Metabolite_name RefMet_name GR_153 GR_186 GR_282 GR_296 GR_384 GR_386 GR_406 GR_415 GR_50 GR_63 PR_100 PR_12 PR_148 PR_150 PR_260 PR_398 PR_401 PR_92 Factors - Experimental factor:GR Experimental factor:GR Experimental factor:GR Experimental factor:GR Experimental factor:GR Experimental factor:GR Experimental factor:GR Experimental factor:GR Experimental factor:GR Experimental factor:GR Experimental factor:PR Experimental factor:PR Experimental factor:PR Experimental factor:PR Experimental factor:PR Experimental factor:PR Experimental factor:PR Experimental factor:PR 1_5-Anhydrosorbitol 1,5-Anhydrosorbitol 443000 706000 313000 1170000 723000 416000 314000 373000 617000 397000 165000 395000 430000 189000 674000 139000 81500 312000 2-Aminoisobutyric acid Aminoisobutyric acid 91700 144000 53400 61700 47900 9930000 1350000 192000 1060000 91600 35300 18400 72500 53300 251000 57700 229000 45200 2-hydroxyglutaric acid 2-Hydroxyglutaric acid 280000 129000 139000 434000 426000 663000 208000 386000 281000 214000 141000 52300 89200 58900 38300 112000 157000 78600 3-Oxoadipic acid 221000 127000 90300 458000 5210000 581000 775000 591000 1810000 146000 89200 13300 29900 46300 162000 137000 224000 9670 3-Phosphoglyceric acid 3-Phosphoglyceric acid 369000 108000 49300 181000 357000 475000 153000 378000 238000 72000 20500 327000 792000 70300 100000 6570 18600 57800 4-Hydroxybutyric acid 4-Hydroxybutyric acid 356000 257000 118000 479000 452000 378000 353000 294000 640000 342000 66600 30600 98100 168000 274000 309000 730000 94700 4-Hydroxyproline cis-4-Hydroxyproline 280000 1040000 170000 214000 522000 650000 576000 1040000 365000 163000 240000 140000 353000 178000 382000 206000 572000 160000 5-Aminopentanoic acid 5-Aminopentanoic acid 38200 238000 6140 52400 41900 714000 50600 43000 366000 73400 77000 38200 4140 6460 19600 34300 23900 70000 Acetaminophen Acetaminophen 590 242 255 1140 663 69200 45600 497 3130 380 229 526 61.3000 431 1190 3430 2720 0.0085 Alpha-Tocopherol alpha-Tocopherol 1280000 7570000 1630000 760000 291000 217000 69400 1210000 398000 622000 386000 378000 102000 36700 1400000 17800 84800 183000 Aminoadipic acid Aminoadipic acid 54400 75800 56200 140000 70900 17500 16000 57500 114000 34600 310 436 364 1510 9660 34000 235000 69.9000 Aminomalonic acid Aminomalonic acid 144000 511000 218000 288000 3540000 772000 69700 606000 343000 159000 20300 7850 121000 47800 265000 298000 287000 3810 Arachidonic acid Arachidonic acid 959000 1830000 654000 1550000 648000 766000 520000 606000 1240000 1200000 661000 717000 816000 179000 202000 113000 145000 561000 Ascorbic acid Vitamin C 1860000 10700000 1720000 4540000 4500000 6790000 5020000 5270000 4610000 1990000 1610000 1510000 2480000 327000 3740000 283000 356000 2180000 Beta-Aminopropionitrile 2400000 6070000 2450000 3880000 2580000 1170000 984000 1500000 2380000 3720000 979000 1700000 1300000 838000 715000 988000 1420000 889000 Cadaverine Cadaverine 1160000 3650000 1120000 1780000 1740000 1940000 1050000 801000 1920000 1300000 531000 364000 266000 181000 249000 171000 243000 390000 Caffeic acid Caffeic acid 892 1890 1030 1580 5000 10300 7710 8750 6500 2570 715 5790 12800 8510 644 13500 991 7390 Cellobiose Cellobiose 10200 21200 2930 22000 1220000 25700 79600 32100 24300 10100 2540 8550 1890 7520 1410 1350 855 21200 Citric acid Citric acid 939000 3420000 1360000 1630000 3730000 999000 910000 1460000 1360000 766000 42000 130000 52700 79000 150000 94000 133000 52900 Creatinine Creatinine 