Metabolite_name RefMet_name B10_007 B12_008 B18_009 B20_010 B4_006 B53_016 B54_017 B55_018 B56_019 B57_020 B11_002 B17_003 B19_004 B21_005 B9_001 B48_011 B49_012 B50_013 B51_014 B52_015 Factors - Treatment Group:F off-HFD Treatment Group:F off-HFD Treatment Group:F off-HFD Treatment Group:F off-HFD Treatment Group:F off-HFD Treatment Group:F off-RD Treatment Group:F off-RD Treatment Group:F off-RD Treatment Group:F off-RD Treatment Group:F off-RD Treatment Group:M off-HFD Treatment Group:M off-HFD Treatment Group:M off-HFD Treatment Group:M off-HFD Treatment Group:M off-HFD Treatment Group:M off-RD Treatment Group:M off-RD Treatment Group:M off-RD Treatment Group:M off-RD Treatment Group:M off-RD 1_5-anhydroglucitol 1,5-Anhydrosorbitol 1798 1634 2901 3380 1558 190 813 2476 907 820 1380 4656 5640 3893 3833 893 638 4509 854 2763 1-monopalmitin MG 16:0/0:0/0:0 4161 2506 3025 2981 4057 512 186 594 551 430 3940 1172 4713 4021 2015 542 512 341 253 528 2_5-dihydroxypyrazine 2,5-Dihydroxypyrazine 24921 28365 28387 34388 12202 412 1413 1632 3562 1020 30542 43657 55804 47076 29470 2534 1644 946 420 936 2-hydroxybutanoic acid 2-Hydroxybutyric acid 57122 76758 15306 17334 43726 5315 4472 4735 3826 3758 149081 22684 23762 30377 46929 3475 4076 5130 5444 4015 2-hydroxyvaleric acid 2-Hydroxyvaleric acid 5989 6861 8900 6235 19236 2814 2520 4507 4334 2805 16388 7381 21004 6047 9722 3709 2523 3236 2859 4260 2-ketoadipic acid Oxoadipic acid 142511 94041 109633 86497 118390 91763 9211 33036 29936 70183 106864 92791 137432 123099 110932 21601 21343 75075 10199 27338 2-ketoglucose dimethylacetal D-Glucosone 4858 4975 5487 6598 2783 319 357 520 848 392 3859 6383 9837 821 4669 483 532 310 115 450 3_6-anhydro-D-galactose 3,6-Anhydro-galactose 482 248 384 347 645 1114 1052 1262 1552 731 331 235 196 133 263 1170 986 865 758 1001 3-hydroxy-3-methylglutaric acid 3-Hydroxymethylglutaric acid 554 272 311 403 387 300 240 208 263 259 250 316 565 533 380 256 272 307 129 303 3-hydroxybutyric acid 3-Hydroxybutyric acid 211415 131130 46444 36812 125977 6360 2517 4936 2023 4003 148959 36522 66098 51974 168237 3402 2144 4132 5305 4259 3-phosphoglycerate 3-Phosphoglyceric acid 4084 5651 13698 3084 1778 897 1505 636 2903 894 5860 7293 16725 8303 5808 1539 1707 567 362 749 4-aminobenzoic acid p-Aminobenzoic acid 589 372 621 454 553 3579 3048 3020 2791 3029 554 389 470 277 542 3061 2842 3243 3381 2951 5-methoxytryptamine 5-Methoxytryptamine 8644 11785 5428 9251 8978 631 580 1166 1558 1046 15166 6695 8089 11140 8497 1522 1220 453 249 804 adenine Adenine 5185 7001 8658 2160 6663 166 567 1352 1776 482 7744 10808 16927 5436 4795 1107 1413 931 322 962 adenosine Adenosine 470 488 809 1844 1150 378 155 1540 6014 604 477 1272 4517 1805 1215 2304 859 343 171 629 adenosine-5-monophosphate AMP 5519 12192 16718 32469 2353 179 189 899 861 416 12588 27969 42151 25803 9990 1081 525 180 153 314 alanine Alanine 10889 99101 68124 52544 119868 48801 151047 76070 152345 131661 250653 88420 52903 60816 287721 128197 119921 35254 98397 112747 allantoic acid Allantoic acid 6567 5934 5652 3870 1832 4453 5743 5145 5901 4561 6174 2960 4993 3318 5074 7993 8239 8399 5837 9473 aminomalonate Aminomalonic acid 8168 15621 7987 15024 6856 4047 1698 2604 4748 3649 14472 17962 16351 15868 8897 3461 3757 1813 1142 4403 arabitol Arabitol 8067 5671 5789 5595 4261 21060 16673 19375 17302 18330 3200 4891 6651 4718 6578 