Metabolite_name RefMet_name E2_1-01-8860 E2_1-02-8861 E2_2-01-8862 E2_2-02-8863 E2_3-01-8864 E2_3-02-8865 control_1-01-8852 control_1-02-8853 control_2-01-8854 control_2-02-8855 control_3-01-8856 control_3-02-8857 Factors - Treatment:17-β-estradiol Treatment:17-β-estradiol Treatment:17-β-estradiol Treatment:17-β-estradiol Treatment:17-β-estradiol Treatment:17-β-estradiol Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control Treatment:Control 17-Hydroxyprogesterone 17alpha-Hydroxyprogesterone 6814 7974 3112 5258 2214 10110 4704 5764 3402 4312 8938 7568 1-Methyladenosine 1-Methyladenosine 692 706 1144 748 470 400 1792 1340 1422 878 1192 1092 2_4-Diaminobutyric acid 2,4-Diaminobutyric acid 14296 12258 33566 28536 53766 50140 29300 26700 51202 56194 15308 13204 2^-Deoxyguanosine 5^-monophosphate dGMP 2416 2524 3494 3616 3064 3608 2544 1978 3066 2708 3664 3624 2-Ethyl-2-hydroxybutyric acid 2-Ethyl-2-hydroxybutyric acid 37078 35918 47728 45742 30236 28900 54634 51002 48736 52232 51790 53312 2-Hydroxyadenine 2-Hydroxyadenine 36540 37378 15726 14138 38084 38004 42140 47800 58240 55158 44602 46120 2-Phenylaminoadenosine 2-Phenylaminoadenosine 45012 48366 92588 73972 47710 45360 114630 98216 135362 95490 88502 80058 2-Phenylbutyric acid 2-Phenylbutyric acid 56260 57248 59266 57020 58922 51314 60676 60586 60924 58712 61314 57832 2-Pyrrolidinone 2-Pyrrolidinone 9176 8776 11254 10832 10546 10018 10586 11184 12840 9080 9040 11232 3_4-Dihydroxyphenylglycol 3,4-Dihydroxyphenylglycol 938 974 1142 992 668 796 1348 1058 1250 906 994 1158 3a_6b_7b-Trihydroxy-5b-cholanoic acid beta-Muricholic acid 289790 287014 270006 280844 265954 276420 253438 247570 256244 237640 256832 236168 3-Hydroxy-4-methoxycinnamic aicd Isoferulic acid 4620 4608 4706 4292 4914 5020 5870 6084 6202 4810 4808 5686 3-Methylindole 3-Methylindole 4422 4334 3878 3278 4066 3558 4200 3758 4666 4196 3490 3228 5-Aminopentanoic acid 5-Aminopentanoic acid 4182 3296 3308 3966 3238 2622 3740 2912 4098 3368 2150 2438 5-Methoxysalicylic acid 5-Methoxysalicylic acid 20360 23222 33984 25878 17528 15562 27922 28946 36114 24706 28838 26732 5-Methoxytryptophol 5-Methoxytryptophol 718 724 1692 1582 844 858 3156 2986 2924 2402 2332 2612 5^-Methylthioadenosine 5'-Methylthioadenosine 110326 104144 111126 109818 105850 88100 98110 95468 109700 107952 101042 104790 7_8-Dihydrobiopterin 7,8-Dihydrobiopterin 1050 1360 1484 2038 1302 1028 650 838 1442 1516 1362 2074 Acetoin Acetoin 179298 175446 384658 309040 412804 202184 349224 308798 407986 324356 219948 207578 Adenine Adenine 74956 70612 100330 103244 90572 85946 93420 96096 91812 97126 78258 87466 Adenosine Adenosine 153044 154300 201464 215530 181878 164412 188028 180662 185630 197824 179958 159476 Adenosine 3^_5^-diphosphate Adenosine 3',5'-diphosphate 19784 20764 26604 26816 33412 34132 38094 37354 36854 35518 37976 37322 Adenosine monophosphate AMP 11892 10530 8630 6904 6116 