Metabolite_name RefMet_name M35 M36 M37 M38 M39 M62 M63 M64 M65 M66 M10 M11 M12 M28 M29 M30 M53 M54 M55 M9 Factors - Group:ALI 6mth Group:ALI 6mth Group:ALI 6mth Group:ALI 6mth Group:ALI 6mth Group:ALI 6mth Group:ALI 6mth Group:ALI 6mth Group:ALI 6mth Group:ALI 6mth Group:Sham 6mth Group:Sham 6mth Group:Sham 6mth Group:Sham 6mth Group:Sham 6mth Group:Sham 6mth Group:Sham 6mth Group:Sham 6mth Group:Sham 6mth Group:Sham 6mth 2-Aminoadipic acid alpha-Aminoadipic acid 16.9500 17.8400 17.5800 13.8500 18.9400 17.3400 12.6000 18.4200 18.8700 19.7100 18.0200 18.5000 17.7600 18.1900 17.7600 17.3900 18.6400 2-Hydroxyglutaric acid 2-Hydroxyglutaric acid 15.0400 14.2200 14.8400 14.7500 15.2100 15.4900 15.1400 14.3800 15.1600 15.4000 16.6100 15.7600 16.0300 15.1100 15.6000 14.7500 13.2200 13.5500 14.5900 14.8700 2-Hydroxypyridine 2-Hydroxypyridine 16.1300 16.2200 16.6300 16.1300 16.7000 16.1200 16.3500 16.9500 16.3700 16.5400 18.0600 16.3400 16.2900 16.2600 16.1400 16.3500 16.4600 16.2300 16.2300 16.8800 2-Phosphoglyceric acid 2-Phosphoglyceric acid 14.7700 13.2300 14.5500 14.2300 12.5800 12.6600 12.9000 12.7600 3-Phosphoglyceric acid 3-Phosphoglyceric acid 15.9900 17.0200 18.0500 16.1000 17.5000 18.9600 18.0500 17.5300 17.4700 16.7400 17.3400 17.4600 17.4600 16.8200 16.3700 17.8200 16.4800 16.3800 Adenine Adenine 13.0400 13.9100 13.0400 13.1900 14.1700 14.2300 15.9100 13.4500 13.3600 12.5600 12.8200 12.5000 12.2400 Adenosine-5-monophosphate AMP 15.6400 16.2200 17.2700 18.1600 19.6500 16.0400 18.5600 17.0500 18.6200 19.7600 18.5600 17.5700 18.6900 17.0700 15.5500 16.5700 16.7500 16.3500 18.9100 16.9500 Adenosine/Inosine 15.8900 14.3100 14.2300 16.3100 14.4900 16.3700 14.8900 16.6900 13.5500 16.8700 14.2500 15.8300 14.0700 15.9700 16.9800 15.5500 16.6500 Alanine Alanine 18.8500 18.8100 19.2000 18.3300 18.9700 19.0100 18.4100 19.4000 18.8700 18.4100 21.1600 19.2200 19.1100 18.4500 19.2500 18.8400 18.4900 19.0300 18.8200 19.6300 alpha-Monopalmitin MG 16:0/0:0/0:0 20.0300 20.2200 20.1100 20.1200 20.5600 20.1400 20.3400 21 20.5000 20.7300 21.0100 20.3000 20.1800 20.0100 20 20.4500 20.3400 20.2700 20.1700 20.5400 alpha-Monostearin MG 18:0/0:0/0:0 22.7300 22.9800 22.8500 22.7400 23.0500 22.6900 22.8100 23.4200 22.9200 23.4100 23.7900 22.8100 22.6800 22.7800 22.7600 23.0900 23 22.8800 22.6700 23.4200 alpha-Tocopherol alpha-Tocopherol 12.3200 12.4500 13.0900 12.5700 13.3700 12.5700 12.6000 12.1100 Aminomalonic acid Aminomalonic acid 15.7400 16.1300 17.2500 16.5900 16.5100 16.2300 16.2900 16.7800 16.2200 16.6300 14.9100 15.3600 