Metabolite_name	RefMet_name	B10_007	B12_008	B18_009	B20_010	B4_006	B53_016	B54_017	B55_018	B56_019	B57_020	B11_002	B17_003	B19_004	B21_005	B9_001	B48_011	B49_012	B50_013	B51_014	B52_015
Factors	-	Treatment Group:F off-HFD	Treatment Group:F off-HFD	Treatment Group:F off-HFD	Treatment Group:F off-HFD	Treatment Group:F off-HFD	Treatment Group:F off-RD	Treatment Group:F off-RD	Treatment Group:F off-RD	Treatment Group:F off-RD	Treatment Group:F off-RD	Treatment Group:M off-HFD	Treatment Group:M off-HFD	Treatment Group:M off-HFD	Treatment Group:M off-HFD	Treatment Group:M off-HFD	Treatment Group:M off-RD	Treatment Group:M off-RD	Treatment Group:M off-RD	Treatment Group:M off-RD	Treatment Group:M off-RD
1_5-anhydroglucitol	1,5-Anhydrosorbitol	1798	1634	2901	3380	1558	190	813	2476	907	820	1380	4656	5640	3893	3833	893	638	4509	854	2763
1-monopalmitin	MG 16:0/0:0/0:0	4161	2506	3025	2981	4057	512	186	594	551	430	3940	1172	4713	4021	2015	542	512	341	253	528
2_5-dihydroxypyrazine	2,5-Dihydroxypyrazine	24921	28365	28387	34388	12202	412	1413	1632	3562	1020	30542	43657	55804	47076	29470	2534	1644	946	420	936
2-hydroxybutanoic acid	2-Hydroxybutyric acid	57122	76758	15306	17334	43726	5315	4472	4735	3826	3758	149081	22684	23762	30377	46929	3475	4076	5130	5444	4015
2-hydroxyvaleric acid	2-Hydroxyvaleric acid	5989	6861	8900	6235	19236	2814	2520	4507	4334	2805	16388	7381	21004	6047	9722	3709	2523	3236	2859	4260
2-ketoadipic acid	Oxoadipic acid	142511	94041	109633	86497	118390	91763	9211	33036	29936	70183	106864	92791	137432	123099	110932	21601	21343	75075	10199	27338
2-ketoglucose dimethylacetal	D-Glucosone	4858	4975	5487	6598	2783	319	357	520	848	392	3859	6383	9837	821	4669	483	532	310	115	450
3_6-anhydro-D-galactose	3,6-Anhydro-galactose	482	248	384	347	645	1114	1052	1262	1552	731	331	235	196	133	263	1170	986	865	758	1001
3-hydroxy-3-methylglutaric acid	3-Hydroxymethylglutaric acid	554	272	311	403	387	300	240	208	263	259	250	316	565	533	380	256	272	307	129	303
3-hydroxybutyric acid	3-Hydroxybutyric acid	211415	131130	46444	36812	125977	6360	2517	4936	2023	4003	148959	36522	66098	51974	168237	3402	2144	4132	5305	4259
3-phosphoglycerate	3-Phosphoglyceric acid	4084	5651	13698	3084	1778	897	1505	636	2903	894	5860	7293	16725	8303	5808	1539	1707	567	362	749
4-aminobenzoic acid	p-Aminobenzoic acid	589	372	621	454	553	3579	3048	3020	2791	3029	554	389	470	277	542	3061	2842	3243	3381	2951
5-methoxytryptamine	5-Methoxytryptamine	8644	11785	5428	9251	8978	631	580	1166	1558	1046	15166	6695	8089	11140	8497	1522	1220	453	249	804
adenine	Adenine	5185	7001	8658	2160	6663	166	567	1352	1776	482	7744	10808	16927	5436	4795	1107	1413	931	322	962
adenosine	Adenosine	470	488	809	1844	1150	378	155	1540	6014	604	477	1272	4517	1805	1215	2304	859	343	171	629
adenosine-5-monophosphate	AMP	5519	12192	16718	32469	2353	179	189	899	861	416	12588	27969	42151	25803	9990	1081	525	180	153	314
alanine	Alanine	10889	99101	68124	52544	119868	48801	151047	76070	152345	131661	250653	88420	52903	60816	287721	128197	119921	35254	98397	112747
allantoic acid	Allantoic acid	6567	5934	5652	3870	1832	4453	5743	5145	5901	4561	6174	2960	4993	3318	5074	7993	8239	8399	5837	9473
aminomalonate	Aminomalonic acid	8168	15621	7987	15024	6856	4047	1698	2604	4748	3649	14472	17962	16351	15868	8897	3461	3757	1813	1142	4403
arabitol	Arabitol	8067	5671	5789	5595	4261	21060	16673	19375	17302	18330	3200	4891	6651	4718	6578	18526	18321	17623	19160	5967