9790 3450 4838 3754 9678 9008 9702 Adenosine triphosphate ATP 1186 1362 1864 1556 3602 3052 3366 2498 1010 3220 3012 3564 Allocholic acid Allocholic acid 3532 3942 6262 6726 6532 6022 7008 6616 7112 7276 4792 4234 Androstenedione Androstenedione 7150 6592 8230 10526 11702 10024 7132 8200 6310 6690 7872 6312 Aspartame Aspartame 3678 3462 3586 3658 3636 3346 3856 3220 3464 3960 4330 2680 Aspirin Aspirin 3558 3394 2954 2884 2896 2734 2870 2854 3328 3148 2810 2732 Atenolol Atenolol 636 590 1876 1274 1624 1520 3046 1892 2679 2626 2590 2380 Benzoic acid Benzoic acid 4572 4758 4138 3906 4714 4562 3970 3884 3884 3982 3888 3858 Carnosine Carnosine 23952 23406 23352 23896 25430 24190 26988 18910 29906 23838 21584 24642 Cinnamaldehyde Cinnamaldehyde 15154 15457 19984 17610 18676 19050 18038 18046 18966 17188 16832 16990 Clotrimazole 1992 2134 1704 1842 2546 1942 1416 1766 1654 1864 2172 2342 Coumarin Coumarin 2686 2838 2690 2590 2592 2576 2630 2362 2692 2992 2540 2662 Cyclic AMP 3',5' cyclic AMP 1014 1152 1538 1210 1320 1620 1634 1690 1532 1766 1924 2054 Cytosine Cytosine 2432 2546 2148 2128 2292 2338 1482 1276 1772 1766 1442 1122 D-Glucurono-6_3-lactone Glucuronolactone 6662 7798 8252 8398 8960 8286 7800 8242 7656 8606 9220 8460 Diacetyl Diacetyl 6708 9846 9318 9406 12318 10088 11878 12306 12430 10512 11440 10370 Diethanolamine Diethanolamine 450 548 306 312 1484 576 1018 1272 1206 880 1052 1550 Dopamine Dopamine 1566 1564 2050 1854 1574 1834 1714 1688 1720 1202 1762 1818 Elaidic acid Elaidic acid 4936 5340 4988 5108 6036 5390 8330 8244 8202 6928 7766 5534 Epinephrine Epinephrine 4468 4398 7258 6298 6480 5782 4150 5618 5286 5022 5578 6394 Folic acid Folic acid 4768 4284 4520 4316 3260 2734 2684 2018 3426 2794 2242 2880 Galactitol Galactitol 14580 16206 15284 15306 14160 14092 14818 15792 14156 15634 15836 14292 Gamma-Caprolactone gamma-Caprolactone 2316 2710 2370 2440 3044 3068 3052 3012 2992 3052 2354 2468 Gluconolactone Gluconolactone 19298 18974 40010 40534 24746 21728 7078 12084 8054 20866 33682 32212 Glucosamine Glucosamine 424 416 610 598 384 542 588 576 Glutathione Glutathione 82958 87824 179124 154850 101490 90748 32882 50074 39990 98554 134094 128832 Glycerophosphocholine sn-Glycero-3-phosphocholine 3614 4026 2928 2852 3662 3882 2988 2672 2950 2618 3720 3886 Guanidinosuccinic acid Guanidinosuccinic acid 35630 36572 54766 48546 47760 31308 39204 40296 33460 40236 24162 20754 Guanosine Guanosine 20158 20662 7042 7590 19076 18364 25076 23742 22912 25756 22922 25762 Guanosine 5^-diphosphate GDP 2784 2816 3410 2384 3124 2804 3502 3556 2022 2516 3254 3576 Guanosine monophosphate GMP 2146 1702 1994 1980 1932 2070 2030 2010 1682 1800 2294 1970 Hydroxyisocaproic acid Hydroxyisocaproic acid 177610 183584 275296 280802 142604 139808 249253 244366 205820 189848 Hyodeoxycholic acid Hyodeoxycholic acid 55682 57964 16766 22904 17614 26844 32806 34686 22988 30718 16218 14542 