Metabolite_name RefMet_name Evocrp1_1 Evocrp1_2 Evocrp1_3 Evocrp1_4 Evocrp1_5 Evocrp1_6 Evocrp2_1 Evocrp2_2 Evocrp2_3 Evocrp2_4 Evocrp2_5 Evocrp2_6 Evocrp3_1 Evocrp3_2 Evocrp3_3 Evocrp3_4 Evocrp3_5 Evocrp3_6 Evocrp4_1 Evocrp4_2 Evocrp4_3 Evocrp4_4 Evocrp4_5 Evocrp4_6 Evocrp5_1 Evocrp5_2 Evocrp5_3 Evocrp5_4 Evocrp5_5 Evocrp5_6 Crp_1 Crp_2 Crp_3 Crp_4 Crp_5 Crp_6 WT_1 WT_2 WT_3 WT_4 WT_5 WT_6 Factors - Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Evolved Genotype:Parent Genotype:Parent Genotype:Parent Genotype:Parent Genotype:Parent Genotype:Parent Genotype:Wildtype Genotype:Wildtype Genotype:Wildtype Genotype:Wildtype Genotype:Wildtype Genotype:Wildtype ADP ADP 0.6503 0.6374 0.6154 0.6624 0.6640 0.6056 0.5982 0.5949 0.5232 0.5538 0.5963 0.6214 0.4467 0.5447 0.5833 0.5054 0.5818 0.5754 0.4531 0.5118 0.3981 0.4671 0.5540 0.4948 0.5965 0.5834 0.4269 0.5754 0.4650 0.5500 0.5883 0.6125 0.5267 0.6060 0.5146 0.6130 0.4851 0.6268 0.6061 0.6079 0.3327 0.3359 alpha-Ketoglutarate 2-Oxoglutaric acid 1.0878 1.5121 1.0537 1.2108 0.8571 1.5148 0.7757 0.6486 0.7542 0.7501 0.9566 0.8683 0.5167 0.6428 0.6931 0.4818 0.8292 0.7298 1.1041 1.1198 0.8156 0.7838 1.1781 0.7108 0.6842 0.6069 0.9198 0.6334 0.6430 0.5960 0.5469 0.5107 0.2598 0.4312 0.5337 0.6424 0.2185 0.1625 0.3259 0.4226 0.2969 0.3382 AMP AMP 1.5142 1.7472 1.2325 1.2015 1.7034 1.6302 1.1089 1.1010 1.1248 1.1232 1.1312 1.2650 1.7220 1.7862 1.8611 1.9462 1.9110 2.0266 1.0389 1.1186 0.6312 1.4750 1.0839 1.5468 0.7145 0.5649 0.4567 0.7120 0.4730 0.6435 1.8372 1.2964 1.9015 0.9012 0.7679 1.8267 0.3532 1.0663 0.5783 1.1487 1.2542 1.2401 ATP ATP 0.4732 0.3639 0.5026 0.4686 0.3841 0.3634 0.5977 0.6038 0.5232 0.3489 0.5716 0.5497 0.2300 0.3138 0.3000 0.2623 0.2952 0.3345 0.4095 0.3629 0.7258 0.2945 0.3851 0.3280 0.7808 0.7838 0.8037 0.7553 0.8402 0.8332 0.3052 0.5126 0.2649 0.7246 0.7531 0.3261 0.9040 0.5189 0.8195 0.5554 0.1515 0.1504 cAMP 3',5' cyclic AMP 0.4285 0.2903 0.4093 0.4275 0.3600 0.2391 0.1887 0.1887 0.0864 0.1003 0.1830 0.0990 0.2043 0.2903 0.3535 0.2138 0.3464 0.3860 0.3219 0.3062 0.8750 0.5001 0.3483 0.4707 0.8726 1.1242 0.5101 0.8410 1.0718 1.3033 2.2169 2.1161 2.0401 3.2951 2.0736 2.3301 0.0424 0.0400 0.0635 0.0472 0.0310 0.0315 Citrate Citric acid 0.2899 0.3654 0.4002 0.2792 0.4264 0.3274 0.2938 0.3032 0.3722 0.3954 0.2949 0.4277 0.2444 0.3401 0.3874 0.2666 0.3815 0.3868 0.5016 0.2386 0.1890 0.2579 0.2476 0.2580 0.1699 0.1797 0.3424 0.1645 0.2716 0.1680 0.1331 0.1718 0.2728 0.2093 0.1364 0.1419 0.3842 0.4531 0.3615 0.2857 0.1946 0.1966 Fructose-1_6-bisphosphate Fructose 1,6-bisphosphate 2.2539 