Metabolite_name RefMet_name E_L3A E_L3B E_L3C E_L3D E_L3E E_L4A E_L4B E_L4C E_L4D E_L4E E_L7A E_L7B E_L7C E_L7D E_L7E E_L8A E_L8B E_L8C E_L8D E_L8E Factors - Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Control diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:PHGDH+/- | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Control diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Genotype:Wild-type | Treatment:Serine/glycine-depleted diet | Sample source:Mouse back of eye Cer 18:1/16:0 Cer 18:1;O2/16:0 1020.7368 890.4384 810.7402 953.3242 642.0182 782.8804 544.1972 774.5039 1167.1588 644.7723 865.5164 1399.2982 805.8821 733.9069 682.7560 675.5376 1010.2725 783.7160 892.1642 778.7868 Cer 18:1/18:0 Cer 18:1;O2/18:0 452.9283 473.3818 473.9499 451.3502 429.8576 406.2297 300.1440 334.3992 587.5147 347.4624 384.1813 375.6894 384.2377 380.9642 351.6999 352.9778 421.7293 366.6610 396.4481 393.1542 Cer 18:1/20:0 Cer 18:1;O2/20:0 1331.3209 1208.0098 1215.1193 1376.5340 1023.0626 1011.5424 1019.8293 965.4711 1247.6856 893.7909 1053.1164 1596.4699 1220.9745 922.7640 900.5563 1077.8667 1342.6720 947.5947 1187.1561 998.8180 Cer 18:1/22:0 Cer 18:1;O2/22:0 1086.7584 1234.0401 1133.0677 1241.7520 917.1916 775.5510 782.3776 791.8018 1192.1197 776.1481 901.4713 1404.9387 897.0171 853.2614 912.1328 894.0316 1197.0371 826.0024 1036.8931 903.2677 Cer 18:1/24:0 Cer 18:1;O2/24:0 943.8668 1076.9867 993.4136 1083.8896 838.0515 766.4062 869.2353 676.7955 964.0293 669.9895 830.2337 1348.2059 848.5361 798.5247 787.9148 772.0529 1018.6682 796.0272 909.5560 831.6234 Cer 18:1/24:1 Cer 18:1;O2/24:1 783.8041 772.6162 686.3855 787.0285 490.8727 627.8073 588.2160 499.8288 803.0502 473.7008 642.5883 917.1119 660.5425 547.3739 588.9797 588.0328 716.0292 533.2089 680.3944 588.6420 DHCer 18:0/16:0 Cer 18:0;O2/16:0 13.3767 14.5255 13.1965 12.9870 10.7478 11.7496 7.5981 11.5353 16.2104 9.6840 12.6896 13.5450 11.7109 10.7803 10.0148 10.5806 15.1226 12.2121 13.1091 12.6244 DHCer 18:0/18:0 Cer 18:0;O2/18:0 2.6591 3.2420 3.3031 3.5717 2.9304 3.0710 2.3156 2.6582 5.0451 2.4656 2.6263 3.0595 2.8310 3.5705 2.6251 2.6536 3.3738 2.8619 3.0371 3.2513 DHCer 18:0/20:0 Cer 18:0;O2/20:0 3.4473 3.7739 3.8855 3.8062 3.4006 3.5766 2.7335 3.1416 5.3869 3.2553 3.4967 3.1601 2.8358 5.7596 3.1115 3.3611 3.8448 3.3911 3.9188 3.8304 DHCer 18:0/22:0 Cer 18:0;O2/22:0 2.9303 2.9281 3.1282 3.6586 2.9088 3.0517 2.8424 2.9051 4.8323 2.9302 2.7003 2.3500 2.7501 2.0828 2.1998 3.1970 3.3372 3.1799 3.2083 3.3386 DHCer 18:0/23:0 Cer 18:0;O2/23:0 0.1860 0.3690 0.6953 0.2699 0.2426 0.3253 0.2413 0.3339 0.4791 0.3586 0.3272 0.2636 0.3687 0.1986 0.2253 0.2374 0.3489 0.3015 0.3656 0.4197 DHCer 18:0/24:0 Cer 18:0;O2/24:0 1.3578 1.8558 1.8950 1.6820 1.5911 1.6637 1.6577 1.3133 2.4644 1.3633 1.1550 1.3728 1.2724 1.2438 1.1263 1.9218 1.6812 1.4405 1.8055 1.6618 DHCer 18:0/24:1 Cer 18:0;O2/24:1 1.4895 1.5190 1.0317 1.5612 0.8656 1.2936 1.0089 1.2210 2.3409 1.3105 1.4636 0.8981 1.2250 1.0248 