1930000 896000 1390000 1790000 938000 45000 229000 3120000 16900000 630000 79800 12300 20800 189000 24700 1390000 1790000 40900 Cysteinylglycine Cys-Gly 31000 1820000 39100 3090000 52000 63600 73900 30100 32800 25600 79000 4120000 4360000 3620000 4650000 15700 3560000 4850000 Cytidine monophosphate CMP 52300 76000 30000 145000 51700 58000 61600 27500 66600 87500 60900 83100 40600 14800 14900 8860 18000 45300 Cytosine Cytosine 137000 957000 476000 332000 173000 157000 52000 58100 51900 93600 1860 551 336 2410 2000 15200 5490 769 D(-)-beta-hydroxy butyric acid 3-Hydroxybutyric acid 26200000 92200000 9760000 87400000 10300000 3920000 7650000 1030000 5160000 8990000 35200000 33400000 8250000 4350000 2280000 7340000 4950000 7680000 D-Fructose Fructose 44600 79800 37000 175000 50000 136000 70100 698000 106000 49200 55800 53000 29600 33300 13800 15300 31900 156000 D-Galactose Galactose 800000 212000 145000 398000 517000 4750000 957000 2140000 1210000 891000 62400 41500 83700 133000 91400 216000 11800000 69100 D-Glucose Glucose 33500000 6030000 7090000 34100000 14500000 26800000 31600000 10300000 26400000 15900000 862000 805000 856000 2780000 5300000 3160000 22000000 490000 Dihydrouracil Dihydrouracil 147000 1300000 4230 106000 72500 407000 4670 7420 6740 2150 2640000 64200 114000 51000 73800 1040000 3960000 2480000 D-Ribose Ribose 349000 445000 84300 274000 254000 1200000 195000 687000 199000 148000 169000 216000 157000 49000 185000 74200 106000 220000 D-Ribose 5-phosphate Ribose 5-phosphate 47700 48300 9860 23800 59700 49600 22600 20100 59500 16100 22200 13200 22200 21400 42800 13000 18900 41200 D-Ribulose 5-phosphate Ribulose 5-phosphate 112000 97600 43600 21100 184000 68900 15800 46200 62300 14900 12500 3220 6280 12400 16100 6910 8990 37300 D-Xylulose L-Ribulose 628000 688000 860000 744000 434000 96700 88400 340000 397000 643000 49000 1690000 51200 65700 124000 56000 38200 45000 Eicosenoic acid Eicosenoic acid 71200 83500 49000 146000 84800 109000 127000 124000 90400 92000 8280 2510 7730 11600 40400 44300 71800 3930 Erythrono-1_4-lactone Erythrono-1,4-lactone 141000 381000 209000 324000 445000 472000 753000 526000 483000 337000 414000 615000 652000 814000 496000 175000 268000 475000 Ethanolamine Ethanolamine 2070000 29400000 1500000 15400000 13900000 6180000 8400000 11300000 20400000 1880000 7150000 1500000 3810000 5120000 8990000 2580000 5250000 8890000 Fructose 6-phosphate Fructose 6-phosphate 16200 59900 45100 96800 1110000 1260000 133000 81400 250000 70200 60400 51500 18900 8130 21600 6700 16200 2420000 Fucose Fucose 50800 830000 81900 2080000 172000 580000 4560000 397000 267000 162000 220000 996000 1350000 153000 393000 178000 31900 233000 Fumaric acid Fumaric acid 548000 1560000 41100 1030000 1330000 358000 888000 975000 2240000 707000 603000 1400000 573000 346000 161000 426000 148000 787000 Galactinol Galactinol 33400 36400 23600 96700 38200 604000 358000 77900 219000 40200 111000 155000 49400 58700 48700 11700 23800 62400 Galactitol Galactitol 3920000 861000 1470000 7040000 2310000 1960000 5600000 1940000 3880000 3080000 235000 322000 578000 501000 1910000 714000 1830000 145000 Galactose 1-phosphate Galactose 1-phosphate 55200 137000 85500 130000 107000 59800 82000 54300 171000 122000 157000 153000 92700 38100 17300 21400 24000 233000 Galacturonic acid Galacturonic acid 27300000 385000 118000 350000 327000 6390000 289000 9910000 524000 140000 9790 4910 22200 11800 193000 282000 386000 10500 Gamma-Aminobutyric acid