18526 18321 17623 19160 5967 asparagine Asparagine 10061 12772 17408 23940 7393 81804 92369 75176 52963 78661 14781 25629 37177 26336 12077 66034 72840 90050 113048 72153 aspartic acid Aspartic acid 281801 268150 263910 414955 253098 129020 205834 144622 160435 144110 359323 619825 756662 548691 394446 153620 161026 139958 178678 135287 beta-alanine beta-Alanine 1816 3241 2709 4486 2310 1712 2368 2189 2456 1685 4113 5208 5896 6693 2203 1879 2099 1864 2246 1764 citric acid Citric acid 107261 97874 113343 134476 92239 33844 37311 38575 50670 32063 114118 147954 232344 159390 120199 42817 36603 33087 29536 33135 citrulline Citrulline 18027 26307 18541 26143 8307 180008 172825 165995 148188 175784 29656 31750 31364 27869 16629 157891 144012 196892 178532 156326 creatinine Creatinine 38363 22798 28538 37385 15813 88497 31776 59228 87134 64550 8625 3334 64279 31983 38701 74399 35356 70170 70995 40839 cyanoalanine Cyanoalanine 2477 1766 2636 2460 1268 2995 8342 3062 4586 7283 2347 3122 4862 2903 3312 5734 5187 3207 5815 5028 cysteine Cysteine 1381 2510 1494 3419 1864 854 8793 2330 8078 3078 4049 4726 5504 1995 2800 5752 4654 1271 1902 1953 cystine Cystine 2596 1043 1837 1694 903 111230 89040 89294 64270 97847 1634 1561 3293 1554 2162 74422 82887 113689 144348 99404 cytosin Cytosine 3965 10114 16828 12943 7818 394 1766 1579 2839 722 8462 14898 27875 18776 6978 1754 1710 1022 613 1151 dehydroascorbic acid Dehydroascorbic acid 2435 2310 8051 8742 1322 171 380 433 2498 174 2002 32679 31596 12729 2987 568 706 410 138 183 diglycerol Diglycerol 17800 14306 21159 23462 11729 1783 1842 2167 3904 1284 17341 25274 34110 24361 20376 3009 1826 1277 818 1306 erythritol Erythritol 16497 14226 14187 11688 532 76458 72318 71930 65497 67399 15811 9625 14264 10052 14158 68264 67632 68622 78532 70104 ethanolamine Ethanolamine 125925 129567 107687 108361 69248 10491 35663 22664 80861 12513 160875 124545 173021 154677 136524 28712 26459 10881 6589 12132 fructose Fructose 64778 52893 54650 47221 1053 386573 317315 351693 334752 342708 61537 33107 52719 33301 50129 343698 329652 355844 365283 342959 fructose-6-phosphate Fructose 6-phosphate 1869 1423 3728 4873 2004 111 156 130 442 99 2324 4668 9284 4041 1600 228 175 107 98 97 fumaric acid Fumaric acid 30660 29731 21132 24453 20917 3046 5118 3667 6254 2844 37669 31943 37498 31567 34371 4419 3855 2613 2486 2717 galactitol Galactitol 13716 10654 11523 8154 312 157790 129064 139830 122257 131742 13650 5562 9123 5811 9920 126554 126327 139175 138651 133950 gluconic acid Gluconic acid 429 264 493 509 236 1232 1147 1339 1894 997 440 251 565 380 329 939 1150 1098 1090 1288 glucose Glucose 239312 193993 193465 125750 48519 1958360 1080509 2111464 1990402 1772245 218236 89607 132921 92384 176354 1988181 1755324 1911919 1188786 2007020 glucose-1-phosphate Glucose 1-phosphate 12484 11093 33166 26459 17554 4894 5238 6600 4978 5026 12656 22761 41272 18530 15530 5068 4763 4757 7191 6149 glucose-6-phosphate Glucose 6-phosphate 3649 3692 7831 11080 6372 689 887 946 837 683 5012 9532 17771 7421 2765 1026 781 641 1543 650 glutamic acid Glutamic acid 122258 118294 225174 272566 97193 94238 139570 95406 118175 87859 120705 381266 505383 346393 184005 99376 100509 92141 109372 77255 glutamine Glutamine 41727 36753 29900 28911 10746 863469 1006540 778741 506862 824652 26107 22133 36874 22751 37455 750107 813051 976489 1184967 796060 glyceric