Metabolite_name RefMet_name FMT1 FMT2 FMT3 FMT4 FMT5 FMT6 FMT7 FMT8 FMT9 FMT10 FMT11 FMT12 FMT13 FMT14 FMT15 FMT16 FMT17 FMT18 Factors - Factor:Control Factor:Control Factor:Control Factor:Control Factor:Control Factor:Control Factor:Control Factor:Control Factor:Control Factor:FMT Factor:FMT Factor:FMT Factor:FMT Factor:FMT Factor:FMT Factor:FMT Factor:FMT Factor:FMT 2_5-Dihydroxybenzoate Gentisic acid 23 21 18 15 18 20 13 23 17 14 40 33 28 19 22 21 2-Hydroxybutyrate 2-Hydroxybutyric acid 22 21 2-Hydroxyglutarate 2-Hydroxyglutaric acid 625 775 271 238 223 287 389 162 250 133 156 174 33 29 22 30 38 35 2-Hydroxypentanoate 2-Hydroxyvaleric acid 132 118 107 52 56 60 53 105 55 58 193 126 2-Isopropylmalate 2-Isopropylmalic acid 2.5000 4.1000 2.6000 3.8000 2.2000 2.7000 2.9000 3.6000 2.4000 3.8000 2-Oxoglutarate 2-Oxoglutaric acid 1197 626 500 929 472 498 628 373 1005 1140 370 166 2-Oxoisopentanoate Ketoisovaleric acid 42 28 3-Hydroxybutyrate 3-Hydroxybutyric acid 154 94 65 43 33 39 41 70 45 99 72 69 61 56 46 73 74 44 3-Methylbutanoate Isovaleric acid 233 136 125 88 107 176 220 146 180 159 79 199 183 100 120 227 299 468 3PG 3-Phosphoglyceric acid 98 105 74 48 42 35 62 109 41 43 55 28 21 19 24 21 16 37 3-Phenyllactate Phenyllactic acid 192 128 142 73 94 99 169 149 129 249 211 200 126 90 100 123 118 115 3-Phenylpropionate Hydrocinnamic acid 464 293 331 293 315 320 456 292 369 303 408 302 307 253 228 255 257 230 4-Oxopentanoate Levulinic acid 34 26 26 30 20 31 35 32 20 34 20 4-Pyridoxate 4-Pyridoxic acid 13 12 13 6.1000 4.7000 6.2000 4.4000 8.8000 6.6000 11 5.7000 7.1000 12 9.3000 14 9.7000 11 11 5-Oxoproline Pyroglutamic acid 1680 654 339 1094 1217 869 356 341 102 1198 854 1029 74 528 781 507 152 219 Acetyl CoA Acetyl-CoA 15 31 31 22 22 22 43 36 40 19 19 13 7.8000 10 9.2000 8.2000 18 14 ADP ADP 79 43 40 28 36 30 44 39 37 36 51 18 14 17 11 11 18 19 AMP AMP 85 56 44 129 112 89 75 50 49 138 133 124 59 29 23 27 33 80 Azelate Azelaic acid 98 80 79 51 57 58 65 99 70 91 52 79 76 72 85 77 88 82 Butyrate Butyric acid 617 308 352 167 238 340 709 354 443 632 376 643 1372 693 864 824 1129 1539 Cholate Cholic acid 35 29 25 96 128 597 35 32 25 122 192 139 691 1260 502 834 352 621 cis-Aconitate cis-Aconitic acid 7.2000 Citraconate Citraconic acid 5.3000 8.7000 6 3.2000 4.4000 4.1000 6.3000 3.8000 4.9000 4 Citramalate Citramalic acid 21 57 24 16 17 13 27 7.4000 15 9.1000 9.5000 29 21 25 21 22 10 Citrate Citric acid 307 623 55 101 152 84 123 152 126 164 157 137 57 43 40 40 33 122 CMP CMP 8.4000 6.8000 10 22 16 13 16 11 10 34 19 25 13 7.4000 12 11 9.5000 18 Cysteate Cysteic acid 59 35 30 40 37 41 47 36 46 56 45 49 5.9000 6.7000 7.4000 9.9000 10 Cysteine S-sulfate Cysteine-S-sulfate 8 6.5000 7 DCA Deoxycholic acid 72 47 57 11 13 81 179 179 223 227 113 Decanoate Capric acid 9.7000 7.4000 9.9000 7.5000 7.3000 10 Dodecanedioate Dodecanedioic acid 6.8000 7.1000 1.5000 6.1000 7.7000 8.5000 13 6.8000 10 38 28 36 29 33 34 dTMP dTMP 25 12 19 21 19 17 20 17 20 45 26 36 27 23 27 22 19 36 F6P Fructose 6-phosphate 40 32 35 38 33 34 40 30 34 57 42 33 18 15 FAD FAD 29 15 10 13 13 10 26 18 28 26 24 12 11 8.5000 6.1000 9.1000 11 Fumarate Fumaric acid 63 28 54 20 G1P Glucose 1-phosphate 25 22 23 35 39 32 29 27 15 38 26 21 16 G6P Glucose 6-phosphate 260 168 133 168 181 147 195 133 110 249 249 132 28 21 28 15 19 31 Glutarate Glutaric acid 92 66 78 35 26 35 30 18 47 56 44 80 38 63 28 25 29 Glycerate Glyceric acid 227 105 116 143 132 149 194 169 125 144 112 191 Glycerophosphate sn-Glycero-3-phosphate 179 155 117 94 142 163 121 237 109 141 131 125 78 72 51 