gamma-Aminobutyric acid 8980000 10300000 5590000 12300000 12300000 43400 9780000 24700000 3690000 12100000 196000 66900 475000 472000 782000 1880000 2820000 275000 Gamma-Tocopherol gamma-Tocopherol 192000 20600 1980 2860 2460 192000 84200 24100 27000 56000 11600 912 250 599 31400 339 4030 2920 Gluconic acid Gluconic acid 1940000 98200 116000 160000 167000 451000 237000 199000 3980000 2870000 68100 171000 110000 196000 21100 25400 52300 116000 Glucose 6-phosphate Glucose 6-phosphate 203000 197000 159000 349000 179000 531000 133000 78200 112000 241000 23500 51500 64400 22200 12000 3610 8210 4850000 Glyceric acid Glyceric acid 392000 719000 457000 634000 365000 915000 243000 651000 263000 377000 262000 355000 326000 114000 160000 63300 100000 263000 Glycerol Glycerol 35400000 3340000 23700000 61500000 35700000 15600000 17400000 21600000 21100000 26000000 2680000 1320000 3900000 21600000 560000 4320000 7360000 2130000 Glycerol 1-octadecanoate 188000 201000 118000 411000 264000 2570000 1070000 741000 2220000 222000 115000 48800 134000 54100 88000 79600 187000 117000 Glycerol 3-phosphate sn-Glycero-3-phosphate 8040000 20100000 9510000 17900000 7630000 4630000 4930000 4320000 8120000 8430000 1990000 6570000 1550000 710000 821000 784000 1170000 3510000 Glycine Glycine 16500000 50700000 19500000 35700000 31100000 12300000 20500000 47200000 32500000 14100000 5750000 1890000 23900000 9200000 18400000 19200000 21100000 2010000 Glycolic acid Glycolic acid 1230000 1160000 349000 1530000 562000 444000 365000 404000 485000 582000 89300 95100 278000 291000 287000 708000 1040000 65300 Glycyl-glycine Gly-Gly 615000 4060000 53000 43600 1140000 1980000 1430000 1490000 1440000 632000 42500 484000 35900 125000 1180000 86700 265000 669000 Heptadecanoic acid Margaric acid 55300 69500 42700 110000 69500 71200 69700 86800 82900 69700 94100 87100 99400 66900 41800 31300 29700 99400 Hydrocinnamic acid Hydrocinnamic acid 18000 69000 3090 22900 10200 311000 44000 9410 186000 18900 911 52.8000 471 748 5620 7260 332000 191 Hydroxylamine Hydroxylamine 4760000 6840000 11200000 4830000 4710000 1900000 27400000 14000000 336000000 3300000 542000 237000 960000 2280000 3330000 9990000 10600000 170000 Hydroxypropionic acid Hydroxypropionic acid 1520000 77900 5150000 1370000 1410000 687000 695000 519000 969000 1010000 24800 6520 45100 112000 228000 2320000 2180000 5190 Hypotaurine Hypotaurine 1010000 2220000 1030000 2210000 2260000 27400000 20200000 9690000 50600000 1690000 361000 131000 277000 782000 1080000 1330000 1730000 421000 Hypoxanthine Hypoxanthine 644000 961000 588000 920000 1330000 1300000 1260000 2270000 1130000 43800 1850000 274000 136000 513000 185000 297000 149000 Inositol 4-phosphate Inositol 4-phosphate 574000 898000 532000 1590000 62300000 5140000 3490000 2390000 6470000 591000 225000 91000 294000 207000 377000 405000 543000 119000 Lactobionic acid Lactobionic acid 272000 203000 82100 546000 433000 74500 374000 460000 449000 303000 4140 2680 140000 150000 22300 14400 242000 29000 L-Alanine Alanine 498000 2120000 485000 653000 484000 250000 827000 911000 252000 387000 906000 903000 1190000 3130000 2090000 449000 584000 564000 L-Asparagine Asparagine 58700 191000 103000 172000 90200 23500 26800 175000 95300 113000 2390 3210 4040 7860 42100 38600 84200 645 L-Aspartic acid Aspartic acid 476000 5210000 1250000 2590000 1830000 557000 1100000 2880000 1300000 570000 112000 45800 164000 235000 1710000 403000 691000 41900 L-Carnitine Carnitine 88700 121000 12700 