Metabolite_name RefMet_name WT1_48h_0mM_1 WT1_48h_0mM_2 WT1_48h_0mM_3 WT3_48h_0mM_1 WT3_48h_0mM_2 WT3_48h_0mM_3 WT7_48h_0mM_1 WT7_48h_0mM_2 WT7_48h_0mM_3 WT8_48h_0mM_1 WT8_48h_0mM_2 WT8_48h_0mM_3 WT1_48h_5mM_1 WT1_48h_5mM_2 WT1_48h_5mM_3 WT3_48h_5mM_1 WT3_48h_5mM_2 WT3_48h_5mM_3 WT7_48h_5mM_1 WT7_48h_5mM_2 WT7_48h_5mM_3 WT8_48h_5mM_1 WT8_48h_5mM_2 WT8_48h_5mM_3 WT1_72h_0mM_1 WT1_72h_0mM_2 WT1_72h_0mM_3 WT3_72h_0mM_1 WT3_72h_0mM_2 WT3_72h_0mM_3 WT7_72h_0mM_1 WT7_72h_0mM_2 WT7_72h_0mM_3 WT8_72h_0mM_1 WT8_72h_0mM_2 WT8_72h_0mM_3 WT1_72h_5mM_1 WT1_72h_5mM_2 WT1_72h_5mM_3 WT3_72h_5mM_1 WT3_72h_5mM_2 WT3_72h_5mM_3 WT7_72h_5mM_1 WT7_72h_5mM_2 WT7_72h_5mM_3 WT8_72h_5mM_1 WT8_72h_5mM_2 WT8_72h_5mM_3 Factors - Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):- Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:48 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):- Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 Time activated with peptide:72 | DFMO treatment (mM):5 1-AMINOCYCLOPROPANE-1-CARBOXYLATE 1-Aminocyclopropanecarboxylic acid 1613412 1947237 1549047 1566656 1248521 1456832 928127 736302 893431 1332273 1749413 1345827 475872 471554 571267 1000434 977265 865405 1018606 909029 1176161 759312 819684 806958 928784 771762 924794 812745 795162 813680 898891 790765 914452 1159705 946254 1042491 730639 789980 841481 909499 1080435 1015395 1597220 1495143 1570105 1073712 1020740 994494 2-Hydroxyphenylalanine 2-Hydroxy-L-Phenylalanine 6068434 6399056 5911660 4793977 4240373 4823969 3295418 2629190 3302840 5118070 6546603 5407577 2025923 1939037 2232064 3694131 3733187 3387473 4074041 3813233 4139896 2693598 2895633 2660322 3630817 3129157 3669404 3367084 3488614 3566866 3739184 3250483 3633919 4387290 3666808 4002746 2667350 3302017 3396412 3195895 3207065 3303786 5296028 5386724 5387606 3218488 3156147 3204483 3-SULFINO-L-ALANINE 3-Sulfino-alanine 70343 83152 82589 135306 119674 129335 120761 79178 133761 91544 118943 101813 65955 55325 77142 127155 103416 99459 91930 90664 114292 72441 78163 61865 60893 59165 65160 31190 47330 37251 82690 70318 85093 38349 33602 31511 65404 80275 93874 79918 88650 97522 103966 109451 96904 159989 138225 163629 5-AMINOLEVULINIC ACID 5-Amino-levulinic acid 1419575 1541396 1368924 2061553 1854483 1933915 143262 138810 151024 617234 722391 641518 100725 99586 107506 543421 523979 513644 106858 110045 117924 157178 166448 168602 107733 109469 111199 113919 107363 112428 180555 156728 181144 149783 129333 136801 123948 147785 139208 279434 298765 276898 1057886 1070285 1078481 155996 125877 138915 5-Hydroxy-N-formylkynurenine 5-Hydroxy-N-formylkynurenine 678066 833487 727126 738929 595576 774628 824065 581909 745608 553035 766924 574917 730444 698848 877527 731384 766752 680703 803983 745464 747216 755899 802177 664737 757610 696457 739420 738278 788062 728858 697720 622592 702702 764463 628199 716924 562147 731356 775477 740396 729595 776663 660947 692828 711230 745277 776970 822448 6C-SUGAR ALCOHOL 740833 917746 768500 130270 101337 123576 64801 56148 63602 49842 77568 51798 36781 36930 41672 57712 50040 54193 56181 66418 77343 301677 295813 276327 93802 81154 104827 101628 121624 116423 29447 21343 36562 60041 61480 56043 60258 74722 84427 44346 44516 46810 128844 126006 120961 60340 61281 50118 ALANINE/SARCOSINE Alanine/Sarcosine 6710583 8091903 6990164 6054730 4750556 5611301 4366046 3330229 4259872 5622164 7053855 5970953 2004455 2015276 2156237 4056031 4154865 3638384 4613589 4307397 5127421 3161162 3517212 3347515 4268491 3665227 4197479 3614211 3665591 3801738 3851734 3409247 3911934 5032156 4428113 4472338 2953236 3721141 4050092 3721515 3889268 3836404 6068107 6015512 6448019 5115024 4721674 4676238 ALDO/KETO-HEXOSE Hexose 1214608 1605051 1274593 1013884 811930 937946 487207 376085 438807 874150 1121961 961026 401835 359923 415929 857721 800477 735495 887382 902025 1024966 1126811 1260281 1112454 550771 456329 524506 601913 647250 651334 690688 596412 635111 814143 677877 699598 569253 714877 805773 605849 601606 584602 869086 840663 817701 691656 566529 636285 Allopurinol Allopurinol 4201612 4582874 4224714 4057092 3472170 3912588 2523369 1863574 2570700 3305699 4305911 3321740 3316426 3226240 3747119 3883683 3782059 3511902 2616164 2315163 2656637 3369547 3430409 3161754 2729405 2287454 2726601 2326814 2360790 2353232 3505362 3010932 3424701 2606141 2449264 2689198 1970721 2534673 2617460 2817256 3064432 3139725 3860939 3955486 4166646 2819976 2813302 2772515 ASPARTATE Aspartic acid 10600000 12000000 10800000 10500000 8702034 10100000 5111591 