Metabolite_name RefMet_name Sample # 29 Sample # 30 Sample # 24 Sample # 25 Sample # 26 Sample # 27 Sample # 28 Sample # 5 Sample # 6 Sample # 7 Sample # 1 Sample # 2 Sample # 3 Sample # 4 Sample # 42 Sample # 43 Sample # 45 Sample # 46 Sample # 44 Sample # 19 Sample # 20 Sample # 21 Sample # 23 Sample # 22 Sample # 37 Sample # 38 Sample # 39 Sample # 40 Sample # 41 Sample # 14 Sample # 15 Sample # 16 Sample # 17 Sample # 18 Sample # 31 Sample # 32 Sample # 33 Sample # 34 Sample # 35 Sample # 36 Sample # 10 Sample # 11 Sample # 12 Sample # 13 Sample # 8 Sample # 9 Factors - group:Control/Colch | genotype:Irlox group:Control/Colch | genotype:Irlox group:Control/Colch | genotype:Irlox IGFRlox group:Control/Colch | genotype:Irlox IGFRlox group:Control/Colch | genotype:Irlox IGFRlox group:Control/Colch | genotype:Irlox IGFRlox group:Control/Colch | genotype:Irlox IGFRlox group:Control/Saline | genotype:Irlox group:Control/Saline | genotype:Irlox group:Control/Saline | genotype:Irlox group:Control/Saline | genotype:Irlox IGFRlox group:Control/Saline | genotype:Irlox IGFRlox group:Control/Saline | genotype:Irlox IGFRlox group:Control/Saline | genotype:Irlox IGFRlox group:HFD+Colch | genotype:Irlox group:HFD+Colch | genotype:Irlox group:HFD+Colch | genotype:Irlox group:HFD+Colch | genotype:Irlox group:HFD+Colch | genotype:Irlox IGFRlox group:HFD/Saline | genotype:Irlox group:HFD/Saline | genotype:Irlox group:HFD/Saline | genotype:Irlox group:HFD/Saline | genotype:Irlox group:HFD/Saline | genotype:Irlox IGFRlox group:IRKO/Colch | genotype:IR -/- group:IRKO/Colch | genotype:IR -/- group:IRKO/Colch | genotype:IR -/- group:IRKO/Colch | genotype:IR -/- group:IRKO/Colch | genotype:IR -/- group:IRKO/Saline | genotype:IR -/- group:IRKO/Saline | genotype:IR -/- group:IRKO/Saline | genotype:IR -/- group:IRKO/Saline | genotype:IR -/- group:IRKO/Saline | genotype:IR -/- group:MIGIRKO/Colch | genotype:IR -/- IGFR -/- group:MIGIRKO/Colch | genotype:IR -/- IGFR -/- group:MIGIRKO/Colch | genotype:IR -/- IGFR -/- group:MIGIRKO/Colch | genotype:IR -/- IGFR -/- group:MIGIRKO/Colch | genotype:IR -/- IGFR -/- group:MIGIRKO/Colch | genotype:IR -/- IGFR -/- group:MIGIRKO/Saline | genotype:IR -/- IGFR -/- group:MIGIRKO/Saline | genotype:IR -/- IGFR -/- group:MIGIRKO/Saline | genotype:IR -/- IGFR -/- group:MIGIRKO/Saline | genotype:IR -/- IGFR -/- group:MIGIRKO/Saline | genotype:IR -/- IGFR -/- group:MIGIRKO/Saline | genotype:IR -/- IGFR -/- cis-Aconitic Acid cis-Aconitic acid 0.0020 0.0020 0.0030 0.0020 0.0020 0.0010 0.0020 0.0050 0.0010 0.0020 0.0380 0.0220 0.0120 0.0120 0.0010 0.0020 0.0020 0.0020 0.0020 0.0060 0.0040 0.0020 0.0040 0.0030 0.0010 0.0030 0.0010 0.0030 0.0020 0.0010 0.0060 0.0040 0.0030 0.0020 0.0030 0.0010 0.0020 0.0020 0.0020 0.0030 0.0030 0.0050 0.0020 0.0010 0.0060 0.0050 Citrate Citric