Metabolite_name RefMet_name Cells # 12 Cells # 13 Cells # 14 Cells # 5 Cells # 6 Cells # 7 Media # 12 Media # 13 Media # 14 Media # 5 Media # 6 Media # 7 Factors - Treatment Factor:cells Treatment Factor:cells Treatment Factor:cells Treatment Factor:cells Treatment Factor:cells Treatment Factor:cells Treatment Factor:media Treatment Factor:media Treatment Factor:media Treatment Factor:media Treatment Factor:media Treatment Factor:media 2-hydroxyglutarate istopomer M0 2-Hydroxyglutaric acid 57.7900 59.3500 56.6200 46.3400 42.8600 41.4200 49.3200 51.4400 48.5100 64.3800 63.6500 62.4500 2-hydroxyglutarate istopomer M+1 2-Hydroxyglutaric acid 11.4700 11.1100 10.7800 9.0700 8.9000 7.9000 9.1800 11.7400 11.2200 9.4100 10.5800 13.8700 2-hydroxyglutarate istopomer M+2 2-Hydroxyglutaric acid 6.7100 6.2100 6.4900 5.8700 7.0400 7.1500 6.3000 5.5900 5.5000 2-hydroxyglutarate istopomer M+3 2-Hydroxyglutaric acid 9.2200 8.3600 9.1300 11.9700 11.9800 12.3100 10.7700 9.9700 10.6500 5.7500 5.5100 5.1600 2-hydroxyglutarate istopomer M+4 2-Hydroxyglutaric acid 0.6700 0.7000 0.8100 1.1700 1.3900 1.4400 1.0900 0.7700 1.2300 0.8700 0.6500 0.6100 2-hydroxyglutarate istopomer M+5 2-Hydroxyglutaric acid 14.0600 14.2000 16.1400 25.4800 27.6900 29.6100 23.2200 20.2600 22.6700 19.4400 19.3200 17.8000 2-hydroxyglutarate istopomer M+6 2-Hydroxyglutaric acid a-Ketoglutarate istopomer M0 2-Oxoglutaric acid 36.8000 59.1400 57.2800 50 49.1000 48.8200 42.7800 50.4600 49.4800 44.3900 44.2900 43.7800 a-Ketoglutarate istopomer M+1 2-Oxoglutaric acid 8.5700 12.1800 12.5100 9.4700 9.1200 9.6800 9.8100 11.0600 10.6600 7.0600 6.3400 6.3800 a-Ketoglutarate istopomer M+2 2-Oxoglutaric acid 5.0300 7.2400 7.2400 7.2000 8.3200 8.2200 7.2800 7.7300 7.7200 5.4100 6.3700 6.2600 a-Ketoglutarate istopomer M+3 2-Oxoglutaric acid 5.2000 8.1100 8.9000 11.2700 11.2600 12.5700 11.5500 10.5100 10.8900 10.5800 10.3100 10.2700 a-Ketoglutarate istopomer M+4 2-Oxoglutaric acid 0.9200 0.2800 0.3900 0.7500 1.0200 0.8400 1.4000 0.9500 0.9700 1.3100 1.4800 1.5300 a-Ketoglutarate istopomer M+5 2-Oxoglutaric acid 33.5300 11.7800 12.3600 20.0700 19.7400 19.1700 26.0500 18.9800 19.9400 29.5800 30.3000 30.9000 a-Ketoglutarate istopomer M+6 2-Oxoglutaric acid 1.6500 a-Ketoglutarate istopomer M+7 2-Oxoglutaric acid 8.3000 1.2600 1.3200 1.2400 1.4300 0.7000 1.1300 0.3100 0.3300 1.6600 0.9100 0.8900 Alanine istopomer M0 Alanine 96.9400 97.1300 97.4800 95.1400 94.8500 94.5700 96.2900 97.0500 97.5000 95.4400 95.4800 95.4600 Alanine istopomer M+1 Alanine 1.3700 1.4500 1.2600 2.2000 2.2200 2.4900 1.6100 1.3600 1.1800 1.5600 1.5800 1.6000 Alanine istopomer M+2 Alanine 1.6900 1.4100 1.2400 2.6300 2.9000 2.9100 2.0800 1.5800 1.3100 2.9800 2.9200 2.9300 Alanine istopomer M+3 Alanine Alanine istopomer M+4 Alanine 0.0100 0.0200 0.0200 0.0300 0.0300 