Metabolite_name RefMet_name Evocrp1_1 Evocrp1_2 Evocrp1_3 Evocrp1_4 Evocrp1_5 Evocrp1_6 Evocrp2_1 Evocrp2_2 Evocrp2_3 Evocrp2_4 Evocrp2_5 Evocrp2_6 Evocrp3_1 Evocrp3_2 Evocrp3_3 Evocrp3_4 Evocrp3_5 Evocrp3_6 Evocrp4_1 Evocrp4_2 Evocrp4_3 Evocrp4_4 Evocrp4_5 Evocrp4_6 Evocrp5_1 Evocrp5_2 Evocrp5_3 Evocrp5_4 Evocrp5_5 Evocrp5_6 Crp_1 Crp_2 Crp_3 Crp_4 Crp_5 Crp_6 WT_1 WT_2 WT_3 WT_4 WT_5 WT_6 Factors - Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Parent Genotype:Parent Genotype:Parent Genotype:Parent Genotype:Parent Genotype:Parent Genotype:Wildtype Genotype:Wildtype Genotype:Wildtype Genotype:Wildtype Genotype:Wildtype Genotype:Wildtype Alanine Alanine 1.1764 1.3861 1.0586 1.0120 0.9496 1.3648 1.6559 1.7327 1.0735 1.1210 1.6703 1.2178 1.0152 1.0872 1.1149 1.1285 1.2198 1.1512 1.5319 1.5953 1.9351 1.7240 1.6024 1.7169 1.9706 2.1463 2.3709 2.0495 1.8629 2.1604 1.6556 1.4069 0.9993 1.1353 1.4235 1.6750 0.4840 0.8811 1.2321 1.6020 0.9963 0.9092 Arginine Arginine 0.4383 0.4151 0.4121 0.4263 0.3496 0.3873 0.5125 0.5087 0.3282 0.3267 0.5031 0.3614 0.3180 0.3395 0.4112 0.3648 0.3832 0.4021 0.3934 0.4068 0.3858 0.3696 0.4076 0.3744 0.5805 0.5396 0.4412 0.5742 0.5466 0.5463 0.4583 0.4170 0.3287 0.3480 0.3870 0.4933 0.3239 0.4115 0.4610 0.5248 0.3369 0.3355 Asparagine Asparagine 0.3560 0.1910 0.3125 0.2917 0.2144 0.1532 0.3341 0.3410 0.1543 0.1602 0.3343 0.1705 0.1757 0.1703 0.1645 0.1835 0.1956 0.1655 0.1020 0.0916 0.2402 0.0738 0.0951 0.0737 0.3521 0.4316 0.1914 0.3364 0.4022 0.4947 0.1823 0.1503 0.0802 0.0952 0.1452 0.1896 0.2429 0.2477 0.2550 0.1592 0.1171 0.1188 Aspartate Aspartic acid 0.3187 0.4480 0.3020 0.2738 0.4314 0.4022 0.4621 0.4765 0.2895 0.3002 0.4622 0.3154 0.2146 0.3127 0.3307 0.2425 0.3571 0.3258 0.4969 0.5603 0.8398 0.7364 0.5706 0.7256 0.8925 0.9888 0.6040 0.8610 1.0609 0.9995 0.8578 0.9847 0.7598 0.3902 0.3948 0.9113 0.2222 0.3039 0.2445 0.3376 0.2778 0.2739 Glutamate Glutamic acid 0.7469 0.6006 0.7247 0.5677 0.4775 0.4490 1.0463 1.0845 0.5187 0.5165 1.0669 0.5724 0.4515 0.4866 0.4952 0.4800 0.5308 0.4851 0.5727 0.5915 0.7215 0.5538 0.5976 0.5556 1.1538 0.9008 0.8815 0.8002 0.8092 1.2231 1.1651 0.8485 0.5921 0.7097 1.2718 1.2234 0.2461 0.3289 0.4258 0.3917 0.2616 0.2635 Glutamine Glutamine 0.3833 0.1148 0.3723 0.2940 0.1228 0.0941 0.5334 0.5338 0.0883 0.0894 0.5242 0.0973 0.0848 0.0990 0.0895 0.0911 0.1061 0.0912 0.0700 0.0708 0.1111 0.0462 0.0684 