acid Glyceric acid 5804 5323 5528 2871 3299 4061 4481 3849 5972 3515 5261 3959 8226 5354 5231 4306 3377 3731 3934 2992 glycerol-alpha-phosphate sn-Glycero-3-phosphate 7245 6590 11797 13307 5309 1144 1532 1617 3132 800 8271 11645 11899 11760 8223 941 1435 926 687 250 glycine Glycine 122775 204003 165188 224879 113920 71101 94056 74994 85880 68633 207872 262534 297764 252441 144033 78880 75080 69088 85996 67052 glycolic acid Glycolic acid 13633 8959 7731 6618 7436 2150 1238 1865 1776 1888 8852 6229 9028 9596 7889 2419 1639 2112 1332 1628 guanosine Guanosine 792 771 512 750 505 116 202 214 1012 120 1094 1052 2027 1323 749 265 268 106 35 101 histidine Histidine 3376 3581 2979 2997 897 43807 64344 54432 49181 62680 3327 2922 4333 3549 3013 47409 51956 78256 73396 50500 hypoxanthine Hypoxanthine 28070 22814 15557 23790 3858 10905 9494 10555 24002 8545 36443 50078 50621 44020 20031 13250 8001 8675 6802 6785 indole-3-lactate Indolelactic acid 345 312 361 253 263 364 375 469 575 589 340 181 386 267 294 612 389 691 376 415 inosine Inosine 7221 5591 1732 4075 661 2532 2129 1640 7949 1723 11026 8268 11732 7283 8831 2713 1989 1581 870 1098 inosine 5^-monophosphate IMP 3566 9647 685 5425 527 46 31 71 129 52 17495 35813 20000 28895 13646 78 38 62 30 73 isocitric acid Isocitric acid 3078 2701 3299 4750 3288 845 845 946 1180 787 2833 5026 6752 4980 3079 1067 775 809 708 837 isoleucine Isoleucine 145380 182077 146573 158914 52962 712476 857134 713540 749658 812789 210360 95096 195316 144148 146555 754458 789059 716018 868667 811979 isomaltose Isomaltose 506 344 448 383 398 369 154 259 351 360 359 320 404 318 415 440 443 304 146 89 isothreonic acid D-Threonic acid 2197 1838 667 1749 446 8553 8656 7212 6513 6738 1612 1777 2770 2108 1848 6688 6998 7884 9505 5140 kynurenine Kynurenine 518 332 292 225 446 436 164 425 560 403 272 320 713 564 284 458 510 526 181 78 lactic acid Lactic acid 172486 148121 119886 129363 40588 229026 319169 278283 257019 270988 172292 175348 200290 127202 175812 309174 266050 341907 125554 266242 leucine Leucine 210170 170500 231342 257261 106349 752055 850399 753473 906848 1002673 253830 280647 353140 269581 214872 869744 969296 759584 851761 953585 levoglucosan Glucosan 2691 1323 4628 2302 1644 2943 930 673 707 650 1462 2054 4600 2180 1955 756 520 656 2856 2601 lysine Lysine 6870 7113 5547 5437 2074 51403 53664 47237 37468 48900 6659 5924 9201 7114 6198 43444 43326 51586 58926 46362 lyxitol L-Arabitol 6602 5287 6122 5327 4212 17237 16170 16039 13643 15175 6387 5296 8053 6390 6223 15607 1508 15938 16749 14556 lyxose Lyxose 685 747 1206 873 553 1534 1356 988 839 1188 1734 1827 2264 1149 876 1268 960 365 1147 301 maleimide Maleimide 27034 22670 71678 69917 25898 4015 1363 8274 15611 15079 21490 87572 9938 87804 38762 12968 7485 4879 2652 14231 malic acid Malic acid 34154 37268 16595 22633 24705 4602 4890 4375 7153 3787 48364 40477 43304 11134 43319 4890 3929 3847 3733 3457 maltose Maltose 601 799 1115 912 570 1450 629 1039 1340 1608 1121 1002 1533 1005 775 495 629 742 959 214 mannitol Mannitol 2429 2298 1750 1370 365 19109 20808 17272 14301 17420 2106 1445 1605 1257 1803 9115 15729 5716 23836 16150 mannose Mannose 1857 2106 1668 1903 586 5498 3312 6926 6864 3470 663 1750 2003 1149 1342 5804 4495 5273 2686 962 methanolphosphate Methanolphosphate 471152 311376 335305 247942 132177 31450 56059 46132 141820 27512 462633 322596 700056 381859 