15.6900 15.4900 14.5600 15.1600 16 15.6200 16.1600 16.1000 Arachidic acid/ 1-Heneicosanol 12.1600 12.1800 12.7900 12.0400 13.3100 13.7700 11.7900 11.5000 12.6900 13.3700 12.9300 10.1800 11.5200 Arachidonic acid (also Eicosapentaenoic acid) Arachidonic acid 15.5900 15.2300 15.4300 15.3500 14.7400 15.6700 16.7500 16.1900 15.8700 16.1200 15.9900 15.8900 15.2800 13.9600 14.6700 14.2900 15.9500 16.0400 15.7100 Aspartic acid Aspartic acid 15.6200 15.5100 15.7900 15.4000 16.5000 16.3000 16.2500 17.0200 17.7000 17.0300 17.5000 15.9300 15.6700 16.0500 16.4100 17.6600 Benzoic acid Benzoic acid 15.8300 15.7800 16.1400 15.7000 16.3700 15.2700 16.1100 16.7000 15.9400 16.2800 17.6000 16.0200 15.8500 15.8000 14.3300 11.3400 16.0900 15.6900 15.6900 16.9100 beta-Alanine beta-Alanine 16.4300 15.6500 16.9300 16.4600 17.6500 16.7200 16.9400 17.4700 15.9100 17.2100 15.4900 15.9800 15.4900 15.9100 15.2700 15.9300 15.9700 15.9100 15.7300 15.9900 beta-Hydroxybutyric acid 3-Hydroxybutyric acid 16.2900 15.3600 15.9100 16.1100 16.0600 14.6300 15.7100 17.6100 15.0600 17.4700 14.1200 15 15.2000 15.4300 beta-Monopalmitin MG 0:0/16:0/0:0 15.0200 15.0800 13.3900 14.1800 13.5400 14.9000 15.4000 14.8600 15.0100 15.7300 14.4100 13.8900 15.0900 15.5900 13.3100 14.3600 beta-Monostearin MG 0:0/18:0/0:0 16.8800 17.2200 16.9600 17.0800 17.6100 16.9600 17.2400 17.8800 17.4700 18.1300 18.1800 17.1600 17.0100 16.9900 16.8300 17.6500 17.6100 17.3000 17.2000 17.5100 Campesterol Campesterol 13.4900 13.4700 Cholesterol Cholesterol 22.0200 22.1500 21.5800 21.4700 22.1200 22.0200 21.8000 22.8000 21.9700 22.7300 23.0800 22.4800 22.0100 22.2600 22.4700 21.9300 22.1300 22.6200 22.4900 22.9400 Citric acid/isocitric acid Citric acid/Isocitric acid 17.5500 16.5800 17.5800 17.8400 18.0900 17.0100 17.9500 18.0700 18.0100 18.6700 18.4000 16.9900 17.3700 17.2700 17.2700 17.2500 17.7600 17.8700 17.5600 16.9100 Creatinine Creatinine 22.7300 22.7200 22.8700 22.5600 22.7000 22.6600 22.8600 23.9300 22.9000 22.9000 24.3000 23.1200 22.9600 22.4800 22.7800 22.4900 22.2900 22.5800 22.1200 23.0600 Dehydroalanine (possibly from cysteine) 2-Aminoacrylic acid 16.0600 16.5300 16.2900 16.0500 16.7900 16.9400 16.7300 16.8300 16.7900 16.8600 14.5600 16.7400 16.8700 16.6900 16.6100 16.0200 14.2800 17.2200 16.7300 17.3800 Dehydroascorbic acid L-Dehydroascorbic acid 16.4500 16.3700 16.9200 16.1300 17.6700 17.0100 17.4100 17.9500 17.3200 16.7100 18.6600 16.9300 17.2600 17.0100 16.9500 16.4900 17.0400 17.0700 16.9300 17.1100 Dihydroxyacetone phosphate Dihydroxyacetone phosphate 