Metabolite_name RefMet_name Old-1 Old-2 Old-3 Old-4 Old-5 Young-1 Young-2 Young-3 Young-4 Young-5 Factors - Age:28m Age:28m Age:28m Age:28m Age:28m Age:8w Age:8w Age:8w Age:8w Age:8w 1-Aminocyclopropane-1-carboxylic acid Homoserinelactone 1-Aminocyclopropanecarboxylic acid 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 1-Methyladenosine 1-Methyladenosine 0 0 0 0 0 0 0 0.0001 1-Methylhistamine 1-Methylhistamine 0.0002 0.0002 0.0001 0.0002 0.0002 0 0 0 0 0 1-Methylhistidine 3-Methylhistidine 3-Methylhistidine 0.0014 0.0018 0.0014 0.0012 0.0018 0.0015 0.0015 0.0017 0.0017 0.0013 1-Methylnicotinamide 1-Methyl nicotinamide 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 2-Aminoisobutyric acid 2-Aminobutyric acid Aminoisobutyric acid 0.0008 0.0009 0.0008 0.0007 0.0012 0.0010 0.0015 0.0014 0.0008 0.0010 2-(Creatinine-3-yl)propionic acid 0.0001 2^-Deoxycytidine Deoxycytidine 0 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 4-Guanidinobutyric acid 4-Guanidinobutanoic acid 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 4-Methylpyrazole Fomepizole 0.0001 0.0001 0.0001 0.0002 0.0001 5^-Deoxy-5^-methylthioadenosine 5'-Methylthioadenosine 0.0001 0 0 0 0 0 0 0 0 0 5-Hydroxylysine 5-Hydroxylysine 0.0002 0.0002 0.0001 0.0002 0.0001 0.0002 0.0002 0.0002 0.0001 6-Aminohexanoic acid 6-Aminocaproic acid 0.0002 0.0004 0.0003 0.0002 0.0003 Acetylcholine Acetylcholine 0.0002 0.0002 0.0002 0.0002 0.0003 0.0001 0.0001 0.0001 0.0001 Adenine Adenine 0.0005 0.0003 0.0003 0.0004 0.0004 0.0004 0.0004 0.0004 0.0003 0.0004 Adenosine Adenosine 0.0016 0.0018 0.0012 0.0015 0.0014 0.0009 0.0017 0.0009 0.0012 0.0010 ADMA Dimethylarginine 0.0002 0.0002 0.0001 0.0002 0.0001 0.0002 0.0002 0.0002 0.0002 0.0001 Ala Alanine 0.0939 0.1125 0.1080 0.0947 0.1046 0.1012 0.1222 0.1422 0.1259 0.1260 Arg Arginine 0.0187 0.0244 0.0070 0.0232 0.0166 0.0148 0.0186 0.0194 0.0171 0.0147 Argininosuccinic acid Argininosuccinic acid 0.0003 0.0004 0.0001 0.0003 0.0003 0.0002 0.0002 0.0002 0.0001 0.0001 Asn Asparagine 0.0038 0.0043 0.0037 0.0062 0.0044 0.0035 0.0043 0.0055 0.0046 0.0050 Asp Aspartic acid 0.0054 0.0102 0.0078 0.0052 0.0060 0.0059 0.0078 0.0078 0.0077 0.0056 Betaine Betaine 0.0096 0.0112 0.0107 0.0169 0.0084 0.0101 0.0131 0.0110 0.0088 0.0083 Butyrylcarnitine CAR 4:0 0.0001 0.0002 0.0002 0.0001 0.0002 0.0003 0.0002 Carboxymethyllysine N(6)-Carboxymethyl-lysine 0.0019 0.0015 0.0013 0.0011 0.0011 0.0003 0.0003 0.0003 0.0003 0.0003 Carnitine Carnitine 0.0182 