asparagine	Asparagine	10061	12772	17408	23940	7393	81804	92369	75176	52963	78661	14781	25629	37177	26336	12077	66034	72840	90050	113048	72153
aspartic acid	Aspartic acid	281801	268150	263910	414955	253098	129020	205834	144622	160435	144110	359323	619825	756662	548691	394446	153620	161026	139958	178678	135287
beta-alanine	beta-Alanine	1816	3241	2709	4486	2310	1712	2368	2189	2456	1685	4113	5208	5896	6693	2203	1879	2099	1864	2246	1764
citric acid	Citric acid	107261	97874	113343	134476	92239	33844	37311	38575	50670	32063	114118	147954	232344	159390	120199	42817	36603	33087	29536	33135
citrulline	Citrulline	18027	26307	18541	26143	8307	180008	172825	165995	148188	175784	29656	31750	31364	27869	16629	157891	144012	196892	178532	156326
creatinine	Creatinine	38363	22798	28538	37385	15813	88497	31776	59228	87134	64550	8625	3334	64279	31983	38701	74399	35356	70170	70995	40839
cyanoalanine	Cyanoalanine	2477	1766	2636	2460	1268	2995	8342	3062	4586	7283	2347	3122	4862	2903	3312	5734	5187	3207	5815	5028
cysteine	Cysteine	1381	2510	1494	3419	1864	854	8793	2330	8078	3078	4049	4726	5504	1995	2800	5752	4654	1271	1902	1953
cystine	Cystine	2596	1043	1837	1694	903	111230	89040	89294	64270	97847	1634	1561	3293	1554	2162	74422	82887	113689	144348	99404
cytosin	Cytosine	3965	10114	16828	12943	7818	394	1766	1579	2839	722	8462	14898	27875	18776	6978	1754	1710	1022	613	1151
dehydroascorbic acid	Dehydroascorbic acid	2435	2310	8051	8742	1322	171	380	433	2498	174	2002	32679	31596	12729	2987	568	706	410	138	183
diglycerol	Diglycerol	17800	14306	21159	23462	11729	1783	1842	2167	3904	1284	17341	25274	34110	24361	20376	3009	1826	1277	818	1306
erythritol	Erythritol	16497	14226	14187	11688	532	76458	72318	71930	65497	67399	15811	9625	14264	10052	14158	68264	67632	68622	78532	70104
ethanolamine	Ethanolamine	125925	129567	107687	108361	69248	10491	35663	22664	80861	12513	160875	124545	173021	154677	136524	28712	26459	10881	6589	12132
fructose	Fructose	64778	52893	54650	47221	1053	386573	317315	351693	334752	342708	61537	33107	52719	33301	50129	343698	329652	355844	365283	342959
fructose-6-phosphate	Fructose 6-phosphate	1869	1423	3728	4873	2004	111	156	130	442	99	2324	4668	9284	4041	1600	228	175	107	98	97
fumaric acid	Fumaric acid	30660	29731	21132	24453	20917	3046	5118	3667	6254	2844	37669	31943	37498	31567	34371	4419	3855	2613	2486	2717
galactitol	Galactitol	13716	10654	11523	8154	312	157790	129064	139830	122257	131742	13650	5562	9123	5811	9920	126554	126327	139175	138651	133950
gluconic acid	Gluconic acid	429	264	493	509	236	1232	1147	1339	1894	997	440	251	565	380	329	939	1150	1098	1090	1288
glucose	Glucose	239312	193993	193465	125750	48519	1958360	1080509	2111464	1990402	1772245	218236	89607	132921	92384	176354	1988181	1755324	1911919	1188786	2007020
glucose-1-phosphate	Glucose 1-phosphate	12484	11093	33166	26459	17554	4894	5238	6600	4978	5026	12656	22761	41272	18530	15530	5068	4763	4757	7191	6149
glucose-6-phosphate	Glucose 6-phosphate	3649	3692	7831	11080	6372	689	887	946	837	683	5012	9532	17771	7421	2765	1026	781	641	1543	650
glutamic acid	Glutamic acid	122258	118294	225174	272566	97193	94238	139570	95406	118175	87859	120705	381266	505383	346393	184005	99376	100509	92141	109372	77255
glutamine	Glutamine	41727	36753	29900	28911	10746	863469	1006540	778741	506862	824652	26107	22133	36874	22751	37455	750107	813051	976489	1184967	796060
