Metabolite_name RefMet_name kim_YiPSC_DCA_11 kim_YiPSC_DCA_13 kim_YiPSC_DCA_14 kim_YiPSC_DCA_4 kim_YiPSC_Citr_25 kim_YiPSC_Citr_39 kim_AiPSC_16 kim_AiPSC_19 kim_AiPSC_glut3_gcn3 kim_AiPSC_glut3_gcn4 kim_AiPSC_ZSCAN10_19 kim_AiPSC_ZSCAN10_7 kim_ESC-E kim_ESC-H kim_YiPSC_1-3 kim_YiPSC_1-8 Factors - Treatment:5mM Disodium acetate Treatment:5mM Disodium acetate Treatment:5mM Disodium acetate Treatment:5mM Disodium acetate Treatment:6mM Sodium Citrate Treatment:6mM Sodium Citrate Treatment:Untreated Treatment:Untreated Treatment:Untreated Treatment:Untreated Treatment:Untreated Treatment:Untreated Treatment:Untreated Treatment:Untreated Treatment:Untreated Treatment:Untreated 2^_4^-DIHYDROXYACETOPHENONE 2',4'-Dihydroxyacetophenone 64500 43200 62700 78900 67100 70800 46500 55600 62900 52200 72000 62100 66900 77700 63300 92800 2^-DEOXYCYTIDINE 5^-MONOPHOSPHATE dCMP 450000 366000 819000 539000 862000 528000 225000 447000 340000 194000 466000 372000 386000 294000 156000 179000 3-HYDROXY-3-METHYLGLUTARATE 3-Hydroxymethylglutaric acid 456000 250000 465000 78200 350000 618000 251000 406000 248000 163000 414000 313000 97400 189000 168000 169000 3-Hydroxydecanoic acid 3-Hydroxydecanoic acid 101000 98800 134000 72300 115000 126000 105000 169000 163000 108000 239000 109000 107000 140000 93800 103000 3-METHYL-2-OXOVALERIC ACID 3-Methyl-2-oxovaleric acid 140000 238000 296000 116000 329000 659000 259000 575000 517000 472000 320000 358000 157000 232000 255000 224000 3-methyladipic acid 3-Methyladipic acid 332000 477000 799000 384000 334000 417000 854000 876000 699000 640000 1220000 847000 482000 467000 451000 543000 3-SULFINO-L-ALANINE 3-Sulfino-alanine 675000 1050000 865000 1140000 548000 1080000 691000 738000 942000 573000 855000 776000 706000 1240000 729000 625000 3-tert-Butyladipic acid Sebacic acid 1000000 768000 1270000 638000 969000 1160000 735000 1230000 898000 847000 1030000 911000 804000 1130000 745000 867000 4-HYDROXYBENZALDEHYDE 4-Hydroxybenzaldehyde 997000 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7130000 8430000 26100000 22500000 12100000 20300000 15700000 19200000 ADP ADP 8990000 4640000 3850000 256000 6730000 6400000 1680000 1550000 1330000 10800000 2650000 2290000 2320000 922000 9250000 13000000 Arachidonic Acid (20:4) Arachidonic acid 4560000 3000000 2110000 756000 1340000 2030000 812000 2260000 11500000 19400000 16700000 31000000 1160000 5290000 2420000 15700000 ASPARAGINE Asparagine 13800000 8520000 11000000 9060000 10000000 8860000 10600000 12900000 11900000 10200000 15100000 14100000 9950000 11600000 13400000 12200000 ASPARTATE Aspartic acid 105000000 46100000 56000000 38100000 69700000 102000000 52200000 65100000 66100000 41200000 78300000 58600000 40100000 45900000 47700000 45800000 BOC-L-Tyrosine_R1 Tyrosine 109000000 94600000 107000000 108000000 125000000 126000000 99000000 115000000 114000000 105000000 119000000 123000000 121000000 130000000 113000000 120000000 BOC-L-Tyrosine_R2 Tyrosine 67200000 54400000 63100000 61500000 76900000 77900000 56700000 70500000 70800000 63200000 73300000 75700000 71500000 80000000 69800000 74800000 C6H12O6-HEXOSE/KETOSE/INOSITOL Hexose 2940000 7540000 7590000 4990000 5780000 6610000 5570000 5400000 4480000 3320000 3540000 5440000 2940000 4760000 2910000 3810000 