Metabolite_name RefMet_name S00014378 S00014379 S00014389 S00014390 S00014395 S00014398 S00014399 S00014402 S00014404 S00014406 S00014408 S00014410 S00014412 S00014414 S00014416 S00014418 S00014420 S00014422 S00014380 S00014381 S00014384 S00014385 S00014386 S00014387 S00014391 S00014397 S00014401 S00014405 S00014407 S00014409 S00014411 S00014413 S00014415 S00014417 S00014419 S00014423 Factors - AMY1 Group:high | Day:Day 35 AMY1 Group:high | Day:Day 35 AMY1 Group:high | Day:Day 35 AMY1 Group:high | Day:Day 35 AMY1 Group:high | Day:Day 35 AMY1 Group:high | Day:Day 35 AMY1 Group:high | Day:Day 35 AMY1 Group:high | Day:Day 35 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:high | Day:Day 6 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 35 AMY1 Group:low | Day:Day 6 AMY1 Group:low | Day:Day 6 AMY1 Group:low | Day:Day 6 AMY1 Group:low | Day:Day 6 AMY1 Group:low | Day:Day 6 AMY1 Group:low | Day:Day 6 AMY1 Group:low | Day:Day 6 AMY1 Group:low | Day:Day 6 AMY1 Group:low | Day:Day 6 2-AMINO-4-METHYLPENTANOIC ACID (LEUCINE) Leucine 17472456 18835608 14618274 17212946 18811696 18009286 18296686 18425490 17300000 19900000 13700000 20000000 14200000 17500000 20200000 21300000 17900000 16200000 16601256 19163976 17992488 19599928 20315786 15157568 20235510 16633163 17633614 18500000 17100000 14100000 19100000 15400000 14800000 16300000 19100000 18000000 3-METHOXYTYROSINE 3-Methoxytyrosine 12919 17075 18167 11628 19678 17763 12787 15647 4671 11740 20590 10856 10319 20557 19985 18312 21597 11782 7461 14821 11199 12791 4-ACETAMIDOBUTANOATE 4-Acetamidobutanoic acid 15725 11308 10776 12079 20831 22507 17794 22644 17051 7604 15507 11926 11789 15244 19196 18019 8019 10292 13689 12654 8776 24120 13219 27440 15790 7651 15319 15991 8755 16168 14164 5?-DEOXY-5?-(METHYLTHIO)ADENOSINE 5'-Methylthioadenosine 29330 75962 24560 37126 48202 31816 44886 49242 110165 148882 216011 213604 226709 214703 113810 156836 204286 440867 79420 32932 57298 32162 35675 32246 44820 31922 34216 177099 247252 347302 165480 236939 337856 212583 163441 215990 5-OXOPROLINE Pyroglutamic acid 196017 381575 187994 217257 368093 274828 360724 427976 525960 634087 464439 27455 460548 449993 579044 777701 588895 703100 422687 400531 390880 290691 287841 350830 329115 303160 384270 448619 624096 410170 440828 596475 580416 612540 ADENOSINE Adenosine 20037 14078 38700 28848 44911 83593 35789 269327 31763 243593 323989 56520 26679 172193 12819 21338 15160 14661 42004 21617 33878 42838 19253 39047 150735 195297 302961 307414 56569 321373 ASPARAGINE Asparagine 11573 43800 22554 15108 43183 20150 43952 48638 27281 22056 17359 25843 15848 18362 20730 20504 21011 19464 6400 23477 33456 43740 54961 11242 51410 25591 9937 5784 17752 9522 9242 15379 17438 32571 23542 CIS-9-PALMITOLEIC ACID Palmitoleic acid 1835 7292 32730 2312 26149 3844 1791 12999 5252 3691 35260 18902 2034 42741 4391 CITRIC ACID Citric acid 109378 482882 204971 194239 369952 240453 386068 345702 337870 455375 88864 394589 166059 212844 331025 914044 311862 70251 55332 215708 353488 280564 408787 240689 317821 283109 393696 354050 449836 116759 512538 268837 93193 216822 724963 274154 DEOXYCYTIDINE Deoxycytidine 18367 19633 9199 20136 22069 26755 21482 17704 21611 20186 1543 14414 16552 17768 20663 25012 18437 24330 20871 18016 33656 22912 2367 D-GLUCOSIDE (METHYL BETA-D-GALACTOSIDE) Methyl beta-D-galactoside 50149 173093 41371 57065 98396 109692 171061 129560 112166 72834 30985 106787 51133 76280 127314 113140 65540 30889 54044 89661 138536 118621 107262 72109 123690 112102 84356 86052 88198 47308 73043 78099 46478 62322 121403 81338 EDTA Edetic acid 72939784 58710344 76619104 68966056 