382729 48921 49013 27567 19300 28597 methionine Methionine 23742 25667 28867 36722 17242 72562 91169 69563 71687 77348 28236 49770 58621 39383 23794 71713 74294 74668 95063 75407 methionine sulfoxide Methionine sulfoxide 9877 10510 8110 8809 5755 18200 11312 6704 9088 9891 14667 8981 13284 10575 10026 8878 7598 9859 11918 8132 myo-inositol Myo-inositol 134325 99468 128010 113355 43350 617051 362015 525714 504159 496691 128336 110661 158704 102892 116062 509843 507459 535733 413713 537565 nicotinamide Niacinamide 12383 15901 15631 19411 6684 6957 7401 7512 6828 6464 20773 29279 39334 24274 16365 8124 7342 5874 5931 6160 ornithine Ornithine 64558 76514 65574 72160 23110 583422 733871 557740 509249 556966 70271 111451 129479 96481 67573 526994 516347 632149 715784 475694 oxalic acid Oxalic acid 47996 64538 13264 12414 37278 455 656 546 799 392 129298 17731 19875 19294 38812 700 451 401 469 820 oxoproline Oxoproline 896928 950208 986086 993258 375293 2267265 2407252 2029186 1857255 2046876 958168 1302484 1706833 1082544 965960 1907961 2064641 2071432 2587205 1977237 palmitoleic acid Palmitoleic acid 446 715 512 316 441 51 22 83 42 61 386 243 475 262 2152 36 26 32 20 58 pantothenic acid Pantothenic acid 1119 907 827 1137 698 1695 1559 1273 1626 1237 1021 883 1825 1590 1165 1460 1636 1379 1558 1524 parabanic acid Parabanic acid 4620 4528 2915 1828 6088 677 898 757 883 570 17250 3920 4184 3923 5757 578 748 719 479 855 phenol Phenol 38941 23585 29616 12477 26656 8554 4651 3568 1055 3617 21753 24191 39352 31583 28300 1659 861 5427 6342 6475 phenylalanine Phenylalanine 21944 44233 44310 52093 12976 111365 101605 104653 100779 101232 30769 70257 83114 61796 29333 99029 96131 105277 110775 103292 phosphate Phosphoric acid 6571984 6579256 6442799 6104752 8483831 635817 386635 991283 943240 675650 5479537 4726603 2374497 5047143 5914589 926937 846547 707442 215439 915897 phosphoenolpyruvate Phosphoenolpyruvic acid 3489 6230 5492 11731 1574 1138 2522 1728 2155 1051 8248 12150 11536 12914 4360 2253 1472 684 824 712 phosphoethanolamine Phosphoethanolamine 52234 38471 76142 124230 56159 3266 13305 10190 19717 6090 76046 159756 171542 190686 59461 10626 11585 3468 2607 4474 phytosphingosine Phytosphingosine 488 280 347 292 451 736 149 894 457 555 145 131 244 508 360 496 1209 935 105 925 proline Proline 60510 61081 58657 71078 56627 80187 326649 87961 217468 233525 78883 96642 128291 85450 113586 178598 248783 90341 203001 192685 pseudo uridine Pseudouridine 506 743 726 426 355 2359 1783 1967 1774 1958 395 335 886 626 1798 1919 1953 2186 2191 2047 putrescine Putrescine 225554 257316 212888 196496 168698 8522 26843 16410 32606 13152 416966 186985 368807 263754 333253 21682 20729 10013 10272 12192 pyrophosphate Pyrophosphate 237210 314141 599635 697384 597834 2724 3073 6687 14882 3849 319916 650376 730434 660584 358343 6607 5516 2617 1176 3344 pyruvic acid Pyruvic acid 116286 107752 6214 8592 141118 2008 4477 3231 5261 2525 86695 40808 37920 40537 71973 4519 3929 2277 1480 2371 ribitol Ribitol 1673 1387 1485 1398 317 7382 6761 6823 6028 6076 1462 1596 1997 1072 1210 6029 6065 6488 6882 6532 ribose Ribose 5727 2246 5492 5508 1897 12429 12047 11467 19534 10546 6750 5955 10526 6211 3899 6933 9402 11015 8982 8757 ribose-5-phosphate Ribose 5-phosphate 2125 2150 3486 4264 2219 998 811 887 828 816 2302 3049 6098 3144 1944 848 870 832 895 852 serine Serine 113774 