0.8108 0.9498 1.7178 1.4648 1.3884 1.2464 doxDHCer 18:0/18:0 27.9869 38.0311 30.5837 43.3919 30.9166 126.2370 108.8373 130.0378 120.5833 111.4017 26.1353 39.4069 27.7824 30.2867 22.8685 116.3031 79.5121 105.9052 112.2837 108.9411 doxDHCer 18:0/20:0 95.5197 89.4560 80.7552 93.1883 68.2194 293.2498 287.7676 347.6948 330.3255 289.2134 80.6040 106.9625 84.3206 65.3203 67.6289 273.6229 294.2514 259.0999 289.0669 313.7290 doxDHCer 18:0/22:0 68.8480 65.8259 56.5626 90.1093 67.8008 176.9513 185.5100 217.0658 264.5385 186.3016 60.9949 89.9343 53.4314 52.9969 53.5689 197.6987 222.3996 182.0423 236.7184 216.6520 doxSA-C18:0 Spisulosine 2.2833 2.4953 2.0853 2.2242 1.8178 5.8512 4.2685 5.0522 6.7855 5.1389 1.5148 1.7453 1.4094 1.6245 1.5657 4.0627 5.1311 4.7056 5.0529 5.5848 Gluc/Gal-Cer 18:1/16:0 HexCer 18:1;O2/16:0 4194.8391 4405.2171 4606.1856 3896.0756 3587.8049 4438.5863 3082.1532 3749.9938 5496.5662 3511.1694 3837.5448 3427.7951 3826.7320 3316.8541 3170.5595 3433.4545 4905.1640 3876.4109 3709.8206 3691.3561 Gluc/Gal-Cer 18:1/18:0 HexCer 18:1;O2/18:0 402.2655 363.8396 345.2948 404.0292 272.3428 354.3615 286.2884 269.7149 443.2006 286.1699 373.2792 285.7332 378.8489 265.8246 237.4876 277.0107 425.7509 327.0745 319.1690 326.1139 Gluc/Gal-Cer 18:1/20:0 HexCer 18:1;O2/20:0 1455.9965 1410.3225 1570.0641 1376.8634 1268.9927 1361.1108 884.3911 1124.5965 1566.3738 1132.1929 1444.9597 1020.2013 1335.1987 1221.6103 1106.4612 1007.5483 1639.1774 1385.8391 1299.7320 1286.6653 Gluc/Gal-Cer 18:1/22:0 HexCer 18:1;O2/22:0 5535.8838 5621.7879 5536.8081 5334.3327 4573.6437 4781.1668 3753.4060 3931.8172 5866.1784 4090.0607 4974.4399 4237.6811 4998.4800 4031.8477 3893.9440 4111.7667 5931.6178 4512.8180 4313.8961 4215.2678 Gluc/Gal-Cer 18:1/24:0 HexCer 18:1;O2/24:0 3659.7101 3631.7451 3829.6904 3575.7855 2959.4624 3216.7644 2368.1956 2382.4557 4094.4180 2518.1921 3266.7290 2928.0598 3530.7852 2745.5687 2598.3920 2616.8118 3667.0576 2903.4849 2687.9061 2964.2285 Gluc/Gal-Cer 18:1/24:1 HexCer 18:1;O2/24:1 1652.0295 858.3848 919.6140 2292.5039 615.4200 1059.1711 1062.4469 497.6790 1504.6819 541.8116 1243.3482 1039.6548 1732.4027 573.8688 565.7296 693.1922 846.8831 791.9690 674.3634 630.3944 Lact-Cer 18:1/16:0 LacCer 18:1;O2/16:0 47.9189 58.4005 57.3596 40.6097 46.5870 47.7016 39.5851 43.2842 72.8372 46.7006 47.6956 53.0063 42.8588 38.4734 36.1787 39.8431 69.9833 51.9921 57.2609 49.3958 Lact-Cer 18:1/18:0 LacCer 18:1;O2/18:0 36.0568 44.0835 37.5456 37.8029 35.8219 32.3420 28.0464 30.3935 36.9841 24.7450 35.4209 29.8939 30.3897 22.7321 28.1789 27.7872 47.0606 34.8074 33.8925 35.9345 Lact-Cer 18:1/20:0 LacCer 18:1;O2/20:0 36.5729 39.0415 39.6316 31.7685 32.1975 36.1819 23.9118 28.3027 47.8206 30.7931 35.3516 23.7960 28.2987 28.8967 24.4807 21.4236 41.2731 33.4709 33.1297 29.6675 Lact-Cer 18:1/22:0 LacCer 18:1;O2/22:0 114.1964 124.7718 130.3364 107.6673 116.6386 110.2713 82.2865 85.3388 133.4536 100.1365 136.0310 81.1729 91.4100 98.5261 93.9244 81.7287 126.8230 