Metabolite_name RefMet_name L1-1 L1-2 L1-3 C-1 C-2 C-3 Factors - Transgene:ALDH1L1 Transgene:ALDH1L1 Transgene:ALDH1L1 Transgene:empty Transgene:empty Transgene:empty 10-Hydroxydecanoic acid 10-Hydroxydecanoic acid 2_3-Diphosphoglyceric acid 2,3-Diphosphoglyceric acid 0.0610 0.0720 0.0720 0.0610 0.0750 0.0720 2-Deoxyglucose 6-phosphate 2-Deoxy-D-glucose 6-phosphate 0.0032 0.0034 0.0033 0.0033 0.0030 0.0032 2-Hydroxyglutaric acid 2-Hydroxyglutaric acid 0.0340 0.0380 0.0380 0.0320 0.0390 0.0400 2-Hydroxyvaleric acid 2-Hydroxyvaleric acid 0.0042 0.0053 0.0062 0.0041 0.0048 0.0058 2-Oxoglutaric acid 2-Oxoglutaric acid 0.1600 0.2000 0.2100 0.1600 0.2100 0.2200 2-Oxoisovaleric acid Ketoisovaleric acid 0.0500 0.0480 0.0520 0.0440 0.0510 0.0540 2-Phosphoglyceric acid 2-Phosphoglyceric acid 0.0056 0.0054 0.0041 0.0067 0.0055 0.0042 3^_5^-ADP Adenosine 3',5'-diphosphate 0.0006 0.0008 0.0007 0.0008 0.0006 3^-CMP / 2^-CMP 0.0012 0.0012 0.0012 0.0008 0.0007 0.0011 3^-Dephospho CoA 3'-Dephospho-CoA 0.0005 0.0009 0.0010 0.0008 0.0013 3-Hydroxy-3-methylglutaric acid 3-Hydroxymethylglutaric acid 0.0200 0.0220 0.0220 0.0180 0.0190 0.0200 3-Hydroxybutyric acid 3-Hydroxybutyric acid 0.0076 0.0078 0.0090 0.0074 0.0091 0.0093 3-Methylcrotonyl CoA_divalent 3-Methylbut-2-enoyl-CoA 0.0006 0.0003 0.0003 0.0005 3-Phosphoglyceric acid 3-Phosphoglyceric acid 0.0350 0.0300 0.0230 0.0360 0.0330 0.0210 4-Acetamidobutanoic acid 4-Acetamidobutanoic acid 0.0008 0.0009 0.0008 0.0008 4-Methyl-2-oxovaleric acid / 3-Methyl-2-oxovaleric acid 0.2800 0.2800 0.2900 0.2700 0.2800 0.3000 5-Aminoimidazole-4-carboxamide ribotide AICAR 0.0031 0.0051 0.0054 0.0005 0.0007 0.0006 5-Oxoproline Pyroglutamic acid 0.2100 0.1800 0.1800 0.2000 0.1900 0.1900 6-Phosphogluconic acid 6-Phosphogluconic acid 0.0079 0.0150 0.0160 0.0087 0.0170 0.0180 Adenosine 5^-phosphosulfate Adenosine phosphosulfate 0.0048 0.0056 0.0062 0.0045 0.0069 0.0067 Adenylosuccinic acid Adenylsuccinic acid 0.0008 0.0009 0.0010 0.0004 0.0005 0.0005 ADP ADP 0.1800 0.1900 0.2000 0.2100 0.1800 0.1900 ADP-glucose / GDP-fucose 0.0180 0.0250 0.0230 0.0190 0.0240 0.0250 ADP-ribose ADP-ribose 0.0061 0.0065 0.0082 0.0068 0.0092 0.0100 AMP AMP 0.0360 0.0420 0.0520 0.0390 0.0430 0.0490 Ascorbate 2-phosphate 0.0008 0.0009 0.0008 0.0008 0.0008 0.0009 ATP ATP 2.5000 2.8000 2.6000 2.4000 2.7000 2.8000 Azelaic acid Azelaic acid 0.0009 cAMP 3',5' cyclic AMP 0.0022 0.0019 0.0017 0.0025 0.0023 0.0017 cCMP / 2^_3^-cCMP 0.0011 0.0012 0.0010 0.0006 0.0008 0.0011 CDP CDP 0.0096 0.0110 0.0130 0.0120 0.0110 0.0130 CDP-choline CDP-choline 0.0008 0.0010 0.0012 0.0008 0.0010 0.0008 