Metabolite_name RefMet_name 5 6 7 8 1 2 3 4 13 14 15 16 10 11 12 9 Factors - Time:24hr | Treatment:Control Time:24hr | Treatment:Control Time:24hr | Treatment:Control Time:24hr | Treatment:Control Time:24hr | Treatment:Englerin (100 nM) Time:24hr | Treatment:Englerin (100 nM) Time:24hr | Treatment:Englerin (100 nM) Time:24hr | Treatment:Englerin (100 nM) Time:48hr | Treatment:Control Time:48hr | Treatment:Control Time:48hr | Treatment:Control Time:48hr | Treatment:Control Time:48hr | Treatment:Englerin (100 nM) Time:48hr | Treatment:Englerin (100 nM) Time:48hr | Treatment:Englerin (100 nM) Time:48hr | Treatment:Englerin (100 nM) 1-Methyladenosine 1-Methyladenosine 51600000 38000000 86400000 24500000 39200000 40100000 43000000 37200000 22000000 52900000 47100000 20200000 12000000 55700000 17500000 17900000 1-Methylhistamine 1-Methylhistamine 1-Methylhistidine 1-Methylhistidine 365000000 133000000 254000000 84500000 148000000 115000000 116000000 94600000 85500000 166000000 181000000 185000000 36400000 211000000 140000000 58600000 1-Methylnicotinamide 1-Methyl nicotinamide 1-Pyrroline-5-carboxylic acid 1-Pyrroline-5-carboxylic acid 9890000 4960000 9590000 3850000 4620000 4140000 4120000 4260000 3030000 6150000 5840000 6470000 1200000 7150000 5600000 2340000 24_25-Dihydrolanosterol 24,25-Dihydrolanosterol 1710000 1470000 1330000 1730000 1150000 1000000 745000 935000 1910000 1440000 1300000 2330000 623000 995000 1080000 752000 24_25-Epoxycholesterol 24,25-Epoxycholesterol 61200 132000 190000 349000 118000 115000 99600 141000 232000 158000 196000 237000 116000 34300 176000 143000 2-Arachidonylglycerol MG 20:4 55200 35300 109000 160000 57200 146000 47900 109000 355000 90200 91400 175000 41000 67700 68300 160000 2-Deoxyguanosine 5-monophosphate dGMP 2-Octenoylcarnitine CAR 8:1(2) 3_3^_5^-Triiodothyronine Liothyronine 185000 124000 322000 172000 158000 175000 119000 318000 126000 153000 157000 78500 33100 200000 273000 125000 3_ 5-Tetradecadiencarnitine CAR 14:2(3,5) 619000 790000 1540000 824000 741000 775000 784000 859000 733000 776000 884000 1300000 206000 637000 903000 239000 3-Hydroxyanthranilic acid 3-Hydroxyanthranilic acid 113000 269000 176000 105000 182000 146000 101000 134000 92200 219000 121000 2220000 68800 135000 1970000 92600 3-Hydroxy-cis-5-tetradecenoylcarnitine CAR 14:1;OH 1030000 1450000 2690000 1400000 2400000 1910000 1960000 2120000 3160000 4230000 3230000 4260000 534000 1230000 1120000 564000 3-Hydroxydodecanoylcarnitine CAR 12:0;OH 286000000 195000000 443000000 181000000 147000000 141000000 141000000 145000000 107000000 151000000 158000000 117000000 75600000 263000000 147000000 113000000 3-Hydroxyhexadecanoylcarnitine CAR 16:0;3OH 1820000 2000000 2690000 2070000 1570000 1200000 1030000 1530000 3480000 3140000 2200000 3450000 1410000 1350000 1990000 1280000 3-Hydroxyhexadecenoylcarnitine CAR 12:1;OH 1830000 2160000 3160000 2230000 6610000 4210000 4280000 5340000 9550000 11900000 10500000 12000000 774000 1510000 1920000 811000 3-Hydroxyhexanoylcarnitine CAR 6:0;3OH 3-Hydroxyiso-/butyrylcarnitine CAR 4:0;OH 21100000 19600000 42100000 16600000 13200000 12500000 11300000 11700000 7620000 14600000 12200000 10800000 8170000 29500000 20000000 12000000 3-Hydroxyisovaleryl Carnitine CAR 4:0;OH,Me 17300000 18100000 