0.0100 0.0100 0.0100 0.0200 0.0100 0.0100 Aspartate istopomer M0 Aspartic acid 66.1000 64.0100 69 47.7600 47.1200 49.0100 97.2900 97.9700 98.1700 98.0600 98.6200 98.6300 Aspartate istopomer M+1 Aspartic acid 11.3000 11.7000 11.4400 10.0700 10.3500 10.8600 0.8700 0.8300 0.6600 0.6400 0.6300 0.6300 Aspartate istopomer M+2 Aspartic acid 8.9100 8.6000 9.0500 11.2600 11.7200 12.8100 0.7300 0.6200 0.5900 0.5200 0.4500 0.4300 Aspartate istopomer M+3 Aspartic acid 7.5600 9.2700 3.8600 20.9800 20.4500 15.5500 0.2000 0.1100 0.1400 0.1200 Aspartate istopomer M+4 Aspartic acid 6.1200 6.4200 6.6500 9.9300 10.3600 11.7700 0.9000 0.4600 0.4500 0.6600 0.3100 0.3000 Aspartate istopomer M+5 Aspartic acid cis-Aconitate istopomer M0 cis-Aconitic acid 65.4600 66.3900 64.8600 64.9300 63.1800 61.0500 54.3600 57.3300 56.3600 74.0500 58.3400 50.6300 cis-Aconitate istopomer M+1 cis-Aconitic acid 12.0600 12.2900 11.9300 8.3700 9.0400 9.1700 11.5500 12.2600 11.8100 6.2200 8.4900 9.2600 cis-Aconitate istopomer M+2 cis-Aconitic acid 8.4200 8.1400 8.9000 8.5900 8.9200 9.3500 12.5700 11.8000 11.6200 7.9600 14.9400 17.0200 cis-Aconitate istopomer M+3 cis-Aconitic acid 5.4100 4.9800 5.1600 5.9000 6.5300 6.8800 5.0300 5.6700 6.1200 4.2600 cis-Aconitate istopomer M+4 cis-Aconitic acid 5.0900 5.0300 5.9100 7.2900 6.9500 7.8900 8.9300 6.2400 6.7400 4.0600 8.1800 8.7800 cis-Aconitate istopomer M+5 cis-Aconitic acid 3.4700 3.1500 3.2000 4.8100 5.2800 5.6000 7.4400 6.5200 7.1200 6.9600 9.4900 9.0500 cis-Aconitate istopomer M+6 cis-Aconitic acid 0.0300 0.0700 0.0700 0.0800 0.0800 0.1200 0.0500 0.3700 cis-Aconitate istopomer M+7 cis-Aconitic acid 0.0500 0.0100 0.0600 0.0400 0.0200 0.0300 0.0600 0.1600 0.3900 0.5500 1.0100 cis-Aconitate istopomer M+8 cis-Aconitic acid Citrate istopomer M0 Citric acid 64.3700 65.6500 64.1500 63.9400 63.0900 60.5300 54.7200 58.7600 57.3200 53.8700 51.4500 49.7300 Citrate istopomer M+1 Citric acid 11.7400 12.0100 11.6100 8.0300 8.3100 8.4400 10.9500 11.6200 11.3300 7.6900 8.8100 9.0900 Citrate istopomer M+2 Citric acid 9.2800 9.1300 9.6500 8.8400 9.2700 9.7600 10.6200 10.1200 10.6100 9.7400 10.5600 10.9100 Citrate istopomer M+3 Citric acid 5.5800 5.1300 5.5300 6.4300 6.8200 7.3500 7.9800 7.1900 7.3900 8.4500 9.4900 9.9200 Citrate istopomer M+4 Citric acid 5.1900 4.6900 5.6100 7.3400 6.8600 7.8200 8.5200 6.5400 7.5500 10.4400 9.2500 9.6500 Citrate istopomer M+5 Citric acid 3.8200 3.3700 3.4200 5.3800 5.6400 6.0700 7.1900 5.7300 5.7900 9.7900 10.4200 10.6400 Citrate istopomer M+6 Citric acid 0.0100 Citrate istopomer M+7 Citric acid 0.0200 0.0300 0.0300 0.0300 0.0200 0.0300 0.0300 0.0400 0.0100 0.0100 0.0300 0.0500 Citrate istopomer M+8 Citric acid Fumarate istopomer M0 Fumaric acid 68.3800 68.4500 67.7100 59.9600 58.1400 54.8200 74.4500 74.6500 72.9000 90.6700 89.6100 76.3600 