Metabolite_name RefMet_name TFL278 TFL290 TFL293 TFL275 TFL272 TFL269 TFL287 TFL284 TFL281 Factors - Sample source:latex | collected month:Aug-22 Sample source:latex | collected month:Dec-22 Sample source:latex | collected month:Jan-23 Sample source:latex | collected month:Jul-22 Sample source:latex | collected month:Jun-22 Sample source:latex | collected month:May-22 Sample source:latex | collected month:Nov-22 Sample source:latex | collected month:Oct-22 Sample source:latex | collected month:Sep-22 1_3-Diaminopropane 1,3-Diaminopropane 0 0 0 1-Deoxynojirimycin 0.0006 0.0012 0.0011 0.0012 0.0011 0.0010 1-Methyl-4-imidazoleacetic acid Methylimidazoleacetic acid 0 0 0 0.0001 0 0.0001 0 0 0 1-Methyladenosine 1-Methyladenosine 0 0 0 0 0 0 0 0 2_4-Diaminobutyric acid 2,4-Diaminobutyric acid 0 0 0 0 0 0 2-Aminoisobutyric acid;2-Aminobutyric acid 0.0005 0.0008 0.0007 0.0013 0.0013 0.0007 0.0006 0.0004 0.0005 2^-Deoxycytidine Deoxycytidine 0 0 0 0 0 0 2-Methylserine 2-Methylserine 0 0 0.0001 0 0 0 0 2^-O-Methylcytidine 2'-O-Methylcytidine 0 0 0 0 3-(3_4-Dihydroxyphenyl)-2-methylalanine;3-Methoxytyrosine 0.0002 0.0002 0.0002 0.0002 0.0002 0.0001 0.0002 0.0002 0.0002 3-Amino-2-piperidone 3-Amino-2-piperidone 0.0009 0.0011 0.0018 0.0015 0.0014 0.0022 0.0023 0.0014 0.0012 3-Aminopropane-1_2-diol (S)-3-Amino-1,2-propanediol 0.0001 0.0002 0.0003 0.0002 0.0001 0.0002 0.0002 0.0001 0.0001 3-Aminopropionitrile 0 0 0 0 0 0 3-Hydroxy-2-methyl-4-pyrone Maltol 0.0155 0.0117 0.0137 0.0084 0.0086 0.0072 0.0125 0.0169 0.0168 3-Hydroxyanthranilic acid 3-Hydroxyanthranilic acid 0 0 0 3-Hydroxyproline cis-3-Hydroxyproline 0.0001 0 0 0.0001 0.0001 3-Methylguanine 3-Methylguanine 0 0 0 3-Methylhistidine;1-Methylhistidine 0.0002 0.0002 0.0003 0.0002 0.0002 0.0002 0.0003 0.0002 0.0002 3-Nitrotyrosine Nitrotyrosine 0 4-Amino-3-hydroxybutyric acid 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 4-Guanidinobutyric acid 4-Guanidinobutanoic acid 0.0002 0.0003 0.0003 0.0003 0.0004 0.0005 0.0002 0.0003 0.0004 4-Methylaminobutyric acid;5-Aminovaleric acid 0.0011 0.0014 0.0021 0.0011 0.0013 0.0009 0.0014 0.0011 0.0010 4-Methylpyrazole Fomepizole 0.0004 0.0008 0.0008 0.0006 0.0007 0.0009 4-Oxopyrrolidine-2-carboxylic acid 4-Oxo-proline 0.0011 0.0012 0.0010 0.0005 0.0007 0.0005 0.0012 0.0008 0.0007 4-(β-Acetylaminoethyl)imidazole N-Acetylhistamine 0 5-Amino-3_4-dihydro-2H-pyrrole-2-carboxylic acid 0.0017 0.0021 0.0022 0.0017 0.0010 0.0014 5-Hydroxylysine 5-Hydroxylysine 0 0 0 0 0 