Caffeic Acid Caffeic acid 127000 90200 116000 122000 120000 118000 86900 115000 120000 112000 125000 125000 141000 153000 136000 149000 CITRATE Citric acid 19100000 23600000 32000000 18100000 36800000 49000000 43400000 58300000 49700000 16100000 79500000 28800000 23300000 52800000 23300000 28600000 CITRIC ACID-13C6 Citric acid 38200000 11700000 14600000 18800000 25600000 21600000 9360000 14200000 16000000 14600000 13500000 23700000 20300000 17100000 21100000 23300000 CMP_R1 CMP 8100000 12600000 17900000 5490000 15700000 18200000 7330000 7880000 6770000 4630000 11500000 10100000 4930000 8310000 7530000 7580000 CMP_R2 CMP 1360000 382000 735000 289000 680000 4120000 363000 407000 346000 539000 945000 1700000 397000 307000 538000 758000 CREATINE Creatine 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617000 594000 528000 615000 607000 492000 615000 561000 586000 Docosahexaenoic Acid (22:6) DHA 3350000 2960000 2330000 918000 1290000 1800000 1110000 2920000 9230000 16300000 13900000 26400000 906000 4280000 1750000 9630000 D-RIBOSE 5-PHOSPHATE/RIBULOSE 5-PHOSPHATE Ribose 15500000 6040000 7630000 416000 7320000 2530000 3260000 3860000 3640000 6480000 17600000 7180000 522000 348000 2550000 3650000 Fumaric Acid Fumaric acid 2570000 1610000 2390000 839000 4270000 7760000 2440000 3410000 3650000 2440000 4290000 1800000 434000 1150000 709000 685000 GLUCONIC ACID/D-GULONIC ACID GAMA-LACTONE Gluconic acid/Gulonolactone 27200000 14900000 16000000 4340000 13000000 26900000 13000000 15900000 12500000 7630000 15000000 10600000 6620000 9270000 8660000 8580000 GLUCOSE/FRUCTOSE_R1 Hexose 39400000 76800000 81500000 52600000 57200000 76500000 55900000 61000000 54200000 37300000 39400000 64700000 37600000 57000000 43900000 46600000 GLUCOSE/FRUCTOSE_R2 Hexose 12700000 24500000 26500000 17100000 19800000 24900000 17700000 20400000 17900000 12500000 13600000 21200000 12300000 19400000 14400000 15800000 GLUTATHIONE Glutathione 127000000 57800000 86500000 11300000 89200000 150000000 118000000 138000000 137000000 79000000 125000000 90600000 30100000 49500000 35600000 32700000 Glyceraldehyde Glyceraldehyde 753000 1780000 2120000 1300000 2060000 3860000 1510000 1680000 1640000 889000 1450000 1700000 1450000 5400000 941000 1100000 GLYCERALDEHYDE/LACTATE 23600000 43400000 70600000 7870000 36600000 75500000 104000000 127000000 108000000 61900000 178000000 44900000 15100000 77500000 19500000 19500000 GLYCERIC ACID Glyceric acid 19700000 13200000 16400000 12300000 50900000 95700000 54700000 81700000 27800000 23600000 27600000 26600000 10700000 9320000 16000000 14600000 GUANINE Guanine 988000 17300000 22000000 6910000 800000 921000 661000 1130000 973000 659000 10000000 1280000 1290000 20500000 5010000 2220000 Guanosine Guanosine 10100000 33200000 42000000 15300000 21100000 22800000 12100000 13400000 14600000 9410000 35100000 13900000 7860000 19400000 12600000 9890000 HYPOXANTHINE Hypoxanthine 91000000 105000000 143000000 52200000 121000000 186000000 118000000 158000000 125000000 90000000 169000000 106000000 55200000 125000000 55700000 57800000 INOSINE Inosine 93600000 66400000 86000000 39600000 109000000 118000000 66300000 83400000 79300000 59300000 120000000 78000000 29500000 52400000 40400000 42500000 ISOCITRIC ACID Isocitric acid 