Metabolite_name RefMet_name TH1707 M1-02_10_1_3409 TH1707 M2-01_11_1_3410 TH1707 M2-02_11_1_3411 TH1707 M3-01_12_1_3412 TH1707 M3-02_12_1_3413 TH1707 M4-01_13_1_3414 TH1707 M4-02_13_1_3415 VehicleEAE M1-01_7_1_3402 VehicleEAE M1-02_7_1_3403 VehicleEAE M2-01_8_1_3404 VehicleEAE M2-02_8_1_3405 VehicleEAE M3-01_9_1_3406 VehicleEAE M3-02_9_1_3407 Factors - Group:Therapeutic Group:Therapeutic Group:Therapeutic Group:Therapeutic Group:Therapeutic Group:Therapeutic Group:Therapeutic Group:Vehicle Group:Vehicle Group:Vehicle Group:Vehicle Group:Vehicle Group:Vehicle 2_2-Dimethylsuccinic acid 2,2-Dimethylsuccinic acid 9280 7100 7322 7486 7304 8512 8144 9486 9026 8682 7268 8886 9216 2-Hydroxycaproic acid 2-Hydroxyhexanoic acid 111688 87318 77618 81168 82904 89782 91432 80916 97558 93550 93408 60356 56478 2-Ketobutyric acid 3-Methyl pyruvic acid 39524 32112 35002 31520 34290 36650 40080 42678 38236 32538 31838 39992 38938 2-Ketohexanoic acid 2-Ketocaproic acid 8510 8146 8652 6092 6090 11126 5810 7304 7896 7656 2-Phenylbutyric acid 2-Phenylbutyric acid 53310 54302 53826 42400 48072 50598 44770 52792 51782 51618 51368 1604 1550 2-Pyrrolidinone 2-Pyrrolidinone 2830 3898 3218 4340 3534 2566 2284 2860 3286 3872 4818 6388 6812 3_4-Dihydroxyphenylglycol 3,4-Dihydroxyphenylglycol 16948 16566 18202 15378 14930 16806 17010 13430 14232 16320 13618 13910 14322 3-Aminoisobutanoic acid 3-Aminoisobutanoic acid 44826 39362 36368 31670 31038 46420 41526 53474 54532 45412 41196 34120 43346 3b-Hydroxy-5-cholenoic acid 3beta-Hydroxy-5-cholenoic acid 74716 72372 74956 75052 74972 72318 77058 71448 70746 69732 75760 16602 18510 3-Hexenedioic acid 3-Hexenedioic acid 3020 1670 2046 2790 2856 4194 3800 3128 2994 3524 3874 3448 3432 5^-Methylthioadenosine 5'-Methylthioadenosine 64062 52308 58022 77044 75194 73216 70898 53600 53128 41452 44564 70282 67364 Acrylamide Acrylamide 378462 692310 699450 737722 708144 738288 735246 733834 727676 661846 678372 762818 735206 Adenine Adenine 482192 201998 196652 597668 587756 577874 574206 367278 355148 770412 9272 Adenosine monophosphate AMP 125264 80392 81030 138264 140928 149544 154802 142184 129648 132450 81270 79794 Adenylsuccinic acid Adenylsuccinic acid 85180 12876 13476 71996 71464 89222 85466 65382 71040 68728 66064 16500 15058 ADP ADP 9226 1792 1754 3418 2774 8070 8926 7744 9152 7050 7028 2164 1656 Benzocaine Benzocaine 63444 47098 42948 70492 71650 72168 75034 70936 69758 53860 48924 76240 72124 Cadaverine Cadaverine 2856 3426 3128 4172 3890 4674 4108 3654 3914 4208 3776 1910 2180 Caffeine Caffeine 451178 343164 362312 358250 337984 357264 375800 316646 315902 316526 331694 177410 164052 Cholic acid Cholic acid 5902 2330 242 358 21166 20168 24052 1374 Cinnamic acid trans-Cinnamic acid 4046 3626 3280 6896 5238 6876 5482 4992 5458 3958 3762 4830 6088 Creatine Creatine 93862 71728 71182 114928 115752 107644 107784 97496 98144 88314 88404 