Metabolite_name RefMet_name LPS_JX06_ATP_1 LPS_JX06_ATP_2 LPS_JX06_ATP_3 LPS_1 LPS_2 LPS_3 LPS_ATP_1 LPS_ATP_2 LPS_ATP_3 Ctrl_C_1 Ctrl_C_2 Ctrl_C_3 Factors - Treatment:JPS+JX06+ATP Treatment:JPS+JX06+ATP Treatment:JPS+JX06+ATP Treatment:LPS Treatment:LPS Treatment:LPS Treatment:LPS+ATP Treatment:LPS+ATP Treatment:LPS+ATP Treatment:No treatment Treatment:No treatment Treatment:No treatment 10[13C]adenosine 0.0001 10[13C]glutathione 10[13C]glutathione disulfide_pos 10[13C]heptadecanoyl carnitine 10[13C]NAD+ 0.0089 0.0077 0.0104 0.0006 0.0013 0.0010 10[13C]S-adenosyl-L-methionine 10[13C]S-methyl-5-thioadenosine 0.0002 0.0002 11[13C]glutathione disulfide_pos 11[13C]heptadecanoyl carnitine 11[13C]NAD+ 11[13C]S-adenosyl-L-methionine 11[13C]S-methyl-5-thioadenosine 1[13C]adenine 1[13C]adenosine 1[13C]betaine 1[13C]carnitine 0.0007 0.0002 0.0002 1[13C]choline 1[13C]glutamine 0.0023 0.0016 0.0019 0.0016 0.0022 0.0014 0.0026 0.0022 0.0030 0.0009 0.0019 0.0010 1[13C]glutathione 0.0053 0.0008 0.0026 0.0004 0.0003 0.0008 0 0.0009 0.0001 1[13C]glutathione disulfide_pos 0.0319 0.0335 0.0303 0.0238 0.0262 0.0258 0.0249 0.0375 0.0259 0.0279 0.0204 0.0281 1[13C]glycine 1[13C]heptadecanoyl carnitine 0.0151 1[13C]methionine 0.0004 1[13C]N6N6N6-Trimethyl-L-lysine 1[13C]NAD+ 0.0210 0.0168 0.0146 0.0173 0.0227 0.0071 0.0162 0.0210 0.0150 0.0162 0.0192 0.0232 1[13C]proline 0.0021 0.0023 0.0019 0.0011 0.0015 0.0017 0.0019 0.0020 0.0025 0.0023 0.0025 0.0034 1[13C]S-adenosyl-L-methionine 1[13C]serine 1[13C]S-methyl-5-thioadenosine 12[13C]glutathione disulfide_pos 12[13C]heptadecanoyl carnitine 12[13C]NAD+ 0 12[13C]S-adenosyl-L-methionine 13[13C]glutathione disulfide_pos 13[13C]heptadecanoyl carnitine 0 13[13C]NAD+ 0.0004 13[13C]S-adenosyl-L-methionine 0 14[13C]glutathione disulfide_pos 14[13C]heptadecanoyl carnitine 0.0089 14[13C]NAD+ 14[13C]S-adenosyl-L-methionine 0.0020 15[13C]glutathione disulfide_pos 15[13C]heptadecanoyl carnitine 15[13C]NAD+ 15[13C]S-adenosyl-L-methionine 16[13C]glutathione disulfide_pos 16[13C]heptadecanoyl carnitine 0 16[13C]NAD+ 17[13C]glutathione disulfide_pos 17[13C]heptadecanoyl carnitine 0.0861 17[13C]NAD+ 18[13C]glutathione disulfide_pos 18[13C]heptadecanoyl carnitine 18[13C]NAD+ 19[13C]glutathione disulfide_pos 19[13C]heptadecanoyl carnitine 19[13C]NAD+ 20[13C]glutathione disulfide_pos 20[13C]heptadecanoyl carnitine 20[13C]NAD+ 