Metabolite_name RefMet_name KO1 KO2 KO3 KO4 WT1 WT2 WT3 WT4 WT5 WT6 Factors - Genotype:Pnpla8-knockout Genotype:Pnpla8-knockout Genotype:Pnpla8-knockout Genotype:Pnpla8-knockout Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type Genotype:Wild-type 2_3-Diphosphoglyceric acid 2,3-Diphosphoglyceric acid 0.0013 0.0009 0.0039 0.0036 0.0025 0.0031 0.0009 0.0034 0.0023 0.0030 2-Amino-3-phosphonopropionic acid 0.0002 0.0003 0.0003 0.0002 2-Hydroxybutyric acid 2-Hydroxybutyric acid 0.0015 0.0021 0.0016 0.0020 0.0023 0.0018 0.0023 0.0026 0.0018 0.0016 2-Hydroxyglutaric acid 2-Hydroxyglutaric acid 0.0007 0.0008 0.0005 0.0015 0.0035 0.0012 0.0008 0.0022 0.0009 0.0019 2-Hydroxyvaleric acid 2-Hydroxyvaleric acid 0.0003 0.0004 0.0006 3^_5^-ADP Adenosine 3',5'-diphosphate 0.0004 0.0003 0.0005 0.0005 0.0004 3^-Dephospho CoA 3'-Dephospho-CoA 0.0006 0.0005 0.0007 0.0008 0.0015 0.0007 0.0010 0.0008 0.0006 0.0006 3-Hydroxybutyric acid 3-Hydroxybutyric acid 0.0180 0.0120 0.0092 0.0110 0.0094 0.0074 0.0100 0.0130 0.0085 0.0058 3-Indoxylsulfuric acid Indoxyl sulfate 0.0002 0.0007 0.0002 0.0004 0.0002 0.0005 0.0003 0.0002 3-Phenylpropionic acid Hydrocinnamic acid 0.0002 0.0003 0.0003 0.0004 0.0014 0.0002 0.0003 0.0006 0.0003 0.0004 3-Phosphoglyceric acid 3-Phosphoglyceric acid 0.0005 0.0005 0.0007 0.0007 0.0005 0.0004 0.0007 0.0006 0.0006 3-Ureidopropionic acid Ureidopropionic acid 0.0003 0.0005 0.0003 0.0003 0.0008 0.0007 0.0006 0.0004 0.0004 4-Acetamidobutanoic acid 4-Acetamidobutanoic acid 0.0002 0.0007 0.0002 0.0009 0.0006 0.0006 0.0008 0.0009 5-Methoxyindoleacetic acid 5-Methoxyindoleacetic acid 0.0003 0.0004 0.0002 5-Oxoproline Pyroglutamic acid 0.0012 0.0009 0.0008 0.0007 0.0017 0.0014 0.0008 0.0050 0.0008 0.0008 6-Phosphogluconic acid 6-Phosphogluconic acid 0.0015 0.0022 0.0015 0.0024 0.0028 0.0031 0.0022 0.0029 0.0030 0.0026 Acetyl CoA_divalent Acetyl-CoA 0.0029 0.0049 0.0042 0.0041 0.0038 0.0041 0.0053 0.0068 0.0061 0.0059 Adenylosuccinic acid Adenylsuccinic acid 0.0049 0.0027 0.0023 0.0017 0.0027 0.0022 0.0031 0.0036 0.0012 0.0013 Adipic acid Adipic acid 0.0003 0.0005 ADP ADP 0.0920 0.0850 0.0670 0.0660 0.0420 0.0790 0.0610 0.0770 0.0790 0.0730 ADP-glucose or GDP-fucose ADP-glucose 0.0007 0.0007 0.0007 0.0008 0.0011 0.0011 0.0011 0.0012 0.0008 0.0011 ADP-ribose ADP-ribose 0.0029 0.0038 0.0045 0.0038 0.0140 0.0079 0.0100 0.0140 0.0062 0.0048 Allantoic acid Allantoic acid 0.0005 0.0003 0.0004 0.0004 0.0003 0.0004 0.0002 0.0003 0.0005 0.0003 AMP AMP 0.1500 0.1100 0.1200 0.1400 