0 0 0 0 5-Methyl-2^-deoxycytidine 5-Methyl-2'-deoxycytidine 0 0 0 0 5-Methylcytidine 5-Methylcytidine 0 0 0 0 0 5-Methylcytosine 5-Methylcytosine 0 0 0 0 0 0 0 0 0 Adenine Adenine 0.0021 0.0012 0.0030 0.0065 0.0038 0.0039 0.0029 0.0033 0.0033 Adenosine Adenosine 0.0001 ADMA Dimethylarginine 0.0009 0.0006 0.0005 0.0009 0.0011 0.0011 0.0006 0.0011 0.0010 Ala Alanine 0.0038 0.0029 0.0038 0.0020 0.0030 0.0021 0.0035 0.0040 0.0036 Ala-Ala;XC0145 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0 0 Albendazole Albendazole 0 allo-Threonine Allothreonine 0.0004 0.0006 0.0006 0.0004 0.0005 0.0003 0.0004 0.0003 0.0005 Aminoacetone Aminoacetone 0.0002 0.0002 0.0002 0.0005 0.0004 0.0003 0.0002 0.0002 Arg Arginine 0.0053 0.0048 0.0053 0.0055 0.0061 0.0045 0.0056 0.0069 0.0057 Argininosuccinic acid Argininosuccinic acid 0.0003 0.0005 0.0005 0.0004 0.0005 0.0004 0.0004 0.0004 0.0005 Asn Asparagine 0.0012 0.0030 0.0012 0.0005 0.0008 0.0006 0.0018 0.0019 0.0010 Asp Aspartic acid 0.0105 0.0241 0.0216 0.0293 0.0183 0.0225 0.0319 0.0224 0.0115 Betaine Betaine 0.0261 0.0289 0.0406 0.0212 0.0199 0.0193 0.0321 0.0276 0.0258 Betaine aldehyde_+H2O Betaine aldehyde 0.0002 0.0002 0.0001 0.0006 0.0004 0.0007 0.0001 0.0003 0.0005 Betonicine Betonicine 0 0 0.0001 0 0 0 0 Cadaverine Cadaverine 0.0001 0.0001 0.0002 0.0004 0.0002 0.0001 0 0 0 Caffeine Caffeine 0.0084 0.0083 0.0084 0.0082 0.0081 0.0089 Carboxymethyllysine N(6)-Carboxymethyl-lysine 0.0001 0.0002 0.0002 0.0002 0.0001 0.0001 0.0002 0.0001 0.0001 Carnitine Carnitine 0.0084 0.0095 0.0108 0.0109 0.0090 0.0095 0.0123 0.0121 0.0087 Choline Choline 0.0050 0.0046 0.0055 0.0046 0.0037 0.0050 0.0023 0.0026 0.0052 cis-4-Hydroxyproline cis-4-Hydroxyproline 0 0 0 0 0 0 0 0 0 Citrulline Citrulline 0.0003 0.0003 0.0003 0.0003 0.0004 0.0003 0.0003 0.0002 0.0003 Creatinine Creatinine 0.0001 0.0002 0.0001 0 0.0001 0 0.0001 0.0001 0.0001 Cystathionine Cystathionine 0 0 Cysteine glutathione disulfide S-Glutathionyl-cysteine 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0004 0.0003 0 Cystine Cystine 0 0 0 0.0005 0 0 0.0001 0.0001 Cytidine Cytidine 0.0004 0.0011 0.0010 0 0 0.0004 0.0004 0.0004 Cytosine Cytosine 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0 Dimethylaminoethanol Dimethylethanolamine 0.0001 0.0001 0.0001 0.0001 0.0001 0 0 0.0001 Ectoine Ectoine 0.0001 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 Ergothioneine Ergothioneine 0 0.0054 0.0050 0.0038 0.0047 Ethanolamine Ethanolamine 0.0051 0.0060 