0.0481 0.4388 0.3446 0.1378 0.4930 0.2849 0.3375 0.4734 0.2459 0.2022 0.1446 0.3535 0.5006 0.2146 0.1927 0.3634 0.0776 0.0523 0.0505 Glycine Glycine 12.2797 0.9841 11.0786 0.6972 0.9387 0.9165 1.0135 1.0028 9.2421 8.8320 0.9805 10.4520 1.6338 1.8842 1.7247 1.7508 2.0460 1.7342 0.7852 0.6705 0.8965 0.9066 0.7724 0.8211 1.0205 0.9170 1.5699 0.6950 1.4133 0.9626 0.9540 0.8890 0.8988 0.9628 0.8658 1.0357 0.3208 0.5264 0.5251 0.7438 0.6614 0.6542 Histidine Histidine 0.3360 0.3225 0.2934 0.2991 0.3131 0.3032 0.3439 0.3515 0.2830 0.2806 0.3458 0.3137 0.2804 0.3175 0.3247 0.3107 0.3627 0.3363 0.3263 0.3259 0.2790 0.3193 0.3096 0.3254 1.3934 0.3056 0.6175 1.3729 0.3429 0.2816 0.3097 0.2894 0.2885 0.2770 0.3013 0.3402 0.2348 0.2782 0.3098 0.3430 0.2120 0.2117 Isoleucine Isoleucine 0.3734 0.5611 0.3674 0.3638 0.5334 0.5083 0.4350 0.5337 0.4224 0.4398 0.3512 0.4767 0.3538 0.4041 0.4465 0.3887 0.4408 0.4498 0.3461 0.3663 0.3360 0.4285 0.3698 0.4413 0.2295 0.2437 0.3540 0.3192 0.2790 0.4302 0.3616 0.3120 0.3823 0.3419 0.4093 0.4290 0.3065 0.3838 0.2782 0.4315 0.3108 0.3257 Leucine Leucine 2.2112 2.0475 2.1170 2.0600 1.7212 1.8789 2.5942 2.5228 1.5808 1.5531 2.5926 1.7486 1.3590 1.4287 1.4509 1.4765 1.5370 1.5110 1.8733 1.8112 2.1006 1.6871 1.8539 1.6840 2.6374 2.4535 2.2336 2.3756 2.4399 2.5165 2.0301 1.7454 1.4537 2.0271 2.4887 2.0863 0.7530 0.9654 1.2745 1.3825 0.9046 0.9224 Lysine Lysine 0.1943 0.1856 0.1808 0.1945 0.1752 0.1734 0.2081 0.2204 0.1489 0.1460 0.2098 0.1626 0.1638 0.1746 0.1913 0.1794 0.1831 0.1902 0.1638 0.1701 0.1843 0.1597 0.1700 0.1661 0.2540 0.2571 0.1885 0.2508 0.2615 0.2711 0.2260 0.2178 0.1734 0.2067 0.2202 0.2252 0.1175 0.1488 0.1795 0.1969 0.1177 0.1092 Methionine Methionine 1.0799 1.3331 1.0314 1.0163 1.0255 1.1890 1.4179 1.4467 0.9876 0.9635 1.4746 1.1008 0.9381 1.0400 1.0749 1.0429 1.0959 1.0510 1.6833 1.6878 2.0552 1.7281 1.6494 1.7101 2.4662 2.4121 1.9334 2.4922 2.6881 2.5139 1.0155 0.9740 0.8064 0.6379 0.7320 1.0935 0.6343 0.8371 0.9908 1.3862 0.8633 0.9090 NAD NAD+ 0.3966 0.3973 0.3871 0.3875 0.3654 0.3607 0.3956 0.3850 0.3159 0.3159 0.3913 0.3494 0.3245 0.3574 0.3736 0.3556 0.3813 0.3772 0.3395 0.3320 0.3198 0.3235 0.3350 0.3215 0.4123 0.4049 0.3353 0.4083 0.4226 0.4219 0.4092 0.3944 0.3577 0.3577 0.3504 0.4319 0.2797 0.3485 0.3595 0.4121 0.2745 0.2804 NADPH NADPH 0.3070 0.3589 0.2923 0.3420 0.3527 0.2976 0.3221 0.3489 0.2653 0.2773 0.3505 