0.2100 0.1100 0.1800 0.1500 0.1200 0.1200 Ascorbate 2-glucoside 0.0002 0.0002 0.0003 0.0003 0.0002 0.0003 0.0003 Ascorbate 2-sulfate 0.0004 0.0003 0.0003 0.0002 0.0004 0.0003 Ascorbic acid Vitamin C 0.0510 0.0420 0.0390 0.0380 0.0610 0.0570 0.0580 0.0530 0.0370 0.0470 ATP ATP 0.0890 0.0990 0.0520 0.0510 0.0110 0.1000 0.0300 0.0770 0.0920 0.0780 CDP CDP 0.0003 0.0004 0.0004 0.0002 0.0007 0.0003 0.0004 CDP-choline CDP-choline 0.0011 0.0010 0.0010 0.0009 0.0020 0.0009 0.0011 0.0016 0.0014 0.0012 Cholic acid Cholic acid 0.0001 0.0004 0.0015 0.0038 0.0002 0.0004 Citric acid Citric acid 0.0110 0.0091 0.0084 0.0079 0.0059 0.0150 0.0110 0.0110 0.0076 0.0087 CMP CMP 0.0013 0.0021 0.0012 0.0017 0.0043 0.0020 0.0020 0.0035 0.0016 0.0018 CMP-N-acetylneuraminate CMP-N-acetylneuraminic acid 0.0002 0.0002 0.0001 0.0002 0.0003 0.0003 0.0003 0.0003 0.0002 0.0003 CoA_divalent Coenzyme A 0.0240 0.0200 0.0150 0.0160 0.0220 0.0220 0.0220 0.0190 0.0190 0.0160 CTP CTP 0.0002 0.0004 0.0004 0.0004 0.0003 Decanoic acid Capric acid 0.0003 Dihydroxyacetone phosphate Dihydroxyacetone phosphate 0.0006 0.0006 0.0025 0.0033 0.0022 0.0029 0.0020 0.0044 0.0024 0.0045 dTDP-glucose dTDP-glucose 0.0002 0.0003 0.0002 0.0003 0.0004 0.0002 0.0003 0.0002 0.0003 Ethanolamine phosphate Phosphoethanolamine 0.0088 0.0077 0.0065 0.0076 0.0140 0.0140 0.0130 0.0110 0.0080 0.0093 Ethyl glucuronide Ethyl glucuronide 0.0130 0.0043 0.0063 0.0010 0.0041 0.0053 0.0013 0.0013 0.0014 FAD_divalent FAD 0.0031 0.0030 0.0024 0.0026 0.0021 0.0021 0.0021 0.0020 0.0028 0.0024 Fructose 1_6-diphosphate Fructose 1,6-bisphosphate 0.0004 0.0010 0.0006 0.0011 0.0005 0.0023 0.0004 0.0015 Fructose 6-phosphate Fructose 6-phosphate 0.0048 0.0072 0.0060 0.0059 0.0097 0.0120 0.0087 0.0110 0.0080 0.0110 Fumaric acid Fumaric acid 0.0190 0.0150 0.0130 0.0080 0.0075 0.0170 0.0140 0.0160 0.0082 0.0076 Galacturonic acid Galacturonic acid 0.0005 0.0007 0.0004 0.0003 0.0009 0.0006 0.0006 0.0006 0.0007 0.0005 GDP GDP 0.0092 0.0055 0.0046 0.0042 0.0028 0.0081 0.0037 0.0059 0.0085 0.0078 GDP-glucose GDP-glucose 0.0012 0.0017 0.0013 0.0015 0.0019 0.0023 0.0014 0.0023 0.0022 0.0021 Gluconic acid Gluconic acid 0.0330 0.0330 0.0280 0.0230 0.0560 0.0380 0.0400 0.0410 0.0350 0.0300 Glucose 1-phosphate Glucose 1-phosphate 0.0018 0.0034 0.0026 0.0032 0.0130 0.0058 0.0041 0.0150 0.0042 0.0055 Glucose 6-phosphate Glucose 6-phosphate 0.0170 0.0290 0.0210 0.0270 0.0370 0.0460 0.0320 0.0440 0.0340 0.0380 Glucuronic acid Glucuronic acid 0.0038 0.0049 0.0035 0.0037 0.0037 