0.0286 0.0219 0.0281 0.0266 0.0265 0.0297 0.0279 0.0290 0.0259 Carnosine Carnosine 0.0888 0.0904 0.0847 0.0704 0.1063 0.0815 0.0807 0.1102 0.0702 0.0891 Choline Choline 0.0080 0.0069 0.0102 0.0168 0.0059 0.0095 0.0114 0.0110 0.0090 0.0094 Citrulline Citrulline 0.0074 0.0101 0.0065 0.0113 0.0074 0.0093 0.0100 0.0093 0.0077 0.0075 Creatine Creatine 0.0718 0.0707 0.0651 0.0690 0.0709 0.0750 0.0737 0.0654 0.0772 0.0733 Creatinine Creatinine 0.0032 0.0036 0.0038 0.0035 0.0047 0.0041 0.0038 0.0043 0.0038 0.0038 Cystathionine Cystathionine 0.0001 0.0001 Cysteine glutathione disulfide S-Glutathionyl-cysteine 0.0001 0 0.0001 0.0001 0 0 0 0 0 0 Cytidine Cytidine 0.0002 0.0001 0.0003 0.0003 0.0002 0.0001 0.0002 0.0002 0.0002 0.0001 Diethanolamine Diethanolamine 0.0007 0.0008 0.0004 0.0004 0.0003 0.0002 0.0002 0.0003 0.0002 0.0002 Diethylaminomalonic acid Diethyl aminomalonate 0.0002 0.0003 0.0003 0.0003 0.0003 0.0003 0.0003 0.0003 0.0003 0.0003 Dyphylline Dyphylline 0.0005 0.0005 0.0005 0.0005 0.0008 0.0008 0.0006 0.0006 0.0006 0.0004 Ethanolamine Ethanolamine 0.0008 0.0010 0.0012 0.0025 0.0009 0.0013 0.0012 0.0014 0.0013 0.0014 GABA gamma-Aminobutyric acid 0.0005 0.0005 0.0006 0.0004 Gln Glutamine 0.1306 0.1353 0.1368 0.1631 0.1276 0.1035 0.1115 0.1283 0.1062 0.1140 Glu Glutamic acid 0.0575 0.0856 0.0617 0.0487 0.0529 0.0585 0.0743 0.0618 0.0602 0.0557 Glu-Glu Glu-Glu 0 0 0 0.0001 0 0 Glutathione (GSH) Glutathione 0.0174 0.0179 0.0197 0.0154 0.0204 0.0247 0.0276 0.0229 0.0206 0.0149 Glutathione (GSSG)_divalent Oxidized glutathione 0.0308 0.0310 0.0276 0.0230 0.0248 0.0238 0.0183 0.0264 0.0256 0.0250 Gly Glycine 0.0837 0.1021 0.1021 0.0869 0.0624 0.1239 0.1147 0.1408 0.1084 0.1161 Gly-Asp Gly-Asp 0.0003 0.0002 0.0003 0.0003 0.0002 0.0002 0.0003 0.0003 0.0003 0.0002 Glycerol Glycerol 0.0478 0.0807 0.0757 0.0581 0.0777 0.0845 0.0614 0.0801 0.0540 0.0518 Glycerophosphocholine sn-Glycero-3-phosphocholine 0.0039 0.0047 0.0054 0.0051 0.0049 0.0027 0.0046 0.0033 0.0037 0.0031 Gly-Gly Gly-Gly 0.0002 0.0001 0.0003 0.0003 0.0003 0.0002 0.0002 0.0002 0.0002 0.0003 Guanosine Guanosine 0.0001 0.0001 0.0001 0.0001 0.0001 0 0.0001 0 0 His Histidine 0.0118 0.0120 0.0112 0.0173 0.0128 0.0096 0.0101 0.0116 0.0110 0.0098 Histamine Histamine 0.0025 0.0029 0.0022 0.0032 0.0022 0.0010 0.0013 0.0009 0.0010 0.0008 Homocarnosine Homocarnosine 0.0739 0.0812 0.0816 0.0896 0.0978 0.0487 0.0435 0.0543 0.0381 0.0444 Homocitrulline Homocitrulline 0.0004 0.0005 0.0005 0.0003 0.0004 