14.1400 13.5000 14.2500 14.0700 14.1500 Docosahexaenoic acid Docosahexaenoic acid 18.4500 17.9900 18.0400 17.6900 18.1800 18.8900 18.8200 18.9900 19.4600 18.8100 18.8600 18.8600 18.9900 18.0700 18.1100 17.5800 17.5500 19.1200 18.6600 18.1800 Ethanolamine Ethanolamine 14.7400 14.7100 15.0600 14.8200 14.9600 15.4800 15.7900 14.6800 15.1400 15.1500 15.7000 15.1400 15.6200 14.3700 14.2600 15.2600 14.4100 14.3300 Fructose 1_6-bisphosphate Fructose 1,6-bisphosphate 15.7200 15.3000 15.6400 17.3100 14.5700 11.5300 Fructose-6-phosphate Fructose 6-phosphate 15.4300 19.4300 13.6400 19.9400 17.2400 17.7800 19.8200 18 20.4900 21.0600 19.3500 19.6500 18.1300 19.6900 17.5000 20.3600 18.4300 15.9800 19.6200 Fructose or similar ketohexose Ketohexose 14.6900 15.0200 12.6100 13.1500 12.6600 12.7700 16.4200 13.0200 14.8300 13.9500 14.6100 12.9100 14.1500 13.0200 14.3300 14.1200 Fumaric acid Fumaric acid 16.8300 16.1100 15.7100 16.2100 16 15.9600 15.9300 16.0100 15.7900 15.5600 17.7300 16.7200 16.6300 15.5500 16.2100 15.2600 14.7300 16.0200 14.0900 16.0200 gamma-Hydroxybutyric acid 4-Hydroxybutyric acid 16.1500 16.1100 15.7700 15.0800 16.0800 Glucose-6-phosphate Glucose 6-phosphate 17.5400 21.3600 14.6300 21.7100 19.0200 20.2100 21.6000 20.3500 20.4900 22.7700 21.5800 21.9300 20.2200 21.6100 19.8500 22.2300 20.7800 18.2900 19.6200 Glucose and other aldohexoses Hexose 21.8700 21.8700 23.0300 20.7200 22.9200 23.3800 22.6400 23.9500 22.4300 23.5100 23.5400 21.1500 21.1900 21.9500 22.6600 22.3700 22.7800 22.6900 21.2100 22.6000 Glutamic acid Glutamic acid 18.0700 17.9300 18.5100 17.0300 18.6200 19.8600 19.6800 19.7200 20.1900 19.8600 17.4200 17.8200 17.8500 17.2000 17.1300 17.6100 18 19.3200 19.6600 16.9600 Glutamine Glutamine 16.3000 16.5400 17.6200 16.6000 16.8800 17.4900 16.6700 19.1700 16.4500 17.6000 16.1100 16.4000 16.2400 15.7100 15.2000 16.2500 17.1700 16.1800 16.5700 16.3900 Glutathione (reduced) Glutathione 15.3100 13.3900 14.3400 14.9200 14.2100 14.9600 12.8200 14.7400 11.3900 Glycerol Glycerol 18.9000 19.2600 19.3800 18.9900 19.5900 18.9100 19.8400 19.2500 22.0100 19.3500 19.9900 19.8300 20.3300 18.9900 19.2900 16.8700 21.9500 20 Glycerol 1-phosphate sn-Glycero-3-phosphate 18.0400 19.7100 20.1200 17.7300 20.4000 19.3000 20.3700 21.4900 20.6600 19.9600 20.6800 20.6700 21.3300 20.0300 20.7200 19.8000 19.8700 20.6800 18.3900 19.0600 Glycine Glycine 21.0600 21.3900 22.2800 21.7300 21.4200 21.3700 21.5100 22.3700 20.2300 21.5700 21.7500 20.9600 21.1000 20.8800 20.4800 20.9600 21 20.7200 21.1100 21.8900 Heptadecanoic