glyceric acid	Glyceric acid	5804	5323	5528	2871	3299	4061	4481	3849	5972	3515	5261	3959	8226	5354	5231	4306	3377	3731	3934	2992
glycerol-alpha-phosphate	sn-Glycero-3-phosphate	7245	6590	11797	13307	5309	1144	1532	1617	3132	800	8271	11645	11899	11760	8223	941	1435	926	687	250
glycine	Glycine	122775	204003	165188	224879	113920	71101	94056	74994	85880	68633	207872	262534	297764	252441	144033	78880	75080	69088	85996	67052
glycolic acid	Glycolic acid	13633	8959	7731	6618	7436	2150	1238	1865	1776	1888	8852	6229	9028	9596	7889	2419	1639	2112	1332	1628
guanosine	Guanosine	792	771	512	750	505	116	202	214	1012	120	1094	1052	2027	1323	749	265	268	106	35	101
histidine	Histidine	3376	3581	2979	2997	897	43807	64344	54432	49181	62680	3327	2922	4333	3549	3013	47409	51956	78256	73396	50500
hypoxanthine	Hypoxanthine	28070	22814	15557	23790	3858	10905	9494	10555	24002	8545	36443	50078	50621	44020	20031	13250	8001	8675	6802	6785
indole-3-lactate	Indolelactic acid	345	312	361	253	263	364	375	469	575	589	340	181	386	267	294	612	389	691	376	415
inosine	Inosine	7221	5591	1732	4075	661	2532	2129	1640	7949	1723	11026	8268	11732	7283	8831	2713	1989	1581	870	1098
inosine 5^-monophosphate	IMP	3566	9647	685	5425	527	46	31	71	129	52	17495	35813	20000	28895	13646	78	38	62	30	73
isocitric acid	Isocitric acid	3078	2701	3299	4750	3288	845	845	946	1180	787	2833	5026	6752	4980	3079	1067	775	809	708	837
isoleucine	Isoleucine	145380	182077	146573	158914	52962	712476	857134	713540	749658	812789	210360	95096	195316	144148	146555	754458	789059	716018	868667	811979
isomaltose	Isomaltose	506	344	448	383	398	369	154	259	351	360	359	320	404	318	415	440	443	304	146	89
isothreonic acid	D-Threonic acid	2197	1838	667	1749	446	8553	8656	7212	6513	6738	1612	1777	2770	2108	1848	6688	6998	7884	9505	5140
kynurenine	Kynurenine	518	332	292	225	446	436	164	425	560	403	272	320	713	564	284	458	510	526	181	78
lactic acid	Lactic acid	172486	148121	119886	129363	40588	229026	319169	278283	257019	270988	172292	175348	200290	127202	175812	309174	266050	341907	125554	266242
leucine	Leucine	210170	170500	231342	257261	106349	752055	850399	753473	906848	1002673	253830	280647	353140	269581	214872	869744	969296	759584	851761	953585
levoglucosan	Glucosan	2691	1323	4628	2302	1644	2943	930	673	707	650	1462	2054	4600	2180	1955	756	520	656	2856	2601
lysine	Lysine	6870	7113	5547	5437	2074	51403	53664	47237	37468	48900	6659	5924	9201	7114	6198	43444	43326	51586	58926	46362
lyxitol	L-Arabitol	6602	5287	6122	5327	4212	17237	16170	16039	13643	15175	6387	5296	8053	6390	6223	15607	1508	15938	16749	14556
lyxose	Lyxose	685	747	1206	873	553	1534	1356	988	839	1188	1734	1827	2264	1149	876	1268	960	365	1147	301
maleimide	Maleimide	27034	22670	71678	69917	25898	4015	1363	8274	15611	15079	21490	87572	9938	87804	38762	12968	7485	4879	2652	14231
malic acid	Malic acid	34154	37268	16595	22633	24705	4602	4890	4375	7153	3787	48364	40477	43304	11134	43319	4890	3929	3847	3733	3457
maltose	Maltose	601	799	1115	912	570	1450	629	1039	1340	1608	1121	1002	1533	1005	775	495	629	742	959	214
mannitol	Mannitol	2429	2298	1750	1370	365	19109	20808	17272	14301	17420	2106	1445	1605	1257	1803	9115	15729	5716	23836	16150
mannose	Mannose	1857	2106	1668	1903	586	5498	3312	6926	6864	3470	663	1750	2003	1149	1342	5804	4495	5273	2686	962
methanolphosphate	Methanolphosphate	471152	311376	335305	247942	132177	31450	56059	46132	141820	27512	462633	322596	700056	381859	382729	48921	49013	27567	19300	28597