115000 111000 104000 83700 74400 161000 162000 378000 237000 294000 419000 274000 160000 287000 493000 L-Cysteine Cysteine 95800 451000 143000 428000 188000 10300 1060000 633000 6730000 79700 148000 179000 135000 84200 130000 116000 127000 116000 L-Dehydroascorbic acid Dehydroascorbic acid 380000 2080000 378000 1700000 17200000 1570000 904000 355000 13000000 17800000 367000 19600 135000 215000 401000 434000 576000 128000 L-Glutamic acid Glutamic acid 18600000 34400000 16800000 38700000 31700000 16500000 26000000 61600000 24600000 25600000 12100000 10500000 18200000 9890000 14800000 13900000 27900000 27900000 L-Glutamine Glutamine 414000 779000 458000 687000 449000 376000 521000 596000 599000 1600 3030 3860 10800 85900 101000 271000 1200 Linoleic acid Linoleic acid 1630000 2470000 1500000 3200000 1300000 1120000 974000 919000 1440000 1620000 668000 836000 347000 225000 353000 194000 261000 872000 L-Isoleucine Isoleucine 719000 4130000 537000 604000 1740000 2450000 7110000 10500000 7340000 804000 593000 310000 1230000 497000 2170000 412000 1510000 788000 L-Lactic acid Lactic acid 312000 557000 320000 368000 392000 380000 2360000 26300 34700 14300 202000 103000 6080 17800 17400 8650 17600 2720 L-Leucine Leucine 2710000 20500000 1900000 2810000 3780000 5650000 9570000 35500000 1900000 1050000 445000 2100000 15700 1350000 17700000 555000 3470000 19600000 L-Lysine Lysine 210000 963000 259000 353000 722000 2080000 1710000 2030000 836000 510000 8850 3800 15800 39600 771000 215000 403000 4160 L-Phenylalanine Phenylalanine 1120000 7850000 1100000 3660000 2590000 5900000 5100000 31200000 2720000 1410000 384000 279000 733000 461000 5240000 687000 1730000 332000 L-Proline Proline 393000 3890000 521000 269000 527000 2080000 2320000 11000000 12800000 378000 1420000 547000 1500000 377000 2870000 330000 844000 3650000 L-Threonine Threonine 4250000 20800000 4170000 4810000 6740000 72100000 28800000 26100000 12400000 137000000 4090000 7670000 5460000 2330000 10200000 2340000 3090000 3160000 L-Tryptophan Tryptophan 194000 939000 95500 362000 187000 645000 677000 4660000 338000 160000 59400 37400 137000 66900 531000 75600 148000 48000 L-Tyrosine Tyrosine 1990000 13300000 1430000 4320000 2630000 6790000 4120000 3550000 2890000 1930000 1420000 1060000 2230000 414000 2560000 270000 705000 1920000 L-Valine Valine 673000 3490000 494000 583000 500000 76900000 14000000 4290000 6740000 885000 1620000 1360000 1480000 544000 5080000 496000 1590000 3060000 Malic acid Malic acid 53100000 461000000 100000000 99300000 26500000 10400000 22700000 11100000 23200000 18500000 570000 677000 3140000 1170000 1470000 3980000 4370000 428000 Malonic acid Malonic acid 562000 933000 301000 1090000 1280000 1520000 2190000 4070000 1020000 566000 1610000 1700000 2330000 1190000 2340000 641000 630000 1060000 Maltose Maltose 1140000 1380000 349000 3120000 2430000 1020000 6260000 3020000 2740000 1170000 206000 110000 215000 623000 178000 738000 994000 139000 MG(0:0/16:0/0:0) MG 0:0/16:0/0:0 102000 107000 65300 151000 89900 103000 81400 96700 80800 102000 145000 102000 60800 27200 21000 20800 34700 159000 MG(0:0/18:1(9Z)/0:0) MG 0:0/18:1(9Z)/0:0 297000 513000 266000 510000 158000 120000 91400 99800 255000 254000 394000 223000 959000 30900 36200 18200 31700 284000 MG(16:0/0:0/0:0) MG 16:0/0:0/0:0 228000 359000 192000 501000 245000 247000 201000 227000 173000 217000 103000 110000 74500 36900 56000 42200 73300 228000 MG(18:1(9Z)/0:0/0:0) MG 18:1(9Z)/0:0/0:0 179000 157000 120000 193000 