acid/Octadecanol 15.7900 15.6800 15.8400 15.7100 16.0900 15.5300 16.0700 16.6400 16.1200 16.5500 17.1000 15.9000 15.9300 15.7700 16.1800 16.1900 15.8900 15.8100 15.7700 16.1100 Hexitols 16.8100 14 14.8500 14.8800 15.4200 14.5800 14.8700 15.9100 15.4000 15.3400 16.7700 14.8500 17.5100 17.6900 17.3800 14.5900 12.2700 14.3800 15 15.5400 Hexuronic acid Hexuronic acid 14.5300 14.3200 15.1300 Hydroxyprolines 15.8600 15.0800 16.3400 15.4600 17.3100 17.3300 16.7200 18.5900 16.7900 17.6200 16.4300 15.6000 14.5300 15.0600 14.5300 15.7300 15.8900 15.7900 15.6200 15.8700 Hypotaurine Hypotaurine 16.1600 16.3000 17.7600 17.5700 17.6300 16.5100 17.3900 16.8200 16.6000 16.6400 16.2300 17.8200 16 16.5900 16.6200 15.6000 16.9900 17 16.7400 Hypoxanthine Hypoxanthine 10.6800 12.0200 13.0300 12.7200 13.5600 15.0500 13.1200 13.5500 12.5900 10.5700 14.0200 Inosine 5^-monophosphate IMP 21.0100 21.1400 19.2700 19.7800 16.7200 21.2800 19.5400 21.9500 20.3300 20.4600 20.8200 20.4800 20.4500 20.2700 21.3500 20.6800 19.6600 21.4100 14.5400 21.5700 Isoleucine Isoleucine 15.3400 14.4400 15.5900 15.1000 15.5200 15.1100 15.8000 16.9100 15.5500 16.0300 16.8500 15.0700 15.9700 15.3700 15.3300 14.4900 14.4400 14.2300 15.1500 15.6100 Ketopentose-5-phosphate 12.9200 13.3400 13.5100 11.9400 13.3300 Lactic acid Lactic acid 23.9600 24.5200 24.5000 23.3700 23.9600 25.3400 24.1800 25.5000 23.9600 23.9600 26.2500 24.5500 24.3900 24.6000 25.1000 24.5100 24.5500 24.3700 22.8100 25.5900 Linoleic acid Linoleic acid 17.0600 16.4900 17.3600 16.8300 17.3900 16.9500 16.5500 17.7900 17.6000 17.4000 16.7000 17.3600 16.6800 16.4000 16.7400 16.4000 16 17.1600 16.5600 16.6700 Lysine Lysine 18.8000 17.6600 19.0300 17.8000 17.7900 19.3700 17.7800 20.6200 18.5200 18.9200 20.1000 19.5500 18.0500 18.3400 18.3100 19.1700 18.2400 18.0800 17.8100 19.1700 Malic acid Malic acid 20.0400 19.2800 18.8700 19.5600 18.7100 19.0900 18.5700 19.2700 18.5000 18.5100 20.4800 19.8800 19.8400 18.7500 19.1600 18.5400 17.8700 18.6900 17.1000 19.1100 Maltose or similar disaccharide Maltose 16.0500 16.2700 16.8100 12.1300 14.5600 18.8200 15.1300 17.7100 15.9700 15.2700 15.6500 15.1000 15 16.3600 17.6200 15.6000 16.3100 16.1900 14.7000 16.7000 Mandelic acid Mandelic acid 15.2500 14.7600 14.6500 16.0100 15.3000 17.0800 15.6500 15.2300 14.7400 15.5300 14.7900 15.6100 15.0800 15.0600 15.1800 Methionine Methionine 15.6200 16.2400 17.0200 17.5000 15.8300 15.9300 16.5000 16.1300 15.6700 16.0500 15.9000 Myoinositol Myo-inositol 20.1300 19.8500 19.7600 19.2000 20.5500 19.9000 20.1200 20.1600 20.1800 