103030 105438 Cyclic AMP 3',5' cyclic AMP 2970 1296 1062 2328 2528 2718 2976 3106 2398 2510 2416 1710 1650 Cytidine Cytidine 2060 1482 2304 2364 2140 2194 2564 2168 1696 1716 2936 2852 D-Alanine D-Alanine 40440 30124 29912 51268 49428 51020 48204 41024 46700 34902 34614 46068 44534 Diacetyl Diacetyl 37768 33482 32662 35052 30178 36712 46244 33926 35060 33368 31308 34364 34572 Glutathione Glutathione 114786 30420 30758 90692 90754 99218 113800 103738 109102 86728 86962 83638 84738 Glycerol Glycerol 23662 19880 22440 33026 22752 28662 19638 21368 20456 24246 27954 22478 18426 Glycerophosphocholine sn-Glycero-3-phosphocholine 22122 16024 15310 24104 22876 21380 22302 18008 17474 16812 16586 16930 16096 Guaifenesin Guaifenesin 11424 7798 9912 10400 9910 8750 11038 5782 5252 5580 6872 10618 7088 Guanine Guanine 79466 77002 71648 110138 117944 98256 97046 125446 120512 88020 88662 173098 181246 Guanosine Guanosine 60520 54358 52872 87090 87720 70446 68514 88212 81856 66090 62666 124920 131704 Guanosine 5^-diphosphate GDP 12520 6106 6000 5000 4972 8000 8192 7628 8550 6344 6944 5486 4334 Guanosine monophosphate GMP 19218 14782 15714 32506 31726 26116 27012 27230 23686 23024 27794 25682 Hyodeoxycholic acid Hyodeoxycholic acid 40544 20862 20834 10166 10190 20716 9662 22992 2374 25740 29904 2802 2562 Hypoxanthine Hypoxanthine 567314 644958 636882 725226 726094 699424 666380 738324 731124 634648 637646 739490 763420 Indole Indole 6430 5456 4420 8120 8782 6928 7030 6570 4508 4646 8720 7184 Indoleacrylic acid Indoleacrylic acid 118188 100112 96894 156606 152826 139976 129226 109872 109374 91618 91528 147588 141986 Inosine Inosine 156374 200234 191136 272244 257928 220740 208310 271120 261938 206876 199744 298234 297036 Isobutyric acid Isobutyric acid 219072 188734 185696 174322 166516 181006 200248 230576 223228 194792 198904 141654 150942 Isovalerylcarnitine CAR 4:0;3Me 9412 7048 8214 17648 17300 12956 13212 10110 9832 20640 20458 18524 14966 L-Acetylcarnitine CAR 2:0 64086 38850 37004 49956 50350 82554 87436 66746 66258 75270 71664 67730 67356 L-Aspartic acid Aspartic acid 18546 14192 14212 24512 23900 20666 21040 18390 17544 24172 23846 L-Carnitine Carnitine 17924 17078 16718 26362 25724 23276 24722 19178 20584 23286 22386 25584 27730 L-Glutamic acid Glutamic acid 33008 30618 31526 54756 47402 50216 51704 26434 32138 32942 32690 31454 L(-)-Nicotine pestanal Nicotine 2924 3390 2728 4862 3718 2784 3118 3338 3852 3008 3198 2524 2598 L-Norleucine Norleucine 3206 2504 1892 3104 2992 3378 2582 3300 3512 3294 2936 4868 4966 L-Tryptophan Tryptophan 29828 20220 18666 35334 34684 31204 30262 33670 27944 20006 23184 35442 37310 Maltitol Maltitol 10774 11456 11512 11632 11668 11628 12550 13202 11796 10998 11148 11308 10922 m-Coumaric acid trans-m-Coumaric acid 5332 3088 3674 5572 6778 4546 3824 5544 7216 2464 2830 7956 8376 Medroxyprogesterone Medroxyprogesterone 22884 