214801 133538 190822 79795 261740 355036 293181 293573 293033 160961 258838 281996 171935 104740 277205 289227 302962 369728 280295 serotonin Serotonin 6989 10838 5748 9848 8978 631 580 1165 1705 1046 15811 7046 8315 11601 9145 1619 1308 453 249 804 sorbitol Sorbitol 17711 16436 17243 11522 1897 218342 168565 189983 173287 180332 13024 9000 16059 7473 13768 184050 177157 194634 193655 190132 spermidine Spermidine 149220 121215 141013 137817 108310 7457 27319 21420 39262 12403 132240 107145 196029 169201 157588 25837 24207 8902 5504 11371 spermine Spermine 1917 1830 2385 3115 3761 672 1727 813 1319 848 1838 1638 2068 4436 1144 1195 1198 513 334 607 succinic acid Succinic acid 11669 12436 10408 8272 8436 17834 17946 15585 12693 14569 11735 10681 15620 11678 15565 13921 14967 15357 20352 14415 sucrose Sucrose 381 835 2326 415 521 83 7 83 86 54 345 917 642 636 830 90 82 67 70 68 taurine Taurine 37607 39614 81191 122828 6641 31 5281 20 6694 17 38386 273666 289841 185649 114209 2146 18 31 14 38 threitol Threitol 601 500 512 490 408 1318 1281 1221 1273 978 735 509 993 939 770 885 1100 1244 114 747 threonic acid Threonic acid 10656 9555 14630 15238 7619 2024 3693 2904 3569 2044 12288 22245 31394 20792 15697 3196 2899 1769 1738 1814 threonine Threonine 20533 35250 26148 28607 18499 41425 89298 43006 64692 68821 36139 39679 48440 31736 30938 56081 66963 44936 70570 61570 thymidine Thymidine 70279 6446 5300 6085 3981 1025 1155 1270 2090 903 10482 7705 11620 7739 5808 828 1136 1034 844 845 thymidine-5-phosphate TMP 2268 2362 1754 2045 849 160 150 158 190 89 2315 2833 3982 2518 1367 153 258 222 58 112 thymine Thymine 11496 11293 6543 9086 4051 486 902 976 1764 489 13233 13059 21159 11124 12264 721 661 563 351 659 trans-4-hydroxyproline trans-4-Hydroxyproline 31969 29320 41943 42277 20547 186543 259114 175059 170556 132229 61855 79647 75387 77649 53233 175790 186716 199411 266380 89514 tryptophan Tryptophan 16699 23310 18454 18633 7845 44178 41259 50437 49567 49196 18103 22249 29367 23351 15444 49382 46600 57755 46127 46361 tyrosine Tyrosine 54937 69037 83859 10432 18456 344215 298713 315032 284326 311026 52749 108410 147185 95774 56555 289343 293386 335113 333695 303173 UDP-N-acetylglucosamine UDP-N-acetylglucosamine 4441 3417 2143 4675 2810 429 442 384 920 189 4299 6268 10728 6385 4218 456 406 182 348 1088 undecanoic acid Undecylic acid 11228 7521 10107 5338 12702 3235 1155 1375 3946 1233 6296 10103 10829 8806 4821 3716 3095 2175 3739 2672 uracil Uracil 13312 16712 18527 11111 15260 2358 3808 5230 5788 2371 18880 13221 21165 14817 8689 4657 4644 5090 3746 4639 urea Urea 28022 26810 3646 1232 586 144511 146373 155566 144438 120954 38672 239 368 374 29997 140600 147152 122248 164324 144531 uric acid Uric acid 845 1123 937 1465 467 2115 2432 2356 2436 2102 958 1330 1973 1436 2395 2159 2175 1969 2292 2055 uridine Uridine 899 771 557 849 462 72 66 76 98 28 1634 1045 1159 1482 511 46 64 57 66 80 valine Valine 59188 74852 61622 64089 45118 193403 327377 182012 283692 324491 111036 78556 89890 68689 97691 292783 307662 193037 285649 301878 xanthine Xanthine 2292 2729 2732 3889 887 2246 1963 2190 2792 1947 2883 4086 6942 5801 2395 2304 2068 2106 2094 1655 xylitol Xylitol 2774 2054 2394 2112 2181 2947 2490 2752 2678 2251 2202 2135 3703 3216 2567 2511 2454 2520 2536 2451 xylose Xylose 387 304 311 430 177 284 285 168 142 276 440 432 475 687 471 282 250 233 297 166