0.2673 0.2614 0.2817 0.3200 0.2808 0.2508 0.3130 0.2686 0.3042 0.3622 0.2812 0.2818 0.1211 0.3912 0.3468 0.0292 0.3185 0.3151 0.3087 0.3529 0.3502 0.3189 0.3466 0.3416 0.3862 0.2700 0.3494 0.3785 0.4193 0.2949 0.2961 Phenylalanine Phenylalanine 0.6291 0.6486 0.6366 0.6329 0.5774 0.6225 0.7106 0.7540 0.5027 0.4964 0.7587 0.5537 0.5076 0.5490 0.5537 0.5475 0.6058 0.5625 0.6275 0.5951 0.8110 0.6718 0.5825 0.6585 0.7995 0.9659 0.7808 0.7997 0.9223 0.9588 0.6626 0.5986 0.5880 0.6713 0.7763 0.6546 0.4078 0.4963 0.6256 0.5625 0.3402 0.3471 Proline Proline 1.6815 1.5558 1.7062 1.7651 1.2408 1.3915 2.3962 2.4020 1.1607 1.1684 2.4540 1.2593 0.9561 1.0179 1.0183 1.0223 1.1065 1.0501 1.5554 1.4972 2.1326 1.3706 1.5374 1.3912 3.6831 3.7380 2.5971 3.5962 3.7707 3.7992 1.3538 0.9881 0.8306 1.2033 1.7242 1.4173 0.7442 0.9634 1.2897 1.1592 0.7703 0.8203 Serine Serine 1.9783 3.1247 2.1912 1.8867 2.1390 2.3007 3.0449 2.9378 2.7327 2.8268 3.0644 2.9872 1.7088 2.1079 2.1280 2.0221 2.1736 2.1912 4.0559 3.5249 1.7472 3.2580 3.4067 3.3087 1.7351 2.0573 15.2202 2.2344 3.6485 1.3525 2.1994 2.1102 2.1027 2.6465 1.9547 2.5099 1.7351 1.5953 1.3008 2.0296 1.3552 1.3847 Threonine Threonine 0.5705 0.5086 0.5643 0.4495 0.4543 0.4185 0.6933 0.6932 0.4006 0.4255 0.6758 0.4744 0.4199 0.4344 0.4579 0.4438 0.4983 0.4487 0.4530 0.4792 0.3069 0.3394 0.4853 0.3488 0.4131 0.3172 0.5173 0.3772 0.3235 0.3333 0.5927 0.4974 0.4273 0.4059 0.4748 0.6466 0.3098 0.3960 0.5390 0.5067 0.2922 0.3072 Tryptophan Tryptophan 0.6708 0.7371 0.6520 0.6412 0.7372 0.7033 0.5607 0.5646 0.5980 0.5848 0.5979 0.6855 0.6311 0.6490 0.6997 0.6850 0.7231 0.6732 0.5621 0.5451 0.4245 0.5983 0.5606 0.5884 0.3858 0.3806 0.4726 0.4138 0.3917 0.3389 0.6206 0.5411 0.5896 0.4636 0.4163 0.6585 0.4441 0.5431 0.5260 0.6649 0.4325 0.4404 Tyrosine Tyrosine 0.3115 0.3207 0.2996 0.2903 0.2894 0.2930 0.3528 0.3647 0.2640 0.2768 0.3596 0.2964 0.2645 0.2922 0.2987 0.2854 0.3226 0.2939 0.2866 0.3297 0.3861 0.3533 0.3343 0.3450 0.4355 0.4552 0.4092 0.4276 0.4686 0.4472 0.2572 0.2472 0.2244 0.2538 0.2292 0.2381 0.2778 0.3392 0.3647 0.4356 0.2864 0.2920 Valine Valine 0.4398 0.4191 0.3641 0.4276 0.3859 0.4314 0.5296 0.4976 0.3610 0.3185 0.5126 0.3865 0.2987 0.2950 0.3197 0.3265 0.3263 0.3063 0.2918 0.3274 0.3365 0.3137 0.3340 0.2830 0.5446 0.3887 0.3886 0.5198 0.3604 0.4751 0.9283 0.7909 0.8423 0.8548 0.9816 0.9157 1.0821 1.3882 1.8430 1.6834 1.1139 1.0550