37300000 13400000 12100000 11600000 10300000 9840000 7530000 13200000 10700000 11100000 5280000 21000000 14600000 8180000 3-Hydroxylinoleylcarnitine CAR 18:2;OH 3950000 6730000 9130000 7480000 5700000 5820000 5010000 6600000 8800000 8090000 6690000 10900000 3380000 5490000 9050000 5270000 3-Hydroxyoleoylcarnitine CAR 18:1(9Z);3OH 437000 761000 1010000 801000 2070000 1530000 2040000 1710000 3920000 3780000 3480000 5160000 313000 368000 580000 473000 5_6-trans-25-Hydroxyvitamin D3 5,6-trans-25-Hydroxyvitamin D3 26100000 12700000 41900000 29600000 14900000 13900000 9040000 21100000 28600000 11000000 15800000 17900000 12200000 11100000 17500000 23400000 5alpha-Cholestanol Dihydrocholesterol 5-Methylthioadenosine 5'-Methylthioadenosine 7a-Hydroxycholesterol 7alpha-Hydroxy-cholesterol 719000 454000 950000 931000 284000 643000 321000 572000 903000 440000 596000 600000 146000 316000 625000 364000 7-Dehydrocholesterol 7-Dehydrocholesterol 610000 468000 940000 687000 291000 246000 251000 436000 692000 270000 408000 461000 272000 226000 533000 311000 7-ketocholesterol 7-Oxo-cholesterol 7810000 7020000 15200000 11400000 4990000 3770000 2590000 6430000 8500000 3450000 4610000 6320000 3610000 3360000 7520000 7440000 7-Methylguanosine 7-Methylguanosine 2170000 1760000 2230000 872000 1860000 1690000 1340000 1580000 1690000 2590000 2540000 3070000 1500000 2040000 1790000 658000 9-Decenoylcarnitine CAR 10:1(9) 1710000 1930000 5570000 1440000 2630000 1850000 1790000 2000000 1240000 4550000 2310000 2210000 739000 2230000 3620000 1200000 9-Hexadecenoylcarnitine CAR 16:1 3630000 4890000 6590000 4060000 11600000 7110000 8050000 8890000 12100000 18000000 15500000 16800000 1760000 2690000 2200000 1550000 Acetylcholine Acetylcholine 74100000 40900000 88800000 39700000 37000000 34200000 36000000 40200000 27000000 34200000 38400000 34800000 15600000 56200000 38200000 25600000 Adenine Adenine Adenosine Adenosine 12300000 6610000 12500000 10500000 45300000 42500000 28600000 22600000 118000000 148000000 92800000 23200000 53700000 50900000 9460000 51800000 Adenosine monophosphate AMP 30300000 21400000 19800000 34700000 4600000 11100000 6750000 21300000 233000000 17900000 15400000 13300000 70400000 4470000 18000000 205000000 Adenosine triphosphate ATP Adipoylcarnitine CAR DC5:0 1300000 1530000 3020000 1590000 1050000 1320000 1040000 1090000 1550000 3360000 1210000 990000 775000 1250000 3330000 1030000 Agmatine Agmatine Alanine Alanine 512000000 307000000 541000000 229000000 417000000 363000000 335000000 360000000 351000000 493000000 532000000 648000000 149000000 546000000 610000000 243000000 Alpha-Tocopherol alpha-Tocopherol 584000 450000 649000 521000 271000 150000 268000 477000 553000 231000 393000 429000 206000 354000 523000 343000 Amphetamine Dextroamphetamine 28600000 24400000 34200000 18500000 24000000 20200000 17400000 20900000 27400000 27200000 31000000 51000000 10300000 20800000 23000000 12900000 Anandamide Arachidonoyl-EA Anserine Anserine Arachidonyl carnitine CAR 20:4 457000 392000 402000 529000 274000 304000 266000 341000 564000 228000 262000 601000 226000 240000 744000 407000 B-Carotene beta-Carotene 7240000 17500000 10700000 4140000 8640000 6670000 3020000 4950000 15100000 9740000 9170000 3850000 6130000 7700000 4530000 5270000 beta-Alanine