Metabolite_name RefMet_name K562_100nM_FA_Inosine_HILIC_1 K562_100nM_FA_Inosine_HILIC_2 K562_100nM_FA_Inosine_HILIC_3 K562_100nM_FA_Vehicle_HILIC_1 K562_100nM_FA_Vehicle_HILIC_2 K562_100nM_FA_Vehicle_HILIC_3 K562_2000nM_FA_Inosine_HILIC_1 K562_2000nM_FA_Inosine_HILIC_2 K562_2000nM_FA_Inosine_HILIC_3 K562_2000nM_FA_Vehicle_HILIC_1 K562_2000nM_FA_Vehicle_HILIC_2 K562_2000nM_FA_Vehicle_HILIC_3 Factors - Treatment:100nM_FA_Inosine Treatment:100nM_FA_Inosine Treatment:100nM_FA_Inosine Treatment:100nM_FA_Vehicle Treatment:100nM_FA_Vehicle Treatment:100nM_FA_Vehicle Treatment:2000nM_FA_Inosine Treatment:2000nM_FA_Inosine Treatment:2000nM_FA_Inosine Treatment:2000nM_FA_Vehicle Treatment:2000nM_FA_Vehicle Treatment:2000nM_FA_Vehicle 2_3-BPG 2,3-Diphosphoglyceric acid 27916530.3600 28464914.9100 27817838.9500 17980351.3800 18528060.5700 18921455.3900 28373622.1600 24826798.4100 26713251.8100 24510761.4100 25762527.4000 25561335.4700 2-hydroxybutyric acid 2-Hydroxybutyric acid 4045274.3320 3166420.1510 3358720.9860 2777836.5750 2505461.4210 2379756.9690 3317568.1360 3585722.8280 3540124.1310 3208167.4050 3417997.5930 3453362.3160 2-hydroxyglutarate 2-Hydroxyglutaric acid 1122436502 1268625699 1046134687 1177419977 1093722514 1234811936 1063046060 1132674327 1082752409 1176531769 1059873834 1099901554 2-oxobutyric acid 3-Methyl pyruvic acid 43155047.3400 51804401.7700 47424067.5500 44140219.3800 44477736.1600 50141083.4900 46836787 44342353.5700 40182513 39854009.9500 49000744.9800 45546164.7700 3-methyl-2-oxopentanoic acid 3-Methyl-2-oxovaleric acid 140938726.6000 122829937.8000 112851817.2000 83703620.3000 93463734.0900 72285921.2000 124670063.3000 115783220.7000 124090140.2000 126642172 140602104.4000 139750270.9000 3-phosphoglycerate 3-Phosphoglyceric acid 37322686.6000 39430468.5800 37894397.3600 31638065.7600 30913425.2500 33633731.0500 38951476.7300 36897580.7900 36295152.8700 40481799.6900 40922123.7600 44457486.8400 6-phosphogluconate 6-Phosphogluconic acid 16380131.7700 16441543.6700 14902515.7100 12998572.2200 12612414.2500 11682489.8900 16326955.9200 16719463.5800 15253371.8900 19329161.0300 20187754.0700 18568356.0300 acetylcarnitine CAR 2:0 231379580.5000 204919633.5000 210077873.7000 238885487 213117761.6000 232235743.5000 208578914 194051179.7000 205483539.2000 179566368 166981770.2000 183951727.9000 Acetyl-CoA Acetyl-CoA 17702182.6600 18145384.0200 19138892.6600 15032009.0100 15401203.7100 14579797.3900 18603967.6200 19007748.2600 18036751.3900 17814070.8400 17860707.6500 17388804.2800 ADP ADP 37110423.3500 38665106.3500 51107398.8200 21361902.2300 25850644.9300 18087774.4500 53053924.2400 55388160.6000 54462214.6400 24873233.1400 32794991.8000 26453942.4700 alanine Alanine 29199770.8700 31470702.4400 30866979.1600 39005866.4200 45510999.2300 46132689.6100 26519863.9100 33949776.8800 33717157.3800 33492901.8100 32547271.5100 38335042.6300 Alpha-Ketoglutarate 2-Oxoglutaric acid 34857028.6500 38714052.0800 37036681.0700 31681656.6300 26279448.6300 31836929.8600 30974833.8500 34048040.7800 30106853.1600 37154471.3700 41600390.0700 39328567.0800 Alpha-Lipoic Acid Lipoic acid 28420636.5300 35313893.3500 32286098.6900 32618113.6700 32871257.3200 35087154.5400 29938369.2100 25465721.0400 25796370.6800 33931671.3000 39819813.1400 37035521.2900 AMP AMP 4358240.5110 4147985.8410 4712635.1530 3351117.7570 3654088.4570 3574853.2900 3933498.3970 3473416.0060 3406089.9130 4419559.5590 4212682.6780 4117679.0410 arginine Arginine 2462899601 2347970020 2617248707 2541818326 2748658955 2533345885 2536977350 2786994297 