methionine	Methionine	23742	25667	28867	36722	17242	72562	91169	69563	71687	77348	28236	49770	58621	39383	23794	71713	74294	74668	95063	75407
methionine sulfoxide	Methionine sulfoxide	9877	10510	8110	8809	5755	18200	11312	6704	9088	9891	14667	8981	13284	10575	10026	8878	7598	9859	11918	8132
myo-inositol	Myo-inositol	134325	99468	128010	113355	43350	617051	362015	525714	504159	496691	128336	110661	158704	102892	116062	509843	507459	535733	413713	537565
nicotinamide	Niacinamide	12383	15901	15631	19411	6684	6957	7401	7512	6828	6464	20773	29279	39334	24274	16365	8124	7342	5874	5931	6160
ornithine	Ornithine	64558	76514	65574	72160	23110	583422	733871	557740	509249	556966	70271	111451	129479	96481	67573	526994	516347	632149	715784	475694
oxalic acid	Oxalic acid	47996	64538	13264	12414	37278	455	656	546	799	392	129298	17731	19875	19294	38812	700	451	401	469	820
oxoproline	Oxoproline	896928	950208	986086	993258	375293	2267265	2407252	2029186	1857255	2046876	958168	1302484	1706833	1082544	965960	1907961	2064641	2071432	2587205	1977237
palmitoleic acid	Palmitoleic acid	446	715	512	316	441	51	22	83	42	61	386	243	475	262	2152	36	26	32	20	58
pantothenic acid	Pantothenic acid	1119	907	827	1137	698	1695	1559	1273	1626	1237	1021	883	1825	1590	1165	1460	1636	1379	1558	1524
parabanic acid	Parabanic acid	4620	4528	2915	1828	6088	677	898	757	883	570	17250	3920	4184	3923	5757	578	748	719	479	855
phenol	Phenol	38941	23585	29616	12477	26656	8554	4651	3568	1055	3617	21753	24191	39352	31583	28300	1659	861	5427	6342	6475
phenylalanine	Phenylalanine	21944	44233	44310	52093	12976	111365	101605	104653	100779	101232	30769	70257	83114	61796	29333	99029	96131	105277	110775	103292
phosphate	Phosphoric acid	6571984	6579256	6442799	6104752	8483831	635817	386635	991283	943240	675650	5479537	4726603	2374497	5047143	5914589	926937	846547	707442	215439	915897
phosphoenolpyruvate	Phosphoenolpyruvic acid	3489	6230	5492	11731	1574	1138	2522	1728	2155	1051	8248	12150	11536	12914	4360	2253	1472	684	824	712
phosphoethanolamine	Phosphoethanolamine	52234	38471	76142	124230	56159	3266	13305	10190	19717	6090	76046	159756	171542	190686	59461	10626	11585	3468	2607	4474
phytosphingosine	Phytosphingosine	488	280	347	292	451	736	149	894	457	555	145	131	244	508	360	496	1209	935	105	925
proline	Proline	60510	61081	58657	71078	56627	80187	326649	87961	217468	233525	78883	96642	128291	85450	113586	178598	248783	90341	203001	192685
pseudo uridine	Pseudouridine	506	743	726	426	355	2359	1783	1967	1774	1958	395	335	886	626	1798	1919	1953	2186	2191	2047
putrescine	Putrescine	225554	257316	212888	196496	168698	8522	26843	16410	32606	13152	416966	186985	368807	263754	333253	21682	20729	10013	10272	12192
pyrophosphate	Pyrophosphate	237210	314141	599635	697384	597834	2724	3073	6687	14882	3849	319916	650376	730434	660584	358343	6607	5516	2617	1176	3344
pyruvic acid	Pyruvic acid	116286	107752	6214	8592	141118	2008	4477	3231	5261	2525	86695	40808	37920	40537	71973	4519	3929	2277	1480	2371
ribitol	Ribitol	1673	1387	1485	1398	317	7382	6761	6823	6028	6076	1462	1596	1997	1072	1210	6029	6065	6488	6882	6532
ribose	Ribose	5727	2246	5492	5508	1897	12429	12047	11467	19534	10546	6750	5955	10526	6211	3899	6933	9402	11015	8982	8757
ribose-5-phosphate	Ribose 5-phosphate	2125	2150	3486	4264	2219	998	811	887	828	816	2302	3049	6098	3144	1944	848	870	832	895	852