0.0025 0.0027 0.0020 0.0070 0.0067 Glutaric acid Glutaric acid 0.0024 0.0016 0.0022 Glycerol 3-phosphate sn-Glycero-3-phosphate 0.0700 0.1000 0.0920 0.0890 0.1600 0.0600 0.1300 0.1100 0.1000 0.1300 GMP GMP 0.0150 0.0190 0.0140 0.0160 0.0250 0.0140 0.0220 0.0190 0.0150 0.0150 GTP GTP 0.0059 0.0043 0.0024 0.0020 0.0005 0.0069 0.0012 0.0037 0.0064 0.0057 Hexanoic acid Caproic acid 0.0006 0.0003 0.0003 0.0003 Hippuric acid Hippuric acid 0.0003 0.0007 0.0002 0.0014 0.0006 0.0007 0.0025 IMP IMP 0.0058 0.0130 0.0077 0.0100 0.0120 0.0100 0.0098 0.0074 0.0180 0.0190 Isethionic acid 2-Hydroxyethanesulfonate 0.0029 0.0030 0.0025 0.0018 0.0010 0.0012 0.0015 0.0012 Isobutyryl CoA_divalent Isobutyryl-CoA 0.0002 0.0010 0.0003 0.0008 0.0031 0.0006 0.0002 0.0013 0.0006 0.0008 Isovalerylalanine Isovalerylalanine 0.0003 0.0003 0.0002 0.0003 0.0004 0.0004 0.0002 0.0003 0.0002 Lactic acid Lactic acid 0.1400 0.2200 0.2100 0.3700 0.4100 0.4700 0.4000 0.6100 0.3300 0.4300 Lauric acid Lauric acid 0.0011 0.0009 0.0010 0.0008 0.0007 0.0010 0.0011 0.0010 0.0010 0.0008 Malic acid Malic acid 0.0870 0.0730 0.0550 0.0260 0.0260 0.1100 0.0680 0.0830 0.0260 0.0340 myo-Inositol 1-phosphate_myo-Inositol 3-phosphate 0.0003 0.0004 0.0005 0.0008 0.0011 0.0008 0.0008 0.0010 0.0008 0.0008 myo-Inositol 2-phosphate myo-Inositol 2-phosphate 0.0003 0.0004 0.0004 0.0004 0.0006 0.0006 0.0009 0.0008 0.0006 N2-Acetylaminoadipic acid N-Acetyl-2-aminoadipic acid 0.0002 N-Acetylalanine N-Acetylalanine 0.0001 0.0002 0.0002 0.0002 0.0002 0.0002 0.0001 N-Acetylasparagine N-Acetylasparagine 0.0003 0.0003 0.0003 0.0003 0.0002 0.0002 N-Acetylglucosamine 1-phosphate N-Acetylglucosamine 1-phosphate 0.0004 0.0003 0.0003 0.0004 0.0005 0.0005 0.0005 0.0003 0.0004 0.0005 N-Acetylglucosamine 6-phosphate N-Acetyl-glucosamine 6-phosphate 0.0003 0.0004 0.0003 0.0003 0.0004 0.0003 0.0003 0.0003 0.0003 0.0003 N-Acetylglutamic acid N-Acetylglutamic acid 0.0150 0.0097 0.0070 0.0068 0.0086 0.0047 0.0035 0.0055 0.0046 0.0067 N-Acetylglutamine N-Acetylglutamine 0.0015 0.0015 0.0015 0.0007 0.0023 0.0019 0.0025 0.0021 0.0010 0.0010 N-Acetylglycine N-Acetylglycine 0.0004 0.0003 0.0003 0.0002 0.0002 0.0002 N-Acetylleucine N-Acetylleucine 0.0003 0.0002 N-Acetylneuraminic acid N-Acetylneuraminic acid 0.0003 0.0003 0.0002 0.0004 0.0005 0.0006 0.0005 0.0004 0.0003 0.0006 NAD+ NAD 0.0460 0.0520 0.0310 0.0430 0.0230 0.0430 0.0290 0.0410 0.0590 0.0460 NADH NADH 0.0029 0.0021 0.0018 0.0009 0.0008 0.0009 0.0010 0.0014 0.0027 0.0013 NADP+ NADP 0.0130 