0.0068 0.0066 0.0054 0.0055 0.0038 0.0037 0.0044 Ethylacetimidate 0.0006 0.0006 0.0008 0.0013 0.0013 0.0005 0.0007 0.0007 0.0010 GABA gamma-Aminobutyric acid 0.0033 0.0015 0.0005 0.0045 0.0049 0.0034 0.0005 0.0034 0.0036 Gibberellic acid Gibberellin A3 0 0 0 0 0 0 0 Gln Glutamine 0.0171 0.0317 0.0118 0.0022 0.0042 0.0015 0.0051 0.0132 0.0039 Glu Glutamic acid 0.0061 0.0067 0.0061 0.0025 0.0035 0.0025 0.0066 0.0048 0.0036 Gluconolactone Gluconolactone 0.0003 0.0003 0.0005 0.0003 0.0004 0.0003 0.0003 0.0003 0.0004 Glucosamine Glucosamine 0.0166 0.0031 0.0030 0.0055 0.0018 0.0070 0.0089 0.0104 0.0032 Glucosaminic acid Glucosaminic acid 0 0 0 0.0001 0 0 0 0.0001 0 Glu-Glu Glu-Glu 0 0 0 0 0 0 0 Glutathione (GSSG)_divalent Oxidized glutathione 0.0004 0.0010 0.0019 0 0.0003 0.0003 0.0018 0.0012 0.0003 Gly Glycine 0.0334 0.0402 0.0397 0.0006 0.0006 0.0005 0.0306 0.0285 0.0319 Gly-Asp Gly-Asp 0 0 0 0 0 0 0 0 0 Glycerol Glycerol 0.0012 0.0188 0.0015 0.0015 0.0022 0.0025 0.0054 0.0020 0.0025 Glycerophosphocholine sn-Glycero-3-phosphocholine 0.0073 0.0196 0.0199 0.0129 0.0213 0.0232 0.0565 0.0523 0.0268 Gly-Gly Gly-Gly 0.0001 0 0.0001 0 0 0.0001 0.0001 Gly-Leu Gly-Leu 0 0 0 0 0 Guanidinosuccinic acid Guanidinosuccinic acid 0 0 0 0 0 0 0 Guanidoacetic acid Guanidoacetic acid 0 0 0.0001 0 0.0001 0.0001 0 0 0.0001 Guanine Guanine 0.0002 0.0003 0.0009 0.0001 0.0013 0.0012 0.0003 0.0003 0.0003 Guanosine Guanosine 0.0006 0.0004 0.0003 0 0.0005 0.0004 0 0.0002 0.0006 Gulonolactone L-Gulonolactone 0.0004 0.0004 0.0005 0.0003 0.0004 0.0004 0.0003 0.0003 0.0003 H-Asp(Gly-OH)-OH 0 0 0 0 0 0 Hercynine Hercynine 0.0043 0.0075 0.0132 0.0087 0.0056 0.0048 0.0113 0.0072 0.0051 Hexylamine Hexylamine 0 His Histidine 0.0072 0.0068 0.0068 0.0073 0.0059 0.0041 0.0030 0.0050 0.0058 Histamine Histamine 0 0 0.0001 0 0 0 0 0 0 Homoarginine Homoarginine 0.0001 0.0002 0.0002 Homocitrulline Homocitrulline 0 0 0 0 0 0 Homoserine Homoserine 0.0006 0.0006 0.0007 0.0009 0.0008 0.0005 0.0007 0.0005 0.0006 Hydroxyproline Hydroxyproline 0 0 0 0 0.0001 0 0.0001 0 0 Hypotaurine Hypotaurine 0 0 0 0 0 0 0 0 0 Hypoxanthine Hypoxanthine 0.0002 0.0001 0.0002 0.0014 0.0006 0.0007 0.0004 0.0004 0.0002 Ile Isoleucine 0.0236 0.0223 0.0207 0.0242 0.0176 0.0169 0.0144 0.0179 0.0213 Imidazole-4-methanol Imidazole-4-methanol 0 0.0003 0 0 0 0.0001 0 0 0 Imidazolelactic acid Imidazolelactic acid 0 0 0 Inosine Inosine 0.0002 0.0002 0.0001 0 0.0002 0.0003 0.0001 0.0003 0.0002 Isoglutamic acid Isoglutamic acid 0.0020 