3867249 5270325 8561602 10700000 8589241 2954051 2720508 3051424 6012788 6050451 5628488 5943213 5583781 6424827 4805221 5278817 4974206 5595961 4708175 5609633 4707562 4677317 4799224 5295453 4533445 5269592 6811877 6009093 6112859 2979887 4268078 4616438 5430280 5695031 5746934 11000000 10600000 11200000 7513125 7257675 7219067 BOC-D-Phenylalanine_R1 46600000 55300000 46600000 43600000 46500000 45000000 42900000 43600000 46500000 42600000 45600000 42900000 49700000 47400000 50200000 45000000 46400000 45200000 46400000 60400000 44300000 48500000 47600000 48700000 45800000 45800000 45100000 45000000 44400000 46800000 42400000 40900000 42800000 43800000 44700000 44700000 39000000 45700000 46800000 47500000 43500000 44700000 43400000 44300000 42400000 48100000 49300000 49300000 BOC-D-Phenylalanine_R2 95454 87505 91696 105035 75845 89476 73395 93948 96157 76034 86018 87398 87461 89064 94449 88708 84605 90015 100338 83028 98275 110620 94393 109414 99408 75405 115431 76211 92945 107727 78602 82856 78000 86040 88775 96216 73943 80397 92472 95183 83416 99679 95470 79889 88816 121889 96208 101594 BOC-L-Tyrosine_R1 Tyrosine 77000000 90500000 79300000 77900000 71100000 77400000 77800000 73100000 79300000 72000000 84800000 71900000 79100000 77400000 81200000 81100000 77800000 79000000 77800000 91800000 80200000 82300000 78900000 80500000 75400000 77500000 78700000 77600000 80900000 81500000 82200000 69100000 81900000 83100000 77900000 81400000 65400000 79900000 79700000 79100000 77900000 76500000 80300000 78300000 76500000 78800000 82600000 80000000 BOC-L-Tyrosine_R2 Tyrosine 393639 383955 411352 404567 368802 406164 358873 417858 352040 426225 358979 332320 405694 379591 402102 410714 344994 366153 380246 346876 476424 447524 366792 532199 327000 347644 414604 439866 413005 403431 404488 345810 505301 439430 350892 373523 532289 471903 425672 368770 462040 312157 394288 383404 511187 385801 415290 493630 C5-SUGAR ALCOHOL Dihydroxyquinoline 366719 358160 355280 232634 37340 206514 243638 200445 226855 320077 387874 337079 35507 74983 55368 237549 223223 227012 146088 151366 145443 101821 114057 144799 194207 110062 203700 187381 191490 210571 193461 220298 211938 206138 202557 202046 214903 224248 229842 179829 143930 159615 330934 339267 309815 244090 259154 234750 Caffeine-D3 Caffeine 7233136 8203732 8022435 7604784 6544796 7317560 7245847 5791684 6721265 6124084 7932885 6258724 7702472 7271807 8143352 7637920 7020603 6701161 7531043 6937448 7079308 6115011 6766703 6081615 8095613 6815257 7916710 7865980 7378749 7526062 7655171 6980030 7522623 7604184 6762261 7679296 6559760 7795247 7752307 8041432 7938291 8354762 7790204 7426749 7466015 7771161 8271357 8382058 CARNOSINE Carnosine 104924 114391 127445 69173 74669 73158 257210 201393 260337 54376 95284 84042 84451 71719 87041 73528 86308 77539 91385 91084 106461 356547 409948 338771 152661 120762 149917 70297 86989 98660 99453 93090 92533 115184 88918 96193 102951 136142 139809 128841 156942 173420 64669 76704 85531 506204 502058 575577 Choline Choline 19000000 20100000 18900000 18900000 15600000 18400000 16500000 13000000 16300000 13100000 17300000 13600000 14900000 14500000 16700000 21000000 20100000 18500000 12800000 11100000 13400000 15300000 16000000 15100000 12500000 10200000 12400000 11400000 11400000 11400000 17000000 14700000 17000000 11400000 9914881 11900000 12100000 14900000 15200000 14800000 15900000 15300000 17600000 17100000 18500000 13600000 13500000 13000000 CITRULLINE Citrulline 1008331 1246214 1232738 780655 691284 767063 2014920 1813602 2031698 527887 607982 534724 680217 692036 719025 773769 749680 729475 19000000 16700000 19300000 2815646 2989276 2726001 6177015 5604799 6067437 9698596 9979363 9657785 994829 855238 936753 11900000 10400000 11100000 1317761 1518634 1512706 2896134 2990149 3034480 633936 636881 663782 1508474 1465140 1445890 CMP CMP 1069521 1222181 1067225 881572 753723 874248 320104 269176 319476 969840 1034787 974921 236470 229485 232801 447568 445502 460256 564332 508345 593495 200021 194942 187131 692613 716893 700101 639393 592608 575537 371739 330348 341541 704730 570351 652225 322839 393736 396690 523434 525378 536945 1030152 1007722 955780 336437 339162 312874 Creatine-D3_R1 Creatine 22400000 23600000 22500000 23600000 20700000 22500000 23700000 20200000 23800000 20700000 24000000 21200000 22000000 22100000 24700000 23800000 23300000 21600000 24500000 22900000 24600000 22900000 24200000 23200000 25100000 22300000 24700000 23300000 22700000 23900000 22300000 21000000 22400000 25500000 21600000 23700000 19600000 