beta-Alanine 7990000 8590000 12200000 5950000 7030000 7400000 5390000 5150000 3750000 3940000 5230000 5180000 3400000 6370000 7090000 3530000 Betaine Betaine 1040000000 612000000 1060000000 431000000 601000000 491000000 444000000 487000000 421000000 701000000 697000000 1000000000 162000000 819000000 907000000 296000000 Betaine aldehyde Betaine aldehyde Bilirubin Bilirubin Biotin Biotin 1550000 1780000 4350000 953000 1720000 1910000 1420000 1410000 1580000 2070000 1840000 2300000 802000 2360000 5200000 757000 BMP(16:0/16:0) BMP(18:1/16:0) BMP(18:1/16:1) BMP(18:1/18:0) BMP(18:1/18:1) BMP(18:1/18:2) BMP(18:1/20:4) BMP(18:1/22:5) BMP(18:1/22:6) BMP(20:4/22:6) BMP(22:5/22:6) BMP(22:6/22:6) Butyrylcarnitine CAR 4:0 706000000 773000000 1650000000 710000000 658000000 581000000 589000000 638000000 391000000 848000000 695000000 705000000 238000000 909000000 751000000 396000000 Carnosine Carnosine 10900000 6850000 12000000 6220000 7000000 7310000 5390000 6840000 6520000 7990000 7870000 12600000 2070000 8930000 14700000 3810000 Ceramide(d18:1/12:0) Cer 18:1;O2/12:0 Ceramide(d18:1/16:0) Cer 18:1;O2/16:0 23200000 21200000 44300000 37700000 47800000 55900000 63300000 29400000 89000000 16600000 12800000 22700000 40100000 22600000 12300000 24600000 Ceramide(d18:1/16:0 OH) Cer 18:1;O2/16:0;O 778000 843000 1840000 1500000 643000 671000 567000 689000 1750000 428000 308000 927000 777000 368000 785000 750000 Ceramide(d18:1/16:1) Cer 18:1;O2/16:1 563000 433000 879000 651000 222000 293000 188000 363000 1250000 264000 225000 566000 316000 144000 351000 449000 Ceramide(d18:1/16:1 OH) Cer 18:1;O2/16:1;O 405000 331000 673000 550000 977000 936000 1050000 364000 1050000 419000 224000 395000 502000 483000 286000 401000 Ceramide(d18:1/16:2) Cer 18:1;O2/16:2 Ceramide(d18:1/16:2 OH) Cer 18:1;O2/16:2;O Ceramide(d18:1/18:0) Cer 18:1;O2/18:0 799000 893000 981000 2620000 7860000 7430000 8830000 4640000 4990000 2570000 1080000 806000 4590000 7130000 1100000 3200000 Ceramide(d18:1/18:0 OH) Cer 18:1;O2/18:0;O 320000 403000 913000 573000 150000 212000 249000 141000 763000 139000 116000 389000 389000 95300 252000 339000 Ceramide(d18:1/18:1) Cer 18:1;O2/18:1 413000 250000 618000 245000 164000 148000 237000 137000 638000 177000 122000 181000 238000 42600 152000 181000 Ceramide(d18:1/18:1 OH) Cer 18:1;O2/18:1;O Ceramide(d18:1/18:2) Cer 18:1;O2/18:2 Ceramide(d18:1/18:2 OH) Cer 18:1;O2/18:2;O Ceramide(d18:1/20:0) Cer 18:1;O2/20:0 Ceramide(d18:1/20:0 OH) Cer 18:1;O2/20:0;O Ceramide(d18:1/20:1) Cer 18:1;O2/20:1 Ceramide(d18:1/20:1 OH) Cer 18:1;O2/20:1;O Ceramide(d18:1/20:2) Cer 18:1;O2/20:2 Ceramide(d18:1/20:2 OH) Cer 18:1;O2/20:2;O Ceramide(d18:1/22:0) Cer 18:1;O2/22:0 14100000 8790000 8370000 8740000 7840000 19000000 8800000 8150000 Ceramide(d18:1/22:0 OH) Cer 18:1;O2/22:0;O Ceramide(d18:1/22:1) Cer 18:1;O2/22:1 Ceramide(d18:1/22:2) Cer 18:1;O2/22:2 Ceramide(d18:1/22:2 OH) Cer 18:1;O2/22:2;O Ceramide(d18:1/23:0) or Ceramide(d18:1/22:1 OH) Ceramide(d18:1/24:0) Cer 18:1;O2/24:0 Ceramide(d18:1/24:0 OH) Cer 18:1;O2/24:0;O 4860000 5250000 3790000 5550000 54200000 66100000 60900000 30700000 25400000 30000000 15900000 23800000 15500000 33500000 17300000 8250000 Ceramide(d18:1/24:1) Cer 18:1;O2/24:1 4790000 3710000 3970000 6690000 44800000 53700000 53200000 31300000 