0.0023 0.0033 0.0021 0.0017 0.0024 0.0026 0.0022 0.0018 Isopropanolamine Isopropanolamine 0 0 0 0 Leu Leucine 0.0273 0.0239 0.0191 0.0021 0.0014 0.0016 0.0207 0.0284 0.0270 Lipoamide Lipoamide 0 0 0 Lys Lysine 0.0190 0.0178 0.0145 0.0222 0.0167 0.0143 0.0117 0.0183 0.0171 Mannosamine 2-Amino-2-deoxy-D-mannose 0.0001 0.0001 0.0001 0.0003 0.0001 0.0001 0.0001 0.0001 0.0001 Met Methionine 0.0010 0.0006 0.0007 0.0032 0.0018 0.0029 0.0016 0.0009 0.0009 Methionine sulfoxide Methionine sulfoxide 0.0001 0 0 Methoxamine Methoxamine 0 0 N1-Acetylspermidine N1-Acetylspermidine 0 0 N-(1-Deoxy-1-fructosyl)valine 0 0 0 0 0 0 N1-Methylguanosine 1-Methylguanosine 0 0 0 0 N2_N2-Dimethylguanosine N2,N2-Dimethylguanosine 0 0 0 0 N5-Ethylglutamine N(5)-Ethyl-glutamine 0.0005 0.0005 0.0008 0.0005 0.0006 0.0005 0.0007 0.0005 0.0005 N6-Acetyllysine N6-Acetyllysine 0.0001 0.0001 0 0.0001 0.0001 0.0001 0 0.0001 0 N6-Methyladenine 0.0001 0 0 N6-Methyladenosine N6-Methyladenosine 0 0 0 0 N6-Methyllysine N(6)-Methyllysine 0.0002 0.0003 0.0002 0.0003 0.0003 0.0003 0.0002 0.0003 0.0002 N6_N6_N6-Trimethyllysine N-6-Trimethyllysine 0.0009 0.0008 0.0009 0.0010 0.0012 0.0012 0.0009 0.0010 0.0008 N-Acetylglucosamine;N-Acetylgalactosamine;N-Acetylmannosamine 0.0002 0.0003 0.0003 0.0004 0.0004 0.0004 0.0003 0.0003 0.0002 N-Acetylglucosylamine N-Acetyl-beta-glucosaminylamine 0.0001 0.0002 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 N-Acetylhistidine N-Acetylhistidine 0 N-Acetylornithine N-Acetylornithine 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 N-Acetylputrescine N-Acetylputrescine 0 0 N-Acetylserine N-Acetylserine 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 N-Amidinoglutamic acid 0 0 0 0 0 0 0 0 N-Ethylglycine N-Ethylglycine 0.0004 0.0002 N’-Formylkynurenine N-Formylkynurenine 0 0 Nicotinamide Niacinamide 0.0010 0.0010 0.0014 0.0009 0.0012 0.0005 0.0013 0.0006 0.0008 Nicotinamide riboside Nicotinamide riboside 0 0.0001 0 0 0 0 Nicotinic acid Nicotinic acid 0.0011 0.0011 0.0013 0.0012 0.0011 0.0013 0.0014 0.0013 0.0013 N-Methylalanine N-Methylalanine 0.0001 N-Methylanthranilic acid 2-(Methylamino)benzoic acid 0 N-Methylaspartic acid N-Methyl-D-aspartic acid 0 0 0 N-Methylglutamic acid N-Methyl-glutamic acid 0 0 0.0001 0 0 0 0 0 N-Methylproline N-Methyl-proline 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 Nω-Methylarginine 0.0008 0.0007 0.0008 0.0009 0.0012 0.0012 0.0009 0.0009 0.0009 Octopamine;Dopamine 0 0 Ophthalmic acid Ophthalmic acid 0 