22300000 22400000 23900000 25500000 25000000 22200000 21900000 23200000 24400000 23200000 24300000 Creatine-D3_R2 Creatine 1805672 1646303 1942564 1668292 1539932 1790105 1859644 1402253 1808477 1406755 1855897 1462450 1616527 1684400 1891796 1989282 1849305 1729493 1883791 1640035 1555015 1880940 1962445 1579941 1865769 1573964 1822619 1793109 1865418 1885414 1841172 1629333 1680040 1768420 1806916 1980568 1270025 1595573 1561819 1952901 1859384 2043439 1727476 1763219 1648588 2175152 2183553 2293484 CYTIDINE 2^_3^-CYCLIC MONO-PHOS-PHATE 2',3' cyclic CMP 40436 37264 35031 11541 5017 10210 18574 17378 19648 29064 32923 27888 264370 261129 302865 25643 24473 21186 3391 5546 5596 126957 124643 119352 13289 13404 15960 6847 3681 3526 32910 24750 33457 6525 6025 11303 29380 40540 40833 16708 14079 18590 18019 18970 25035 78301 73948 81426 D-GLUCOSAMINE 6-PHOSPHATE Glucosamine 6-phosphate 20590 8757 56226 30179 11114 12910 27914 9377 30145 7223 30849 14034 17017 6476 11627 5921 13763 100296 82562 96766 17511 22281 14510 36480 28520 38367 73677 55414 57600 7182 9159 6884 59272 62532 73983 6450 12548 8553 20618 26813 22172 22558 29945 43478 27855 45603 32784 Dimethyl pthalate (DMP) 100575 130417 112099 129160 103295 132292 109413 85929 115770 88262 113616 98652 102526 105051 116486 153664 129972 115330 135318 139300 114822 125968 131413 117363 114581 97723 111391 106662 109949 105115 124567 112932 128440 130959 120094 134161 78427 116180 121418 132853 132066 143008 114574 102899 108560 117071 131698 126084 D-Ribose Ribose 195202 256562 210631 146663 141236 144120 222570 177284 222135 178182 233052 191369 241355 235621 269733 199926 195511 189116 127826 122628 131574 316840 347622 317420 124710 105659 115987 93208 92628 91235 277967 266733 284829 129538 106720 113603 134849 152870 175008 153102 166663 175490 229472 221251 213206 272582 236455 264092 Formyl-5-hydroxykynurenamine Formyl-5-hydroxykynurenamine 360669 454530 377829 392658 310712 381006 419479 302227 412423 268284 434284 273874 369635 333625 445672 405816 404297 344802 399658 359912 390469 385437 441800 350427 446932 316047 409464 378863 413838 387990 352447 303605 336993 387257 307893 398451 285886 388663 381949 434589 385698 423566 359494 363498 349571 403669 416755 415108 Formylkynurenine N-Formyl-L-kynurenine 1016230 1083058 1058532 1077466 898133 1072711 997688 754168 1030377 863379 1080371 929689 958005 1000202 1033866 1059656 989485 947300 1023977 937691 989289 1038206 961555 918223 966712 941676 1006572 987271 1051020 1018953 982747 906871 908369 1042329 955527 1110846 752431 955352 1047272 1017115 955238 1064481 1013461 936691 910118 1068744 1083212 1029804 GLUCOSAMINE/MANNOSAMINE 611307 593209 647364 497709 452347 485532 266931 237324 253033 325589 424891 371676 183397 169634 194735 488645 490217 432920 502163 462563 546254 775582 787297 710031 270252 227735 254445 300279 276021 291486 305309 290360 311909 257052 228152 273273 268161 275375 289625 247085 253887 248266 343491 346087 359241 280274 276714 291743 GLUCOSE/FRUCTOSE-PHOSPHATE 537182 580902 575986 492601 428473 437357 11775 12123 18581 518059 605373 493485 14122 7128 19062 240216 225952 213424 190980 164708 180074 18308 19985 7393 141550 120796 149189 152991 165604 146093 124065 123819 123816 211361 194312 216735 85792 97171 112411 143894 133119 140184 649290 587995 598534 29741 14416 26001 Glycerophosphocholine sn-Glycero-3-phosphocholine 1175222 1346482 1246197 1056558 872029 971508 1632203 1469138 1680408 987834 1153605 1054091 1940826 1986090 2138999 1398570 1430058 1292616 1608588 1508752 1651477 1974454 2083302 1965187 1967787 1829361 2053373 1599211 1494748 1668621 1436798 1352422 1462495 1796760 1442955 1722389 1607311 1798256 1824674 1631453 1604818 1548997 1073183 1164317 1169379 1573414 1648177 1575075 GLYCINE Glycine 1837730 2107299 1809439 1888134 1556623 1656382 853745 718340 851813 1759227 2000586 1646782 573165 582810 590369 1232214 1171859 1141003 1059011 1069673 1241626 786467 904951 860136 953796 919530 996705 972327 934791 1013164 1025048 926345 1075836 1408016 1161842 1267505 802381 983641 963217 967269 1102884 1066322 1822755 1805680 2032202 1265569 1161047 1098118 GUANIDINOACETATE_R1 Guanidoacetic acid 148087 159928 145432 176337 139140 161634 124689 97634 133364 135075 148357 126551 109398 105454 121455 133648 124517 116190 116452 100745 143328 121491 130015 121877 129201 119864 127788 117196 122791 122705 118508 101062 106809 137712 124052 118094 152360 154913 166219 135215 130440 122130 152227 150913 158207 120074 112623 123085 GUANIDINOACETATE_R2 