4090000 5790000 4290000 8220000 8910000 11700000 12400000 21200000 15900000 5350000 26000000 7790000 13800000 25500000 12400000 14300000 L-2-PHOSPHOGLYCERIC ACID 2-Phosphoglyceric acid 20700000 3110000 3540000 14200 15900000 6340000 14600000 17500000 2700000 15300000 10900000 19000000 63800 55200 1770000 2990000 L-ARGININE Arginine 15900000 15000000 16500000 7370000 10800000 10800000 15800000 21400000 19700000 16700000 24900000 26000000 21000000 24800000 23000000 26900000 L-CYSTATHIONINE Cystathionine 2750000 229000 688000 973000 1790000 1900000 296000 379000 1010000 280000 786000 1030000 644000 1210000 1170000 1100000 L-CYSTEINE Cysteine 612000 624000 587000 917000 501000 716000 461000 501000 772000 638000 678000 685000 802000 1470000 743000 532000 L-GLUTAMIC ACID Glutamic acid 137000000 104000000 127000000 76300000 119000000 175000000 89400000 101000000 138000000 73800000 200000000 111000000 51200000 72700000 69800000 74800000 L-GLUTAMINE Glutamine 53200000 39600000 45400000 28600000 48900000 77900000 37300000 49700000 51100000 34400000 94700000 54800000 29900000 45400000 33700000 37800000 L-HISTIDINE Histidine 39500000 35000000 41200000 26100000 33700000 34200000 37700000 44800000 41700000 30200000 60400000 41800000 27800000 36800000 36800000 37600000 Linoleic Acid (18:2) Linoleic acid 117000 49100 44200 24500 37800 62200 27800 58400 213000 281000 326000 499000 26000 87400 49500 199000 L-ISOLEUCINE_R1 Isoleucine 2370000 797000 1290000 469000 1400000 1880000 998000 1840000 1380000 892000 2950000 2540000 991000 1740000 1310000 1540000 L-ISOLEUCINE_R2 Isoleucine 894000 485000 901000 191000 715000 1120000 673000 1230000 845000 492000 1610000 1210000 434000 904000 671000 727000 LL-2_6-DIAMINOHEPTANEDIOATE 2,6-Diaminopimelic acid 18500000 3020000 7180000 5250000 13000000 10100000 2670000 3610000 6990000 2010000 9780000 9280000 6130000 12700000 7080000 7900000 L-METHIONINE Methionine 21800000 10200000 14400000 6150000 18000000 20400000 14300000 24100000 21700000 15000000 31700000 27700000 16000000 23800000 18300000 22900000 L-Tryptophan-13C11 Tryptophan 3560000 5000000 5090000 6130000 4550000 4370000 4700000 6810000 6160000 7020000 5540000 4580000 5700000 5470000 5660000 5690000 L-TYROSINE Tyrosine 11600000 9210000 11300000 3650000 9590000 13200000 11700000 19700000 14900000 11900000 20800000 17100000 8610000 13900000 10700000 12300000 L-VALINE Valine 2730000 1490000 2790000 557000 2170000 3280000 2030000 3730000 2580000 1400000 4860000 3960000 1480000 3260000 2240000 2450000 LysoPC (18:1) LPC 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150000 1120000 22400 LysoPE (22:6) LPE 22:6 113000 100000 98200 91800 62500 63400 120000 279000 236000 391000 524000 498000 58600 95000 55500 173000 MALATE Malic acid 117000000 87200000 113000000 49500000 154000000 236000000 119000000 164000000 156000000 107000000 206000000 121000000 34600000 83800000 51400000 54400000 Mannitol Mannitol 5410000 5690000 6950000 1130000 8640000 15400000 5110000 6350000 5850000 4190000 12200000 3910000 1180000 4140000 1160000 1330000 Mono-(2-Ethylhexyl) Phthalate Dimer Monoethylhexyl phthalic acid 4060000 3080000 1840000 671000 1090000 1850000 1050000 2080000 8170000 13500000 9250000 16800000 674000 3950000 2460000 10700000 Monobutyl phthalate