0 0.0001 0 0 0 0.0001 0 0 Ornithine Ornithine 0.0039 0.0034 0.0041 0.0037 0.0037 0.0035 0.0056 0.0059 0.0035 Oxalic acid Oxalic acid 0 0 0 Phe Phenylalanine 0.0181 0.0170 0.0192 0.0232 0.0141 0.0142 0.0105 0.0134 0.0153 Phosphorylcholine Choline phosphate 0.0063 0.0086 0.0129 0.0060 0.0049 0.0029 0.0073 0.0045 0.0053 Pipecolic acid Pipecolic acid 0.0009 0.0015 0.0022 0.0007 0.0015 0.0012 0.0010 0.0010 0.0009 Piperidine Piperidine 0 0 Pro Proline 0.0135 0.0137 0.0099 0.0144 0.0170 0.0090 0.0107 0.0130 0.0133 Putrescine Putrescine 0.0002 0.0002 0.0003 0.0003 0.0003 0.0001 0.0003 0.0002 0.0003 Pyrazole 1H-pyrazole 0 Pyridoxal Pyridoxal 0 0 0 Pyridoxine Pyridoxine 0 0.0001 0.0001 0.0001 Pyroglutamine Pyroglutamine 0.0001 0.0002 0.0002 0.0001 0.0001 0.0001 Saccharopine Saccharopine 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0.0001 S-Adenosylhomocysteine S-Adenosylhomocysteine 0 0 Sarcosine Sarcosine 0.0001 S-Carboxymethylcysteine S-Carboxymethyl-cysteine 0 0 0 0 0 0 0 0 0 SDMA Symmetric dimethylarginine 0.0002 0.0002 0.0001 0.0003 0.0003 0.0003 0.0002 0.0003 0.0002 Ser Serine 0.0068 0.0086 0.0066 0.0079 0.0071 0.0086 0.0086 0.0096 0.0072 Ser-Glu Ser-Glu 0 0 0 0 S-Methylglutathione S-Methylglutathione 0 0 0 0 0 S-Methylmethionine S-Methylmethionine 0.0004 0.0004 0.0004 0.0002 0.0001 0 0.0001 0.0001 0.0002 Spermidine Spermidine 0.0004 0.0005 0.0006 0.0003 0.0004 0.0003 0.0005 0.0006 0.0005 Spermine Spermine 0.0004 0.0005 0.0005 0.0003 0.0003 0.0003 0.0005 0.0005 0.0004 Stachydrine Stachydrine 0.0008 0.0011 0.0015 0.0009 0.0008 0.0009 0.0011 0.0011 0.0008 Succinyladenosine Succinyladenosine 0.0015 0.0010 0.0012 0.0008 0.0011 0.0012 Theobromine Theobromine 0.0011 0.0013 0.0013 0.0014 0.0011 0.0010 Thiaproline 0.0001 0 0 0.0002 0 0 0.0001 0.0001 0 Thr Threonine 0.0016 0.0013 0.0009 0.0066 0.0020 0.0018 0.0021 0.0033 0.0008 Thr-Asp Thr-Asp 0 threo-3-Hydroxyaspartic acid 0 0 0 0 0 0 0 threo-β-Methylaspartic acid 0 0 Thymidine Thymidine 0 0 0 0.0001 0 0.0001 0 0 0 trans-Glutaconic acid Glutaconic acid 0.0001 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 Trigonelline Trigonelline 0.0328 0.0389 0.0375 0.0315 0.0340 0.0332 0.0402 0.0380 0.0359 Trimethylamine Trimethylamine 0 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0 Trimethylamine N-oxide Trimethylamine N-oxide 0 0 0 0 Trp Tryptophan 0.0043 0.0044 0.0042 0.0069 0.0047 0.0035 0.0027 0.0046 0.0045 Tryptamine Tryptamine 0 0 0 0 0 Tyr Tyrosine 0.0104 0.0071 0.0068 0.0137 0.0084 0.0075 