Hypoxanthine Hypoxanthine 179562 191810 213342 220792 207594 203876 208428 197474 228268 249928 225990 229914 Indole Indole 27276 27214 27814 25358 25752 20150 24550 24312 29638 25746 22148 22128 Indoleacrylic acid Indoleacrylic acid 156778 157150 143190 142482 140828 112546 130402 134012 163218 147038 115838 116350 Inosine Inosine 73038 78902 82566 82750 80720 84382 106072 107714 94774 98158 93046 96910 Isobutyric acid Isobutyric acid 225082 222974 419316 348942 525200 217580 404650 340276 530622 390930 256926 241186 Isovalerylcarnitine CAR 4:0;3Me 314368 288336 316798 334004 320290 311408 379606 405340 422288 392800 384286 370162 L-Acetylcarnitine CAR 2:0 39906 44844 46804 45102 51992 45880 43388 43716 46470 39346 40034 39944 Leucinic acid Leucinic acid 34840 34000 43796 44426 47380 48356 49150 51026 52012 46422 40700 38496 L-Fucose Fucose 2200 2240 2332 2102 2646 2452 2242 2676 2602 2600 2376 2104 L-Glutamic acid Glutamic acid 1330 878 1026 1226 1332 936 712 1048 1090 1198 1202 1280 L-Leucine Leucine 18214 18516 16262 16226 15146 17416 16536 15764 16124 18026 14784 16558 L-Methionine Methionine 9794 9920 7622 7740 8432 10168 7530 8546 6008 7870 7798 7582 L-Norleucine Norleucine 8784 8626 9824 9702 11448 11492 9318 9144 8078 7716 8016 8270 L-Phenylalanine Phenylalanine 34424 35508 28176 31606 30406 28330 29842 32546 31642 28850 29146 27724 L-Proline Proline 1464 1874 1308 2320 1746 1530 1370 1196 1616 1384 2008 1546 L-Thyronine Thyronine 2174 2154 2116 2250 2254 2326 2090 2242 1946 2150 2514 2322 L-Tryptophan Tryptophan 37524 37752 34336 34212 33574 29124 34588 30358 39106 34084 28780 29116 L-Tyrosine Tyrosine 8502 9270 2620 2582 4620 4598 3906 3248 5148 5676 3284 3344 Maltitol Maltitol 49178 51456 42808 51288 53814 44736 51980 51538 50142 49346 52760 50128 Mannitol Mannitol 32118 33584 29096 30412 34110 28494 31282 32136 37278 35278 33060 32828 m-Coumaric acid trans-m-Coumaric acid 12678 10704 9896 9686 9244 8866 8498 9426 9438 9798 10424 9542 Methylhippuric acid Methylhippuric acid 9436 9216 9998 9852 9046 8326 10346 8960 11408 9006 9244 8366 Methyl propenyl ketone Methyl propenyl ketone 1382 1376 1602 1388 804 788 2198 1348 1914 1518 1816 1918 Metoprolol Metoprolol 7564 6978 9978 8684 12144 4282 10108 9642 11588 8048 5440 5228 Mevalonic acid Mevalonic acid 9600 10614 8826 12706 15198 8518 12134 12936 8652 12798 13394 13932 N-Acetylglutamic acid N-Acetylglutamic acid 1246 1338 2434 1602 1844 1968 1342 1536 1898 1618 2032 1992 N-Acetyl-L-alanine N-Acetylalanine 18404 18370 16040 18316 19192 18888 18794 17904 18478 18492 19842 20254 N-Acetylserotonin N-Acetylserotonin 6500 7008 9586 8794 8242 7996 9384 7554 14038 14674 7716 7318 Niacinamide Niacinamide 39296 37398 29988 28680 38984 38208 22670 28494 17816 16632 29940 32402 Nicotinic acid Nicotinic acid 37860 39480 29344 29164 36204 37874 34638 35708 36758 38134 43094 38720 N-Methyl-D-aspartic acid N-Methyl-D-aspartic