20.5900 21.4000 20.1900 20.2600 20.4400 20.5400 19.6900 20.1100 20.2600 20.1500 20.6100 Myoinositol-2-phosphate myo-Inositol 2-phosphate 14.5900 14.5400 15.9600 13.6200 14.6700 13.8700 14.1300 14.0900 13.9300 14.0600 15.1600 13.3200 14.6200 Myristic acid or Pentadecanol Myristic acid 17.5800 17.8400 17.7100 17.5600 18.0500 17.2200 17.8600 18.6300 18.0300 18.1700 19.2500 17.5800 17.5900 17.7900 17.8500 17.8500 17.7800 17.5700 17.6000 18.1100 N-Acetylaspartic acid N-Acetylaspartic acid 15.6500 14.1200 13.5100 Nicotinamide Niacinamide 15.2500 14.7300 14.7600 14.6500 15.4800 16.0100 15.3000 17.0800 15.6500 15.2300 14.7400 14.2500 15.5300 14.7900 15.6100 15.0800 15.0600 15.1800 Oleic acid Oleic acid 17.5700 17.6800 17.8800 17.5500 18.4300 17.7800 17.6400 18.3600 18.1400 18.0600 18.0800 17.7700 17.4500 18.0900 18.0300 17.8500 18.1400 18.4600 17.8100 18.2400 O-Methylphosphate Methanolphosphate 12.9900 13.0100 13.5300 14.2200 14.9200 Ononitol or similar methoxyinositol 12.9000 15.2000 15.0900 15.3100 16.2400 15.1100 15.7000 16.3000 14.1300 14.2600 14.5500 15.3800 14.4100 14.8600 15.0200 13.9200 15.2100 O-Phosphocolamine Phosphoethanolamine 14.8800 14.7700 15.0200 15.7000 16.7000 15.6900 16.2500 13.1800 16.7500 16.2700 12.8200 15.0600 15.5100 15.7900 15.8400 15.6500 16.2200 16.5400 16.4400 14.0400 Ornithine Ornithine 14.2500 14.3100 14.1200 14.8500 12.4900 15.6700 14.6000 15.9700 14.2300 13.5500 14.4300 13.6300 13.6500 Palmitic acid Palmitic acid 21.5500 21.6600 21.5500 21.7500 21.9000 21.5700 21.8700 22.6700 22.1000 22.0100 22.8400 21.8300 21.8800 21.6700 21.7300 21.7000 21.6500 21.8000 21.6900 22.0500 Palmitoleic acid Palmitoleic acid 15.3500 16.2700 15.6500 14.4600 13.6800 15.6300 14.8000 15.1400 Pantothenic acid Pantothenic acid 12.0300 12.7500 12.7100 12.8800 Pentadecanoic acid/Hexadecanol 13.6900 13.7600 13.6400 13.8300 13.5000 14.4700 14.3300 14.3000 13.9100 15.3600 14.1900 14.5400 14.0800 14.3100 14.1900 13.6100 13.5400 Pentitols Arabitol 13.1300 12.7600 14.1000 15.1100 15.1400 14.8600 13.8300 13.1000 13.8300 14.1600 Phenylalanine Phenylalanine 15.8200 14.3900 15.1600 15.7700 16.0300 16.4900 16.0400 17.4600 16.5500 16.5000 16.9700 15.8900 15.7700 15.6600 15.2300 15.7400 15.5700 15.8500 15.8200 15.6100 Phosphoenolpyruvic acid Phosphoenolpyruvic acid 14.1500 14.8700 12.5700 13.8500 15.5800 13.6500 13.1600 14.3900 13 13.9600 14.2300 13.2300 14.1300 13.5100 13.3100 12.7400 Phosphoric acid Phosphoric acid 25.2000 25.3500 25.0200 25.2500 25.3400 25.4200 25.1600 25.8300 25.6500 25.4300 26.1800 25.3800 25.3400 25.0800 