21[13C]heptadecanoyl carnitine 21[13C]NAD+ 2[13C]adenine 2[13C]adenosine 0.0026 0.0023 0.0032 0.0029 0.0037 0.0029 0.0027 0.0028 0.0030 0.0029 0.0020 0.0021 2[13C]betaine 2[13C]carnitine 2[13C]choline 2[13C]glutamine 0.0012 0.0013 0.0013 0.0017 0.0015 0.0018 0.0002 0.0005 0.0004 0.0057 0.0055 0.0052 2[13C]glutathione 0.0587 0.0554 0.0576 0.0402 0.0389 0.0421 0.0392 0.0344 0.0391 0.0337 0.0309 0.0333 2[13C]glutathione disulfide_pos 0.0983 0.0950 0.0930 0.0675 0.0667 0.0679 0.0653 0.0537 0.0682 0.0292 0.0312 0.0455 2[13C]glycine 0.0038 0.0009 0.0012 0.0011 2[13C]heptadecanoyl carnitine 2[13C]methionine 2[13C]N6N6N6-Trimethyl-L-lysine 0.0097 0.0040 2[13C]NAD+ 0.0306 0.0319 0.0296 0.0240 0.0247 0.0306 0.0439 0.0447 0.0440 0.0297 0.0282 0.0263 2[13C]proline 0.0019 0.0029 0.0028 0.0055 0.0044 0.0050 0.0016 0.0023 0.0021 0.0109 0.0107 0.0077 2[13C]S-adenosyl-L-methionine 2[13C]serine 0.0033 0.0013 0.0012 0.0008 0.0006 0.0017 0.0138 0.0106 0.0110 0.0027 0.0023 2[13C]S-methyl-5-thioadenosine 0.0006 0.0002 0.0018 0.0024 0.0020 0.0009 0.0014 0.0010 22[13C]heptadecanoyl carnitine 23[13C]heptadecanoyl carnitine 24[13C]heptadecanoyl carnitine 3[13C]adenine 0.0001 0 0 3[13C]adenosine 0.0012 0.0019 0.0016 0.0001 0.0008 0.0003 0.0003 3[13C]betaine 3[13C]carnitine 3[13C]choline 3[13C]glutamine 0.0004 0.0004 0.0003 0.0004 0.0003 0.0005 0.0001 0.0001 0 0.0022 0.0018 0.0021 3[13C]glutathione 0.0117 0.0105 0.0110 0.0055 0.0052 0.0058 0.0055 0.0059 0.0064 0.0052 0.0047 0.0056 3[13C]glutathione disulfide_pos 0.0261 0.0225 0.0257 0.0125 0.0097 0.0095 0.0112 0.0132 0.0108 0.0181 0.0119 0.0129 3[13C]heptadecanoyl carnitine 3[13C]methionine 3[13C]N6N6N6-Trimethyl-L-lysine 0.0002 0.0002 0.0005 0.0010 0.0004 0.0004 0.0005 3[13C]NAD+ 0.0062 0.0086 0.0086 0.0130 0.0112 0.0124 0.0086 0.0089 0.0110 0.0083 0.0080 0.0084 3[13C]proline 0.0004 0.0007 0.0008 0.0014 0.0011 0.0013 0.0004 0.0006 0.0005 0.0034 0.0039 0.0030 3[13C]S-adenosyl-L-methionine 0.0001 3[13C]serine 0.0076 0.0076 0.0066 0.0130 0.0141 0.0125 0.0021 0.0018 0.0019 0.0112 0.0074 0.0137 3[13C]S-methyl-5-thioadenosine 0 0.0019 0.0011 0.0016 0 3-Hydroxybutyrylcarnitine CAR 4:0;3OH 0.8020 0.7444 0.7471 0.6000 0.5599 0.5744 0.9728 0.9699 0.9470 0.6252 0.6419 0.6508 3-Hydroxybutyrylcarnitine-1 CAR 4:0;3OH 0.0033 0.0496 3-Hydroxybutyrylcarnitine-10 0.0231 3-Hydroxybutyrylcarnitine-11 3-Hydroxybutyrylcarnitine-2 CAR 