serine	Serine	113774	214801	133538	190822	79795	261740	355036	293181	293573	293033	160961	258838	281996	171935	104740	277205	289227	302962	369728	280295
serotonin	Serotonin	6989	10838	5748	9848	8978	631	580	1165	1705	1046	15811	7046	8315	11601	9145	1619	1308	453	249	804
sorbitol	Sorbitol	17711	16436	17243	11522	1897	218342	168565	189983	173287	180332	13024	9000	16059	7473	13768	184050	177157	194634	193655	190132
spermidine	Spermidine	149220	121215	141013	137817	108310	7457	27319	21420	39262	12403	132240	107145	196029	169201	157588	25837	24207	8902	5504	11371
spermine	Spermine	1917	1830	2385	3115	3761	672	1727	813	1319	848	1838	1638	2068	4436	1144	1195	1198	513	334	607
succinic acid	Succinic acid	11669	12436	10408	8272	8436	17834	17946	15585	12693	14569	11735	10681	15620	11678	15565	13921	14967	15357	20352	14415
sucrose	Sucrose	381	835	2326	415	521	83	7	83	86	54	345	917	642	636	830	90	82	67	70	68
taurine	Taurine	37607	39614	81191	122828	6641	31	5281	20	6694	17	38386	273666	289841	185649	114209	2146	18	31	14	38
threitol	Threitol	601	500	512	490	408	1318	1281	1221	1273	978	735	509	993	939	770	885	1100	1244	114	747
threonic acid	Threonic acid	10656	9555	14630	15238	7619	2024	3693	2904	3569	2044	12288	22245	31394	20792	15697	3196	2899	1769	1738	1814
threonine	Threonine	20533	35250	26148	28607	18499	41425	89298	43006	64692	68821	36139	39679	48440	31736	30938	56081	66963	44936	70570	61570
thymidine	Thymidine	70279	6446	5300	6085	3981	1025	1155	1270	2090	903	10482	7705	11620	7739	5808	828	1136	1034	844	845
thymidine-5-phosphate	TMP	2268	2362	1754	2045	849	160	150	158	190	89	2315	2833	3982	2518	1367	153	258	222	58	112
thymine	Thymine	11496	11293	6543	9086	4051	486	902	976	1764	489	13233	13059	21159	11124	12264	721	661	563	351	659
trans-4-hydroxyproline	trans-4-Hydroxyproline	31969	29320	41943	42277	20547	186543	259114	175059	170556	132229	61855	79647	75387	77649	53233	175790	186716	199411	266380	89514
tryptophan	Tryptophan	16699	23310	18454	18633	7845	44178	41259	50437	49567	49196	18103	22249	29367	23351	15444	49382	46600	57755	46127	46361
tyrosine	Tyrosine	54937	69037	83859	10432	18456	344215	298713	315032	284326	311026	52749	108410	147185	95774	56555	289343	293386	335113	333695	303173
UDP-N-acetylglucosamine	UDP-N-acetylglucosamine	4441	3417	2143	4675	2810	429	442	384	920	189	4299	6268	10728	6385	4218	456	406	182	348	1088
undecanoic acid	Undecylic acid	11228	7521	10107	5338	12702	3235	1155	1375	3946	1233	6296	10103	10829	8806	4821	3716	3095	2175	3739	2672
uracil	Uracil	13312	16712	18527	11111	15260	2358	3808	5230	5788	2371	18880	13221	21165	14817	8689	4657	4644	5090	3746	4639
urea	Urea	28022	26810	3646	1232	586	144511	146373	155566	144438	120954	38672	239	368	374	29997	140600	147152	122248	164324	144531
uric acid	Uric acid	845	1123	937	1465	467	2115	2432	2356	2436	2102	958	1330	1973	1436	2395	2159	2175	1969	2292	2055
uridine	Uridine	899	771	557	849	462	72	66	76	98	28	1634	1045	1159	1482	511	46	64	57	66	80
valine	Valine	59188	74852	61622	64089	45118	193403	327377	182012	283692	324491	111036	78556	89890	68689	97691	292783	307662	193037	285649	301878
xanthine	Xanthine	2292	2729	2732	3889	887	2246	1963	2190	2792	1947	2883	4086	6942	5801	2395	2304	2068	2106	2094	1655
xylitol	Xylitol	2774	2054	2394	2112	2181	2947	2490	2752	2678	2251	2202	2135	3703	3216	2567	2511	2454	2520	2536	2451
xylose	Xylose	387	304	311	430	177	284	285	168	142	276	440	432	475	687	471	282	250	233	297	166