74 84 87 Glycolate Glycolic acid 209 273 322 249 265 257 413 269 265 282 215 401 337 326 387 305 362 Heptanoate Heptylic acid 8.2000 Hexanoate Caproic acid 20 14 12 14 15 8.7000 21 Isethionate 2-Hydroxyethanesulfonate 38 26 32 26 31 31 39 39 33 57 33 65 12 17 Isocitrate Isocitric acid 13 15 13 12 13 21 13 14 Lactate Lactic acid 880 1130 1051 1042 1812 1176 1081 1563 751 1169 1222 1166 1735 4521 1539 1611 1440 1919 Malate Malic acid 255 642 155 126 202 138 96 182 88 275 137 173 38 38 42 30 30 37 Malonate Malonic acid 256 342 289 129 157 185 200 419 224 199 109 141 N-Acetylaspartate N-Acetylaspartic acid 71 133 68 92 75 90 63 58 46 180 99 116 76 90 44 51 81 102 N-Acetylglucosamine 1-phosphate N-Acetyl-D-glucosamine 1-phosphate 96 52 47 35 50 56 37 40 32 50 46 31 21 19 15 26 26 65 N-Acetylglucosamine 6-phosphate N-Acetyl-glucosamine 6-phosphate 91 69 65 35 53 53 75 85 71 56 39 27 17 15 17 30 24 37 N-Acetylglutamate N-Acetylglutamic acid 248 233 186 109 90 100 196 115 171 173 147 113 66 64 43 44 53 76 N-Acetylmethionine N-Acetylmethionine 18 16 49 11 9.7000 11 16 11 17 10 8.9000 6.1000 11 5.1000 14 9.8000 8 13 N-Acetylneuraminate N-Acetylneuraminic acid 56 49 53 22 18 23 17 20 30 30 27 8.4000 7.2000 12 6.7000 20 NAD+ NAD 1096 444 450 470 371 340 902 372 602 497 739 336 256 270 201 228 274 343 NADP+ NADP 51 22 23 18 25 18 43 31 31 14 23 16 12 11 11 11 13 13 Nicotinate Nicotinic acid 104 137 173 99 114 132 72 170 82 152 41 128 21 75 24 21 Octanoate Caprylic acid 12 11 8.8000 7.1000 6.8000 12 O-Phosphoserine Phosphoserine 50 31 25 15 27 19 75 77 55 17 16 11 8.1000 5.9000 6.7000 11 8.2000 13 Pantothenate Pantothenic acid 9.4000 11 6.3000 18 11 17 8 5.3000 3.6000 6.7000 7.1000 Pelargonate Pelargonic acid 14 12 11 6.7000 7.4000 13 20 22 11 15 9.7000 26 25 27 21 28 27 Pentanoate Valeric acid 356 Phthalate Phthalic acid 4 3 3.3000 2.5000 2.6000 2.5000 2.2000 2.2000 1.9000 3.8000 3.6000 3.5000 2.6000 3.1000 3.3000 2.4000 2.2000 2 p-Hydroxyphenylacetate 4-Hydroxyphenylacetic acid 156 107 226 100 293 Pimelate Pimelic acid 22 8 14 9.7000 13 7.9000 11 8.3000 11 19 25 13 8.9000 6.9000 9.8000 5.5000 8.4000 7.1000 Proline betaine Proline betaine 16 15 8.5000 3.9000 4.6000 4.5000 13 25 12 4.9000 4.4000 10 5.3000 11 10 13 15 Propionate Propionic acid 3431 3153 3518 2280 2872 4450 5057 3318 4391 3545 1896 3474 9132 5902 6336 4956 5660 8975 Ru5P Ribulose 5-phosphate 34 24 45 39 29 21 39 96 34 60 S7P Sedoheptulose 7-phosphate 69 59 58 50 45 44 62 45 60 65 47 49 8.6000 6.7000 14 20 Sebacate Sebacic acid 4.9000 3.8000 3.4000 3.1000 3.9000 4.1000 4.9000 7.8000 8.5000 5.2000 5.4000 5.5000 7.8000 7 7.4000 8.3000 7.7000 8.7000 Shikimate Shikimic acid 250 187 117 153 163 211 190 203 177 44 36 29 50 40 30 51 38 72 Succinate Succinic acid 3691 7612 2872 1535 1443 1555 1745 3961 1590 2598 1693 1911 955 622 558 482 522 654 Taurocholate Taurocholic acid 125 294 276 254 149 474 87 180 102 988 640 492 55 218 60 59 49 68 Threonate Threonic acid 152 203 204 93 131 214 156 243 159 154 177 265 161 78 180 299 354 484 trans-4-Hydroxy-3-methoxycinnamate trans-Ferulic acid 44 18 43 29 49 42 46 54 18 26 46 31 18 21 23 17 UDP UDP 50 26 32 19 33 33 58 29 33 33 44 18 12 15 15 14 15 22 UDP-glucose UDP-glucose 44 25 23 9.5000 14 14 41 12 17 14 36 9.6000 8.2000 10 8.4000 6.4000 9 9.6000 UDP-glucuronate UDP-glucuronic acid 23 18 14 UDP-N-acetylglucosamine UDP-N-acetylglucosamine 136 45 51 15 29 39 73 33 58 21 44 17 27 34 29 38 36 54 UMP UMP 46 20 27 95 77 60 40 41 27 132 97 71 30 18 24 17 22 59 Urate Uric acid 64 60 54 66 57 48 39 61 43 99 77 81 55 64 49 42 55 68