0.0004 0.0005 0.0004 0.0004 0.0004 Homoserine Homoserine 0.0002 0.0002 0.0004 0.0003 0.0003 Hydroxyproline Hydroxyproline 0.0099 0.0130 0.0090 0.0096 0.0094 0.0296 0.0330 0.0305 0.0308 0.0256 Hypotaurine Hypotaurine 0.0035 0.0040 0.0036 0.0093 0.0026 0.0042 0.0051 0.0044 0.0036 0.0029 Hypoxanthine Hypoxanthine 0.0007 0.0007 0.0005 0.0005 0.0006 0.0006 0.0007 0.0004 0.0005 0.0004 Ile Isoleucine 0.0176 0.0156 0.0151 0.0149 0.0162 0.0130 0.0183 0.0144 0.0134 0.0114 Inosine Inosine 0.0018 0.0015 0.0012 0.0013 0.0015 0.0011 0.0014 0.0007 0.0010 0.0008 Isovalerylcarnitine CAR 4:0;3Me 0.0002 Leu Leucine 0.0289 0.0291 0.0231 0.0256 0.0316 0.0202 0.0313 0.0252 0.0238 0.0212 Lys Lysine 0.0385 0.0380 0.0189 0.0350 0.0303 0.0334 0.0460 0.0482 0.0429 0.0353 Malonylcarnitine CAR DC3:0 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 Met Methionine 0.0062 0.0061 0.0041 0.0052 0.0060 0.0046 0.0065 0.0071 0.0048 0.0057 Methionine sulfoxide Methionine sulfoxide 0.0007 0.0005 0.0002 0.0003 0.0007 0.0005 0.0004 0.0004 0.0005 0.0003 N5-Ethylglutamine N(5)-Ethyl-glutamine 0.0007 0.0007 0.0006 0.0006 0.0005 0.0007 0.0008 0.0009 0.0006 0.0008 N6-Methyllysine N(6)-Methyllysine 0.0007 0.0008 0.0004 0.0005 0.0006 0.0010 0.0013 0.0012 0.0015 0.0010 N6_N6_N6-Trimethyllysine N-6-Trimethyllysine 0.0011 0.0014 0.0012 0.0012 0.0010 0.0009 0.0011 0.0013 0.0013 0.0012 N8-Acetylspermidine N8-Acetylspermidine 0 0.0001 0 0 N-Acetyllysine N(2)-Acetyllysine 0.0003 0.0003 0.0004 Nicotinamide Niacinamide 0.0112 0.0132 0.0103 0.0102 0.0113 0.0108 0.0129 0.0103 0.0140 0.0133 N_N-Dimethylglycine Dimethylglycine 0.0008 0.0007 Nω-Methylarginine 0.0001 0.0001 O-Acetylcarnitine CAR 2:0 0.0261 0.0301 0.0249 0.0287 0.0299 0.0315 0.0317 0.0283 0.0284 0.0283 O-Acetylhomoserine 2-Aminoadipic acid 0.0004 0.0005 0.0005 0.0003 0.0005 0.0005 0.0004 0.0005 0.0004 0.0004 Ornithine Ornithine 0.0019 0.0022 0.0011 0.0013 0.0024 0.0020 0.0034 0.0035 0.0023 0.0022 Phe Phenylalanine 0.0128 0.0156 0.0111 0.0174 0.0172 0.0113 0.0129 0.0113 0.0100 0.0112 Phosphorylcholine Choline phosphate 0.0009 0.0014 0.0011 0.0013 0.0014 0.0017 0.0022 0.0021 0.0018 0.0014 Pipecolic acid Pipecolic acid 0.0014 0.0019 0.0013 0.0009 0.0017 0.0014 0.0014 0.0014 0.0015 0.0013 Pro Proline 0.0240 0.0286 0.0240 0.0268 0.0252 0.0241 0.0337 0.0355 0.0264 0.0287 Putrescine Putrescine 0.0002 0.0002 0.0003 0.0002 0.0003 0.0001 0.0002 0.0002 0.0003 0.0003 Pyridoxamine 5^-phosphate Pyridoxamine 5'-phosphate 0.0002 0.0003 