Guanidoacetic acid 13284 15329 17720 31342 32902 15979 29010 26565 39705 16731 35536 12842 101095 100925 125863 16769 14118 16026 24397 23489 29013 33098 40513 35613 17642 16460 20475 14992 11338 12834 25495 32249 25711 30496 26517 31416 104174 142111 144249 20192 20754 10585 14261 14067 10949 35066 31790 35262 HEXOSE-6-PHOSPHATE Hexose 6-phosphate 468860 506009 515813 392500 391736 446597 34713 37706 39717 458077 511690 480917 17610 20590 24123 195367 206732 214427 179060 164623 181332 27461 29597 31113 146118 149281 164315 160518 144936 153757 108720 111072 111529 187272 184748 203447 104699 112850 106480 131485 126706 124864 518309 511548 521894 41006 40547 45298 HEXOSE-DISACCHARIDE_R1 Hexose disaccharide 474249 519154 510784 335817 289044 332738 491021 353337 455068 202025 248856 203565 162196 168956 165273 229180 241365 244479 547479 499899 518977 273647 252012 229755 252321 214336 231041 552475 655561 557158 113696 116580 119847 284524 258770 276679 187704 218764 216826 296069 257286 336725 265568 224441 202476 538826 476389 515656 HEXOSE-DISACCHARIDE_R2 Hexose disaccharide 575962 781046 617271 39710 34642 38481 57609 58447 63580 51137 55796 51927 36825 34296 38827 45723 50670 36990 80149 67121 77704 51380 54500 54529 37316 37073 37199 58492 55834 52232 33959 28597 31929 52889 46920 49528 73872 92792 84916 26463 32076 25666 84461 81826 73329 103235 87530 99472 Isocytosine 2-Amino-4-hydroxypyrimidine 3977249 5047692 3998529 3657028 2829663 3413290 876719 569290 818832 3126049 4537709 3255291 1390133 1369560 1611532 2281528 2141048 1826369 1415241 1299180 1487379 1492542 1674953 1443379 1463333 1154446 1423431 1068706 1099121 1125271 1810063 1509081 1785461 1520586 1219269 1478818 772746 1000059 1024824 1408510 1481544 1564237 4462441 4243156 4391207 1278869 1178525 1227876 Lactose Lactose 370667 290441 375402 7985 19640 9622 8615 4962 6726 6543 6869 7382 7653 6320 7741 7659 20151 15748 48205 37701 38076 13784 17067 7727 6274 6381 7417 5784 8336 6748 7344 6244 8705 6405 5102 9441 6508 8625 4513 5949 7884 7177 40537 46816 43299 24271 27123 30396 L-ALLOTHREONINE Allothreonine 244587 251754 240927 198221 167067 194172 181599 122432 159194 188442 266361 192489 84963 74030 88885 187587 180739 161685 205549 167833 194861 140817 169486 132475 158738 142021 194517 134268 158340 142612 167141 147548 144782 211005 191352 211343 114793 127479 137050 147162 151516 160532 221244 213927 215805 184270 184966 205524 L-ARGININE Arginine 92000000 99800000 93000000 82900000 72500000 77300000 62200000 49100000 56600000 80000000 95400000 83300000 20400000 21500000 22700000 59600000 59600000 60300000 37100000 33600000 38600000 40500000 44000000 38300000 50500000 45100000 50900000 48300000 51700000 49300000 55700000 50900000 56200000 56300000 48500000 56300000 50300000 57200000 58000000 59400000 65600000 66400000 88500000 87600000 91800000 65700000 65400000 67300000 L-ASPARAGINE Asparagine 7174324 7925327 7129421 6001092 5476813 5722867 2109025 1719861 2070257 5783757 6883926 6191512 1334220 1290628 1380552 3525907 3593523 3342861 3687298 3732830 4141929 1667757 1855871 1788453 3303462 2893625 3165179 3096821 3232383 3219503 3183030 3006936 3199349 4261605 3774392 3727875 2415652 2857201 3206928 2664750 2977331 2918506 6373663 6566855 6797182 2338547 2205906 2229032 L-CYSTEIC ACID Cysteic acid 17586 32586 24835 142872 133805 142054 143825 117303 144927 91628 108712 79863 98414 63996 84878 59827 53001 59058 65409 59106 66206 118881 127953 105874 54544 47034 54965 13268 14260 11335 45656 50272 41580 14846 13076 14699 72976 90214 92999 55279 62320 57769 48288 56610 59069 133240 149309 137275 L-CYSTEINE Cysteine 316041 451477 334405 117322 78196 98448 23590 16189 20380 61673 103964 64424 17930 17226 19602 60414 63995 51296 27739 17440 26525 16946 14868 14453 44943 27491 46775 79107 88863 79878 33656 27870 27992 61740 40094 54358 33103 38138 44806 36360 50101 59926 166442 172294 189844 30612 28134 33258 L-Cystine Cystine 462584 557462 470201 837695 745396 742849 291776 239523 291049 511791 545575 522151 98997 108647 113917 452106 454574 428433 223723 214162 222494 119884 126318 119863 175207 152157 186342 145454 157075 177560 208226 196425 202525 137430 119506 125421 235718 232835 238071 247478 242496 247202 601517 610055 602972 387550 347965 333339 Leu Pro_R1 Leu-Pro 90091 100316 90042 80815 67067 72383 118483 110964 120394 70916 79334 69424 91032 81002 96773 77270 59676 52122 93323 86743 98225 105952 85192 101518 114503 101486 116562 115932 121023 110186 60992 49888 57826 102238 90433 98565 70421 87886 91218 