acid 2944 3050 4058 3682 4616 4010 3606 3110 3494 2706 2948 3366 N_N-Dimethylformamide N,N-Dimethylformamide 1320 1480 1314 1476 1336 1640 1784 1778 1256 1438 1860 1662 Nutriacholic acid 7-Ketolithocholic acid 177572 181198 130424 145980 193664 202292 218848 225166 142766 218216 216752 228326 o-Tyrosine o-Tyrosine 6838 7218 2334 2050 3430 3664 2696 2970 3736 4318 2476 1898 Pantothenic acid Pantothenic acid 50266 52986 60034 62082 60322 53504 50684 54620 48638 47322 52928 57644 Phenol Phenol 1594 1358 1582 1700 1492 1122 1124 1496 1380 1464 1414 1242 Phenylacetaldehyde Phenylacetaldehyde 24410 25158 22346 20974 20490 22370 24748 22648 25432 22262 25380 23866 Phosphocreatine Phosphocreatine 62470 62458 96974 100496 137854 54804 77598 68144 122154 89846 59326 62064 Pregnenolone sulfate Pregnenolone sulfate 44656 49996 50260 52320 51694 42458 58306 57046 55396 57772 58246 54498 Propionic acid Propionic acid 17378 16952 26378 20646 35860 24330 21260 16610 31718 22880 20650 22466 Propranolol 1612 1326 642 1094 1060 788 664 860 1212 998 1370 1052 Pyridine Pyridine 8142 5434 7670 6258 5498 5948 5052 6520 4536 5480 5168 6522 Pyridoxine Pyridoxine 4212 4930 3320 3574 2648 3430 2370 3306 2706 2634 2374 2482 Pyrrolidonecarboxylic acid Pyroglutamic acid 51648 56576 34494 37614 30326 32948 36384 34574 24684 27936 20614 20794 Pyruvaldehyde Pyruvaldehyde 7770 7854 9306 9080 9954 10956 11552 9632 10210 11064 10632 9154 Quinaldic acid Quinaldic acid 1466 1484 1890 2228 1806 1654 852 600 1730 1702 1922 1926 Saccharopine Saccharopine 3880 3004 8098 7112 9610 9802 6068 5022 8596 5414 4450 3254 S-Adenosylhomocysteine S-Adenosylhomocysteine 3452 3358 3104 3840 4192 3440 5020 5130 5084 5422 4538 5052 Salicin Salicin 2248 1912 6284 1742 5468 4286 7530 7280 7458 6924 6610 7290 Sebacic acid Sebacic acid 19612 24716 36758 33300 39314 38276 34042 28706 35150 41002 31508 30664 Spermine Spermine 40898 46682 42638 41696 40994 41436 42508 44976 46800 45118 41352 43814 Sphinganine Sphinganine 4650 4882 2920 2496 3836 3154 15082 15686 14536 13746 13150 9282 Sphingosine Sphingosine 8472 8234 5922 5126 7252 6254 11128 11422 11436 11198 13060 11472 Succinylacetone Succinylacetone 11660 13046 7994 9126 16048 15328 18272 17694 9496 17250 17952 16470 Terephthalic acid Terephthalic acid 1732 2386 4974 3368 5580 1956 5604 4500 5690 5274 3096 2422 Trimethylamine Trimethylamine 4292 5128 5216 4592 5866 5610 5110 4944 5088 3504 4444 4230 Uracil Uracil 5950 6392 5946 6928 6328 4900 6152 6462 6628 6874 7412 6954 Urea Urea 3074 2148 2300 2570 2520 2424 3684 2966 2682 3084 2266 2668 Uric acid Uric acid 26702 28906 30828 29178 28750 30910 19608 21062 23310 23642 23974 26662 Uridine Uridine 6568 6938 3350 2912 7088 4808 12028 10122 7492 9124 9802 9498 Xanthine Xanthine 1522 1346 2578 1780 2064 1926 2252 2306 2998 2626 3654 3018 Xanthosine Xanthosine 3764 3770 4274 4942 3326 3122 8336 6464 6430 6428 8276 7240