25.2800 25.1900 24.6700 25.1400 24.8700 25.9500 Proline Proline 12.6400 12.3600 14.1500 14.1200 12.4300 14.6100 12.7400 12.3600 Pyrophosphate Pyrophosphate 15.0700 16.6700 19.5900 18.9600 20.2300 16.3300 19.3500 18.6500 19.5700 19.2700 20.6000 18.0200 18.9100 18.2600 16.9200 17.0500 18.8100 16.7900 20.4900 17.1000 Pyruvic acid Pyruvic acid 15.2200 17.2900 17.4600 15.7200 16.1900 17.3800 16.9000 18.2900 16.7100 16.6200 18.5700 15.8800 16.1500 17.3300 17.5700 17.5300 17.8500 17.2400 15.0800 18.1500 Serine Serine 17.9900 17.0600 17.5700 17.8600 17.6900 18.2000 17.8400 18.7200 17.6400 18.1100 18.7200 17.2500 17.2800 17.0500 16.8700 17.1300 16.9200 17.3000 17.6700 17.5000 Squalene Squalene 13.8500 13.7500 13.5200 13.6800 14.2300 14.0100 13.6700 14.4300 Stearic acid Stearic acid 21.8600 22.0400 21.8800 21.9900 22.0100 21.7900 22.1600 22.9400 22.2400 22.4300 23.2300 22.1400 22.1500 21.9100 21.9700 22.0700 22.0600 22 21.9200 22.3300 Succinic acid Succinic acid 16.6800 17.7200 18.1400 16.0400 17.8200 18.0800 19.4900 18.5800 18.8900 17.0200 9.0400 16.7400 Sucrose and similar disaccharides Hexose disaccharide 14.7600 15.3400 16.6600 15.4400 17.4600 15.2700 15.0800 14.3300 13.6600 14.2200 14.1000 13.4000 Taurine Taurine 24.9600 24.9400 25.2500 25.0100 25.3700 25.1600 25.3600 25.7100 25.0200 25.3500 25.8100 25.0500 25.2100 24.8000 24.9500 24.7100 24.6000 25.1400 25.0100 25.1800 Threonine Threonine 18.6300 17.7000 17.8400 17.7100 18.1400 18.2300 17.9000 18.4600 17.9300 17.7800 19.2000 17.7600 17.7500 17.3500 17.1400 17.2300 16.5800 17.7600 17.8100 18.2300 Trisaccharide Hexose trisaccharide 15.0900 16.8300 17.0400 11.9200 18.7200 15.5900 18.1300 15.0800 15.9400 15.4500 12.8700 16.5800 17.6700 16.2500 16.9700 16.8300 17.0500 Tryptophan Tryptophan 12.7500 12.8600 13.6200 13.7700 14.9100 13.4600 13.8700 15.0500 13.6900 12.7900 13.7500 13.6200 13.4000 12.6000 13.7200 Tyrosine Tyrosine 15.7700 15.7300 16.3200 16.6700 16.2600 16.5700 16.7800 17.9200 16.2100 16.5600 18.3200 16.1600 16.1200 16.1600 15.8400 15.8800 15.9500 15.7100 15.9300 16.5600 Urea Urea 22.9100 22.9400 23.2800 22.6300 23.0500 22.5700 22.8500 23.5100 23.0100 22.8900 24.5200 22.8400 22.5900 23.2200 23.0700 22.6400 22.1300 22.4100 22.5500 24.1200 Uric acid Uric acid 14.6400 13.7900 14 12.5600 13.3700 11.5000 13.3200 12.5300 14.5100 13.2800 13.9000 14.3900 13.2100 12.7900 13.4100 13.6300 Valine Valine 16.3200 15.6800 15.9500 16.9200 16.6900 16.1700 16.5100 16.8900 17.3400 16.5700 17.9800 16.6300 16.5300 16.6500 16.4800 15.5100 15.3400 15.7300 16.2500 17.4200