78117 63335 67643 66759 58590 69541 142028 163848 144356 Leu Pro_R2 Leu-Pro 39147 38936 37252 34187 27160 22714 43955 42476 45503 22902 26097 21650 36289 41880 37258 24767 23349 20352 34928 36114 32304 39806 40714 35837 47885 32673 39513 42676 42409 38258 22352 18958 22170 36604 30226 43747 27074 32644 33639 26696 27340 27053 28769 28702 18935 55882 51187 59901 L-GLUTAMINE Glutamine 27300000 29700000 27800000 16700000 14000000 16300000 7960118 6225226 7791776 17700000 23400000 18700000 3081180 2885313 3385846 9492540 9381159 8592913 14200000 11600000 13700000 6199385 6747882 6031831 12400000 9859495 12200000 10100000 10400000 10200000 10100000 8781619 9698763 13400000 11800000 13600000 6932736 8561807 8460341 8555394 9217105 9103992 18800000 19100000 19900000 7736231 7691520 7853224 L-HISTIDINE Histidine 4659708 5034873 4602123 3430009 3264719 3424663 1922901 1780983 1845619 3873036 4446080 3974402 1260558 1221562 1300334 2599986 2657804 2506233 3537399 3251770 3871403 2365100 2554257 2341028 2458361 2279481 2465824 2721474 2875976 2881572 2257929 2143910 2347780 3689853 3113616 3517723 2045841 2208297 2318357 2865670 3175681 3150097 3996913 4157444 4169879 2873643 2985276 3086031 L-Isoleucine Isoleucine 10700000 12000000 11200000 8909591 7639348 8415457 8252943 6782348 8037578 9382152 11700000 10700000 4118440 3924057 4236860 6028615 6056371 5714882 8430012 8377925 8327220 6274954 6629679 6649820 7301005 6648428 7339971 5828902 5859370 6038339 6348160 5893436 6372691 7732602 6770506 7298544 4592018 5299751 5447908 6335357 6556518 6323639 10200000 10500000 10900000 9536624 9182784 9124453 L-KYNURENINE Kynurenine 80224 71267 75516 56347 46400 52332 40766 27610 44826 32163 49747 33719 28901 24108 35095 35945 36082 35969 38772 33131 41809 31361 32305 31817 28464 32228 33211 42508 44390 36876 34161 39920 36863 42619 30280 39895 28339 34037 34246 29282 23895 25271 63780 50556 53512 40644 42993 38728 L-LEUCINE Leucine 25700000 27600000 25700000 21200000 17800000 19600000 17900000 14400000 17900000 21300000 26900000 23100000 8598897 8441066 9067508 14100000 14400000 13200000 18800000 17800000 18900000 12500000 13300000 13100000 16700000 14900000 16400000 13100000 13400000 14300000 14700000 12800000 14700000 16900000 14800000 16000000 10100000 12400000 12600000 13500000 14000000 14100000 23400000 24100000 24600000 18500000 18800000 17800000 L-Leucine 13C6 Leucine 12800000 14800000 13200000 14700000 9137707 13100000 14700000 8230694 14800000 8134454 14600000 9096552 10800000 10200000 14300000 14500000 14700000 10900000 14600000 10900000 14900000 13300000 14800000 12600000 15300000 10100000 15300000 13800000 14200000 15000000 12600000 8798118 12400000 15500000 10600000 14700000 7901690 12600000 13200000 14600000 15600000 15400000 12800000 12900000 13800000 14600000 15000000 14200000 L-Leucine-D10 Leucine 11600000 12800000 11600000 12400000 10000000 11500000 12600000 9945218 12400000 9154176 12900000 10500000 11300000 11200000 12000000 12500000 12100000 11300000 12500000 12100000 12600000 11700000 12300000 12200000 12600000 11000000 12600000 12100000 12000000 12600000 11000000 10200000 11900000 12800000 11400000 12500000 9117494 11700000 12000000 12600000 12900000 13200000 11600000 11300000 12300000 12400000 12400000 12700000 L-LYSINE Lysine 8836478 10200000 8758166 7652605 6008188 6924513 7252058 5856866 7608413 8144042 10000000 8131269 3135391 2935913 3341542 5357068 5200757 4726199 7054099 6632567 7429658 4451157 4796212 4584268 6487462 5419047 6245340 5222089 5239337 5421310 5150188 4724866 5216815 6479077 5628750 5771838 4015341 4897940 5151732 5171647 5195159 5246099 8723835 8295433 9226562 8034767 7766232 7654842 L-METHIONINE Methionine 3958699 4699204 3982920 1777872 1435899 1615925 20486 16468 23356 1654149 2112217 1708930 26720 20670 26649 1001122 983557 916882 250429 247751 269914 4490 4749 4848 637683 584772 623311 2164423 2193057 2353940 407629 368468 410412 2182537 1719183 1928706 326370 377453 391003 831753 855197 852437 3377882 3533401 3719605 27026 25953 20414 L-Phenylalanine 13C6 Phenylalanine 9047840 9155449 9011128 8930185 8312728 8900846 9478066 7848069 9221315 7698113 9418431 8082798 8631264 8770596 9353951 9368780 9447004 8708408 9565515 9264221 9609072 9180138 9551582 9329788 9372214 8775326 9418949 9120838 9511742 9294646 9060690 8462135 9082308 9497524 8889293 9451569 7971807 8901877 9383814 9807242 9397093 9755930 9095208 9123134 9138094 8886535 9216325 8983165 L-PROLINE Proline 32300000 40100000 32700000 29400000 24500000 27600000 16800000 13000000 16700000 26400000 34900000 