2960924773 2261218868 2473240857 2397513256 argininosuccinate Argininosuccinic acid 31623916.9700 31627569.1500 35845861.5500 33029313.1100 28335611.4200 31750969.6900 31969232.2500 32074544.8700 31012602.7600 40515049.8000 36812935.8300 38242710.6500 asparagine Asparagine 939959160.9000 912396131.7000 848739317.7000 1012742258 1017981641 1039079851 839152978.5000 850331988.1000 816452370.2000 995870521.6000 950727918 959653901.9000 aspartate Aspartic acid 226170538.6000 214320570.8000 193869381.8000 268354646.7000 254539094.4000 276804232.3000 195182659.1000 173932095 183080561.9000 214577813.1000 188893566.5000 198310296.5000 ATP ATP 404944607.6000 449402232.1000 622537388 280678569.7000 353639848.1000 236272535 606009802 564413194.2000 552836017.5000 325327269.9000 399660151.9000 328251386 beta-alanine beta-Alanine 158362089.4000 162826671.9000 162513174 172640328.2000 169366404.4000 181987810.8000 159644970.1000 165464556.4000 152792840.4000 185046657.7000 165891147.7000 179744013.3000 Butyrylcarnitine CAR 4:0 22179755.9900 20284773.9400 19661760.2900 20622393.4300 18411473.3300 20528789.8600 19221599.5900 20750509 21399021.6500 23366264.3400 22801734.6100 24356207.1400 C5-Carnitines 130590406.8000 124477569 126005227.5000 169669274.9000 146623561.4000 171245154.5000 118775440.4000 114429904.8000 124940493.1000 149639915.6000 139836819.8000 151611609.5000 carnitine Carnitine 172461379.4000 161585695.1000 162990685.2000 164684537.7000 163058923.2000 169712342.9000 166962488.3000 171842114.9000 173807909.1000 196954595.9000 176081655.1000 196194990.1000 CDP-choline CDP-choline 797874.6299 843872.3426 820765.2981 582546.8330 788684.5103 670797.5022 900941.5314 711616.9966 651109.2590 964662.3112 650279.0066 866781.9569 cis-aconitate cis-Aconitic acid 25445734.6200 24909780.3100 26284315.8400 28424504.6800 27390270.4100 27098014.0200 24031999.7000 27397948.2700 26147933.6400 26440510.8600 24618821.4000 26186648.8200 citrate Citric acid 760826455.2000 748854503.1000 748684152.6000 910300235.7000 811823753.1000 837739638.8000 727766138.3000 800987628.2000 777085794.9000 764307094.3000 764615030.5000 767780478.9000 Coenzyme-A Coenzyme A 7432296.5590 8260704.6230 7507671.5550 6481675.3660 7021450.8950 7174045.8670 4925484.3180 8549628.6100 8417812.4090 5529453.0660 6100720.7040 8293395.9450 creatine Creatine 929287845 1060333731 1021058336 1396363666 1383195589 1462709711 948809246.2000 1251234400 1123862291 1071779849 1163464420 1230012950 CTP CTP 18433918.1400 20425940.5800 28697366.6900 35436149.7600 43947182.0900 30413588.0300 28732552.7800 25720471.7800 25330864.5200 31355671.9300 39658126.5300 30280996.7200 dATP dATP 5447330.1750 5612354.7720 7424747.4780 1955609.1080 2838059.8740 2009190.0250 8145570.9600 7239708.2000 7417971.3350 3245744.7450 3429464.8270 3073200.2280 dCTP dCTP 1235891.9950 1303628.7180 1964657.7900 677946.1194 962062.3745 641308.3350 1982326.9700 1731895.1490 1640909.1040 1221988.9710 1306488.3610 1032034.7960 dihydroxyacetonephosphate Dihydroxyacetone phosphate 12926900.0100 11125326.1700 10447157.5900 6042305.7510 5885170.1890 5575560.7020 11149503.6100 11428225.3000 11157547.6000 11098713.1300 8748535.5720 8744466.8960 erythrose-4-phosphate Erythrose 4-phosphate 843923.0667 713785.6159 735423.3666 984006.1756 616214.0881 831366.8604 829093.0577 622006.7339 905354.3698 829193.2583 796680.8243 845750.5145 F6P G1P 19809495.7500 20028267.3300 17568105.4800 20731759.6900 19889702.6800 18859966.1800 18961874 19246350.0400 18042983.1100 21299300.2400 20441556.1400 20324633.8200 folic acid Folic acid 