Metabolite_name	RefMet_name	E_L3A	E_L3B	E_L3C	E_L3D	E_L3E	E_L4A	E_L4B	E_L4C	E_L4D	E_L4E	E_L7A	E_L7B	E_L7C	E_L7D	E_L7E	E_L8A	E_L8B	E_L8C	E_L8D	E_L8E
Factors	-	Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye	Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye
Cer 18:1/16:0	Cer 18:1;O2/16:0	1020.7368	890.4384	810.7402	953.3242	642.0182	782.8804	544.1972	774.5039	1167.1588	644.7723	865.5164	1399.2982	805.8821	733.9069	682.7560	675.5376	1010.2725	783.7160	892.1642	778.7868
Cer 18:1/18:0	Cer 18:1;O2/18:0	452.9283	473.3818	473.9499	451.3502	429.8576	406.2297	300.1440	334.3992	587.5147	347.4624	384.1813	375.6894	384.2377	380.9642	351.6999	352.9778	421.7293	366.6610	396.4481	393.1542
Cer 18:1/20:0	Cer 18:1;O2/20:0	1331.3209	1208.0098	1215.1193	1376.5340	1023.0626	1011.5424	1019.8293	965.4711	1247.6856	893.7909	1053.1164	1596.4699	1220.9745	922.7640	900.5563	1077.8667	1342.6720	947.5947	1187.1561	998.8180
Cer 18:1/22:0	Cer 18:1;O2/22:0	1086.7584	1234.0401	1133.0677	1241.7520	917.1916	775.5510	782.3776	791.8018	1192.1197	776.1481	901.4713	1404.9387	897.0171	853.2614	912.1328	894.0316	1197.0371	826.0024	1036.8931	903.2677
Cer 18:1/24:0	Cer 18:1;O2/24:0	943.8668	1076.9867	993.4136	1083.8896	838.0515	766.4062	869.2353	676.7955	964.0293	669.9895	830.2337	1348.2059	848.5361	798.5247	787.9148	772.0529	1018.6682	796.0272	909.5560	831.6234
Cer 18:1/24:1	Cer 18:1;O2/24:1	783.8041	772.6162	686.3855	787.0285	490.8727	627.8073	588.2160	499.8288	803.0502	473.7008	642.5883	917.1119	660.5425	547.3739	588.9797	588.0328	716.0292	533.2089	680.3944	588.6420
DHCer 18:0/16:0	Cer 18:0;O2/16:0	13.3767	14.5255	13.1965	12.9870	10.7478	11.7496	7.5981	11.5353	16.2104	9.6840	12.6896	13.5450	11.7109	10.7803	10.0148	10.5806	15.1226	12.2121	13.1091	12.6244
DHCer 18:0/18:0	Cer 18:0;O2/18:0	2.6591	3.2420	3.3031	3.5717	2.9304	3.0710	2.3156	2.6582	5.0451	2.4656	2.6263	3.0595	2.8310	3.5705	2.6251	2.6536	3.3738	2.8619	3.0371	3.2513
DHCer 18:0/20:0	Cer 18:0;O2/20:0	3.4473	3.7739	3.8855	3.8062	3.4006	3.5766	2.7335	3.1416	5.3869	3.2553	3.4967	3.1601	2.8358	5.7596	3.1115	3.3611	3.8448	3.3911	3.9188	3.8304
DHCer 18:0/22:0	Cer 18:0;O2/22:0	2.9303	2.9281	3.1282	3.6586	2.9088	3.0517	2.8424	2.9051	4.8323	2.9302	2.7003	2.3500	2.7501	2.0828	2.1998	3.1970	3.3372	3.1799	3.2083	3.3386
DHCer 18:0/23:0	Cer 18:0;O2/23:0	0.1860	0.3690	0.6953	0.2699	0.2426	0.3253	0.2413	0.3339	0.4791	0.3586	0.3272	0.2636	0.3687	0.1986	0.2253	0.2374	0.3489	0.3015	0.3656	0.4197
DHCer 18:0/24:0	Cer 18:0;O2/24:0	1.3578	1.8558	1.8950	1.6820	1.5911	1.6637	1.6577	1.3133	2.4644	1.3633	1.1550	1.3728	1.2724	1.2438	1.1263	1.9218	1.6812	1.4405	1.8055	1.6618
DHCer 18:0/24:1	Cer 18:0;O2/24:1	1.4895	1.5190	1.0317	1.5612	0.8656	1.2936	1.0089	1.2210	2.3409	1.3105	1.4636	0.8981	1.2250	1.0248	0.8108	0.9498	1.7178	1.4648	1.3884	1.2464
doxDHCer 18:0/18:0		27.9869	38.0311	30.5837	43.3919	30.9166	126.2370	108.8373	130.0378	120.5833	111.4017	26.1353	39.4069	27.7824	30.2867	22.8685	116.3031	79.5121	105.9052	112.2837	108.9411