2.8146 2.0310 2.8332 2.2680 2.7347 2.6277 3.0466 2.7618 0.7625 2.9950 2.9821 2.1977 2.4139 2.3880 2.4288 2.6977 2.4739 2.9021 0.2950 0.7119 2.6469 2.4860 2.8705 2.0157 0.5784 13.1824 1.9665 2.3644 1.2953 1.7099 1.3947 1.2284 2.0448 1.8927 1.8072 1.6544 2.6201 3.2062 3.1381 2.3595 2.2676 Fructose-6-Phosphate Fructose 6-phosphate 1.0050 0.9563 0.8083 0.9547 0.9452 0.9426 1.1965 1.2058 1.0553 0.9614 1.1344 1.1844 0.7009 0.8537 0.8871 0.8031 1.0252 0.9540 1.0162 0.9917 1.3181 1.6581 1.2045 1.6089 1.0421 1.0956 4.2411 1.0225 0.7647 1.2389 1.4008 1.1045 0.9816 2.1240 2.1202 1.3432 0.9775 1.4863 1.7161 1.1162 0.7188 1.2670 Glucose-6-Phosphate Glucose 6-phosphate 1.0043 1.1997 0.9557 0.9367 1.2634 1.0990 1.3431 1.2926 1.3131 1.4514 1.3013 1.4149 0.7742 0.9908 0.9354 0.8459 1.0731 0.9535 1.6021 1.7344 1.3427 2.4994 1.8177 2.6496 1.0522 1.1446 1.9045 0.9897 1.8343 1.1011 1.2100 1.0375 1.1917 1.8712 1.8783 1.2039 0.8738 1.0151 1.0666 0.5804 0.7864 0.7867 Glycerate-3-phosphate 3-Phosphoglyceric acid 0.8605 1.7384 0.7286 0.8550 1.1743 1.5659 1.0941 1.1049 1.2457 1.2027 1.0952 1.3454 0.9169 1.2529 1.3054 0.9834 1.3212 1.3473 1.4346 1.8857 2.7667 2.8866 1.8462 2.8345 2.2927 2.0464 1.6386 2.2617 2.4974 2.5767 2.0628 2.7116 2.2718 2.2235 2.0241 2.2122 0.3102 0.5193 0.4038 1.2879 0.9971 0.9888 Malate Malic acid 4.3052 6.6597 4.2991 4.2799 4.6936 6.0799 5.9398 5.9709 5.5009 5.7430 5.8321 6.3029 4.4312 4.8179 5.4729 4.7118 5.4182 5.9181 5.6780 5.6412 3.7813 5.2727 5.6662 5.3476 4.5972 3.4310 6.3026 4.5688 3.5192 3.1551 6.9631 6.8794 4.1097 5.0782 5.4814 7.4101 2.3300 1.6996 0.9352 5.8727 3.1298 3.5497 Phosphoenolpyruvate Phosphoenolpyruvic acid 0.2045 0.5529 0.1962 0.1969 0.1901 0.4985 0.4473 0.4406 0.4442 0.4511 0.4460 0.5020 0.2780 0.3277 0.4268 0.3044 0.3780 0.4244 1.1014 1.1781 4.0828 1.5567 1.1360 1.5637 3.2012 3.2890 3.0487 3.0943 3.3452 3.3186 2.4256 2.0797 2.3280 1.7808 2.0304 2.5583 0.0521 0.0464 0.0499 0.8043 0.2904 0.2861 Pyruvate Pyruvic acid 1.0043 1.1997 0.9557 0.9367 1.2634 1.0990 1.3431 1.2926 1.3131 1.4514 1.3013 1.4149 0.7742 0.9908 0.9354 0.8459 1.0731 0.9535 1.6021 1.7344 1.3427 2.4994 1.8177 2.6496 1.0522 1.1446 1.9045 0.9897 1.8343 1.1011 0.9767 1.4510 0.5626 1.1337 1.1557 1.0437 0.4478 0.8506 1.3267 1.3856 0.8275 0.8214 Ribose-5-Phosphate Ribose 5-phosphate 4.6540 10.7919 7.1687 3.3626 8.4650 5.8178 2.3390 2.5996 3.2925 1.9605 3.7990 2.5710 7.1080 9.9149 9.3424 7.7319 20.8613 15.4196 1.5177 1.3982 0.9041 3.1574 4.0593 4.2120 5.6738 2.0383 2.3279 1.9900 0.8013 3.3051 7.4259 4.5166 8.9029 3.7342 4.0548 7.8913 1.0347 2.2842 2.6599 2.3725 1.5455 2.8539