4:0;3OH 0.1368 0.1723 0.1468 0.1556 0.1770 0.1549 0.0199 0.0251 0.0335 0.1806 0.1228 0.1615 3-Hydroxybutyrylcarnitine-3 0.0059 0.0514 0.0119 0.0093 0.0076 3-Hydroxybutyrylcarnitine-4 0.0572 0.0833 0.0798 0.2444 0.2572 0.2126 0.0120 0.1823 0.1765 0.1801 3-Hydroxybutyrylcarnitine-5 3-Hydroxybutyrylcarnitine-6 3-Hydroxybutyrylcarnitine-7 0 0 3-Hydroxybutyrylcarnitine-8 0.0040 0.0067 0.0073 0.0050 0.0075 3-Hydroxybutyrylcarnitine-9 0 4[13C]adenine 4[13C]adenosine 0.0030 0.0037 0.0021 0 0.0022 0.0003 0.0014 4[13C]betaine 4[13C]carnitine 4[13C]choline 0 4[13C]glutamine 0.0004 0.0002 0.0003 0.0005 0.0004 0.0005 0 0 0.0020 0.0017 0.0021 4[13C]glutathione 0.0109 0.0100 0.0103 0.0071 0.0068 0.0074 0.0039 0.0042 0.0054 0.0061 0.0056 0.0064 4[13C]glutathione disulfide_pos 0.0203 0.0224 0.0215 0.0130 0.0152 0.0174 0.0074 0.0058 0.0100 0.0138 0.0109 0.0138 4[13C]heptadecanoyl carnitine 4[13C]methionine 0.0008 0.0007 0.0008 0.0006 0.0013 0.0020 0.0009 0.0007 0.0008 0.0010 0.0014 0.0030 4[13C]N6N6N6-Trimethyl-L-lysine 4[13C]NAD+ 0.0037 0.0032 0.0029 0.0208 0.0217 0.0233 0.0066 0.0061 0.0023 0.0197 0.0193 0.0185 4[13C]proline 0.0004 0.0006 0.0007 0.0018 0.0013 0.0017 0.0003 0.0004 0.0003 0.0042 0.0040 0.0033 4[13C]S-adenosyl-L-methionine 4[13C]S-methyl-5-thioadenosine 0.0021 0.0019 0.0023 0.0004 0.0002 5[13C]adenine 0.0003 0.0005 0.0006 0.0001 0.0001 0 0.0001 0.0004 0.0006 0.0001 0.0001 0 5[13C]adenosine 0.0019 0.0030 0.0027 0.0707 0.0744 0.0719 0.0023 0.0041 0.0038 0.0287 0.0318 0.0308 5[13C]betaine 5[13C]carnitine 5[13C]choline 0 5[13C]glutamine 0 0 0.0001 0.0001 0 0.0003 0.0003 0.0004 5[13C]glutathione 0.0029 0.0028 0.0032 0.0016 0.0017 0.0019 0.0008 0.0016 0.0013 0.0010 0.0015 5[13C]glutathione disulfide_pos 0.0068 0.0065 0.0068 0.0013 0.0016 0.0030 0.0002 0.0013 0.0021 0.0013 0.0009 0.0020 5[13C]heptadecanoyl carnitine 5[13C]methionine 5[13C]N6N6N6-Trimethyl-L-lysine 5[13C]NAD+ 0.0248 0.0261 0.0243 0.2687 0.2562 0.2690 0.0399 0.0374 0.0379 0.1720 0.1603 0.1718 5[13C]proline 0 0.0001 0 0.0005 0.0015 0.0009 0.0001 0.0012 0.0012 0.0019 5[13C]S-adenosyl-L-methionine 0.0009 0.0005 0.0005 0.0182 0.0193 0.0207 0.0048 0.0068 0.0033 0.0056 5[13C]S-methyl-5-thioadenosine 0.0315 0.0301 0.0327 0.0114 0.0122 0.0114 6[13C]adenosine 6[13C]carnitine 6[13C]glutathione 6[13C]glutathione disulfide_pos 0.0004 0.0015 0.0017 0.0005 6[13C]heptadecanoyl carnitine 