Metabolite_name RefMet_name MCJ KO CD19-BBz CART_1 MCJ KO CD19-BBz CART_2 MCJ KO CD19-BBz CART_3 MCJ KO CD19-BBz CART_4 WT CD19-BBz CART_1 WT CD19-BBz CART_2 WT CD19-BBz CART_3 WT CD19-BBz CART_4 Factors - factor:MCJ KO | Sample source:T-Cells factor:MCJ KO | Sample source:T-Cells factor:MCJ KO | Sample source:T-Cells factor:MCJ KO | Sample source:T-Cells factor:WT | Sample source:T-Cells factor:WT | Sample source:T-Cells factor:WT | Sample source:T-Cells factor:WT | Sample source:T-Cells 3-Methyleneoxindole 3-Methyleneoxindole 109759.1000 116509.4000 118826.9000 122928.6000 107182.1000 81971.7100 111309.6000 121574.8000 5-Hydroxyisourate 5-Hydroxyisouric acid 56298.6900 86484.1200 95102.9500 90302.2700 61375.4700 75428.1500 43838.4800 76877.5400 5-Oxoproline Pyroglutamic acid 6828328 6147630 6911890 7221250 9190771 5751874 8419663 8360978 acetyl-carnitine (acyl-C2) CAR 2:0 785650.8000 770561.3000 814609.2000 706110.2000 618760.9000 609696.9000 595332 679534.3000 Acetylcholine Acetylcholine 517535.2000 522618.2000 540154.7000 562411.2000 353667 368839.1000 434279.3000 387372.8000 Adenine Adenine 2181581 2459223 2231389 2729003 2045558 1979711 2059359 1872918 Adenosine Adenosine 2353503 2402693 1510885 1581484 1914259 1080486 2395523 1323620 ADP ADP 377326.6000 471596.1000 613402.7000 381522.7000 192898.8000 164063.2000 151915 186493.9000 Allantoate Allantoic acid 246724.8000 275889.5000 265316.6000 292002.8000 401791.5000 266614.3000 391021.5000 414176.3000 AMP AMP 36996660 47375260 45433750 55747920 35515510 37689240 40821240 35090290 Anthranilate 2-Aminobenzoic acid 141108.7000 130119.5000 120866.8000 121913.2000 78141.6500 76254.4100 90995.0100 251173.4000 Argininosuccinate Argininosuccinic acid 53439 109909.8000 117585.5000 119640.6000 83243.6000 108403.5000 62496.8400 74438.8400 Ascorbate Vitamin C 253225.1000 393053.6000 283050.3000 264809.5000 306599.2000 292930.4000 252818.2000 281781 butanoyl-l-carnitine (acyl-C4) CAR 4:0 74722.0300 56788.9900 57362.7500 45174.4400 50854.9500 46403.2200 50090.3600 49512.2700 Choline Choline 5203778 4727862 4532216 4229265 3224907 3885290 3862851 3901493 CMP CMP 286132.8000 403849.5000 349496.7000 487927.7000 378148.1000 346206.5000 382826.3000 366437.1000 Creatine Creatine 5761802 6652140 6652768 7176420 5177788 6588714 4733909 4985474 Creatinine Creatinine 1070186 1191026 572555.8000 976383.8000 877739.8000 1099076 1062474 844304.8000 Cys-Gly Cys-Gly 2580867 2235762 2676760 2037312 2045320 1810221 1934998 1624655 Cytidine Cytidine 51369.2500 82231.5500 69420.4400 124965.9000 70830.4200 64305.0900 64315.2200 59809.1600 Cytosine Cytosine 349136.8000 358298.5000 295816.5000 476999.9000 330017.3000 279875.9000 286526.6000 260101 dAMP dAMP 28630.0400 23555.8900 21198.9100 31695.0500 37690.0100 43403.9400 33439.3100 45304.2700 Dehydroascorbate Dehydroascorbic acid 380837.4000 381146.1000 340566.7000 340860.3000 309890 232302.8000 285360.2000 249096.5000 Ectoine Ectoine 396198.6000 344297.6000 302579 231293.7000 176738 120542.9000 162277.4000 145142.7000 gamma-Glutamyl-Se-methylselenocysteine gamma-Glutamyl-Se-methylselenocysteine 105142.3000 115559.9000 113414.1000 115571 146896.1000 121124.3000 169048.4000 160805.3000 gamma-L-Glutamyl-L-cysteine gamma-Glutamylcysteine 252164 212365.3000 278628.2000 258832.5000 183657.3000 171131.7000 206872.2000 179775.6000 Glutathione Glutathione 82059820 69900010 88248770 63110770 67228420 61479730 64665080 61079530 Glutathione disulfide Oxidized glutathione 504896.9000 424291.7000 487633.1000 450908 333620.8000 350272.5000 