27500000 7681454 7366404 8779665 17300000 16900000 15000000 19000000 17500000 21200000 12800000 14100000 12900000 16000000 13600000 16300000 13800000 14000000 14200000 14600000 12800000 14800000 19700000 15600000 17700000 10500000 12800000 13500000 14600000 15500000 15400000 29300000 29200000 30400000 19100000 17700000 17600000 L-SERINE Serine 9875451 11600000 9714832 8747341 6778504 7826422 5243155 3486231 4957188 7514069 10700000 8044335 3122406 3015413 3469825 6462947 6321790 5655232 6746015 6168657 7863440 5161426 5823944 5179429 6318515 5111265 6311876 5804385 6098741 6170382 5971394 4849682 5923330 9585403 7566627 8695427 4318381 5987751 6343544 5380149 6142100 6147788 9012117 8891697 9838242 6899637 6447166 6795871 L-Tyrosine 13C6 Tyrosine 1654346 1735377 1610260 1643519 1500456 1662098 1662679 1408673 1668343 1411957 1731307 1488928 1538116 1501100 1660409 1732875 1684475 1580858 1686258 1635205 1738196 1610327 1672896 1622948 1762369 1580623 1813459 1598652 1696363 1693885 1680275 1459810 1664617 1820145 1571390 1707025 1357037 1628023 1675969 1767932 1714551 1754209 1592688 1640446 1645882 1727310 1682835 1720595 Methionine Sulfoxide Methionine sulfoxide 8608714 8975094 8636717 10300000 9133350 10000000 9327186 8098739 9134336 11400000 12900000 11600000 5074769 5034447 5575793 7425012 7060541 6485345 11200000 9711503 11300000 7143308 7479345 6879796 8916451 7785044 8621923 4047783 4141698 4033301 8784174 8139766 8595545 6391417 5696854 6097198 6414654 7188660 7307176 6515764 6849908 6896560 8383494 8398306 8575204 10200000 10000000 10200000 METHYL BETA-D-GALACTOSIDE Methyl beta-D-galactoside 45893 42989 44122 39758 41941 39540 13918 9772 13259 63795 96689 71967 16180 18376 17630 32665 29629 21022 33119 31312 35465 19358 26655 18198 62688 48277 65574 50861 53862 55499 41891 42310 40207 42422 39689 40842 80962 93067 92914 123560 107021 124640 43799 50603 45274 36263 23376 27671 N-ACETYL-HEXOSAMINE N-Acetylhexosamine 193086 201795 187034 165437 148535 185254 11205 55004 56878 54226 7523 13992 18382 97447 92030 93530 26405 26302 22352 21325 16866 21155 24311 18815 26829 25628 28731 27608 57425 48313 53830 34276 26330 29696 32121 51621 47052 91151 75178 83118 181560 187695 167644 18046 13948 13340 N-ACETYL-L-LEUCINE N-Acetylleucine 227390 191818 210667 300384 293008 292233 1495684 1361430 1564169 976878 1056810 994595 152736 175813 180023 182593 176640 181309 680017 619434 678173 263211 260988 272260 802400 747778 808629 340237 348905 333650 305796 278151 295689 279866 304995 333702 140186 163388 172626 526571 480682 476035 289405 294393 310086 262850 257523 249903 N-ACETYLNEURAMINATE N-Acetylneuraminic acid 205829 209754 217622 160649 144765 140000 61604 48397 55157 165959 194321 187743 33519 42906 42110 37178 50305 38160 108124 97592 108312 38848 40418 36822 117011 127398 118655 116503 114574 117446 31318 28231 25286 131622 106899 135463 80184 98229 97870 76278 86184 84251 170107 157071 166458 73295 62236 66842 N-ACETYLPUTRESCINE N-Acetylputrescine 747025 740709 783001 720852 674453 738937 568083 469505 550623 646687 754201 635665 373160 372341 404532 630431 614158 580239 653052 580802 704857 514070 529970 502705 644220 561464 668341 629404 666791 637703 621578 555347 619383 703265 642269 676177 549008 587584 632139 679509 703957 703094 715947 688743 721030 506814 535956 543874 N-ALPHA-ACETYL-L-LYSINE N(2)-Acetyllysine 98892 116210 101827 62879 47871 60348 44077 36941 48236 55806 72197 55435 22739 18524 25088 40953 41214 41900 73497 55972 71177 28401 32325 29841 49083 45766 56989 55684 55909 53053 37983 36584 43229 58221 48017 70833 37853 43014 42066 37299 34835 35735 55368 48874 61751 38150 32204 32568 N-BOC-L-Aspartic Acid Aspartic acid 2581829 2799771 2478571 2478700 2238556 2457844 2530133 2077340 2570370 2032699 2582191 2190386 2602769 2464348 2666483 2640722 2561024 2480386 2536205 2746340 2661793 2605486 2608636 2607227 2687331 2395255 2574953 2544238 2647381 2622710 2673918 2298981 2502336 2935134 2611894 2641998 1959950 2583528 2590904 2645960 2678841 2590689 2474459 2550962 2419581 2607630 2630150 2676824 N-BOC-L-tert-Leucine 2472554 3025947 2680473 2164671 2009230 2368802 2250564 2014180 2327966 1883738 2171587 1979274 2299130 2343718 2387107 2284334 2222799 2209465 2461753 3147165 2310705 1827830 1806361 1835870 2325297 2234583 2266094 2434254 2458230 2396945 2520886 2241285 2360714 2290220 2308896 2429724 1976466 2452257 2457180 2716941 2347079 2490300 2339329 2280148 2218855 2606168 2572666 2360607 N-BOC-L-Tryptophan_R1 Tryptophan 26000000 28400000 27900000 27500000 26400000 