acid 0.1140 0.0900 0.0870 0.0910 0.1190 0.0810 0.1100 0.0840 0.0620 0.0730 0.0880 0.1180 0.0610 0.0590 0.0840 0.0740 0.0750 0.0930 0.0900 0.0480 0.0790 0.0590 0.1030 0.0820 0.0980 0.0890 0.0570 0.0900 0.1050 0.0560 0.0970 0.0800 0.0730 0.1140 0.1650 0.1600 0.1640 0.1550 0.1630 0.1350 0.1660 0.1290 0.1460 0.1400 0.1410 0.1610 Fumarate Fumaric acid 0.3110 0.2230 0.1650 0.2180 0.2610 0.2160 0.2080 0.1550 0.1620 0.1610 0.1760 0.2050 0.2330 0.1450 0.1850 0.2340 0.2020 0.2310 0.1650 0.1560 0.1510 0.2120 0.1650 0.1410 0.1970 0.2760 0.2320 0.3030 0.2460 0.1510 0.2630 0.2400 0.1710 0.3260 0.4300 0.3830 0.4480 0.4510 0.3730 0.4020 0.4320 0.2860 0.4460 0.3250 0.4360 0.4170 Glutamate Glutamic acid 0.2050 0.1680 0.3500 0.3980 0.2270 0.3600 0.3610 0.3620 0.2570 0.4870 0.4350 0.3760 0.3000 0.3690 0.1500 0.1830 0.2820 0.3600 0.3050 0.2040 0.1170 0.1310 0.0930 0.2230 0.5470 0.4640 0.3140 0.4400 0.6940 0.3430 0.7060 0.4000 0.4070 0.7090 1.0530 1.0710 1.1100 1.0580 1.2670 0.8300 1.2250 0.9580 1.4110 0.8770 1.1310 1.3270 Isocitrate Isocitric acid 0.0540 0.1060 0.0770 0.0790 0.0460 0.0750 0.0320 0.0390 0.0190 0.0540 0.0590 0.0620 0.0230 0.0540 0.0020 0.0030 0.0020 0.0500 0.2780 0.0140 0.0030 0.0020 0.0030 0.0280 0.1580 0.1220 0.2100 0.1660 0.2890 0.0760 0.1490 0.0500 0.0650 0.1350 0.0160 0.0090 0.0050 0.0030 0.0060 0.0030 0.0790 0.0750 0.0630 0.0290 0.0390 0.0320 Ketoglutarate 2-Oxoglutaric acid 0.0050 0.0060 0.0100 0.0080 0.0060 0.0070 0.0060 0.0110 0.0160 0.0130 0.0120 0.0100 0.0100 0.0120 0.0050 0.0050 0.0080 0.0050 0.0050 0.0080 0.0060 0.0060 0.0060 0.0070 0.0070 0.0060 0.0050 0.0050 0.0060 0.0100 0.0080 0.0080 0.0080 0.0080 0.0050 0.0050 0.0050 0.0040 0.0050 0.0050 0.0080 0.0090 0.0070 0.0070 0.0060 0.0070 Lactate Lactic acid 29.1990 33.4480 30.1180 29.3780 32.5280 32.1850 30.7720 30.4470 26.6370 28.7180 28.2520 31.5670 27.0850 28.5060 29.8220 29.5240 32.3750 29.1440 13.2790 27.8640 30.9080 29.6570 27.2800 25.0660 27.2520 31.7250 26.2960 25.2790 26.4830 24.7450 25.8960 25.3740 22.5450 25.1580 20.5130 13.2820 19.6100 22.8560 17.5540 25.3290 15.9580 18.8390 16.0450 12.5040 25.2920 22.2330 Malate Malic acid 0.2850 0.2140 0.1930 0.1830 0.2430 0.1890 0.1960 0.1390 0.1470 0.1570 0.1470 0.1820 0.2200 0.1270 0.1560 0.2080 0.1690 0.2000 0.1380 0.1500 0.1300 0.2010 0.1520 0.1280 0.2100 0.2770 0.2220 0.2810 0.2370 0.1770 0.2660 0.2320 0.1730 0.3230 0.3860 0.3550 0.4240 0.4280 0.3790 0.3630 0.4240 0.3270 0.4370 0.3350 0.4280 0.4780 Oxaloacetate Oxaloacetic acid Succinate Succinic acid 0.0790 0.0660 0.0620 0.1040 0.0840 0.0500 0.0660 0.0690 0.0620 0.0690 0.0950 0.1550 0.1020 0.0710 0.0950 0.1020 0.0700 0.0990 0.0870 0.1200 0.1060 0.1400 0.1380 0.0980 0.0390 0.0500 0.0360 0.0900 0.0430 0.0530 0.0460 0.0660 0.0660 0.0760 0.0570 0.0360 0.0310 0.0600 0.0570 0.0530 0.0620 0.0510 0.0720 0.0410 0.0930 0.0900