Monobutylphthalate 344000 529000 563000 114000 196000 269000 302000 263000 545000 375000 385000 307000 1840000 983000 393000 484000 N-Acetylaspartylglutamic acid N-Acetyl-Asp-Glu 164000 826000 1420000 1270000 38500 36200 38100 51300 29900 24600 55500 30900 134000 427000 112000 98300 N-ACETYL-DL-GLUTAMIC ACID_R1 N-Acetylglutamic acid 16300000 7410000 13500000 483000 1460000 4150000 13100000 17800000 6730000 2260000 17400000 6740000 738000 1600000 2390000 2140000 N-ACETYL-DL-GLUTAMIC ACID_R2 N-Acetylglutamic acid 414000 6910000 166000 373000 151000 249000 176000 237000 58400 2210000 155000 4580000 729000 31100 53400 101000 N-ACETYL-D-MANNOSAMINE N-Acetyl-mannosamine 27900000 18900000 20500000 22800000 27700000 54800000 18200000 24600000 15400000 9130000 18300000 17700000 14900000 49500000 12100000 11600000 N-ACETYL-HEXOSAMINE N-Acetylhexosamine 1510000 1430000 1560000 2150000 1580000 4850000 950000 1280000 1240000 812000 1210000 822000 1650000 8450000 1030000 872000 N-ACETYL-L-ALANINE N-Acetylalanine 6190000 6480000 9010000 1780000 5480000 6600000 7340000 12400000 9420000 7000000 13700000 10100000 3810000 7430000 5450000 5730000 N-ACETYL-L-ASPARTIC ACID N-Acetylaspartic acid 55800000 72700000 108000000 12200000 35600000 42600000 50700000 28700000 694000 45700000 2580000 1330000 3900000 9010000 63500000 46100000 N-ACETYLNEURAMINATE N-Acetylneuraminic acid 14900000 11000000 14900000 9870000 15100000 20100000 11800000 15100000 12300000 8950000 15100000 13100000 10600000 13200000 10700000 11500000 N-BOC-L-Aspartic Acid_R1 Aspartic acid 60000000 45700000 61500000 41500000 65500000 64600000 49900000 75400000 67400000 58900000 78400000 72700000 57000000 70900000 60700000 65100000 N-BOC-L-Aspartic Acid_R2 Aspartic acid 12300000 9490000 12500000 8510000 12900000 13100000 10500000 15400000 13700000 12100000 15900000 15200000 11600000 14300000 12300000 13100000 N-BOC-L-tert-Leucine_R1 27200000 20600000 23700000 23700000 29000000 28000000 18300000 29700000 28200000 24900000 29300000 29500000 26200000 30400000 28700000 30900000 N-BOC-L-tert-Leucine_R2 11600000 7980000 10100000 9690000 12300000 12000000 7560000 12500000 11600000 10400000 12400000 12300000 11000000 12700000 12100000 12700000 N-BOC-L-Tryptophan_R1 Tryptophan 33700000 29700000 30800000 32200000 44400000 41900000 27800000 33000000 41200000 30600000 38700000 40400000 44700000 46600000 34600000 39100000 N-BOC-L-Tryptophan_R2 Tryptophan 28300000 25400000 26500000 27400000 37200000 34200000 22800000 27000000 33600000 25700000 31600000 34100000 38300000 38200000 29300000 32500000 NICOTINAMIDE Niacinamide 1370000 1180000 1420000 570000 2220000 2600000 1150000 1400000 870000 774000 1990000 1370000 351000 1030000 426000 486000 N-METHYL-L-GLUTAMATE_R1 N-Methyl-glutamic acid 399000 269000 389000 230000 434000 1600000 498000 654000 1050000 426000 1080000 502000 211000 934000 308000 172000 N-METHYL-L-GLUTAMATE_R2 N-Methyl-glutamic acid 414000 286000 291000 230000 442000 327000 492000 691000 302000 433000 490000 468000 211000 375000 308000 346000 OROTIC ACID Orotic acid 1220000 858000 1320000 1340000 2350000 3700000 2670000 3240000 1570000 318000 3490000 3100000 1130000 4190000 1290000 1050000 Pantetheine Pantetheine 107000 245000 303000 449000 1430000 4660000 306000 391000 