28000000 30000000 26300000 29000000 23600000 27300000 25700000 29100000 28800000 31400000 26900000 27100000 25800000 30200000 30000000 28600000 30000000 30800000 28900000 27200000 25100000 26100000 27400000 27000000 27300000 24600000 22400000 24600000 28400000 24200000 28000000 22700000 27000000 27200000 27900000 27400000 27900000 26500000 25600000 25800000 29900000 30200000 30600000 N-BOC-L-Tryptophan_R2 Tryptophan 1193412 1027898 1251826 1206377 1136102 1186847 1278055 1325309 1209081 1148928 1117585 1123447 1321793 1306708 1418278 1012522 1110923 1018935 1238424 1277772 1253257 1308834 1336889 1462982 1049806 1077090 1059259 1117941 1055062 1080649 983634 945387 1090574 1192386 996687 1110553 1232009 1191000 1161717 1171086 1373423 1095700 1040607 1059920 1240687 1289704 1337389 1287368 NEPSILON_NEPSILON_NEPSILON-TRIMETHYLLYSINE N-6-Trimethyllysine 466915 536499 502245 299575 285255 353940 675647 602086 709032 345922 419644 343645 112079 119553 146439 259826 240585 210088 399360 355610 397457 356596 389940 336080 401662 334983 388608 263199 264444 253814 284466 275809 270126 310957 284343 325878 311274 369996 386553 350635 362824 363211 590641 570274 619428 751602 758587 841380 N-METHYL-D-ASPARTIC ACID N-Methyl-D-aspartic acid 40600000 46900000 40700000 42400000 34600000 39400000 18900000 15100000 18500000 31200000 39400000 34000000 8692212 8697740 9732451 23100000 24000000 21400000 19800000 17800000 21300000 14400000 15200000 14100000 17300000 15100000 17600000 14400000 14500000 14600000 18300000 16600000 18900000 21300000 17400000 19300000 14200000 17000000 17400000 21400000 22900000 22500000 38200000 38600000 40100000 23000000 23100000 22600000 N(PAI)-METHYL-L-HISTIDINE 3-Methylhistidine 216548 186853 188942 111346 114547 125750 56174 37493 51435 97330 129995 99106 7365 13553 23205 49322 59558 59687 66855 49823 77877 61182 59633 54906 98054 62117 80700 53662 60172 64825 54918 45124 59039 78739 64248 90375 298219 361852 383722 55811 73211 64250 136018 117369 133769 74996 62689 71550 ORNITHINE Ornithine 1016182 1224307 1032670 782494 642814 723128 1093050 872950 1101070 593130 772570 608905 696266 601666 697176 964215 911436 900191 884974 858627 958782 1498330 1620224 1581875 837926 734638 821672 639270 662163 658239 805389 756402 849684 1090220 1012054 976420 585401 715931 834817 758690 777485 796649 689536 654199 743890 2033080 1906681 1815604 Orthophosphate Phosphoric acid 3464835 5027452 3485616 3925622 2763492 3285279 1670095 1173892 1552324 2930400 3814248 2962473 1535171 1376554 1586819 2187984 2137812 1915345 1555851 1562512 1989105 1998660 2215987 2037178 2265536 1729985 2168210 1803440 1709030 1845751 1624912 1296844 1656243 2286828 1741731 1772134 1181684 1627800 1941960 1467106 1669947 1702223 4093268 3798202 4224366 2712501 2287945 2488290 Pantothenic Acid Pantothenic acid 208078 218957 222085 211167 200738 262280 66328 52281 68242 151373 187391 138810 51496 50267 50017 209187 222356 192599 79638 86903 82360 69626 75344 55962 70347 69412 72893 73584 71072 72953 131337 114992 132452 83117 88120 94171 84907 108554 100968 142060 133661 138002 169162 187397 153329 52772 62082 59548 PEG n5 Pentaethylene glycol 3014747 3208663 2821619 2933817 2397500 2637037 19700000 15800000 20300000 2873017 3637900 2918740 9852247 9971233 10900000 4523799 4165236 3714045 6938520 6713592 7532754 16400000 15900000 16400000 10900000 9295829 10500000 6481601 5966733 6135825 4946293 4722391 4945620 5786167 5430348 5507693 4124491 5291561 4774632 7004800 7270770 7168867 5583244 5721760 6437889 22400000 22800000 24100000 Phenylalanine Phenylalanine 14600000 14900000 14900000 11700000 10600000 11700000 9336425 7546689 9045910 13200000 15800000 13800000 5028376 5099409 5490014 8479251 8308658 7861881 10300000 10000000 10500000 7063406 7535350 7362998 9164984 8148146 9146089 7989076 8526116 8068904 8859206 8042796 8658113 9496016 8895557 9604492 6513440 7550419 7920095 8047405 7679854 8055565 14000000 13900000 14200000 9093113 9356795 9119449 Phenylalanine-HCOOH 2734807 2899644 2706980 2138074 1976407 2235951 1779545 1475201 1717897 2483256 3120649 2581932 945845 915218 1037685 1613565 1592518 1481809 1929459 1893587 1981295 1432048 1410748 1348700 1768370 1543712 1683398 1463029 1582385 1527784 1659419 1513814 1631579 1775125 1689633 1801667 1266148 1403777 1465811 1481098 1500132 1549186 2610803 2625028 2661902 1719155 1713051 1765892 PHOSPHOCHOLINE Choline phosphate 3579451 3837594 3762379 4120128 3696572 4034682 557280 451387 476857 2095357 2381816 2173538 640984 642694 691806 1495651 1446421 1395743 