112000 75300 289000 93500 280000 232000 207000 182000 115000 66900 64700 60100 119000 413000 Mitobronitol Mitobronitol 25600000 2260000 110000 2270000 568000 15000000 9800000 554000 7550000 647000 87500 1250000 167000 1070000 418000 220000 116000 134000 myo-Inositol Myo-inositol 48500000 59000000 33300000 129000000 52200000 14200000 49400000 33400000 84000000 64400000 15700000 58300000 24300000 18600000 19100000 22200000 37400000 19300000 Myristic acid Myristic acid 292000 436000 29400 615000 397000 311000 304000 264000 415000 346000 330000 308000 1290000 161000 175000 84900 136000 302000 N-Acetyl-D-glucosamine N-Acetylglucosamine 3670 53300 3870 5040 6800 253000 209000 95900 38200 63100 1890 8590 6070 4840 36400 2670 7510 8990 N-Acetyl-D-Glucosamine 6-Phosphate N-Acetyl-glucosamine 6-phosphate 83200 94400 29200 60900 2170000 703000 280000 232000 197000 1230000 728 223 1810 8860 51500 82400 235000 20600 N-Acetyl-L-aspartic acid N-Acetylaspartic acid 428000 729000 366000 539000 270000 229000 194000 209000 295000 365000 181000 104000 41100 27200 40300 34700 66600 49500 N-Acetylneuraminic acid N-Acetylneuraminic acid 42000 201000 76200 109000 133000 1830000 1340000 439000 6300000 57200 12200 21900 54700 26000 133000 37500 65300 43100 N-Acetylserine N-Acetylserine 174000 497000 140000 416000 309000 344000 272000 369000 374000 350000 1030000 741000 1310000 371000 456000 268000 494000 1550000 Niacinamide Niacinamide 1880000 5390000 1900000 385000 3190000 1600000 2220000 2180000 2780000 2100000 248000 14400 528000 68500 407000 449000 921000 327000 Oleic acid Oleic acid 4750000 6360000 4370000 9410000 4780000 3900000 3600000 2980000 4800000 5010000 1380000 853000 1120000 959000 1500000 909000 1300000 971000 Ornithine Ornithine 140000 617000 65600 218000 249000 554000 397000 438000 277000 137000 89900 124000 116000 77500 467000 31900 139000 78400 Oxoglutaric acid 2-Oxoglutaric acid 1460000 2270000 720000 457000000 18400000 2770000 3840000 4470000 3760000 9220000 174000 51800 148000 194000 434000 1040000 1010000 68100 Palmitic acid Palmitic acid 7930000 26900000 6780000 13400000 7750000 14100000 26400000 5620000 8960000 34000000 12400000 16800000 12400000 10600000 10800000 2870000 3840000 17600000 Palmitoleic acid Palmitoleic acid 203000 216000 154000 342000 172000 179000 170000 144000 250000 219000 288000 737000 254000 91900 101000 67100 79100 225000 Panose Panose 454000 152000 52800 331000 248000 22700 199000 217000 437000 163000 13200 10100 7370 96600 4070 68100 232000 15900 Pantothenic acid Pantothenic acid 61700 25200 18600 51300 29700 22200 9810 20200 16100 26000 172000 18100 27900 6300 4880 2620 4730 10700 Pelargonic acid Pelargonic acid 223000 382000 350000 429000 280000 151000 99000 128000 143000 191000 46400 48100 48600 37500 31200 49900 142000 34200 Phosphate Phosphoric acid 133000000 175000000 174000 2280000 563000 582000 121000000 38700000 13300000 2560000 4170000 890000 1910000 2430000 5660000 3800000 111000000 110000000 Phosphoenolpyruvic acid Phosphoenolpyruvic acid 82800 39800 22000 48200 139000 152000 27100 121000 31600 18900 79.4000 1030 26.5000 3700 28300 186 2020 30.1000 Phosphoethanolamine Phosphoethanolamine 22900000 48600000 17400000 32600000 32200000 12600000 24100000 16200000 27000000 18800000 14500000 21900000 12300000 2780000 3630000 1600000 2660000 15700000 Propylene glycol Propylene glycol 321000000 1040000000 634000000 892000000 560000000 471000000 437000000 490000000 379000000 342000000 386000000 