cis-Aconitic acid cis-Aconitic acid 0.0330 0.0330 0.0350 0.0290 0.0290 0.0330 Citraconic acid Citraconic acid 0.0014 0.0012 0.0015 0.0013 0.0015 0.0015 Citric acid Citric acid 0.5900 0.6100 0.6400 0.5300 0.5600 0.5800 CMP CMP 0.0043 0.0048 0.0054 0.0044 0.0046 0.0051 CMP-N-acetylneuraminate CMP-N-acetylneuraminic acid 0.0360 0.0380 0.0390 0.0340 0.0380 0.0380 CoA_divalent Coenzyme A 0.0290 0.0420 0.0440 0.0300 0.0500 0.0500 CTP CTP 0.1800 0.2000 0.1800 0.1800 0.1900 0.2000 Cysteic acid Cysteic acid 0.0014 0.0020 0.0021 0.0019 0.0018 0.0017 Cysteinesulfinic acid 3-Sulfino-alanine 0.0190 0.0180 0.0170 0.0190 0.0190 0.0170 dADP dADP 0.0010 0.0008 0.0008 0.0011 0.0009 0.0009 dAMP dAMP 0.0003 0.0004 0.0003 0.0004 0.0003 0.0003 dATP dATP 0.0110 0.0120 0.0110 0.0110 0.0120 0.0120 dCDP dCDP 0.0006 0.0008 0.0008 0.0005 0.0007 0.0008 dCTP dCTP 0.0110 0.0110 0.0110 0.0110 0.0120 0.0120 Deamido-NAD+ Nicotinic acid adenine dinucleotide 0.0018 0.0020 0.0017 0.0012 0.0014 0.0012 Decanoic acid Capric acid 0.0029 0.0036 0.0038 0.0031 0.0035 0.0036 Dihydroorotic acid Dihydroorotic acid 0.0011 0.0015 0.0013 0.0010 0.0014 0.0013 Dihydroxyacetone phosphate Dihydroxyacetone phosphate 0.0250 0.0340 0.0310 0.0230 0.0490 0.0470 dTDP dTDP 0.0014 0.0016 0.0023 0.0018 0.0018 0.0018 dTDP-glucose dTDP-glucose 0.0023 0.0026 0.0026 0.0023 0.0025 0.0025 dTMP dTMP 0.0010 0.0011 0.0012 0.0008 0.0011 0.0009 dTTP dTTP 0.0260 0.0270 0.0270 0.0260 0.0300 0.0280 dUMP dUMP 0.0021 0.0019 0.0016 0.0019 0.0018 0.0017 Ethanolamine phosphate Phosphoethanolamine 0.0061 0.0047 0.0036 0.0058 0.0045 0.0037 FAD_divalent FAD 0.0064 0.0073 0.0067 0.0066 0.0073 0.0074 FMN FMN 0.0007 0.0008 0.0006 0.0008 0.0008 Fructose 1_6-diphosphate Fructose 1,6-bisphosphate 0.0640 0.0830 0.0730 0.0670 0.0910 0.0840 Fructose 6-phosphate Fructose 6-phosphate 0.0320 0.0620 0.0650 0.0310 0.0630 0.0650 Fumaric acid Fumaric acid 0.1300 0.1400 0.1400 0.1300 0.1400 0.1400 GDP GDP 0.0190 0.0200 0.0210 0.0230 0.0180 0.0220 GDP-glucose/GDP-mannose/GDP-galactose 0.0120 0.0170 0.0170 0.0120 0.0170 0.0190 Glucaric acid Glucaric acid Gluconic acid Gluconic acid 0.0200 0.0180 0.0180 0.0170 0.0160 0.0170 Glucose 1-phosphate Glucose 1-phosphate 0.0290 0.0400 0.0390 0.0290 0.0400 0.0420 Glucose 6-phosphate Glucose 6-phosphate 0.1300 0.2400 0.2400 0.1200 0.2300 0.2600 Glucuronic acid/ Galacturonic acid 0.0013 0.0014 0.0013 0.0012 0.0015 0.0018 Glutaric acid Glutaric acid 0.0046 0.0052 0.0051 0.0047 0.0052 0.0050 Glyceraldehyde 3-phosphate Glyceraldehyde 3-phosphate 0.0032 0.0018 0.0035 0.0030 0.0043 0.0047 Glyceric acid Glyceric acid 0.0031 0.0029 