1320595 1292683 1383271 540975 541405 521134 1503511 1352286 1464875 1582800 1639274 1590166 614521 552606 566652 1776247 1625797 1852644 716216 771659 864581 1146083 1159391 1187949 2727205 2706360 2822065 646118 604349 663516 PUTRESCINE Putrescine 5812099 5243237 5650200 4696556 5242714 4901774 335225 365514 313157 5071626 4856335 5174700 247421 347691 219305 449567 413722 432634 2049730 1992964 1934588 355779 320901 342361 1644124 1646431 1507436 1620879 1559760 1618743 350280 372573 295764 2154824 2396621 2040489 397195 312331 348450 458291 414145 444446 5251426 5699633 5486489 430628 445489 339486 Pyroglutamic Acid Pyroglutamic acid 3042625 3401197 3209924 2943125 2517251 2853867 1819076 1525939 1796875 1798189 2183998 1852370 1432373 1331512 1507075 2563025 2564900 2370896 2408402 2315746 2511866 3539758 3566110 3488598 2279427 2128027 2276796 2340823 2366116 2334395 2054774 1914706 1978097 4964783 4468134 4899387 3236562 3815680 3641621 2905445 2979064 2925094 2098749 2116534 2203652 2848084 2681774 2780995 Ribulose 5-Phosphate Ribulose 5-phosphate 78369 72435 73932 82781 70930 84560 48099 39535 40304 83384 85340 75388 21867 25965 28266 50815 48350 49561 62653 54052 52944 29998 30980 35059 58295 50583 48737 52277 43955 37090 46413 44069 34905 50239 55180 56800 40298 35184 34215 37352 36034 38513 74095 86149 70776 49503 50195 41065 S-(5^-ADENOSYL)-L-METHIONINE S-Adenosylmethionine 193816 174382 192658 144343 154390 160753 21906 17909 17616 130450 157969 123680 16602 18059 14973 115009 106091 111845 54433 50450 48021 64415 61627 56679 56616 56820 62774 68677 83108 62330 95857 91889 88589 72070 80400 74530 44232 53320 45415 84725 87671 80476 140762 146906 165944 15276 22207 21236 SPERMINE Spermine 2910964 3181191 3233452 1587838 1266800 1604342 499520 340265 602807 1446307 2208744 1620210 509835 433392 466401 1794264 1809759 1410765 1825281 1583616 1633948 122576 137216 98774 2211373 1935304 2175208 2607281 3215486 2870425 2133333 1916316 2166897 1888633 1790965 2243316 1728492 2142692 2242306 1884756 1896354 1965894 2196440 1925383 1848346 560011 474834 436943 TAURINE Taurine 2064632 2205614 2172479 3571957 3139540 3550762 152621 125755 152769 1135624 1320629 1115875 164367 172581 195312 605123 601829 521331 375970 303280 355660 210546 245981 197415 400328 344893 384643 379324 394690 386566 229660 200396 211389 371267 312228 359356 203197 248495 273196 327881 323132 332728 1791064 1738764 1839767 164870 187497 163582 THREONINE/HOMOSERINE Threonine/Homoserine 12400000 14800000 12900000 10800000 8749251 10000000 7134257 5836273 7227005 11200000 13500000 11000000 3472828 3357236 3777642 7632690 7084543 6618913 8789577 8204105 9449730 5980684 6539848 6248244 7888480 6534532 7599580 6607953 6826518 6844956 7119555 6424071 7164475 10000000 8515912 8899883 5401589 6440441 6815742 7028004 7449649 7155930 11600000 11700000 12100000 8338150 7799492 7934829 Tryptophan Tryptophan 4505343 4968888 4583573 4049731 3213527 3783608 2753366 2153405 2734270 3868779 4754185 4108627 1933768 1842170 2092528 3079819 3078633 2781153 3220343 3044884 3097918 2578959 2565893 2560991 2861141 2668078 3051790 2745257 2801116 2682003 2640850 2536529 2766117 3309623 2916768 3262905 2070530 2530164 2713975 3009339 3086460 2958709 4219828 4038624 4343977 2873430 2915165 2848796 Tryptophan-2_3_3-D3 Tryptophan 26900000 29000000 27400000 28500000 24700000 27800000 25600000 22500000 27300000 23700000 28200000 25000000 25600000 24300000 26400000 29000000 28200000 26900000 27200000 27000000 26700000 26800000 25800000 27800000 28200000 27500000 29900000 27400000 28400000 27800000 25800000 25400000 26400000 29700000 27000000 29600000 22000000 26100000 27400000 31200000 30400000 29900000 27500000 27500000 27300000 27000000 27900000 27100000 Tryptophan-2_3_3-D3-NH3 Tryptophan 8350262 9251700 8546635 8671458 7378349 8791757 8507068 6802631 8707445 7129563 9402851 7485767 7689006 7192237 8450175 9059092 8683873 8143545 8581054 7972522 8416878 8555577 8466596 8398969 9161956 8202207 9541354 8395214 9133461 8678312 7994494 7554389 8125703 9385947 8231352 9625087 6660725 7943906 8445000 9655241 9703480 9717669 8850766 8329168 8616309 8489366 8633538 8748733 Tryptophan-NH3 Tryptophan 1505562 1687643 1511542 1285027 1033657 1212363 931597 661041 907148 1235000 1627308 1279612 623437 592106 700378 1034452 1007744 900844 1019886 909352 1058034 857441 884651 837276 1012803 898300 1049693 928031 938771 896140 889892 775581 912982 1187080 977149 1150378 704727 854483 864585 1022588 1086063 1010967 1486072 1393998 1442559 957230 962557 963049