439908.2000 345591.3000 GMP GMP 3903462 5009770 3893602 5243548 5196508 4458117 5188418 4493158 g-Oxalo-crotonate 4-Oxalocrotonic acid 38439.6300 29265.3400 23571.9600 62519.3100 54072.8400 43222.3500 47714.7000 50868.5300 Guanidinoacetate Guanidoacetic acid 145252.1000 163708.1000 170739.6000 182407.4000 113637 128295.4000 102793.8000 127159.5000 Guanine Guanine 1182391 1424175 1105561 1550463 1397137 1260923 1377803 1264460 Guanosine Guanosine 127640.8000 133580.2000 130700.6000 176768.9000 99374.7800 131166.4000 100462.3000 137092.4000 Hexadecenoyl-carnitine (acyl-C16:1) CAR 16:1 29753.6500 27310.7200 24645.4700 28878.3400 11781.9300 11879.7900 31447.8600 26438.6800 hexanoyl-L-carnitine (acyl-C6) CAR 6:0 40433.9600 39697.0200 59966 62707.1600 25401.2800 30309.2900 38629.7000 29021.2900 Homocarnosine Homocarnosine 578504.8000 747302.4000 1007291 966757.2000 642766.9000 679692.1000 777400.5000 1004225 Hypotaurine Hypotaurine 249120.2000 314781 360660.5000 340369.4000 272966.5000 321640.2000 229491.9000 253244.8000 Hypoxanthine Hypoxanthine 2064268 1661591 1906416 2635113 2586442 2251369 2179575 2058654 IMP IMP 93931.5700 55801.0800 95920.7300 122842.4000 112426.1000 63151.5500 43833.1800 66928.0200 Indole-3-acetaldehyde Indoleacetaldehyde 86200.8800 83387.2600 71885.3200 62432.1400 50228.3900 53816.4600 63512.9100 61611.5900 Indole-3-acetate Indoleacetic acid 33807.9100 26837.9500 23201.4800 28196.4200 22670.9700 25459.1500 25484.2900 24670.5000 Indolepyruvate Indolepyruvate 84724.5500 49792.3900 82357.9800 120409.6000 68129.7300 61251.0600 76607.9400 81111.9300 Inosine Inosine 234127.7000 209468.8000 214015.7000 358613 260858.9000 270459.9000 206688.2000 231771.1000 L-alanine Alanine 1637607 2132121 2116687 2287936 1560974 1860581 1569585 1809974 L-arginine Arginine 9816144 11296820 8652307 10939020 9474497 9690346 8696651 8866196 L-asparagine Asparagine 278499.3000 449202.2000 470385.2000 499535.5000 366180.8000 448378.4000 323211.7000 369701.5000 L-aspartate Aspartic acid 1772503 2600101 2738762 3014410 2126716 2682148 1893171 2323962 L-Carnitine Carnitine 1796599 1848186 1387678 1430163 1346911 1248948 1488786 1356636 L-Citrulline Citrulline 33514.6200 57404.3800 48709.6100 43118.4100 71532.2000 70962.6900 75121.2200 78022.5000 L-cysteine Cysteine 29179.1500 42591.9800 35181.6600 42745.1200 36903.5900 39842.3900 33297.9500 33459.1800 L-cystine Cystine 23995.6400 28793.0900 23110.2300 24356.8100 19560.6800 18091.3700 18358.9100 20575.7400 L-glutamate Glutamic acid 4209810 5663506 6202686 6222770 5148734 6169774 4316300 4601535 L-glutamine Glutamine 1101014 1477172 1297373 1405208 1131900 1385852 943984.8000 1057698 L-histidine Histidine 432550.2000 546134.3000 508735.3000 559171.1000 661184.2000 501516.5000 588026.3000 698885.8000 L-leucine/isoleucine Leucine 7540604 7634414 6560772 6775482 5859734 6118064 6318552 6438852 L-lysine Lysine 408594.7000 331521.5000 384127 390379.9000 339298.1000 343652.8000 355650.7000 408541.8000 L-methionine Methionine 1840196 2034489 1925362 1788372 1628233 1278501 1627498 1538566 L-Methionine S-oxide Methionine sulfoxide 147734.5000 88623.3800 101842.4000 100555.5000 99382.9100 66533.9300 99130.6500 58440.1100 L-octanoylcarnitine (acyl-C8) CAR 8:0 16225.3900 16382.9800 22199.1600 21193.7000 11968.0500 11860.1900 12134.8600 11483.6400 L-Palmitoylcarnitine (acyl-C16) CAR 16:0 68576.5200 59447.4100 101208.5000 103265.4000 25785.2700 25822.0500 92625.8100 75484.4300 L-phenylalanine Phenylalanine 2943106 2643999 2360224 2219698 2344554 2354135 2706233 3192963 