0.0053 0.0082 0.0092 Tyramine Tyramine 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 Tyrosine methyl ester Methyl tyrosinate 0 Uracil Uracil 0.0003 0.0004 0.0005 0.0012 0.0011 0.0009 0.0002 0.0002 0.0002 Uridine Uridine 0.0004 0.0011 0.0010 0.0004 0.0010 0.0015 0.0004 0.0004 0.0005 Urocanic acid Urocanic acid 0 0 0 0.0002 0 0.0001 0 0 0 Val Valine 0.0438 0.0394 0.0358 0.0016 0.0013 0.0012 0.0269 0.0342 0.0372 Xanthine Xanthine 0.0021 0.0001 0.0002 0.0001 XC0016 0.0014 0.0016 0.0011 XC0029 0.0001 0.0001 0 XC0040 0 0.0001 0.0002 XC0065 0 0 0 XC0071 0.0002 0.0002 0.0001 XC0089 0 0 XC0126 0.0001 0.0001 0.0001 XC0144 0 XC0154 0.0021 0.0021 0.0031 β-Ala beta-Alanine 0.0009 0.0008 0.0013 0.0008 0.0009 0.0009 0.0013 0.0009 0.0009 β-Cyanoalanine Cyanoalanine 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0 0 γ-Butyrobetaine 3-Dehydroxycarnitine 0.0015 0.0016 0.0019 0.0016 0.0015 0.0017 0.0017 0.0017 0.0012 γ-Glu-Ala gamma-Glutamylalanine 0.0059 0.0020 0.0041 0.0018 0.0025 0.0006 0.0006 0.0010 0.0031 γ-Glu-Arg_divalent 0.0004 0.0001 0.0002 0.0001 0.0001 0 0 0.0001 0.0002 γ-Glu-Asn 0.0002 0.0002 0.0002 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 γ-Glu-Asp 0.0001 0.0001 0.0001 0.0001 0 0.0001 0.0001 0 0 γ-Glu-Citrulline 0 0 0 0 0 0 0 γ-Glu-Gln gamma-Glutamylglutamine 0.0058 0.0081 0.0120 0.0049 0.0046 0.0010 0.0016 0.0014 0.0055 γ-Glu-Glu gamma-Glutamylglutamic acid 0.0036 0.0014 0.0021 0.0008 0.0008 0.0003 0.0003 0.0003 0.0011 γ-Glu-Gly gamma-Glutamylglycine 0.0009 0.0004 0.0006 0.0005 0.0004 0.0002 0.0001 0.0001 0.0004 γ-Glu-His gamma-Glutamylhistidine 0.0001 0.0001 0.0001 0.0001 0.0001 0 0 0 0.0001 γ-Glu-Leu;γ-Glu-Ile 0.0018 0.0008 0.0010 0.0013 0.0008 0.0002 0.0001 0.0002 0.0009 γ-Glu-Lys_divalent 0.0014 0.0006 0.0007 0.0008 0.0005 0.0001 0.0001 0.0002 0.0006 γ-Glu-Met gamma-Glutamylmethionine 0 0 0 0.0001 0.0001 0 0 0 0 γ-Glu-Ornitine;H-Asp(Lys-OH)-OH 0.0001 0 0.0001 0.0001 0 0 0 0 0.0001 γ-Glu-Phe gamma-Glutamylphenylalanine 0.0007 0.0003 0.0005 0.0004 0.0002 0 0 0.0001 0.0003 γ-Glu-Ser gamma-Glu-Ser 0.0002 0.0001 0.0001 0.0001 0.0001 0 0 0 0.0001 γ-Glutamyl-S-Allylcysteine 0 0 0 0 0 0 0 0 0 γ-Glu-Thr gamma-Glutamylthreonine 0.0001 0 0.0001 0.0001 0.0001 0 0 0 0 γ-Glu-Trp 0.0002 0.0002 0.0003 0.0003 0.0002 0 0 0.0001 0.0002 γ-Glu-Tyr gamma-Glutamyltyrosine 0.0005 0.0002 0.0003 0.0003 0.0002 0 0 0.0001 0.0003 γ-Glu-Val gamma-Glutamylvaline 0.0017 0.0006 0.0009 0.0008 0.0005 0.0002 0.0001 0.0002 0.0007 γ-Glu-Val-Gly 0 0 0 0 0 0 0 0