286000000 490000000 171000000 124000000 118000000 2590000 391000000 Protocatechuic acid Protocatechuic acid 33700 46000 23700 43900 5140000 344000 219000 112000 167000 653000 132000 355000 51500 26800 30000 20300 26200 97600 Putrescine Putrescine 33500 461000 61100 87400 226000 422000 13200000 822000 752000 98500 449000 278000 188000 28000 261000 48600 34300 527000 Pyroglutamic acid Pyroglutamic acid 2450 6750000 4040000 68100 8690 60500 12400000 4630000 11800000 103000 36700 14100000 18300 9140000 22600000 9680 15900000 309000 Pyrophosphate Pyrophosphate 830000 945000 2290000 6300000 1390000 114000 272000 229000 1230000 5120000 964000 309000 522000 212000 58600 270000 839000 302000 Quinic acid Quinic acid 1800 6420 533 11500 4400 283 24000 26100 8650 2260 7470 4690 6340 15900 4720 9520 5910 6950 Quinolinic acid Quinolinic acid 3870 74200 21100 9540 138000 13200 4910 204000 299000 4040 591 1840 556 1150 1900 4270 5290 2270 Ribitol Ribitol 232000 155000 99900 306000 161000 197000 145000 136000 178000 163000 52500 12200 9000 23200 37400 23400 53400 3210 Sarcosine Sarcosine 263000 602000 88700 982000 805000 24300000 1130000 34000 1420000 624000 845 12900 99000 284000 1490000 1330000 1080000 10600 Serine Serine 3350000 21600000 97900000 29800000 108000000 16000000 7650000 11800000 10900000 32000000 2210000 4150000 3950000 3250000 28000000 8370000 10000000 14800000 Serotonin Serotonin 27200 100000 20600 227000 126000 202000 4070000 1490000 1380000 169000 9360 55700 27700 22800 164000 63500 206000 50500 Sorbitol Sorbitol 44800 29600 49100 97700 83600 3290000 1750000 16500 43400 888000 370000 209000 189000 139000 61800 3670000 1450000 57100 Spermidine Spermidine 125000 895000 183000 208000 498000 684000 557000 592000 464000 351000 88300 56000 155000 21900 269000 42900 42000 292000 Spermine Spermine 44400 77100 19100 99300 30100 36000 160000 107000 45700 51600 66900 25200 91700 82400 109000 56800 50400 139000 Squalene Squalene 65800 964000 214000 160000 100000 76900 95500 172000 149000 151000 225 2780 3540 3190 628000 27800 89100 2090 Stearic acid Stearic acid 7040000 6300000 4420000 11000000 7760000 7740000 9050000 6810000 9820000 6550000 7060000 5690000 6900000 4340000 3850000 2010000 1630000 8620000 Succinic acid Succinic acid 3510000 13700000 5090000 6350000 6890000 6970000 48100000 23300000 77200000 4580000 2490000 558000 3660000 2230000 3000000 5640000 7430000 909000 Sucrose Sucrose 9300 28300 7310 105000 17400 35900 24000 20300 25400 23600 15300 7570 16200 24200 21800 46300 66400 4770 Threonic acid Threonic acid 303000 1090000 511000 1300000 1800000 1070000 1760000 1400000 1050000 1040000 1450000 1370000 616000 346000 480000 797000 480000 1380000 Trehalose Trehalose 375000 489000 1420 14200 12100 318000 368000 409000 439000 428000 4240 8450 51600 225000 30400 82900 331000 17300 Uracil Uracil 98400 2000000 202000 178000 367000 1450000 401000 1340000 621000 263000 479000 1680000 611000 903000 4840000 2280000 998000 460000 Urea Urea 28500000 44400000 14700000 43500000 530000000 168000000 49400000 116000000 113000000 282000000 7040000 2770000 11700000 17300000 20000000 12600000 38900000 5460000 Uridine Uridine 24800000 81200000 2020000 11200000 8410000 4380000 3460000 3070000 6520000 4600000 50000 93500 456000 604000 1100000 267000 830000 683000 Uridine diphosphate-N-acetylglucosamine UDP-N-acetylglucosamine 251000 1460000 446000 787000 756000 631000 980000 774000 959000 577000 861000 663000 963000 191000 259000 166000 152000 709000