16069.9943 751157.1218 701865.2915 908587.5987 468714.9438 790376.8543 538065.2989 formyl methionine N-Formylmethionine 26484364.2300 26159166.7500 24755827.0100 20514368.1800 19525483.6300 19420675.8900 24326887.6700 17790616.0400 19071371.5200 26031782.8200 25816836.2400 26537456.8600 Fructose-1_6-bisphosphate Fructose 1,6-bisphosphate 45745043.6600 47258446.1200 51497312.6300 33213798.0300 32954849 34391980.9400 44757735.8100 43865620.5200 43989975.6500 39913072.3100 43020976.7800 40765998.5600 fumarate Fumaric acid 84312715.4600 84380579.6100 83031779.9700 58069884.5600 60564896.3100 59214354.0500 84213013.6200 82889817.4300 79555794.6500 88206266.6800 85918236.9200 93701722.5000 GAR GAR 15206.0242 29505992.2000 27072418.8700 30416636.9000 14310497.6800 14474068.5500 13158779.2500 GDP GDP 3364959.8660 3266488.4790 3202566.2530 2012067.5550 2282782.2800 2364955.0460 3048058.8530 3417492.0680 3646976.0370 3191726.5100 3342972.8780 3388511.6630 Glucose-6-phosphate Glucose 6-phosphate 20894236.2700 20734491.5900 18962740.1400 26343559.2400 23546910.7200 24322986.2600 20611850.6800 20879466.3400 19521237.5500 24414771.2000 23330981.7600 23823796.6100 glutamate Glutamic acid 1880425690 1902178052 1622813018 2071216662 1864922577 2055958414 1647139969 1510510128 1598037278 1957414715 1740298216 1842753505 glutamine Glutamine 7735368317 8015080232 7950549109 9290749471 9590815893 9504237648 7809530823 8234746528 8017573894 8433095336 8271781963 8267180877 glycerate Glyceric acid 189576947.9000 201804496 194883226.3000 217196127.8000 206600160.3000 231070483.9000 193122147.1000 240534627.5000 218821828.6000 200444761.2000 205324902.3000 208841288.4000 Glycerol-3-Phosphate sn-Glycero-3-phosphate 21948918.0700 21888474.4500 21463131.0700 14127482 14226099.3300 13206861.3900 21670461.1000 21624943.7400 21017500.0600 19418718.9300 19065804.7900 19938242.8600 Glycerophosphocholine sn-Glycero-3-phosphocholine 20429666615 20093173140 21033937151 7170782848 7523021460 7250291508 18830801008 21296280148 21258616527 13616364746 14107126196 14950675962 glycine Glycine 41815155.8300 40356111.7700 35867932.5100 45782800.8000 41022971.0500 45314740.7500 68966143.3100 68910683.4100 67211072.3100 72271692.6100 63675538.7400 66525511.7600 GSH Glutathione 4225351624 5467620808 4884573289 4548571403 4573489134 4703643325 4559525215 3041474556 2784605138 4951583205 5004570310 4907125978 hydroxyproline gammaALA 155394463.8000 159660133.6000 140107574.3000 195090666.7000 165763048 198638545.8000 141370131.9000 123043921.7000 124851208.3000 191093856.3000 165648509.3000 177241916.4000 hypotaurine Hypotaurine 2916640.8270 3284122.0090 3417136.4970 3606345.9770 4008631.6390 3129365.6830 3240627.7350 2958079.0840 2356922.2500 3103578.5590 3121016.6600 3084005.6190 hypoxanthine Hypoxanthine 1434022844 1332376611 1381406215 1472591.9260 1081994.4080 1382656.0050 1433524024 1505148022 1437190026 1628495.5280 1624939.0300 1401883.8650 IMP IMP 6503116.6960 6215874.5700 5791554.7020 7479965.7210 7397888.2450 8206158.2270 6009806.4140 6259602.4950 5707452.7130 12637778.0600 11735909.1300 12619867.1700 leucine Leucine 2200767877 1941528876 2011114274 2170014668 2022864016 2122053718 2018006242 2183622236 2198737942 2050808859 1920346805 2129164883 lysine Lysine 59951049.1900 55315713.9900 58524544.6700 63720031.0400 75063454.7300 60294355.6900 59890433.0500 63411951.2900 67291891.6200 50176783.5000 56565016.3400 50482955.8500 malate Malic acid 900797716.3000 878169565.2000 915382617.2000 650047155.1000 662989873.5000 652173620.7000 862744792 