L-proline Proline 12292660 14385920 13907360 13842290 9453505 10765260 9427457 10355620 L-serine Serine 386744.7000 566277.7000 637541.5000 787477.4000 750107.7000 699896.8000 603004.6000 778602.2000 L-threonine Threonine 271374.6000 389165.1000 429592.2000 473229.5000 410822.1000 457620.2000 366732.2000 429815.2000 L-tryptophan Tryptophan 1207147 1209066 1166954 1255822 1169436 946013.8000 1171434 1162017 L-tyrosine Tyrosine 3792917 3816349 3004382 2874980 3590117 2120591 3372709 2435818 L-valine Valine 6208846 6386062 5819806 6601522 5458792 6064960 6007768 5817142 N-Acetyl-L-citrulline N-Acetylcitrulline 94885.4400 248451.2000 96684.2300 84767.3200 101746.6000 148805.8000 218326.1000 153648.3000 NAD+ NAD 882142.1000 910126.3000 1119133 891170.4000 427988.1000 611790.5000 470638 590737.4000 NADP+ NADP 13050.1200 14033.0900 18497.1500 17892.2400 5944.6480 4702.0770 3955.1110 6155.7060 Nicotinamide Niacinamide 16338690 20371110 15552190 20396270 21011410 17360390 20466720 20197780 N-Succinyl-L-glutamate 5-semialdehyde 48660.3900 53142.7100 54627.5000 53622.9600 25476.8400 32440.4100 26563.5100 28664.7400 Octadecanoyl-L-carnitine (acyl-C18) CAR 18:0 22221.7800 254316.7000 25376.8700 92576.4600 24538.2300 10639.3200 80052.6800 32577.5000 O-Decenoyl-L-carnitine (acyl-C10:1) 22603.3200 32466.4500 29756.5800 33181.1200 23410.6700 24079.2700 29065.2900 22997.4800 O-dodecenoyl-carnitine (acyl-C12:1) CAR 12:1 1486989 1249311 1613914 1657771 1421730 1980051 1862438 1734403 O-octadecenoyl-L-carnitine (acyl-C18:1) CAR 18:1 24955.7400 25115.7700 21565.8400 29061.5100 11460.8300 11977.5800 47281.3300 28718.5400 Ornithine Ornithine 157608.4000 206632.3000 217007.8000 232587.5000 347157 219038 290127.9000 367067.1000 O-tetradecanoyl-L-carnitine (acyl-C14) CAR 14:0 27347.7600 25429.0200 39969.9100 38373.4400 5699.2410 2329.7180 25782.4900 13839.5900 Phosphoserine Phosphoserine 64139.7700 68949.1400 83072.5200 64131.7000 58135.7300 57209.1100 48172.9800 64588.5600 propionyl-carnitine (acyl-C3) CAR 3:0 187646.9000 225789.4000 163514.9000 159785 104950.9000 144916.5000 136092.4000 157642.3000 Putrescine Putrescine 132702.4000 83762.6200 64386.0800 71458.2700 60132 56292.7800 131177.8000 67566.4100 S-Adenosyl-L-homocysteine S-Adenosylhomocysteine 104394.3000 78656.7700 98485.4300 100371 80175.1200 81068.8700 112079 79766.9800 S-Adenosyl-L-methionine S-Adenosylmethionine 188482.3000 156553.1000 137030.6000 177016.3000 151653.6000 151432.1000 161634.1000 175776.7000 Spermidine Spermidine 284191.7000 270282.8000 325427.5000 216473.2000 200398 152133.4000 333433.6000 288685.4000 Spermine Spermine 55700.5800 49597.9200 96055 59683.5200 40694.3700 24330.6700 54350.1100 64880.2500 Sphingosine Sphingosine 198160.3000 174840.7000 170430.5000 206426.8000 66541.2500 100253.3000 231344.9000 193211.5000 Taurine Taurine 3985802 4890046 4682844 5102597 3990009 4621702 3696854 4335012 trans-4-Hydroxy-L-proline trans-4-Hydroxyproline 651177.5000 827619.2000 812960.8000 951099.3000 688776.5000 813576 604331 700445.5000 UDP UDP 92282.3800 103437.4000 114533.4000 121617 88846.9900 80037.0700 76711.0200 78554.7300 UMP UMP 656865.8000 927946.5000 770534.5000 1087464 893351.7000 801612.2000 799320.7000 664863.2000 Uracil Uracil 132097.4000 130337.7000 143446.6000 175422.1000 170400 113466.4000 145534.8000 127921.6000 Urate Uric acid 786828.8000 857789.4000 769502.1000 712302.5000 761466.3000 754633.8000 702935.4000 767341.8000 Xanthine Xanthine 318553.8000 296458.7000 282762.5000 350826.2000 270286.6000 211436.8000 268019.8000 230413