60178184 61203468 57525808 60075420 59400000 64600000 66200000 57200000 62200000 50800000 49700000 48200000 63400000 33800000 65607828 62638036 60483092 61282476 58179768 76913256 55719312 64803028 30143704 58300000 65600000 58300000 55600000 58200000 61100000 62500000 57800000 55500000 GUANINE Guanine 224608 230034 154188 192608 201224 180801 221005 197368 222716 235912 115748 232395 146787 8377 259893 265013 7546 176568 239336 190566 233374 234514 141698 237455 188893 213838 213749 1777 3972 148859 149842 256142 2242 HIPPURIC ACID Hippuric acid 113716 722291 76561 90601 109524 262299 113546 471040 83409 187108 434675 136717 71951 791842 122175 317362 402609 71220 1529096 839430 959400 5065 734687 129180 1264315 783363 823563 705127 157771 26265 805200 330080 HYPOXANTHINE Hypoxanthine 3192 3347 3926 7987 2539 138862 298705 253798 6931 276784 829067 14816 89850 63378 2790498 11283 6510 5406 1257 187666 430051 1237397 143506 91680 1094796 144774 205817 748454 INOSINE 5^-MONOPHOSPHATE (IMP) IMP 6817 2717 1677 365107 683668 584052 49142 781063 1087853 737034 878454 8572 7208 26131 14342 10937 570947 1068699 869439 760849 836639 515632 1077158 ISOLEUCINE Isoleucine 9491392 9499933 7169106 8294179 9439524 9046855 8868694 9065788 9159623 10400000 6613124 10300000 7105117 9036462 10500000 11300000 8159358 7468135 8637178 9156707 8619694 9681147 9894078 7999820 9351217 8290887 8998695 9711238 9459023 6949986 9833652 7636842 7547118 7987570 9629082 8395802 KYNURENINE Kynurenine 174074 190054 92005 149752 119350 223560 175014 199436 323602 173498 82145 149734 182636 129718 223234 178242 146524 155186 180784 233014 184189 233853 187068 139629 205294 203362 188573 242768 164811 111927 225741 176137 135608 339228 130303 122357 L-CARNITINE Carnitine 176717 315337 98372 100523 194215 183599 1056226 284201 352274 584485 748469 335388 449886 1448161 1124864 429182 99324 156068 762158 214798 219529 168809 130403 203610 188546 155525 564684 577862 461422 258076 564792 378836 428967 498911 465312 L-THYROXINE Thyroxine 18782 23132 7195 19115 18278 24464 17861 15356 10847 5558 1044 16880 3834 11201 8741 3397 1432 15193 13779 25149 24199 18560 16715 21886 21063 19843 1221 8530 2327 2354 2640 11375 METHIONINE Methionine 4778203 5040567 3399647 4221559 4522836 4022442 4904651 4362426 4768649 5051250 2616099 5050588 3195413 4323093 5464398 5667305 3932894 3330353 3883582 5242145 4262222 5156924 5196417 3116280 4999725 4183940 4728227 4731250 3985926 3452635 4036871 3141707 3024910 3331106 5350541 4719273 N-ACETYL-DL-METHIONINE N-Acetylmethionine 74223 136168 91428 56963 148700 79889 77097 144786 52003 86458 46292 66320 54162 103420 66725 86954 54765 119505 118657 95649 112362 125566 74369 127322 78543 86554 69826 54237 48856 79547 40486 45344 62121 63471 82515 N-ACETYL-D-TRYPTOPHAN N-Acetyl-D-tryptophan 112696 281562 114948 95295 161318 153463 133330 224843 94530 144479 56588 118920 98545 81860 123608 121945 107599 55717 184974 247814 92557 194555 172420 125235 163719 128882 111170 110939 82138 65911 154892 97218 51129 115745 91183 90495 N-ACETYLLEUCINE N-Acetylleucine 11600 36428 258136 202340 39692 22574 12034 41582 18830 42949 12559 13825 27894 207770 354978 11671 260819 32594 28519 16260 16853 14180 34417 31202 16099 28880 279775 17505 24189 22482 379884 26783 113352 15981 236383 23914 NICOTINAMIDE Niacinamide 1061681 1932344 716065 1547810 1439253 1026263 1022157 2599443 6550785 7347619 12600000 8689137 13500000 14200000 6886328 5456857 12600000 11000000 1676645 1022411 1568509 997564 1177052 1627544 1241597 1453195 1152205 10300000 10100000 15900000 9014835 13400000 15700000 11300000 7171121 13100000 N-NITROSODIETHANOLAMINE