doxDHCer 18:0/20:0		95.5197	89.4560	80.7552	93.1883	68.2194	293.2498	287.7676	347.6948	330.3255	289.2134	80.6040	106.9625	84.3206	65.3203	67.6289	273.6229	294.2514	259.0999	289.0669	313.7290
doxDHCer 18:0/22:0		68.8480	65.8259	56.5626	90.1093	67.8008	176.9513	185.5100	217.0658	264.5385	186.3016	60.9949	89.9343	53.4314	52.9969	53.5689	197.6987	222.3996	182.0423	236.7184	216.6520
doxSA-C18:0	Spisulosine	2.2833	2.4953	2.0853	2.2242	1.8178	5.8512	4.2685	5.0522	6.7855	5.1389	1.5148	1.7453	1.4094	1.6245	1.5657	4.0627	5.1311	4.7056	5.0529	5.5848
Gluc/Gal-Cer 18:1/16:0	HexCer 18:1;O2/16:0	4194.8391	4405.2171	4606.1856	3896.0756	3587.8049	4438.5863	3082.1532	3749.9938	5496.5662	3511.1694	3837.5448	3427.7951	3826.7320	3316.8541	3170.5595	3433.4545	4905.1640	3876.4109	3709.8206	3691.3561
Gluc/Gal-Cer 18:1/18:0	HexCer 18:1;O2/18:0	402.2655	363.8396	345.2948	404.0292	272.3428	354.3615	286.2884	269.7149	443.2006	286.1699	373.2792	285.7332	378.8489	265.8246	237.4876	277.0107	425.7509	327.0745	319.1690	326.1139
Gluc/Gal-Cer 18:1/20:0	HexCer 18:1;O2/20:0	1455.9965	1410.3225	1570.0641	1376.8634	1268.9927	1361.1108	884.3911	1124.5965	1566.3738	1132.1929	1444.9597	1020.2013	1335.1987	1221.6103	1106.4612	1007.5483	1639.1774	1385.8391	1299.7320	1286.6653
Gluc/Gal-Cer 18:1/22:0	HexCer 18:1;O2/22:0	5535.8838	5621.7879	5536.8081	5334.3327	4573.6437	4781.1668	3753.4060	3931.8172	5866.1784	4090.0607	4974.4399	4237.6811	4998.4800	4031.8477	3893.9440	4111.7667	5931.6178	4512.8180	4313.8961	4215.2678
Gluc/Gal-Cer 18:1/24:0	HexCer 18:1;O2/24:0	3659.7101	3631.7451	3829.6904	3575.7855	2959.4624	3216.7644	2368.1956	2382.4557	4094.4180	2518.1921	3266.7290	2928.0598	3530.7852	2745.5687	2598.3920	2616.8118	3667.0576	2903.4849	2687.9061	2964.2285
Gluc/Gal-Cer 18:1/24:1	HexCer 18:1;O2/24:1	1652.0295	858.3848	919.6140	2292.5039	615.4200	1059.1711	1062.4469	497.6790	1504.6819	541.8116	1243.3482	1039.6548	1732.4027	573.8688	565.7296	693.1922	846.8831	791.9690	674.3634	630.3944
Lact-Cer 18:1/16:0	LacCer 18:1;O2/16:0	47.9189	58.4005	57.3596	40.6097	46.5870	47.7016	39.5851	43.2842	72.8372	46.7006	47.6956	53.0063	42.8588	38.4734	36.1787	39.8431	69.9833	51.9921	57.2609	49.3958
Lact-Cer 18:1/18:0	LacCer 18:1;O2/18:0	36.0568	44.0835	37.5456	37.8029	35.8219	32.3420	28.0464	30.3935	36.9841	24.7450	35.4209	29.8939	30.3897	22.7321	28.1789	27.7872	47.0606	34.8074	33.8925	35.9345
Lact-Cer 18:1/20:0	LacCer 18:1;O2/20:0	36.5729	39.0415	39.6316	31.7685	32.1975	36.1819	23.9118	28.3027	47.8206	30.7931	35.3516	23.7960	28.2987	28.8967	24.4807	21.4236	41.2731	33.4709	33.1297	29.6675
Lact-Cer 18:1/22:0	LacCer 18:1;O2/22:0	114.1964	124.7718	130.3364	107.6673	116.6386	110.2713	82.2865	85.3388	133.4536	100.1365	136.0310	81.1729	91.4100	98.5261	93.9244	81.7287	126.8230	119.5581	106.7450	108.1648