36300000 25600000 18400000 21500000 10600000 31600000 12800000 10600000 Ceramide(d18:1/24:2) Cer 18:1;O2/24:2 Ceramide(d18:1/24:2 OH) Cer 18:1;O2/24:2;O Ceramide(d18:1/25:0) Cer 18:1;O2/25:0 72800 132000 208000 136000 2510000 3120000 3070000 1270000 675000 523000 219000 445000 295000 1740000 293000 321000 Ceramide(d18:1/26:0) Cer 18:1;O2/26:0 Ceramide(d18:1/26:0 OH) Cer 18:1;O2/26:0;O Ceramide(d18:1/26:1) Cer 18:1;O2/26:1 Ceramide(d18:1/26:1 OH) Cer 18:1;O2/26:1;O Ceramide(d18:1/26:2) Cer 18:1;O2/26:2 Ceramide(d18:1/26:2 OH) Cer 18:1;O2/26:2;O Cholesterol Cholesterol 896000 598000 2450000 1090000 5590000 4590000 8440000 1870000 1790000 2370000 4630000 820000 1090000 15300000 2100000 694000 Choline Choline 1760000000 1540000000 3360000000 1580000000 1280000000 1250000000 1320000000 1540000000 1240000000 1770000000 1640000000 2700000000 477000000 1940000000 2430000000 886000000 Cobalamin Vitamin B12 303000 483000 888000 650000 242000 332000 263000 390000 640000 452000 414000 667000 333000 259000 493000 353000 Coenzyme Q10 Coenzyme Q10 Coenzyme Q9 Coenzyme Q9 CoQ10H2 Coenzyme Q10 CoQ9H2 Coenzyme Q9 Corticosterone Corticosterone 687000 571000 1140000 1050000 783000 409000 640000 857000 1030000 963000 702000 1070000 219000 576000 789000 381000 Cortisone Cortisone 35800 83600 152000 95500 56000 75500 70100 83600 49000 47200 27800 74900 18600 28600 117000 24400 Creatinine Creatinine 374000000 285000000 605000000 225000000 289000000 250000000 275000000 263000000 202000000 408000000 322000000 184000000 87400000 411000000 190000000 138000000 Cyanocobalamin Cyanocobalamin 296000 155000 367000 150000 188000 140000 193000 163000 148000 157000 211000 343000 51300 273000 252000 110000 Cysteamine Cysteamine Cysteine Cysteine 7880000 4870000 9850000 8600000 7010000 6050000 5010000 9210000 6800000 5000000 6720000 10100000 1250000 6090000 8150000 3950000 Cysteineglutathione disulfide S-Glutathionyl-cysteine Cytidine Cytidine 4990000 2360000 4030000 2940000 23900000 18700000 19900000 24700000 5950000 10700000 8820000 9830000 495000 2160000 1580000 1680000 Cytidine monophosphate CMP 4460000 2790000 3340000 4060000 3530000 4290000 2900000 6680000 7350000 1790000 2920000 3620000 1560000 2590000 3540000 3690000 Cytosine Cytosine 15500000 8390000 19200000 5560000 6560000 6630000 5310000 3280000 2690000 6940000 5220000 5050000 1490000 9490000 4950000 2610000 Decanoylcarnitine CAR 10:0 4250000 4200000 9570000 3910000 4490000 3590000 3690000 3450000 4080000 12800000 9540000 8970000 971000 5490000 4330000 1610000 Dehydroepiandrosterone Dehydroepiandrosterone Deoxyadenosine Deoxyadenosine Deoxyadenosine monophosphate dAMP 536000 759000 362000 743000 302000 345000 164000 528000 810000 88100 186000 182000 227000 237000 392000 908000 Deoxycytidine monophosphate dCMP 165000 383000 313000 333000 103000 93500 60900 233000 229000 21000 44700 92900 25500 47500 141000 103000 Deoxyinosine monophosphate dIMP 13900000 20300000 58100000 15100000 17700000 23800000 28200000 15000000 17900000 21200000 23800000 94300000 10100000 19300000 121000000 11800000 Deoxyuridine monophosphate dUMP Desmosterol Desmosterol 856000 588000 780000 866000 625000 279000 284000 518000 875000 492000 408000 674000 302000 383000 847000 482000 DHC(18:1/16:0) Hex2Cer 18:1;O2/16:0 767000 