9914 11132 10146 11582 8298 5430 21584 24686 24884 20088 714 Methylhippuric acid Methylhippuric acid 5420 6544 5200 5834 5004 5142 5784 5560 5998 4826 4854 5452 5450 N-Acetyl-L-alanine N-Acetylalanine 3112 2880 2982 3018 3390 2956 2938 2738 2598 2726 2852 3256 3136 N-Acetyl-L-aspartic acid N-Acetylaspartic acid 15820 11910 11558 18766 18560 17180 18860 15504 17030 15520 15076 20648 Niacinamide Niacinamide 13482 1832 1546 5098 4812 10840 12892 10316 12374 10740 10280 2712 3062 N_N-Dimethylformamide N,N-Dimethylformamide 16370 31800 40030 83044 64572 85068 18406 16652 14294 10734 49194 90688 Normetanephrine Normetanephrine 5302 4984 4978 6386 6458 5956 6200 6136 6976 4378 4408 6956 8110 Nutriacholic acid 7-Ketolithocholic acid 35938 32514 34768 21236 19836 44984 33708 15988 16446 22554 21362 676 616 o-Tyrosine o-Tyrosine 5918 5222 4438 6786 8618 6782 6896 7026 7800 2912 3412 9920 10632 Pantothenic acid Pantothenic acid 93470 73722 71698 115524 104324 97210 96844 98356 107834 71872 73616 121604 123984 Phenylacetaldehyde Phenylacetaldehyde 80258 92648 87680 87298 77218 83270 62748 90364 89934 91462 85668 1732 Phenylacetic acid Phenylacetic acid 1886 2114 2646 1822 2076 1952 1600 2616 2442 2988 2638 2178 2480 Phosphocreatine Phosphocreatine 3582 3098 3102 3218 3138 Phosphoric acid Phosphoric acid 6274 3854 4430 5956 5892 5266 4856 5706 6030 4906 5826 7402 6508 Propionic acid Propionic acid 5638 4330 5176 2856 6078 7054 5948 484 1570 2424 2930 3402 4446 Propylene glycol Propylene glycol 20648 19172 19170 20252 19594 20124 25912 20912 20568 17088 18884 20952 20668 Pyridine Pyridine 19722 11872 11574 16958 22634 19892 16024 25032 24344 14562 22908 14016 24316 Pyroglutamic acid Pyroglutamic acid 145388 96222 93390 161960 157810 130444 164906 136462 160222 115092 111312 151680 157514 Rhamnose Rhamnose 4494 4972 5184 4476 4456 5524 5394 4480 4216 4234 3736 4948 3980 Saccharopine Saccharopine 2426 5410 7270 4184 5994 4310 4682 2768 2870 2346 5446 5636 5356 S-Adenosylhomocysteine S-Adenosylhomocysteine 11808 13568 13098 18128 17186 17908 17504 19538 17344 11896 11866 22058 20970 Sorbitol Sorbitol 11768 12782 13154 11884 12296 12584 12788 11272 11450 11984 11844 12160 12154 Spermine Spermine 27558 16398 16602 17368 18542 24190 20172 24706 23826 16240 16720 7010 6368 Sphinganine Sphinganine 27664 20910 18334 13516 24890 16182 13622 13272 12426 306 328 Sphingosine Sphingosine 5448 9670 6654 8648 9222 5966 3786 5328 5800 5594 5578 1020 948 Succinic acid Succinic acid 14392 17662 17528 18870 19386 15010 14604 19552 20358 9848 9968 31156 30402 Uracil Uracil 5652 4322 4998 8252 7508 7790 8352 4718 5752 4628 4540 5970 4482 Urea Urea 3298 2692 3644 3074 3460 2952 2816 2076 3040 3070 2944 2448 2798 Uridine Uridine 3682 3076 3152 5120 4026 4434 4912 2232 3132 2456 2462 3338 3304 Valeric acid Valeric acid 3300 2350 2622 3542 2974 3512 4682 3026 3366 2846 2794 3358 3756