898364968.5000 872590109.1000 981287687.4000 940692027.5000 1038878261 malonyl-CoA Malonyl-CoA 1216617.8380 1376128.4590 1167944.1120 919094.6530 918629.2654 809840.0090 1171193.1600 1424810.4810 1179587.1300 1258110.0570 1129243.1810 1269230.2850 methionine Methionine 800411936.1000 772606698 802145860.1000 864634580.7000 852023017.8000 863411067.4000 773013002.8000 778698527.7000 819069076.5000 797104546.8000 759918211.1000 731197429.2000 methylthioadenosine Methylthioadenosine 409637876.6000 341885853.6000 359943738.1000 311285636.2000 305916038.8000 285768955.5000 381124954.3000 428654105.2000 491792387.4000 372643885.8000 347750693.8000 370165087.1000 N-acetylaspartate N-Acetylaspartic acid 24659854.2400 29452087.4800 23612772.2500 37773763.6500 34962836.6100 33049695.0400 27491540.6800 23493276.3300 22442135.7900 35500162.9100 30098052.5200 25985359.2700 N-acetylmethionine N-Acetylmethionine 8395244.2630 7746210.6290 8075289.8070 3770858.0150 3277129.7550 3456740.8860 8229445.6590 7521520.9730 9311917.0150 7244391.1140 5311058.6920 7090277.6500 N-acetylphenylalanine N-Acetylphenylalanine 1409909.0410 1458302.7920 1160618.9030 989059.7988 1053237.3000 1182496.6360 1214452.4360 1117073.3060 1178436.8520 1313356.4750 1205458.8600 1184700.4170 NAD. NAD 378325394 410442948.2000 378145190.1000 367723160.7000 352957096.6000 354903234.5000 367178629 390679772.6000 384855822.2000 406195551.8000 391893122.5000 398280218.6000 NADP NADP 11479012.9200 11428593.0900 10248721.4200 9811498.7960 14337125.7000 11814355.8400 10105390.4500 11980194.5700 12514367.1900 11017708.9200 13540623.3900 11156912.0900 niacinamide Niacinamide 226518526.6000 218231054.8000 199302718.3000 234711791.5000 249871424.9000 204734344.2000 225314736.9000 282237874.3000 319609923.1000 227230986.3000 232429329.6000 225298004.3000 O-phosphoethanolamine Phosphoethanolamine 1560312.4990 1816532.3680 1806595.1750 3013785.0330 2959486.3630 3247978.5630 1743723.4850 1864717.0120 1745085.7860 2115772.7720 2140022.9090 2261643.7890 Pantothenate Pantothenic acid 939131178.4000 946519798.2000 986242627 766948760.6000 764094560.2000 761524677.1000 978568359.3000 1043239461 966925222.4000 868482303.1000 853456315.7000 874100624.8000 phenylalanine Phenylalanine 241767418.7000 207170476.1000 218104604.5000 234939162 213133420.6000 240271569.9000 202755267.5000 202915595.3000 204225108.9000 210072463.9000 196350200.2000 212117302.4000 phosphocholine Choline phosphate 18997816798 20104033245 21072199212 15982022679 15346991584 14957183878 19614345124 23244848636 21833673422 17777775205 16857361119 17622876623 phosphocreatine Phosphocreatine 102789597.2000 110561173.4000 108484829.3000 109292117.1000 110135141 107008914.5000 108359552.7000 105802126.8000 93562124.8100 104469355.7000 102003094.5000 96254251.9900 phosphoenolpyruvate Phosphoenolpyruvic acid 16309552.4800 18659313.1300 18891376.1800 13421563.4500 14911227.1300 14978849.7200 18181149.3600 16742477.8700 17196983.4200 19309292.2500 21050162.6900 21009962.3700 proline Proline 9195979021 9285640865 9766159106 10647375402 10232692129 10163812712 9481128593 10025042519 9600355341 10534459293 9738497765 10449748552 propionylcarnitine CAR 3:0 70391378.5100 61311072.6700 63616964.7000 68445622.9500 58715879.1200 66148285.9800 55692807.2300 54450087.4700 59169154.6100 71376464.1300 62640434.5300 70018794.1900 PRPP Phosphoribosyl pyrophosphate 833710.5723 901402.2491 856833.9854 30363306.8500 33892030.9200 31241608.7100 1114315.0320 5037562.6490 5110096.0890 4939400.7210 Pyridoxine Pyridoxine 280431881 262266726.5000 