.8609	192.6799	209.6886	137.0125	173.5182	165.7734	391.5044	385.9784	422.3388
L-Lactate	Lactic acid	48.2818	53.7160	40.9074	39.1760	50.8068	49.1325	68.3696	56.8923	55.9006	57.8437	66.5780	70.3829	59.6967	61.9322	56.8854	39.1054	48.5501	46.1914	82.8453	64.1373	91.9993	60.9022	46.6279	50.5139	45.4391	46.4681	33.5094	48.1733	48.1354	37.9833	41.8029	46.8383	41.7078	37.4368	34.1675	50.9756
Malic acid	Malic acid	105.2871	122.4102	94.3479	99.4120	109.5893	123.2148	415.4620	230.7087	386.4865	265.6866	272.7201	410.4503	204.8083	209.1098	258.9057	207.4941	219.9265	201.1323	308.2885	253.5419	270.8039	241.4677	282.9169	284.9887	129.5479	315.3657	200.7840	311.8864	369.5949	197.4287	351.8182	351.6140	297.7758	402.6532	386.2249	494.1172
Malonic acid	Malonic acid	33.5195	22.9878	47.8677	55.8393	46.3670	35.3752	21.6850	16.4451	14.3792	18.9363	23.3917	19.6341	31.4640	23.2540	24.9872	35.4118	25.6466	35.0168	19.1755	16.5502	38.5984	33.9653	47.1672	29.8731	46.0604	48.9919	31.6118	29.8024	32.0869	28.2819	37.2317	36.2133	35.0866	43.1734	54.8856	61.2559
Methylmalonic acid	Methylmalonic acid	167.9215	172.9768	95.6717	163.8627	161.3883	177.7999	169.1637	161.4386	124.4822	145.2088	136.3872	154.9958	213.3916	176.7340	158.2283	115.1594	160.1514	173.6224	172.9264	165.0676	207.1497	168.5814	137.1373	95.4687	164.7119	170.8068	178.3686	91.4287	186.8343	189.0484	115.4916	159.1807	177.8026	130.6345	76.3636	190.9438
N-Acetylglutamic acid	N-Acetylglutamic acid	80.2269	63.6798	43.9942	69.4756	50.0219	57.6454	59.8393	84.5930	55.9800	89.4462	112.0923	83.3981	89.8400	74.8117	59.8374	75.1578	80.5002	72.4764	49.0842	46.5558	97.4380	110.2130	59.1513	67.1409	82.9731	77.4706	90.4201	81.3391	52.8890	71.2519	65.7389	76.5783	61.8205	55.7549	44.5386	68.1377
Oxalic acid	Oxalic acid	8.0560	8.2712	5.8498	5.7218	7.3383	8.2923	9.2687	8.9231	7.7002	9.8498	9.1397	10.7654	9.2933	8.3029	7.8374	6.4896	7.7773	6.4518	10.6627	9.1939	13.0951	8.2987	7.3035	6.7949	7.0998	7.6595	5.2163	7.6605	5.9262	5.5981	5.7117	7.0801	6.6078	5.6707	5.0362	8.4930
p-Hydroxyphenylpropionic acid		10.2270	10.2930	11.7976	9.8899	10.0903	9.3970	13.4029	14.3593	14.2165	14.6248	12.1033	14.1438	11.6650	13.1994	13.2984	11.6553	12.1870	12.2149	10.5601	10.5102	11.3441	11.4073	14.2323	14.1276	10.5804	9.8447	11.1328	11.5800	10.1759	9.9276	11.0536	11.4205	9.6477	9.6270	13.0347	13.0218
Succinic acid	Succinic acid	162.4978	180.0732	94.9399	142.4400	154.0553	189.0683	154.0386	154.8296	125.1063	142.7655	122.0281	155.3676	208.5175	156.0138	147.2414	111.0106	166.6679	174.6178	163.8578	155.7812	183.3161	168.6923	139.7294	88.2937	162.7897	153.3641	157.0228	91.4495	176.4993	193.0358	109.9764	154.6210	154.0529	125.9616	74.0466	178.8955
Taurochenodeoxycholic acid	Taurochenodeoxycholic acid	60.1890	43.9188	22.5127	41.1059	58.2893	51.2675	18.6381	6.4420	17.0519	8.5418	14.1213	16.1864	23.7813	13.4780	19.0400	21.7192	18.4344	17.8741	14.1171	14.1215	14.5746	18.6964	21.4105	6.8793	47.2469	29.1447	26.1948	38.9206	31.7882	39.3757	50.2258	31.4238	35.6199	27.9848	22.5612	31.0097
Taurocholic acid	Taurocholic acid	17.8543	25.0512	11.7575	26.6432	39.0248	19.8942	23.2482	20.4221	21.9432	21.2991	19.7055	21.3835	26.6438	21.9221	20.3846	26.5932	22.8679	18.4104	19.1901	14.9576	20.6530	22.3716	9.9149	18.6929	24.2354	11.6411	16.2032	24.5468	16.6015	8.1208	27.3332	10.9773	22.6359	21.5182	18.9547	18.0134
Taurodeoxycholic acid	Taurodeoxycholic acid	60.1890	43.9188	22.5127	41.1059	58.2893	51.2675	18.5135	6.4420	17.0367	8.5089	14.5937	16.2815	23.7675	13.7187	18.9360	21.7192	19.1403	18.4888	14.0769	14.5650	15.0164	18.6740	20.8702	6.8793	47.2469	29.1447	26.1948	38.9206	31.7882	39.3757	50.2258	31.4238	35.6199	27.9848	22.5612	31.0097
Tauroursodeoxycholic acid	Tauroursodeoxycholic acid	28.1244	22.1059	10.4299	18.3617	29.6625	25.1281	8.7407	3.2985	7.3665	4.0546	6.9445	7.3826	10.8561	7.1967	8.3764	10.2857	8.9700	8.5865	7.2812	7.3906	7.4689	9.2941	10.3993	3.1863	22.7716	13.3191	13.1742	18.5987	14.9004	19.4636	24.4848	15.1890	18.3402	14.4453	10.5726	13.4817
Uridine	Uridine	20.6180	21.6947	23.0105	18.0230	23.1103	27.8522	20.0712	17.2062	12.7518	18.5245	20.3046	19.3599	21.6621	21.8910	23.1419	19.7414	15.6695	20.8143	28.9013	18.6853	19.0500	26.2186	21.4997	20.5988	20.3090	19.8129	16.1660	20.8534	18.3120	19.2073	22.8966	17.1656	15.2693	8.7655	13.3612	9.5922