310000 262000 551000 170000 87200 349000 73900 64100 Plasmenyl-LysoPE (P-18:1) LPE P-18:1 1350000 1400000 1090000 353000 598000 979000 300000 755000 3720000 6850000 5180000 12000000 538000 2000000 1090000 4890000 Proline Proline 625000 188000 1100000 94000 488000 367000 472000 704000 251000 160000 1120000 3250000 133000 538000 270000 185000 PYRIDOXAL Pyridoxal 324000 652000 627000 398000 925000 1900000 657000 717000 845000 424000 395000 284000 351000 734000 234000 237000 PYRIDOXINE Pyridoxine 207000 240000 332000 85600 382000 626000 296000 440000 419000 262000 564000 245000 118000 297000 138000 158000 S-(5^-ADENOSYL)-L-HOMOCYSTEINE S-Adenosylhomocysteine 913000 396000 617000 287000 965000 1000000 559000 716000 689000 393000 605000 740000 391000 1100000 253000 283000 Salicylic Acid-D4 Salicylic acid 2360000 2050000 2350000 2050000 2730000 2690000 1540000 2520000 2640000 2400000 2680000 2740000 2730000 2870000 2470000 2710000 SARCOSINE/BETA-ALANINE 3570000 4170000 4910000 1330000 4530000 10200000 3780000 5090000 5090000 3330000 7090000 3540000 1500000 2660000 1810000 2140000 (S)-DIHYDROOROTATE 4,5-Dihydroorotic acid 639000 544000 689000 287000 904000 1630000 653000 1270000 1090000 325000 1990000 1230000 302000 973000 337000 371000 S-HEXYL-GLUTATHIONE S-Hexyl-glutathione 896000 266000 279000 127000 1010000 1150000 76800 136000 186000 112000 334000 578000 210000 67000 198000 255000 SUCCINATE Succinic acid 57100000 37500000 53300000 19300000 71800000 101000000 38200000 58800000 52300000 29800000 74500000 42800000 5640000 34800000 15000000 16100000 SUCCINIC ACID-13C4 Succinic acid 700000 601000 650000 850000 811000 674000 552000 793000 821000 858000 659000 764000 1110000 882000 1080000 1160000 TAURINE Taurine 38100000 11600000 14300000 8830000 24700000 35200000 16900000 17800000 18900000 9820000 32800000 13600000 5080000 9140000 4580000 3680000 THREONINE/HOMOSERINE Threonine/Homoserine 16400000 19500000 22800000 9380000 19500000 24500000 22000000 25900000 22900000 17900000 32400000 28100000 15700000 26200000 18200000 20400000 THYMIDINE 5^-MONOPHOSPHATE TMP 308000 234000 232000 636000 695000 131000 124000 148000 395000 195000 162000 281000 487000 284000 139000 169000 Tryptophan Tryptophan 10800000 14000000 17500000 6010000 11900000 17900000 18700000 27500000 20800000 15100000 29900000 19900000 9570000 17200000 12100000 12800000 UDP UDP 8330000 113000 373000 52000 1040000 2050000 166000 167000 319000 428000 574000 648000 162000 133000 338000 291000 URACIL Uracil 65100000 59200000 81300000 32600000 96000000 150000000 63100000 106000000 95300000 41700000 142000000 93300000 33200000 86400000 40000000 41600000 URATE Uric acid 903000 449000 591000 221000 895000 1350000 793000 1090000 645000 720000 593000 818000 363000 519000 427000 543000 URIDINE Uridine 24100000 24300000 39500000 3980000 27500000 22700000 8810000 12000000 18000000 36700000 41000000 23200000 3300000 5810000 8140000 15000000 URIDINE-5-MONOPHOSPHATE UMP 14000000 15100000 28300000 7040000 39900000 29000000 21700000 30800000 16700000 7820000 36600000 26600000 4590000 14500000 8160000 8840000 XANTHINE Xanthine 69000000 50300000 80500000 18400000 94000000 120000000 92900000 137000000 113000000 91100000 138000000 110000000 49300000 88000000 50400000 59100000