0.0028 0.0029 0.0026 0.0026 Glycerol 2-phosphate sn-Glycero-2-phosphate 0.0014 0.0016 0.0016 0.0014 0.0015 0.0015 Glycerol 3-phosphate sn-Glycero-3-phosphate 0.0590 0.0860 0.0930 0.0580 0.0750 0.0860 GMP GMP 0.0062 0.0073 0.0086 0.0063 0.0074 0.0085 GTP GTP 0.4300 0.4700 0.4400 0.4300 0.4700 0.4800 Heptanoic acid Heptylic acid 0.0021 0.0024 0.0017 0.0020 0.0026 Hexanoic acid Caproic acid 0.0013 0.0012 0.0013 0.0011 0.0013 0.0015 Hippuric acid Hippuric acid 0.0017 0.0016 0.0014 0.0017 0.0015 0.0013 HMG CoA_divalent 3-Hydroxy-3-methylglutaryl-CoA 0.0120 0.0120 0.0110 0.0110 0.0120 0.0120 IMP IMP 0.0023 0.0022 0.0019 0.0021 0.0020 0.0019 Isethionic acid 2-Hydroxyethanesulfonate 0.0003 0.0004 Isobutyric acid / Butyric acid 0.0027 0.0018 0.0020 0.0021 0.0018 0.0020 Isocitric acid Isocitric acid 0.0140 0.0110 0.0120 0.0110 0.0110 Isovaleric acid / Valeric acid 0.0042 0.0030 0.0032 0.0031 0.0029 0.0029 Isovalerylalanine / N-Acetylleucine 0.0003 0.0005 0.0007 0.0004 0.0005 0.0003 Lactic acid Lactic acid 1.9000 2 2.1000 1.8000 2 2.3000 Lauric acid Lauric acid 0.0093 0.0071 0.0090 0.0200 0.0086 0.0077 Malic acid Malic acid 1.3000 1.3000 1.3000 1.3000 1.4000 1.4000 Malonyl CoA_divalent Malonyl-CoA 0.0007 0.0007 0.0003 0.0005 0.0005 myo-Inositol 1-phosphate / myo-Inositol 3-phosphate 0.0140 0.0170 0.0160 0.0140 0.0150 0.0150 myo-Inositol 2-phosphate myo-Inositol 2-phosphate 0.0029 0.0028 0.0017 0.0017 Myristoleic acid Myristoleic acid 0.0007 0.0006 0.0006 0.0008 0.0008 0.0008 N2-Acetylaminoadipic acid N-Acetyl-2-aminoadipic acid 0.0039 0.0043 0.0047 0.0050 0.0051 0.0056 N-Acetylasparagine N-Acetylasparagine 0.0038 0.0031 0.0034 0.0029 0.0027 0.0028 N-Acetylaspartic acid N-Acetylaspartic acid 0.2500 0.2800 0.2800 0.2800 0.3200 0.3100 N-Acetylglucosamine 1-phosphate N-Acetylglucosamine 1-phosphate 0.0220 0.0280 0.0250 0.0210 0.0280 0.0240 N-Acetylglucosamine 6-phosphate N-Acetyl-glucosamine 6-phosphate 0.0062 0.0066 0.0062 0.0052 0.0062 0.0057 N-Acetylglutamic acid N-Acetylglutamic acid 0.0690 0.0750 0.0760 0.0730 0.0840 0.0820 N-Acetylglutamine N-Acetylglutamine 0.0023 0.0024 0.0024 0.0019 0.0024 0.0022 N-Acetylglycine N-Acetylglycine 0.0007 0.0006 0.0006 0.0005 0.0006 N-Acetylneuraminic acid N-Acetylneuraminic acid 0.0260 0.0350 0.0390 0.0240 0.0350 0.0380 N-Acetyl-β-alanine N-Acetylbetaalanine 0.0097 0.0100 0.0089 0.0075 0.0092 0.0100 NAD+ NAD 0.3000 0.3400 0.3500 0.3000 0.3400 0.3400 NADH NADH 0.0260 0.0240 0.0220 0.0230 0.0230 0.0240 NADP+ NADP 0.0200 0.0320 0.0270 0.0160 0.0220 0.0280 NADPH_divalent NADPH 0.0220 0.0150 0.0170 0.0260 0.0250 0.0210 N-Carbamoylaspartic acid