1220000 2920000 1580000 783000 1190000 1690000 1070000 4190000 944000 526000 1690000 1590000 415000 939000 747000 DHC(18:1/22:0) Hex2Cer 18:1;O2/22:0 DHC(18:1/24:0) Hex2Cer 18:1;O2/24:0 DHC(18:1/24:1) Hex2Cer 18:1;O2/24:1 Dimethylglycine Dimethylglycine 315000000 234000000 511000000 168000000 210000000 188000000 197000000 170000000 244000000 265000000 237000000 230000000 71900000 298000000 301000000 108000000 Dimethyl-L-arginine Dimethylarginine 72200000 24300000 48800000 17300000 25200000 20900000 23000000 22700000 17800000 31100000 30300000 24900000 6890000 41000000 26100000 12200000 Dodecanoylcarnitine CAR 12:0 4280000 4670000 9610000 4820000 5300000 4560000 3700000 4250000 6710000 11100000 8520000 9950000 1720000 5100000 3610000 2180000 Dodecenoylcarnitine CAR 12:1 1430000 1340000 3550000 1410000 1600000 1510000 1370000 1530000 1690000 3430000 2800000 2610000 467000 1760000 2900000 550000 Dopamine Dopamine 7180000 5400000 6530000 2500000 7000000 5730000 5520000 4670000 4440000 9800000 8180000 10500000 3480000 3800000 5500000 1130000 Epicatechin Epicatechin Epinephrine Epinephrine Ergosterol Ergosterol 80400 132000 214000 119000 135000 221000 86700 190000 159000 130000 199000 182000 93000 129000 187000 84300 Estradiol beta-Estradiol Estriol Estriol Estrone Estrone Ethanolamine Ethanolamine FMN FMN Gamma-glutamyl-Alanine gamma-Glutamylalanine Gamma-glutamyl-Cysteine gamma-Glutamylcysteine Gamma-glutamyl-Isoleucine gamma-Glutamylisoleucine 1170000 229000 604000 862000 315000 218000 315000 1430000 1720000 408000 409000 3890000 153000 476000 564000 1060000 Gamma-glutamyl-Valine gamma-Glutamylvaline GC(18:1/16:0) HexCer 18:1;O2/16:0 2680000 8010000 7660000 8900000 31000000 37100000 52900000 36700000 106000000 29900000 13500000 51900000 8220000 4510000 9460000 6590000 GC(18:1/20:0) HexCer 18:1;O2/20:0 12200 32100 16500 7940 748000 851000 804000 267000 179000 369000 210000 261000 9410 165000 94600 33000 GC(18:1/22:0) HexCer 18:1;O2/22:0 17400 17500 123000 32700 7350000 8760000 7110000 2730000 671000 2340000 1780000 1980000 361000 1820000 761000 263000 GC(18:1/24:0) HexCer 18:1;O2/24:0 GC(18:1/24:1) HexCer 18:1;O2/24:1 34100 252000 171000 252000 7600000 10300000 10300000 2820000 3190000 4280000 1970000 3820000 333000 2490000 972000 356000 Gluconolactone Gluconolactone 311000 364000 818000 360000 340000 314000 361000 363000 257000 267000 287000 560000 143000 327000 23800 190000 Glucosamine Glucosamine Glyceraldehyde Glyceraldehyde 65200000 45200000 83800000 39000000 41100000 37900000 36300000 40900000 37800000 51200000 55800000 72300000 11500000 47500000 52900000 19700000 Glycerophosphocholine sn-Glycero-3-phosphocholine 1040000000 683000000 1260000000 595000000 1270000000 1120000000 1050000000 1220000000 1160000000 1370000000 1390000000 1530000000 225000000 793000000 794000000 316000000 Glycine Glycine 793000 741000 1170000 620000 1000000 914000 507000 671000 1120000 848000 1160000 1600000 410000 675000 631000 514000 Guanosine Guanosine Guanosine monophosphate GMP 816000 1340000 961000 1460000 1590000 1900000 643000 1480000 4490000 527000 771000 693000 2740000 961000 1560000 4660000 Hexanoylcarnitine CAR 6:0 Histamine Histamine 17200000 8240000 18600000 5530000 6670000 5940000 7120000 6700000 2470000 7640000 6650000 5430000 