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 0.0002 S-Adenosylhomocysteine S-Adenosylhomocysteine 0.0001 0.0001 0 0 0 0.0001 0 0.0001 0 0.0001 S-Adenosylmethionine S-Adenosylmethionine 0.0006 0.0006 0.0006 0.0006 0.0005 0.0005 0.0005 0.0004 0.0005 0.0004 Sarcosine Sarcosine 0.0011 0.0009 0.0010 0.0007 0.0010 0.0014 0.0012 0.0014 0.0015 0.0013 SDMA Symmetric dimethylarginine 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 Ser Serine 0.0170 0.0194 0.0172 0.0238 0.0172 0.0148 0.0178 0.0229 0.0193 0.0187 Serotonin Serotonin 0.0001 0 0 0 0 0 0 S-Lactoylglutathione S-Lactoylglutathione 0.0002 0.0002 0.0004 0.0002 0.0002 0.0004 0.0005 0.0002 0.0004 0.0002 S-Methylcysteine Methylcysteine 0.0001 0.0001 0.0002 0.0001 0.0001 0.0001 0.0002 0.0001 0.0001 S-Methylmethionine S-Methylmethionine 0.0001 Spermidine Spermidine 0.0005 0.0006 0.0004 0.0007 0.0005 0.0007 0.0011 0.0006 0.0009 0.0010 Spermine Spermine 0.0001 0.0001 0.0001 0.0002 0.0001 0.0002 0.0002 0.0002 0.0002 0.0002 Stachydrine Stachydrine 0.0023 0.0030 0.0023 0.0023 0.0028 0.0025 0.0019 0.0018 0.0017 0.0014 Taurine Taurine 0.2691 0.2788 0.2478 0.2749 0.2865 0.2438 0.2624 0.2552 0.2431 0.2484 Taurocyamine Taurocyamine 0.0002 0.0006 0.0006 0.0008 0.0005 0.0007 Thiamine Thiamine 0 0 0 0 0 Thr Threonine 0.0236 0.0239 0.0179 0.0183 0.0227 0.0168 0.0252 0.0278 0.0233 0.0207 threo-β-Methylaspartic acid 0.0005 trans-Glutaconic acid Glutaconic acid 0.0006 0.0007 0.0005 0.0009 0.0007 Triethanolamine Triethanolamine 0.0001 0.0001 0.0001 0.0001 0.0001 0.0001 Trigonelline Trigonelline 0.0004 0.0006 0.0003 0.0003 0.0007 0.0005 0.0004 0.0004 0.0005 0.0003 Trimethylamine N-oxide Trimethylamine N-oxide 0.0007 0.0007 0.0006 0.0003 0.0009 0.0006 0.0005 0.0005 0.0006 0.0006 Trp Tryptophan 0.0023 0.0027 0.0019 0.0030 0.0026 0.0022 0.0023 0.0021 0.0017 0.0019 Tyr Tyrosine 0.0120 0.0148 0.0078 0.0118 0.0126 0.0089 0.0109 0.0090 0.0070 0.0119 Urea Urea 0.2961 0.3396 0.2591 0.1623 0.3870 0.2876 0.2641 0.2343 0.2295 0.2185 Uridine Uridine 0.0002 0.0002 0.0002 0.0003 0.0003 0.0002 0.0002 0.0002 Urocanic acid Urocanic acid 0.0003 0.0002 0.0003 0.0003 0.0001 0.0001 0.0001 Val Valine 0.0341 0.0366 0.0265 0.0278 0.0350 0.0264 0.0382 0.0335 0.0297 0.0298 β-Ala beta-Alanine 0.0054 0.0049 0.0046 0.0028 0.0045 0.0061 0.0078 0.0078 0.0063 0.0068 β-Ala-Lys 0.0001 0.0001 0.0001 0.0001 0.0002 0.0002 0.0001 0.0001 γ-Butyrobetaine 3-Dehydroxycarnitine 0.0024 0.0031 0.0026 0.0040 0.0028 0.0030 0.0027 0.0027 0.0027 0.0028