Metabolite_name RefMet_name m02d m06c m18b m07a-S5A m11a-S5A m13a-S5A m15a-S5A m11a m14b m17b m05b m13a m14a m01c m03c m07a m01a m02a m08a m01b-S5A m07b-S5A m08a-S5A m09a-S5A m01d m07c m11b m01a-S5A m06b-S5A m10b-S5A m18a-S5A m03d m15b m16b m04c m12a m15a m04d m05c m08c m03a m04a m05a m11b-S5A m13b-S5A m14a-S5A m17a-S5A m04b-S5A m06a-S5A m10a-S5A m12b-S5A m02c m03b m10a m09b m10b m13b m02a-S5A m05b-S5A m14b-S5A m16a-S5A m04b m06a m09a m03a-S5A m04a-S5A m09b-S5A m12a-S5A m16a m17a m18a m06b m07b m12b m02b-S5A m03b-S5A m05a-S5A m08b-S5A m01b m02b m08b PS.079 PS.057-10.4 PS.057-10.6 BG1C0473-11 PS.158 BG1C0466-12 PS.120-13.3 PS.120-13.9 BG1C0466-13 BG1C0473-13 PS.132 Bgsng8064 PS.170 PS.004 Bgsng8119 Bgsng8169-28 Bgsng8169-30 Bgsng8153 BG1C0462 PS.011 Factors - Cage:1 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:26-member | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:26-member | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:26-member | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:26-member | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:BthetaBxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:BthetaBxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:BthetaBxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Btheta | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Btheta | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Btheta | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Bxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Bxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Bxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Germfree | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Germfree | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Germfree | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:1 | Microbiota:Germfree | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:26-member | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:26-member | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:26-member | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:26-member | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:BthetaBxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:BthetaBxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:BthetaBxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Btheta | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Btheta | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Btheta | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Bxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Bxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Bxylan | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Germfree | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Germfree | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Germfree | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:2 | Microbiota:Germfree | Diet:NAD-precursor sufficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Btheta | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Btheta | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Btheta | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Bxylan | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Bxylan | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Bxylan | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Germfree | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Germfree | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:3 | Microbiota:Germfree | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:26-member | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Btheta | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Btheta | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Btheta | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Bxylan | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Bxylan | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Bxylan | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Germfree | Diet:NAD-precursor deficient | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Germfree | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Germfree | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:4 | Microbiota:Germfree | Diet:NA-supplementeded | Age (months):NA | WLZ:NA | Health phenotype:NA Cage:NA | Microbiota:NA | Diet:NA | Age (months):10.3 | WLZ:-2.7 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):10.4 | WLZ:-3.8 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):10.6 | WLZ:-2.81 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):11 | WLZ:-0.82 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):12.5 | WLZ:-3.48 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):12 | WLZ:0.2 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):13.3 | WLZ:-3.16 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):13.9 | WLZ:-2.17 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):13 | WLZ:-0.3 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):13 | WLZ:-0.93 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):14.1 | WLZ:-3.01 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):15 | WLZ:0.6 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):16.2 | WLZ:-3.5 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):21.9 | WLZ:-2.03 | Health phenotype:Malnourished Cage:NA | Microbiota:NA | Diet:NA | Age (months):25 | WLZ:1.7 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):28 | WLZ:- | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):30 | WLZ:1.77 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):6 | WLZ:1.58 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):8 | WLZ:-0.43 | Health phenotype:Healthy Cage:NA | Microbiota:NA | Diet:NA | Age (months):9.9 | WLZ:-5.54 | Health phenotype:Malnourished Aspartate Aspartic acid 143.1900 138.3400 164.2000 84.7400 65.3600 187.8900 52.5600 3.8300 10.6500 5.2300 3.7700 8.5400 10.3900 8.2500 6.6500 8.7400 301.6700 213.5800 171.6900 10.5700 9.8100 16.8600 6.6000 148.1400 141.3500 121.1900 71.2900 56.8400 56.5000 77.6700 14.4900 8.1300 6.4300 5.9400 6.0700 7.4900 35.3300 11.2000 10.1200 215.2000 122.8700 204.8400 14.2600 57.8300 20.8700 31.8800 113.7500 101.7400 94.8900 204.5500 18.0700 11.3000 11 6.1900 6.1100 20.0700 90.0900 79.0900 109.5600 86.6100 250.6500 224.2900 162.7700 119.9300 117.9300 131.8200 94.3200 9.8100 14.6400 10.1500 5.6800 6.2500 11.5700 109.2400 115.0300 111.7000 79.3200 173.3700 229.2100 256.1900 6.2900 181 192.5200 204.4200 92.8800 568.1500 15.1400 70.1700 206.8700 629.3700 439.4800 1879.0900 111.6400 59.1500 79.0500 138.8900 346.1300 134.2200 683.4500 23.8700 NAD NAD 0.7490 1.1820 0.9700 0.0980 0.0150 0.0670 0.0370 0.6120 0.5350 1.4960 2.9270 1.5070 0.5250 0.1990 0.7510 0.1100 0.4160 0.2280 0.2500 0.0120 0.0220 0.0230 0.0270 0.6310 0.5130 0.6740 0.0210 0.0230 0.0300 0.0410 0.4990 0.7830 0.5390 0.9830 0.3150 0.3200 0.5460 0.4160 0.2390 0.1970 0.1610 0.2160 0.0090 0.0080 0.0270 0.0210 0.0150 0.0200 0.0170 0.0180 1.3650 2.4510 1.0490 0.5800 1.3410 1.2640 0.0150 0.0180 0.0280 0.0190 0.1730 0.3730 0.2000 0.0170 0.0240 0.0200 0.0270 1.6300 1.0820 2.1090 1.0490 0.4570 1.3060 0.0150 0.0420 0.0240 0.0110 0.2230 0.2650 0.3110 0.3900 0.5130 1.0750 0.0620 0.5820 0.0390 0.2500 0.3290 0.1380 0.8550 0.4590 0.0780 0.7120 0.1540 0.0850 0.0890 0.0360 0.0500 0.0110 0.2300 Nam Niacinamide 0.1410 0.1950 0.1440 0.1030 0.0730 0.0900 0.0670 0.1870 0.1030 0.0770 0.0750 0.0780 0.0190 0.0050 0.0660 0.1820 0.1110 0.0730 0.1090 0.1590 0.0650 0.0670 0.1160 0.1110 0.5820 0.1810 0.0960 0.0130 0.0110 0.0090 4.2340 5.3670 4.9860 2.2160 1.6570 2.7010 1.1060 1.2540 1.1370 2.7860 3.0430 3.6020 2.2110 1.5520 1.4860 1.6380 1.4570 2.6390 0.0020 0.0020 0.0080 0.0110 0.1500 Nicotinic acid Nicotinic acid 0.3190 0.2320 0.2330 5.1300 9.7300 7.3000 6.7900 0.0010 0.0030 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.2650 0.1470 0.1050 4.3200 3.5600 4.0800 3.6300 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 0.0010 2.3700 1.7200 2.3300 2.5800 0.0030 0.0050 0.0050 0.0050 0.0030 0.0080 0.0030 0.0070 0.0070 2.2000 1.8800 3.8400 1.1700 0.0030 0.0030 0.0040 0.0060 0.0050 0.0040 0.0040 0.0040 0.0100 0.0600 0.1700 0.2100 1.3900 0.0100 2.6800 0.1000 0.2600 6.0200 0.9000 0.0200 2.1600 0.0100 0.1700 3.1800 4.0100 6.3000 0.1100 0.3700 0.1800 v-cADPR-x 0.4310 0.3380 0.2780 0.0100 0.0070 0.0160 0.0100 0.2000 0.3040 0.3470 0.1800 0.1600 0.1500 0.7670 0.8380 0.6190 0.1810 0.1900 0.1770 0.0050 0.0050 0.0040 0.0050 0.2840 0.2610 0.2610 0.0100 0.0110 0.0100 0.0100 0.1940 0.2770 0.3560 0.1470 0.1740 0.1570 0.8670 0.9350 0.8790 0.2200 0.1320 0.2090 0.0060 0.0060 0.0030 0.0020 0.0100 0.0100 0.0070 0.0150 0.1490 0.1560 0.1340 0.6720 1.2130 0.4790 0.0030 0.0050 0.0070 0.0050 0.1570 0.1530 0.1530 0.0070 0.0110 0.0080 0.0100 0.2090 0.1690 0.1700 1.1480 0.7570 0.8150 0.0030 0.0050 0.0030 0.0030 0.1150 0.2050 0.2060 0.0020 0.0020 0.0050 0.0100 0.0050 0.0050 0.0020 0.0060 0.0110 0.0090 0.0050 0.0610 0.0020 0.0030 0.0070 0.0020 0.0030 0.0030 0.0030 0.0030