Fumarate istopomer M+1 Fumaric acid 12.7800 12.6700 12.3100 12.6700 13.0800 12.5000 0.4000 Fumarate istopomer M+2 Fumaric acid 12.9400 10.7500 10.9200 14.8600 15.1900 15.5400 7.9900 9.2100 8.4800 3.3700 4.1900 6.2900 Fumarate istopomer M+3 Fumaric acid 0.5300 2.5700 3.1700 2.0900 3.4600 3.8500 4.3300 4.4400 7.1700 1.3500 1.2600 2.4700 Fumarate istopomer M+4 Fumaric acid 5.3600 5.5700 5.9000 10.4200 10.1300 13.2900 13.2300 11.3000 11.4400 4.4400 4.9400 14.6200 Fumarate istopomer M+5 Fumaric acid 0.1700 0.0100 0.2600 Glutamate istopomer M0 Glutamic acid 59.8300 60.6600 58.9500 49.6000 48.0100 46.4600 43.3600 50.3700 49.8100 44.6300 44.1700 43.9200 Glutamate istopomer M+1 Glutamic acid 12.0600 12.2600 12.1500 10.0900 10.1900 9.8600 9.6100 11.2600 10.8700 5.5800 5.6200 5.4100 Glutamate istopomer M+2 Glutamic acid 6.8900 6.8300 7.0700 7.6400 8.4000 8.4600 7.1800 7.7500 7.7200 5.2600 5.9100 5.7400 Glutamate istopomer M+3 Glutamic acid 8.9000 8.1700 8.8000 12.3200 12.2500 13.0700 12.1900 10.7200 11.0300 11.0400 10.6000 10.5500 Glutamate istopomer M+4 Glutamic acid 0.7100 0.5100 0.5100 0.9200 0.9900 1.0100 1.1600 0.8000 0.8000 1.3100 1.3800 1.4100 Glutamate istopomer M+5 Glutamic acid 11.6100 11.5700 12.5200 19.4400 20.1700 21.1400 26.5000 19.0900 19.7700 32.1800 32.3300 32.9800 Glutamate istopomer M+6 Glutamic acid Glutamine istopomer M0 Glutamine 49.7000 21.8100 30.6200 12.0100 10.7000 9.7500 15.4100 13.6700 25.6200 2.3600 2.3100 2.2000 Glutamine istopomer M+1 Glutamine 5.3100 3.2100 5.1100 1.1200 1.0200 1.5400 2.3300 2.0400 4.3600 0.2700 0.2200 0.2900 Glutamine istopomer M+2 Glutamine 12.8900 1.9900 3.6900 0.8100 0.4500 0.9200 1.5000 1.3800 3.2300 0.2000 0.2000 0.2200 Glutamine istopomer M+3 Glutamine 8.5200 2.7600 5.2100 1.4900 1.3800 1.6500 2.3600 2.0500 4.6900 0.5700 0.5400 0.6000 Glutamine istopomer M+4 Glutamine 1.2900 3.0700 2.4100 3.7000 3.8200 3.7800 3.3200 3.4400 2.6700 4.0300 4.0800 4.1000 Glutamine istopomer M+5 Glutamine 22.2900 66.8900 52.7700 80.5200 82.5000 81.8400 75.0100 77.3600 59.3100 92.4600 92.3100 92.4500 Glutamine istopomer M+6 Glutamine isoCitrate istopomer M0 Isocitric acid 63.6500 64.8500 63.3100 63.2600 61.6600 59.3000 52.1100 53.8500 52.7300 85.4800 63.6000 54.6300 isoCitrate istopomer M+1 Isocitric acid 13.3100 12.6400 12.3800 9.1300 9.4800 9.6200 11.0800 12.5500 12.2700 3.2000 3.3400 5.4600 isoCitrate istopomer M+2 Isocitric acid 8.7700 9.0200 9.6600 9.0600 9.2600 9.9800 10.0300 10.3100 10.3900 3.0900 5.9800 7.8100 isoCitrate istopomer M+3 Isocitric acid 5.8500 5.1400 5.2500 6.2100 6.7800 7.2100 9.0400 7.0700 8.6300 1.7900 6.5500 13.4100 isoCitrate istopomer M+4 Isocitric acid 4.5300 4.8200 5.5800 6.7300 6.8800 7.7600 6.9400 6.3700 5.2800 3.6100 8.5100 2.3200 isoCitrate istopomer M+5 Isocitric acid 3.6100 3.3500 3.4500 5.2300 5.5100 5.8500 