N-Nitrosodiethanolamine 10581 14441 25952 6779 5536 29639 15613 19932 33948 8148 19497 12159 3617 4755 20834 16454 14577 8157 25451 13802 16695 4989 5828 3067 18239 8809 15482 OPHTHALMIC ACID Ophthalmic acid 33446 30362 54964 32086 65377 32979 55169 53013 158552 104013 178876 143779 242687 361459 138049 158449 353746 345876 67335 45989 32666 58292 56272 42083 76862 56418 68889 237541 175274 233856 164414 275881 217569 320627 148723 319946 OXOGLUTARIC ACID (ALPHA-KETO-GLUTARATE) 2-Oxoglutaric acid 20211 8759 11976 19608 14766 15812 11878 5617 9583 9622 24721 20831 3229 15126 8079 15016 18209 14254 9148 6403 9377 20685 9424 PANTOTHENIC ACID Pantothenic acid 738997 873054 859871 776189 1227213 906883 961528 1091444 740269 1132108 498778 941377 566889 745471 977939 824521 738989 661662 739219 1051420 678639 978968 1149607 582770 1151418 947940 808679 401390 545595 575390 760406 519303 389958 769298 807368 836804 PIMELIC ACID Pimelic acid 54280 59997 32898 47493 36602 49443 19442 48630 72690 42563 55945 73462 75958 36813 48874 56875 35470 152391 77547 40147 41300 6104 RIBOFLAVIN (VITAMIN B2) Riboflavin 28492 28172 33277 105099 66314 102718 109435 32901 103082 31150 45252 40578 37335 47173 36998 79141 74946 50553 76471 82057 35626 41989 70871 54712 51608 SALICYLAMIDE Salicylamide 2437 15325 6359 THYMIDINE (M+H) Thymidine 35108 39819 43073 34042 59060 62652 34616 29597 43623 34425 41108 36172 35839 32843 45276 33970 22930 24807 1121 1159 TRYPTOPHAN Tryptophan 16687969 19230984 10872039 14863575 15427525 19927826 18447926 17432100 18500000 16500000 7510625 21300000 9880903 12000000 21100000 21000000 10900000 3503589 12004898 18712380 17720408 20926540 17318044 13795321 18962754 15944549 16955888 15900000 15400000 9236598 15000000 8717312 8161945 11200000 18200000 11200000 TYROSINE Tyrosine 10900989 10796418 7258469 10401963 10578244 11091199 11966633 12360948 9451700 13200000 6860251 13100000 8784576 11000000 14400000 11500000 8287856 9141739 9439000 11835825 8895005 14469439 10919934 7850288 12267150 9021613 12555387 11100000 10900000 8272009 10700000 7105761 6975767 9509001 10800000 11600000 URIC ACID Uric acid 277629 820690 548508 255404 950038 530855 641340 2018896 428971 1001087 269271 384083 761546 218608 339924 355627 39360 187587 1043556 671417 358807 282861 797951 916099 828810 541259 402802 20246 617803 435195 54273 9288 175791 269779 291422 342977 URIDINE (M+H) Uridine 712547 714686 476457 715277 742184 802404 826265 528758 810755 255693 444531 521440 844229 693995 444938 498680 629442 765066 943296 729794 526700 807566 608707 804883 1210 628495 99251 502542 634681 690263 VALINE Valine 3964099 3642137 3155236 3776702 3998152 3980447 4011000 4012720 3637845 830448 2271656 3618620 2662186 431247 3654525 4234081 4114149 4010440 3401537 3970526 3782089 4241740 4238197 3274665 4209260 3253598 3807899 4271746 3314842 2918202 3741188 2932134 2997938 2938060 4142998 4134564 XANTHINE Xanthine 4014 16140 10182 1286 2851 1926 190691 4522 166726 509591 20733 941239 3217 1280 312220 524804 556469 124679 77867 645015 14642 8150 281004 XANTHOSINE Xanthosine 2129 2368 3871 5951 4675 4268 80587 13019 36963 30244 10089 38899 65600 8696 30645 260258 3088 5490 2960 2688 6516 7136 6560 3852 2159 85984 66374 107574 29391 25852 99202 24932 1426 XANTHOSINE 5^-PHOSPHATE XMP 2345 2881 12715 32123 32151 20209 54502 43573 16473 128374 67626 4011 60699 29022 61733 51789 62680 36939 103512 88645 XANTHURENIC ACID Xanthurenic acid 36000 108291 31286 48160 41453 71564 51224 60085 65822 40766 58152 41904 82861 69697 67702 29426 76559 127310 43941 66260 38537 78959 39475 11001 66853 99415 57002 82128 70517 51625 72256 80011 82350 49810 65571