1520000 9890000 5540000 2310000 Homocysteine Homocysteine Hydroxycholesterol Species 114000 108000 218000 277000 45800 89200 50400 112000 215000 109000 124000 154000 32800 60000 79700 101000 Hydroxykynurenine Hydroxykynurenine Hydroxyproline Hydroxyproline 441000000 231000000 415000000 163000000 217000000 178000000 181000000 182000000 153000000 286000000 257000000 314000000 59800000 317000000 297000000 111000000 Hypoxanthine Hypoxanthine 27100000 14900000 26500000 11100000 30700000 24300000 23700000 24500000 19800000 36500000 38100000 52000000 3110000 18200000 20400000 5430000 Indole Indole 8630000 5360000 10900000 4660000 6470000 5040000 5370000 6420000 4590000 9070000 7470000 11100000 253000 7390000 6700000 2660000 Indoleacrylic acid Indoleacrylic acid Isovalerylcarnitine CAR 4:0;3Me 204000000 231000000 529000000 214000000 220000000 177000000 181000000 186000000 122000000 287000000 196000000 210000000 69900000 300000000 225000000 113000000 L-Acetylcarnitine CAR 2:0 841000000 869000000 1460000000 675000000 595000000 532000000 457000000 496000000 369000000 570000000 547000000 576000000 323000000 1020000000 983000000 485000000 Lanosterin Lanosterol 412000 302000 495000 2060000 155000 338000 229000 321000 361000 478000 354000 433000 170000 346000 424000 204000 L-Asparagine Asparagine 81000000 37900000 71300000 36400000 34000000 32000000 32000000 44100000 45600000 44000000 50600000 66800000 12500000 46000000 37300000 26000000 Lathosterol Lathosterol 306000 258000 251000 526000 285000 289000 101000 162000 267000 585000 356000 512000 208000 177000 147000 147000 L-Carnitine Carnitine 535000000 372000000 788000000 334000000 280000000 106000000 253000000 277000000 201000000 274000000 299000000 213000000 139000000 500000000 264000000 211000000 L-Cystathionine Cystathionine 534000 388000 637000 320000 336000 254000 220000 300000 263000 259000 265000 436000 95200 405000 663000 196000 L-Glutamine Glutamine 481000000 250000000 370000000 184000000 253000000 237000000 227000000 234000000 290000000 252000000 303000000 517000000 144000000 290000000 300000000 180000000 L-Glutarylcarnitine CAR DC5:0 L-Histidine Histidine 265000000 80100000 156000000 61200000 67900000 64800000 72600000 92800000 83100000 83300000 112000000 76300000 16300000 96200000 45300000 42400000 L-Histidinol L-Histidinol L-Homoserine Homoserine Linoleylcarnitine CAR 18:2 703000 1240000 2040000 1090000 3210000 1880000 2170000 2780000 3780000 5590000 5100000 5670000 541000 744000 1070000 404000 L-Isoleucine Isoleucine 2390000000 3370000000 5280000000 2490000000 2950000000 2670000000 2330000000 2720000000 3040000000 3760000000 3800000000 4760000000 1160000000 3710000000 4330000000 1750000000 L-Kynurenine Kynurenine 85700 120000 90500 87100 109000 49500 127000 108000 232000 102000 215000 193000 108000 74500 212000 140000 L-Lysine Lysine 492000000 255000000 367000000 187000000 254000000 235000000 228000000 237000000 287000000 254000000 305000000 518000000 136000000 286000000 293000000 177000000 L-Methionine Methionine 731000000 439000000 830000000 343000000 507000000 421000000 418000000 417000000 360000000 593000000 620000000 763000000 129000000 620000000 643000000 206000000 L-Palmitoylcarnitine CAR 16:0 20500000 29000000 45500000 28200000 69700000 46800000 47500000 63100000 