255505631.9000 243584821.4000 277450088.6000 233183066.5000 286555961.3000 270064037 286207829.4000 261116370.6000 284727108.4000 278370084.1000 pyruvate Pyruvic acid 18544760.7700 19068810.9600 15838338.9700 9791812.0720 10657186.9600 10839103.8100 15600038.9900 12339135.9600 7557977.9740 17018851.3900 20797135.6300 19872208.6800 quinolinic acid Quinolinic acid 705841.4556 689740.8482 802769.0332 721584.2369 807421.0179 849431.4352 586148.0285 630013.9544 719934.6001 640352.0593 750211.4463 580514.6276 Ribose-1-phosphate Ribose 1-phosphate 306494.9492 316390.5387 263305.8735 2877906.1430 2545250.9730 2836572.1880 298161.6353 320327.7768 304777.3782 649171.2796 619662.4633 646905.8249 Ribose.Ribulose.5.phosphate.3Me.Lys 3489098.0310 3454863.5440 3034127.0580 3231854.8140 3060312.2150 3177471.5770 3025222.4010 3124855.7010 3243149.1090 3595944.8620 3411144.7620 3480276.7290 S-Adenosyl-L-Homocysteine S-Adenosylhomocysteine 7722575.5180 8291463.0830 8568367.4960 7219944.3880 7440247.7890 6256299.7720 7951664.3620 10069769.7500 9560004.6560 7713284.4300 6989234.6260 8273395.0200 Sedoheptulose-7-phosphate Sedoheptulose 7-phosphate 5914587.2810 6466964.5610 5369502.4900 4237614.9210 4157913.7040 3962112.9230 5711459.3350 6049801.1440 5623838.8190 5038516.4640 4882547.4380 4786247.3040 serine Serine 130407182.5000 121299568.3000 115657185.1000 124758573 126442292.8000 133024035.1000 74223798.2200 72782298.4000 69442370.9700 55915011.2200 57413599.6000 51398459.1600 succinate Succinic acid 51424882.4900 40907896.8400 33881340.2800 35203302.4500 33822836.8400 36664800.2200 42153372.7500 62137154.3100 52002551.5500 45505817.6100 38678940.0500 43089870.2800 taurine Taurine 46555778.8500 44845443.5600 43674281.3700 49303623.9200 47231918.0700 47627183.3000 41241239.7700 46005746.3600 40560528.3500 44544284.3000 46032468.4900 46365910.4200 threonine Threonine 353015671.1000 430604463.9000 455703809 513977791.8000 572993847 475284021.7000 398444817.1000 336141996.5000 323674459.2000 432888090.5000 477550983.6000 448232126 tryptophan Tryptophan 327312627 313235875.6000 321330670.8000 327063490.6000 312022986.6000 317586800.7000 318399542 300000400.2000 303884209.1000 314112909.6000 292402828.4000 286659758.2000 tyrosine Tyrosine 764580657.1000 733481616.8000 748542616.7000 802033439.2000 795914470.6000 791325867.6000 734442219.5000 804779836.9000 810785490.2000 781150505.6000 700446679.1000 760145520 UDP UDP 2650713.7590 2666554.8280 2992438.5220 5953542.7190 5977603.1890 6348854.6150 2608790.1540 3635394.3770 4522929.2130 4597212.3170 5774758.5690 5328957.7770 UDP.GlcNAc UDP-N-acetylglucosamine 133102843 133937328 127385073 139572950.3000 133672965.5000 133766515.4000 123555268.3000 129297354.6000 121669281.5000 187196641.9000 169838073 181776612.9000 UMP UMP 691663.8392 714852.4061 786751.1671 1112514.5230 1050302.2310 1218879.9170 574922.7092 584968.3934 633720.8725 1091333.2490 1104025.3170 1169841.6150 Ureidosuccinic acid N-Carbamoylaspartic acid 24812720.1300 24850143.0600 23927937.3400 1272605.9910 1435801.5240 1365094.7380 20189596.2200 20615039.9800 20460017.9400 3468230.9230 3347421.9610 3890598.4440 UTP UTP 109689611.3000 126829965.3000 164436201.9000 302816510.8000 375537780.1000 259455600.5000 166325939.5000 149220234.7000 143469271 246232218.5000 286032110.2000 231583129 xanthine Xanthine 483484.0163 413183.0466 382757.8380 376686.0507 359220.7733 542307.4777 xanthosine Xanthosine 76422.0233 93784.3696 109186.5172 68947.4022 78945.4720 119729.2188 99147.0356 58474.9268 68516.9250 90595.4652 61874.5270 55936.2871