10.6400 9.8600 10.5700 2.3800 10.7900 13.9000 isoCitrate istopomer M+6 Isocitric acid 0.2700 0.1500 0.3700 0.3700 0.4200 0.2600 1.4600 isoCitrate istopomer M+7 Isocitric acid 0.0400 0.0200 0.1600 0.1300 0.4600 1.2300 1.0100 isoCitrate istopomer M+8 Isocitric acid Lactate istopomer M0 Lactic acid 96.9300 96.4800 97.4700 92.4700 92.5400 92.6900 96.9300 97.5200 97.9100 96.4700 96.2300 96.4600 Lactate istopomer M+1 Lactic acid 1.2700 1.8200 1.2900 3.1400 2.9500 3.0500 1.1900 1.0800 0.8700 0.9500 1.1300 1.0400 Lactate istopomer M+2 Lactic acid 0.8300 0.7200 0.5500 1.6800 1.8200 1.6900 0.5300 0.5300 0.4600 0.6000 0.7600 0.7100 Lactate istopomer M+3 Lactic acid 0.9200 0.9200 0.6300 2.7000 2.6600 2.5500 1.3100 0.8200 0.7100 1.9600 1.8500 1.7700 Lactate istopomer M+4 Lactic acid 0.0300 0.0300 0.0400 0.0300 0.0500 0.0500 0.0200 0.0100 0.0200 Malate istopomer M0 Malic acid 66.9200 67.7500 66.6200 56.8800 55.4100 53.4200 55.0900 58.8200 58.5900 56.9500 56.8200 55.9500 Malate istopomer M+1 Malic acid 13.9800 13.4200 13.4300 13.2700 13.5100 13.4200 9.0900 9.6400 9.0100 6.0800 6.8500 6.7500 Malate istopomer M+2 Malic acid 10.6400 9.9900 10.5800 14.7800 15.4400 16.0400 11.1800 10.8700 10.8000 9.5000 10.1100 10.4000 Malate istopomer M+3 Malic acid 2 1.7500 1.9600 2.9100 3.3200 3.6300 6.3700 6.6900 7.7900 6.8200 8.2600 8.3600 Malate istopomer M+4 Malic acid 6.4600 7.1000 7.4000 12.1600 12.3200 13.4900 18.2600 13.9700 13.8200 20.6600 17.9700 18.5300 Malate istopomer M+5 Malic acid Proline istopomer M0 Proline betaine 88.9400 89.5100 92.7800 88.9600 87.8800 88.7500 95.0200 93.2200 93.5300 98.8800 98.2400 98.4100 Proline istopomer M+1 Proline 2.1200 2.6900 1.4800 1.3600 1.4600 1.5900 1.2500 1.7700 1.5200 0.2200 0.3300 0.3100 Proline istopomer M+2 Proline 2.6700 3.0600 2.1800 2.1000 2.7500 3.0300 1.4200 1.9500 1.8600 0.2200 0.3900 0.3400 Proline istopomer M+3 Proline 0.2500 0.1000 0.0800 0.1600 0.1100 0.0600 0.0300 0.0600 0.0500 Proline istopomer M+4 Proline 3.6100 4.1200 3.3600 3.4800 5.1600 5.5400 2.1500 2.8900 2.9500 0.4600 0.8200 0.7300 Proline istopomer M+5 Proline 0.0300 0.0600 0.0400 0.0200 0.1300 0.1200 0.1100 Succinate istopomer M0 Succinic acid 66.7200 65.9700 64.3900 58.1300 56.2000 53.8300 42.3400 46.4400 45.7400 46.8000 44.4700 34.9800 Succinate istopomer M+1 Succinic acid 14.6700 14.5700 14.5600 13.3600 13.7300 13.7400 22.8400 22.9800 21.6800 10.3200 13.7100 30.6000 Succinate istopomer M+2 Succinic acid 11.9800 11.4300 12.2100 16.1900 16.9400 18 12.2200 11.9700 12.3200 12.2500 12.7100 9.2200 Succinate istopomer M+3 Succinic acid 0.5200 0.4100 0.3900 0.7400 0.8000 0.8300 0.9600 0.8200 0.8700 1.1100 1.4100 1.3000 Succinate istopomer M+4 Succinic acid 6.1200 7.6200 8.4500 11.5700 12.3300 13.6100 21.6500 17.7900 19.3900 29.5200 27.7000 23.8900 Succinate istopomer M+5 Succinic acid