6[13C]N6N6N6-Trimethyl-L-lysine 6[13C]NAD+ 0.0037 0.0038 0.0054 0.0010 0.0021 0.0019 0.0023 6[13C]S-adenosyl-L-methionine 0 6[13C]S-methyl-5-thioadenosine 0.0013 0.0002 0.0003 0.0004 0.0004 0.0006 0 7[13C]adenosine 0 7[13C]carnitine 7[13C]glutathione 7[13C]glutathione disulfide_pos 7[13C]heptadecanoyl carnitine 0 0.0001 0.0007 0.0010 0.0008 0.0007 0.0004 0.0009 0.0001 7[13C]N6N6N6-Trimethyl-L-lysine 7[13C]NAD+ 0.0072 0.0055 0.0057 0.0002 0.0045 0.0025 0.0040 7[13C]S-adenosyl-L-methionine 0.0149 0.0082 0.0045 0.0019 0.0020 0.0004 0.0206 0.0181 0.0162 0.0048 0.0014 7[13C]S-methyl-5-thioadenosine 0.0001 8[13C]adenosine 8[13C]glutathione 0.0001 0 0 0.0002 0.0002 0 8[13C]glutathione disulfide_pos 8[13C]heptadecanoyl carnitine 0.0152 0.0251 0.2591 0.0004 0.3620 0.2814 0.2495 0.1478 0.3337 0.0348 8[13C]N6N6N6-Trimethyl-L-lysine 8[13C]NAD+ 0.0009 8[13C]S-adenosyl-L-methionine 0.0012 8[13C]S-methyl-5-thioadenosine 9[13C]adenosine 9[13C]glutathione 9[13C]glutathione disulfide_pos 9[13C]heptadecanoyl carnitine 0.1798 9[13C]N6N6N6-Trimethyl-L-lysine 9[13C]NAD+ 0.0003 0.0013 9[13C]S-adenosyl-L-methionine 9[13C]S-methyl-5-thioadenosine adenine Adenine 0.9997 0.9995 0.9994 0.9999 0.9999 1 0.9998 0.9996 0.9994 0.9998 0.9999 1 adenosine Adenosine 0.9954 0.9947 0.9941 0.9222 0.9163 0.9214 0.9950 0.9931 0.9932 0.9654 0.9656 0.9654 Betaine Betaine 1 1 1 1 1 1 1 1 1 1 1 1 carnitine Carnitine 1 0.9993 1 1 1 0.9998 1 1 1 0.9998 1 1 choline Choline 1 1 1 1 1 1 1 1 1 1 1 1 glutamine Glutamine 0.9956 0.9965 0.9962 0.9957 0.9955 0.9959 0.9970 0.9972 0.9965 0.9888 0.9887 0.9892 glycine Glycine 0.9962 1 0.9991 1 0.9988 1 1 1 1 1 0.9989 1 GSH Glutathione 0.9105 0.9204 0.9152 0.9456 0.9470 0.9426 0.9504 0.9546 0.9473 0.9528 0.9577 0.9532 GSSG Oxidized glutathione 0.8163 0.8185 0.8210 0.8819 0.8801 0.8763 0.8910 0.8886 0.8831 0.9098 0.9247 0.8977 heptadecanoyl carnitine CAR 17:0 0.9847 1 0.9748 0.9849 0.6541 0.8198 0.6281 0.7178 0.7497 0.8518 0.6653 0.9651 methionine Methionine 0.9987 0.9993 0.9992 0.9994 0.9987 0.9980 0.9991 0.9993 0.9992 0.9990 0.9986 0.9970 N6N6N6-Trimethyl-L-lysine N-6-Trimethyllysine 0.9998 0.9998 1 1 0.9995 0.9990 0.9996 0.9903 0.9960 0.9996 1 0.9995 N-acetylneuraminic acid N-Acetylneuraminic acid 0.9728 0.9761 0.9750 0.9676 0.9709 0.9687 0.9603 0.9632 0.9628 0.9627 0.9654 0.9654 N-acetylneuraminic acid-1 0.0012 0.0002 N-acetylneuraminic acid-10 