119.5581 106.7450 108.1648 Lact-Cer 18:1/24:0 LacCer 18:1;O2/24:0 121.0002 143.3287 132.0583 105.2363 102.8043 103.7382 76.7985 79.6596 124.1603 86.4808 116.3434 96.2361 106.6898 94.5314 92.6365 74.9579 139.0218 101.1055 113.0659 106.5486 Lact-Cer 18:1/24:1 LacCer 18:1;O2/24:1 23.5800 27.9196 28.3881 19.9790 24.3375 21.8737 18.5071 18.6917 27.8421 20.9996 22.1658 23.0983 16.8550 20.4758 23.0239 14.3767 25.9048 24.9488 23.7545 21.6821 SA-C18:0 Sphinganine 7.8454 7.5163 7.4162 6.5640 6.6072 9.2342 6.5486 6.3266 8.2332 6.3934 6.6350 6.2034 5.8603 4.7821 5.3049 6.8865 8.1605 6.5581 7.8551 7.6014 SM-C14:0 SM 18:1;O2/14:0 69.4371 72.3248 63.6406 76.1070 57.7481 71.3218 59.8357 55.7164 62.0823 47.3251 59.7543 87.5285 65.2256 57.0143 58.1518 56.8039 73.9365 58.0147 65.3121 65.9671 SM-C16:0 SM 18:1;O2/16:0 10927.1744 11661.7242 11085.2140 11606.0186 10518.4888 11202.6940 7975.3640 9381.5734 12697.5008 8833.8249 11233.2646 9507.6752 10430.6588 10069.2167 9877.0673 8722.4262 11895.9362 10350.4355 10950.8175 11205.6705 SM-C18:0 SM 18:1;O2/18:0 3714.9752 3986.0976 3974.4993 4110.5777 3875.2939 3767.5484 2910.8619 3208.5819 4396.0255 3268.3291 3794.1166 3176.0820 3571.5040 3517.3458 3498.0501 3233.0997 4050.2055 3635.9940 3694.2030 3802.6282 SM-C18:1 SM 18:1;O2/18:1 945.6890 897.1476 870.5660 989.8103 878.8256 795.4581 728.7004 814.4773 864.6186 686.8570 816.6077 770.7355 819.3422 712.9326 696.5067 772.8744 958.2722 748.8720 883.4612 812.7408 SM-C20:0 SM 18:1;O2/20:0 6775.3536 6934.6921 7404.1334 7562.7904 7148.2595 6642.0094 5476.9441 5818.8371 7037.6797 5604.8808 7152.7105 5486.0717 6703.0721 6135.0883 6090.0549 5928.8419 7244.7357 6324.9001 6869.1619 6913.7209 SM-C20:1 SM 18:1;O2/20:1 1103.8443 1027.3474 1212.2126 1322.8941 1344.0233 1137.5012 919.4399 1040.4072 987.1224 865.7875 1235.4550 777.0484 1158.2841 1085.7544 1034.3384 1014.4455 1171.5428 1093.1528 1244.5288 1232.2250 SM-C22:0 SM 18:1;O2/22:0 8426.6612 9070.4958 8878.7425 9588.7505 8608.9367 8748.7670 6744.0985 7593.0534 9400.5084 6919.4971 8879.6808 7611.2588 8590.3199 7698.6033 7643.4668 6807.2040 9255.2534 8121.3146 8890.0120 8823.3856 SM-C22:1 SM 18:1;O2/22:1 3157.2529 3057.9933 3517.4537 3507.9647 3770.6599 3229.3791 2657.2466 3123.0220 3022.8569 2673.5060 3569.8269 2313.7214 3282.7101 3120.6329 2890.4176 2851.6610 3492.7496 3023.6688 3545.7856 3615.9539 SM-C24:0 SM 18:1;O2/24:0 5973.8400 6626.6475 6493.3954 6773.5785 6387.6312 6214.1524 5075.1122 5572.4042 6753.7392 5067.1426 6311.5613 5773.1897 6232.4760 5398.0138 5519.6350 5415.0822 6363.1041 5886.0480 6379.7959 6497.9269 SM-C24:1 SM 18:1;O2/24:1 4905.7434 5462.1979 4992.0464 5143.8126 4343.7493 4975.8062 3831.1394 4044.5431 5497.0520 3755.5790 4958.8621 4528.5349 4845.4809 4160.1804 4215.2856 4052.6129 4882.1523 4439.7483 4792.3737 4993.7594 SO-C18:1 Sphingosine 76.9197 74.9872 63.2093 70.8607 66.6901 69.1536 56.7400 58.4735 78.5909 56.9847 69.5672 65.4745 64.1361 51.9456 53.0328 60.7265 74.8506 58.4782 70.4799 65.5251