N-Carbamoylaspartic acid 0.0230 0.0200 0.0180 0.0240 0.0210 0.0190 N-Glycolylneuraminic acid N-Glycolylneuraminic acid 0.0012 0.0015 0.0013 0.0011 0.0012 0.0015 Octanoic acid Caprylic acid 0.0015 0.0021 0.0018 0.0019 0.0024 O-Phosphoserine DL-O-Phosphoserine 0.0051 0.0026 0.0020 0.0091 0.0058 0.0033 O-Succinylhomoserine o-Succinylhomoserine 0.0039 0.0044 0.0047 0.0036 0.0050 0.0047 P1_ P4-Di(adenosine-5^) tetraphosphate_divalent 0.0008 0.0007 0.0008 0.0007 0.0006 Pantothenic acid Pantothenic acid 0.0570 0.0570 0.0530 0.0530 0.0550 0.0490 Pelargonic acid Pelargonic acid 0.0061 0.0071 0.0093 0.0056 0.0069 0.0080 Phosphocreatine Phosphocreatine 0.0850 0.0870 0.0720 0.0690 0.0800 0.0680 Phosphoenolpyruvic acid Phosphoenolpyruvic acid 0.0160 0.0140 0.0096 0.0160 0.0140 0.0092 Phthalic acid Phthalic acid 0.0009 0.0007 Phytic acid_divalent Myo-inositol hexakisphosphate 0.0110 0.0180 0.0190 0.0085 0.0180 0.0190 PRPP Phosphoribosyl pyrophosphate 0.1700 0.2100 0.2300 0.1600 0.2200 0.2500 Pyruvic acid Pyruvic acid 0.0910 0.1200 0.1200 0.0920 0.1100 0.1400 Quinic acid Quinic acid 0.0022 0.0036 0.0021 0.0028 0.0018 0.0018 Rhein Rhein 0.0059 0.0064 0.0064 0.0060 0.0063 0.0064 Ribose 5-phosphate Ribose 5-phosphate 0.0095 0.0081 0.0110 0.0120 0.0150 0.0160 Ribulose 1_5-diphosphate Ribulose 1,5-bisphosphate 0.0005 0.0009 0.0005 0.0004 0.0004 Ribulose 5-phosphate Ribulose 5-phosphate 0.0120 0.0150 0.0150 0.0130 0.0200 0.0200 Sedoheptulose 7-phosphate Sedoheptulose 7-phosphate 0.0140 0.0200 0.0250 0.0190 0.0240 Succinic acid Succinic acid 0.0580 0.0570 0.0640 0.0560 0.0620 0.0560 Succinyl CoA_divalent / Methylmalonyl CoA_divalent Succinyl-CoA 0.0007 0.0006 0.0006 0.0008 0.0010 Sulfotyrosine Sulfotyrosine 0.0005 0.0005 0.0003 Tartaric acid Tartaric acid 0.0008 Terephthalic acid Terephthalic acid 0.0037 0.0032 0.0036 0.0032 0.0039 0.0037 Thiamine diphosphate Thiamine diphosphate 0.0016 0.0013 0.0013 0.0012 0.0013 0.0014 Threonic acid Threonic acid 0.0500 0.0530 0.0540 0.0470 0.0520 0.0520 UDP UDP 0.0520 0.0600 0.0710 0.0600 0.0580 0.0660 UDP-glucose / UDP-galactose 0.4400 0.4700 0.4500 0.4400 0.4900 0.4800 UDP-glucuronic acid UDP-glucuronic acid 0.1600 0.2100 0.1900 0.1600 0.2000 0.2000 UDP-N-acetylgalactosamine / UDP-N-acetylglucosamine 0.5200 0.5900 0.5900 0.5000 0.5800 0.5800 UMP UMP 0.0240 0.0240 0.0290 0.0210 0.0230 0.0240 Undecanoic acid Undecylic acid Uric acid Uric acid 0.0006 0.0009 0.0005 0.0008 0.0006 0.0006 UTP UTP 0.8300 0.8800 0.8500 0.7800 0.8400 0.8700 XMP XMP 0.0004 0.0003 0.0003 0.0004 0.0003 Xylulose 5-phosphate Xylulose 5-phosphate 0.0008 0.0007 0.0007 0.0005 0.0008 0.0008