0.0110 0.0082 0.0100 0.0090 0.0110 0.0095 0.0120 0.0130 0.0120 NADPH_divalent NADPH 0.0006 0.0003 0.0003 0.0004 0.0036 0.0018 0.0035 N-Glycolylneuraminic acid N-Glycolylneuraminic acid 0.0013 0.0012 0.0010 0.0017 0.0022 0.0021 0.0018 0.0020 0.0022 0.0024 Pantothenic acid Pantothenic acid 0.0009 0.0006 0.0005 0.0002 0.0005 0.0008 0.0006 0.0006 0.0004 0.0003 Pelargonic acid Pelargonic acid 0.0005 0.0003 0.0004 0.0004 0.0006 0.0004 0.0004 0.0004 0.0004 0.0006 Phenaceturic acid Phenylacetylglycine 0.0003 0.0002 Phosphocreatine Phosphocreatine 0.0002 0.0006 0.0002 0.0004 0.0003 0.0002 0.0004 0.0006 Propionyl CoA_divalent Propionyl-CoA 0.0002 0.0003 0.0004 0.0003 0.0008 0.0003 0.0004 0.0007 0.0002 0.0003 PRPP Phosphoribosyl pyrophosphate 0.0002 0.0002 0.0002 0.0002 0.0002 0.0003 0.0004 0.0002 Pyruvic acid Pyruvic acid 0.0052 0.0046 0.0052 0.0060 0.0059 0.0089 0.0062 0.0084 0.0056 0.0061 Rhein Rhein 0.0005 0.0003 0.0004 0.0005 0.0006 0.0008 0.0007 0.0009 0.0007 0.0008 Ribose 5-phosphate Ribose 5-phosphate 0.0008 0.0011 0.0028 0.0020 0.0015 0.0012 0.0014 0.0016 0.0017 0.0011 Ribulose 5-phosphate Ribulose 5-phosphate 0.0089 0.0120 0.0100 0.0110 0.0150 0.0100 0.0100 0.0110 0.0130 0.0140 Sedoheptulose 7-phosphate Sedoheptulose 7-phosphate 0.0050 0.0085 0.0040 0.0051 0.0050 0.0110 0.0044 0.0072 0.0068 0.0050 Succinic acid Succinic acid 0.0360 0.0290 0.0320 0.0350 0.0540 0.0680 0.0490 0.0690 0.0430 0.0510 Taurocholic acid Taurocholic acid 0.0360 0.0210 0.0160 0.0450 0.0370 0.0220 0.0740 0.0590 0.0200 0.0330 Thiamine diphosphate Thiamine diphosphate 0.0012 0.0011 0.0009 0.0009 0.0004 0.0006 0.0005 0.0007 0.0012 0.0010 Threonic acid Threonic acid 0.0011 0.0010 0.0007 0.0011 0.0014 0.0014 0.0010 0.0021 0.0010 0.0009 UDP UDP 0.0072 0.0052 0.0033 0.0027 0.0017 0.0088 0.0029 0.0059 0.0086 0.0075 UDP-glucose or UDP-galactose 0.0300 0.0220 0.0220 0.0410 0.0440 0.0650 0.0500 0.0580 0.0490 0.0550 UDP-glucuronic acid UDP-glucuronic acid 0.0071 0.0061 0.0026 0.0015 0.0011 0.0011 0.0017 0.0007 0.0033 0.0030 UDP-N-acetylgalactosamine or UDP-N-acetylglucosamine 0.0260 0.0270 0.0190 0.0240 0.0420 0.0400 0.0290 0.0410 0.0280 0.0290 UMP UMP 0.0220 0.0280 0.0180 0.0240 0.0390 0.0220 0.0320 0.0250 0.0270 0.0270 Uric acid Uric acid 0.0003 0.0003 0.0003 UTP UTP 0.0065 0.0056 0.0021 0.0019 0.0004 0.0094 0.0011 0.0044 0.0080 0.0064 Xanthine Xanthine 0.0023 0.0016 0.0025 0.0047 0.0028 0.0008 0.0017 0.0023 0.0047 0.0045 Xanthosine Xanthosine 0.0003 0.0005 0.0005 0.0009 0.0007 0.0003 0.0005 0.0006 0.0014 0.0014