83500000 117000000 97400000 116000000 10200000 18700000 19400000 12200000 L-Phenylalanine Phenylalanine 811000000 529000000 1020000000 460000000 645000000 529000000 497000000 551000000 497000000 770000000 786000000 1050000000 153000000 691000000 807000000 264000000 L-Proline Proline 1490000000 766000000 1640000000 757000000 897000000 781000000 894000000 978000000 742000000 1040000000 1100000000 1120000000 318000000 1300000000 1220000000 544000000 L-Serine Serine 44200000 22100000 41300000 21100000 23500000 20000000 22900000 29500000 31100000 26700000 34200000 47400000 5980000 23700000 18000000 12200000 L-Tryptophan Tryptophan 751000000 401000000 849000000 365000000 535000000 427000000 450000000 479000000 395000000 666000000 643000000 854000000 117000000 597000000 627000000 212000000 L-Tyrosine Tyrosine 11700000 8870000 13300000 6630000 9400000 8250000 6720000 7000000 10800000 9860000 12700000 19900000 3860000 7690000 10500000 5080000 L-Valine Valine 1500000000 1090000000 1850000000 880000000 1140000000 992000000 890000000 1000000000 1050000000 1440000000 1460000000 1760000000 322000000 1290000000 1410000000 555000000 LysoPC(16:0) LPC 16:0 6330000 7680000 12100000 7460000 3180000 2940000 3520000 4160000 2160000 2180000 1380000 1920000 2360000 3120000 3560000 2720000 LysoPC(18:0) LPC 18:0 31300 252000 118000 338000 21600 65300 211000 501000 1560000 289000 18300 491000 1570000 22500 209000 863000 Malonylcarnitine CAR DC3:0 18900000 18500000 39800000 15100000 13400000 11800000 10700000 10500000 9830000 15000000 12200000 10200000 7570000 28700000 19300000 10900000 Melatonin Melatonin Metanephrine L-Metanephrine 7860000 20500000 26400000 18100000 23300000 21100000 10100000 15800000 15200000 23600000 28000000 23700000 6360000 24300000 27300000 9300000 Methionine sulfoxide Methionine sulfoxide 173000 90300 243000 105000 137000 94400 75000 94700 101000 164000 156000 256000 32300 89000 182000 46200 Methylcobalamin Methylcobalamin Methylcysteine Methylcysteine 6210000 4670000 6800000 3140000 4500000 3600000 3210000 3710000 4550000 4760000 5750000 7980000 1730000 4800000 5050000 2580000 Myristoylcarnitine CAR 14:0 6740000 9490000 16300000 8790000 15500000 12000000 11400000 14100000 20700000 24800000 19700000 22000000 3770000 6130000 4830000 4470000 N-Acetylornithine N-Acetylornithine N-acetylputrescine N-Acetylputrescine N-acetylserine N-Acetylserine 10500000 17500000 48900000 28600000 6050000 9920000 10700000 17900000 7580000 5160000 6570000 18900000 9480000 12000000 13000000 17500000 Niacinamide Niacinamide 944000000 979000000 1370000000 1010000000 681000000 592000000 698000000 868000000 896000000 1350000000 1120000000 1590000000 322000000 1020000000 1130000000 591000000 Nicotinamide N-oxide Nicotinamide N-oxide Norepinephrine Norepinephrine 163000 150000 397000 228000 150000 156000 89700 182000 256000 263000 259000 623000 150000 241000 437000 193000 Normetanephrine Normetanephrine O-acetylserine O-Acetylserine Octadecanoylcarnitine CAR 18:0 13500000 19900000 29000000 17100000 74400000 48400000 45500000 59900000 128000000 137000000 135000000 157000000 7220000 9280000 12200000 7880000 Octanoylcarnitine CAR 8:0 5550000 6230000 13900000 5310000 6090000 5380000 4990000 6080000 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