Lact-Cer 18:1/24:0	LacCer 18:1;O2/24:0	121.0002	143.3287	132.0583	105.2363	102.8043	103.7382	76.7985	79.6596	124.1603	86.4808	116.3434	96.2361	106.6898	94.5314	92.6365	74.9579	139.0218	101.1055	113.0659	106.5486
Lact-Cer 18:1/24:1	LacCer 18:1;O2/24:1	23.5800	27.9196	28.3881	19.9790	24.3375	21.8737	18.5071	18.6917	27.8421	20.9996	22.1658	23.0983	16.8550	20.4758	23.0239	14.3767	25.9048	24.9488	23.7545	21.6821
SA-C18:0	Sphinganine	7.8454	7.5163	7.4162	6.5640	6.6072	9.2342	6.5486	6.3266	8.2332	6.3934	6.6350	6.2034	5.8603	4.7821	5.3049	6.8865	8.1605	6.5581	7.8551	7.6014
SM-C14:0	SM 18:1;O2/14:0	69.4371	72.3248	63.6406	76.1070	57.7481	71.3218	59.8357	55.7164	62.0823	47.3251	59.7543	87.5285	65.2256	57.0143	58.1518	56.8039	73.9365	58.0147	65.3121	65.9671
SM-C16:0	SM 18:1;O2/16:0	10927.1744	11661.7242	11085.2140	11606.0186	10518.4888	11202.6940	7975.3640	9381.5734	12697.5008	8833.8249	11233.2646	9507.6752	10430.6588	10069.2167	9877.0673	8722.4262	11895.9362	10350.4355	10950.8175	11205.6705
SM-C18:0	SM 18:1;O2/18:0	3714.9752	3986.0976	3974.4993	4110.5777	3875.2939	3767.5484	2910.8619	3208.5819	4396.0255	3268.3291	3794.1166	3176.0820	3571.5040	3517.3458	3498.0501	3233.0997	4050.2055	3635.9940	3694.2030	3802.6282
SM-C18:1	SM 18:1;O2/18:1	945.6890	897.1476	870.5660	989.8103	878.8256	795.4581	728.7004	814.4773	864.6186	686.8570	816.6077	770.7355	819.3422	712.9326	696.5067	772.8744	958.2722	748.8720	883.4612	812.7408
SM-C20:0	SM 18:1;O2/20:0	6775.3536	6934.6921	7404.1334	7562.7904	7148.2595	6642.0094	5476.9441	5818.8371	7037.6797	5604.8808	7152.7105	5486.0717	6703.0721	6135.0883	6090.0549	5928.8419	7244.7357	6324.9001	6869.1619	6913.7209
SM-C20:1	SM 18:1;O2/20:1	1103.8443	1027.3474	1212.2126	1322.8941	1344.0233	1137.5012	919.4399	1040.4072	987.1224	865.7875	1235.4550	777.0484	1158.2841	1085.7544	1034.3384	1014.4455	1171.5428	1093.1528	1244.5288	1232.2250
SM-C22:0	SM 18:1;O2/22:0	8426.6612	9070.4958	8878.7425	9588.7505	8608.9367	8748.7670	6744.0985	7593.0534	9400.5084	6919.4971	8879.6808	7611.2588	8590.3199	7698.6033	7643.4668	6807.2040	9255.2534	8121.3146	8890.0120	8823.3856
SM-C22:1	SM 18:1;O2/22:1	3157.2529	3057.9933	3517.4537	3507.9647	3770.6599	3229.3791	2657.2466	3123.0220	3022.8569	2673.5060	3569.8269	2313.7214	3282.7101	3120.6329	2890.4176	2851.6610	3492.7496	3023.6688	3545.7856	3615.9539
SM-C24:0	SM 18:1;O2/24:0	5973.8400	6626.6475	6493.3954	6773.5785	6387.6312	6214.1524	5075.1122	5572.4042	6753.7392	5067.1426	6311.5613	5773.1897	6232.4760	5398.0138	5519.6350	5415.0822	6363.1041	5886.0480	6379.7959	6497.9269
SM-C24:1	SM 18:1;O2/24:1	4905.7434	5462.1979	4992.0464	5143.8126	4343.7493	4975.8062	3831.1394	4044.5431	5497.0520	3755.5790	4958.8621	4528.5349	4845.4809	4160.1804	4215.2856	4052.6129	4882.1523	4439.7483	4792.3737	4993.7594
SO-C18:1	Sphingosine	76.9197	74.9872	63.2093	70.8607	66.6901	69.1536	56.7400	58.4735	78.5909	56.9847	69.5672	65.4745	64.1361	51.9456	53.0328	60.7265	74.8506	58.4782	70.4799	65.5251