0.0003 0.0003 0.0004 0.0002 0.0004 0.0012 0.0006 0.0008 N-acetylneuraminic acid-11 0.0006 0.0004 0.0002 N-acetylneuraminic acid-2 N-Acetylneuraminic acid 0.0139 0.0127 0.0126 0.0123 0.0127 0.0116 0.0273 0.0284 0.0282 0.0120 0.0112 0.0128 N-acetylneuraminic acid-3 0.0112 0.0098 0.0107 0.0174 0.0152 0.0182 0.0060 0.0047 0.0060 0.0167 0.0165 0.0173 N-acetylneuraminic acid-4 N-acetylneuraminic acid-5 0.0013 0.0004 0.0005 N-acetylneuraminic acid-6 0.0003 0.0008 0.0002 0.0041 0.0006 0.0009 0.0035 0.0028 0.0014 N-acetylneuraminic acid-7 0.0003 0.0009 0.0011 0.0002 0.0001 0.0004 N-acetylneuraminic acid-8 0.0002 0.0002 0.0008 0.0005 0.0024 0.0018 0.0009 N-acetylneuraminic acid-9 0.0004 0.0009 0.0010 0.0011 0.0004 0.0011 0.0009 0.0004 0.0014 0.0012 0.0014 NAD+ NAD 0.9134 0.9133 0.9199 0.6363 0.6454 0.6348 0.8849 0.8816 0.8889 0.7470 0.7593 0.7446 O-acetylcarnitine CAR 2:0 0.5841 0.5623 0.5697 0.3100 0.3081 0.3085 0.7932 0.7942 0.7874 0.4780 0.4723 0.4769 O-acetylcarnitine-1 0.0136 0.0145 0.0146 0.0277 0.0270 0.0270 0.0061 0.0055 0.0065 0.0314 0.0314 0.0313 O-acetylcarnitine-2 CAR 2:0 0.4023 0.4231 0.4157 0.6623 0.6649 0.6645 0.2006 0.2003 0.2061 0.4906 0.4963 0.4918 O-acetylcarnitine-3 O-acetylcarnitine-4 O-acetylcarnitine-5 0 0 0.0001 0.0001 0 O-acetylcarnitine-6 O-acetylcarnitine-7 0 O-acetylcarnitine-8 O-acetylcarnitine-9 proline Proline 0.9952 0.9934 0.9939 0.9898 0.9900 0.9893 0.9957 0.9948 0.9945 0.9780 0.9777 0.9806 propionyl-carnitine CAR 3:0 0.9979 0.9988 0.9988 0.9950 0.9955 0.9953 0.9980 0.9990 0.9978 0.9745 0.9738 0.9756 propionyl-carnitine-1 0.0010 0.0007 0.0003 0.0039 0.0018 0.0010 0.0004 0.0153 0.0146 0.0132 propionyl-carnitine-10 propionyl-carnitine-2 0.0004 0.0016 0.0026 0 0.0010 0.0067 0.0078 0.0079 propionyl-carnitine-3 0 0.0002 0.0001 0.0011 0.0011 0.0011 0.0034 0.0035 0.0033 propionyl-carnitine-4 propionyl-carnitine-5 0.0006 0.0003 0.0007 0.0001 0 0.0015 0.0009 0.0011 0.0002 0.0003 0.0001 propionyl-carnitine-6 propionyl-carnitine-7 0.0001 0.0001 propionyl-carnitine-8 propionyl-carnitine-9 S-adenosyl-L-methionine S-Adenosylmethionine 0.9842 0.9913 0.9950 0.9798 0.9787 0.9789 0.9782 0.9751 0.9838 0.9885 0.9967 0.9930 serine Serine 0.9892 0.9912 0.9922 0.9862 0.9852 0.9858 0.9841 0.9876 0.9871 0.9861 0.9926 0.9840 S-methyl-5-thioadenosine 5'-Methylthioadenosine 1 0.9982 0.9996 0.9625 0.9640 0.9607 1 0.9994 1 0.9874 0.9858 0.9875